• Biotechnology and Bioprocess Engineering:BBE
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• 제9권2호
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• pp.86-92
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• 2004

In this paper miniaturized disposable micro/nanofluidic components applicable to bio chip, chemical analyzer and biomedical monitoring system, such as blood analysis, micro dosing system and cell experiment, etc are reported. This system includes various microfluidic components including a micropump, micromixer, DNA purification chip and single-cell assay chip. For low voltage and low power operation, a surface tension-driven micropump is presented, as well as a micromixer, which was implemented using MEMS technology, for efficient liquid mixing is also introduced. As bio-reactors, DNA purification and single-cell assay devices, for the extraction of pure DNA from liquid mixture or blood and for cellular engineering or high-throughput screening, respectively, are presented.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 춘계학술대회
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• pp.178-181
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• 2012

본 논문에서는 퍼지 콘트라스트와 HOG 기법을 이용한 감시 시스템을 제안한다. 제안된 감시 시스템은 감시 영상에서 명암 대비를 강조하기 위해 퍼지 콘트라스트 기법을 적용한 후, 감시 전/후 영상에 Substraction기법을 적용한다. Substraction 기법이 적용된 영상에서 히스토그램의 변화가 클 경우에는 침입자의 침입으로 간주한다. 침입으로 간주된 영상에서 감시 대상의 물체를 감시할 영상과 침입자를 실시간으로 추적하기 위한 영상으로 구분한다. 감시 대상의 물체를 감시할 영상에서는 퍼지 이진화를 적용한다. 퍼지 이진화를 적용한 영상에서 Blob 기법을 적용하여 객체화한 후, 침입된 침입자의 영상을 저장한다. 침입자를 실시간으로 추적할 영상에서는 HOG 기법을 적용한 후, SVM을 이용하여 움직이는 사람의 객체를 추적한다. 제안된 방법을 실시간 영상에 적용한 결과, 제안된 감시 시스템이 효율적으로 침입자를 감시하는 것을 확인할 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제16권2호
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• pp.167-174
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• 1995

Development of a noninvasive intensive care system calls for the use of evoked potentials (EPs) as a means of diagnosing traumatic head-injured patients. The experiment entails surgically placing two subarachnoid bolts and a subdural balloon through the skull to simulate a subdural hematoma. Using various levels of intracranial pressure (ICP) and/or different sizes of balloons, auditory evoked potentials (AEPs) were recorded from a rabbit. Six positive peak latencies ($P_1 - P_6$) and five negative peak latencies ($N_l- N_5$) were extracted from an averaged AEP waveform. Multiple regression analyses were performed for determining. a relationship between the ICP and AEP peak latencies. The results indicate that a major correlation of ch, mges on AEP peak latencies is due to mechanical forces of a mass (inflated balloon simulating a hematoma) in the distortion of the brain matter rather than increased ICP itself.

• Journal of the Optical Society of Korea
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• 제14권2호
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• pp.65-76
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• 2010

Plasmonic-based biosensing technologies have been successfully commercialized and applied for monitoring various biomolecular interactions occurring at a sensor surface. In particular, the recent advances in nanofabrication methods and nanoparticle syntheses provide a new route to overcome the limitations of a conventional surface plasmon resonance biosensor, such as detection limit, sensitivity, selectivity, and throughput. In this paper, optical and physical properties of plasmonic nanostructures and their contributions to a realization of enhanced optical detection platforms are reviewed. Following vast surveys of the exploitation of metallic nanostructures supporting localized field enhancement, we will propose an outlook for future directions associated with a development of new types of plasmonic sensing substrates

• 전기학회논문지
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• 제63권7호
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• pp.940-944
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• 2014

In this research, we designed representative motion patterns that possibly occurred in sleep situation and evaluated the feasibility of the smartphone based movement recording technique. For this, we designed 7 motions such as posture change, head movement, arm movement (vertical, horizontal), leg movement and hand movement (flipping, folding). Movement was recorded by using the smartphone and the actimetry device simultaneously for comparing the feasibility of smartphone based recording. As a result of experiment, we found that the smartphone based movement recording well reflects the body movement, however, it shows the limitation in recording the small local movement such as hand motion compared with the reference actimetry device, Actiwatch.

• 대한의용생체공학회:의공학회지
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• 제28권3호
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• pp.392-396
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• 2007

In this paper, we develop a new system to visualize the blood flow map in skin tissue, using the technique of Laser Speckle Flowgraphy (LSFG). The measuring unit consists of the laser diode, imaging system, line sensor, scanning mirror, and one-board microcomputer. The speckle signal is analyzed and sent to a PC, where the blood flow in a tissue area of $14mm{\times}26 mm$ is evaluated and displayed in a 2-D color map. It is demonstrated that the new LSFG instrument is useful to evaluate the degree of allergic reaction in patch test.

• 대한전자공학회논문지
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• 제25권11호
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• pp.1335-1341
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• 1988

A pH-ISEFET microprobe for in vivo measurements has been fabricated by combining ISFET (SL-IIS) chip and capillary thin film reference electrode. A two-step TCE oxidation for the gate oxide layer and multilayer encapsulation using silicone rubber and epoxy were specially used for the improvement of the stability and temperature dependence of the ISFET's. The measured sensitivit, response time and temperature dependence of the pH-ISFET microprobes are 50 mV/pH, less than one second, and - 0.01 pH/$^{\circ}$ , respectively. By operating continuously more than 40 days, a long term stability of 0.016 pH/day is obtained. The result of pH monitoring of femoral arterial blood in a rabbit is fairly good agreement with the value of blood gas analysis.

• BMB Reports
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• 제46권1호
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• pp.9-16
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• 2013

In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mammalian cells have evolved sophisticated mechanisms for monitoring the quality of mRNAs. The faulty transcripts harboring PTC are subject to nonsense-mediated mRNA decay (NMD), nonsense-mediated translational repression (NMTR), nonsense-associated alternative splicing (NAS), or nonsense-mediated transcriptional gene silencing (NMTGS). In this review, we briefly outline the molecular characteristics of each pathway and suggest mRNA quality control mechanisms as a means to regulate normal gene expression.

• 한국세라믹학회지
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• 제48권6호
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• pp.577-583
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• 2011

Stabilized biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by controlled coprecipitation method for hyperthermia application. ESR measurements determined that all of the interactions in the individual SPIONs (1 nm and 11 nm) were antiferromagnetic in nature because the ions contributed to the magnetization with a range of magnetic moments. In-situ monitoring of the temperature increment was performed, showing that the microwave absorption rate of the SPIONs was dispersed in an appropriate host media (polar or non-polar solvents) during microwave irradiation. Microwave absorption energy rates and heat loss of SPIONs in solvent were calculated by non-linear data fitting with an energy balance equation. The microwave absorption rates of SPIONs dispersed in solvent linearly increases when the concentration of SPIONs increases, implying that the microwave absorption rate can be tunable by changing the concentration of SPIONs.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 추계학술대회
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• pp.66-68
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• 2012

본 논문에서는 자체 개발한 Java Platform 기반의 뇌파 분석 도구와 Android 기반의 Mobile 기기를 연계하여 중증 장애인의 상태 및 상황 등을 모니터링 할 수 있는 시스템을 제시한다. 제안된 시스템은 뇌파 측정기, 뇌파 분석 툴(PC Client) 그리고 Mobile 기기(Android)로 크게 3부분으로 구성된다. 뇌파 측정기로부터 수집된 원 주파수에서 저주파 대역의 잡음을 제거하기 위해 고주파 필터를 적용한 후, 적용된 데이터를 주파수 영역에서 분석하기 위해 FFT를 적용한다. FFT를 적용한 데이터를 Power Spectrum 분석 기법을 이용하여 Theta, Delta, Alpha, SMR, Beta 파형의 값을 추출하고, 14 채널의 뇌파 측정 위치에 따른 상관관계 분석기법을 통해 중증 장애인의 상태를 표현한다. 본 논문에서 제안한 방법으로 실험한 결과, 중증 장애인 모니터링 시스템에 효율적으로 적용되는 것을 확인하였다.