• 한국초등과학교육학회지:초등과학교육
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• 제27권1호
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• pp.75-82
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• 2008

The purpose of this study was to examine the consistency and balance of learning objectives of units and instructional units according to grades and educational domains. Educational domains were cognitive(scientific knowledge), scientific inquiry(inquiry process skills), affective(scientific attitude), and science-technology-society(STS). Learning objectives of life field of the 7th elementary science curricular teaching guidebooks were analysed. Scientific inquiry process skill objectives(43.5%) were most dominant in units, but cognitive objectives(53.9%) were most dominant in instructional units. STS objectives were most recessive in both units and instructional units. Especially, objectives of units and instructional units were shown no consistency by grade. The results of this study suggested that the textbooks and teaching guidebooks should be developed consistently by considering learning activities and contents on the basis of background and properties of science curriculum.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1997년도 한국생물과학협회 학술발표대회
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• pp.325-325
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• 1997

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• 한국과학교육학회지
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• 제7권1호
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• pp.1-17
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• 1987

The rectnt studies on the learning of the scientific concepts have suggested that most students have misconceptions related to the contents to be learned and that those misconceptions exert their influences on the subsequent learning of the content Those facts necessitate the identification of the misconceptions before the instructions and the preparation of the instructional materials based on those misconceptions identified. Several studies also revealed that such biological areas as cell division, reproduction and fertilization were ranked among the most difficult areas for high school students to learn. Therefore, this study had its triple objectives as follows: (1) Identification of misconceptions in such areas as cell division, reproduction and fertilization. (2) Investigation of the current high school biology textbook I's as the sources of those misconceptions. (3) Development of teaching materials based on the misconceptions identified and the problems in the textbooks analyzed. This study identified several misconceptions held by high school students of biological concepts related to the conceptual areas of life-continuity, and found the problems in learning of the high school biology textbooks. Based on the misconceptions and the problems, a teaching/learning model and its content material were developed at the final course of this study.

• 한국과학교육학회지
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• 제23권1호
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• pp.1-8
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• 2003

The purpose of present study was to develop teaching-learning materials based virtual reality technology(VRT), and to examine the effect of it on the knowledge achievement of biology. Authoring tool of virtual reality(VR) was 3D Webmaster made in Superscape Ltd., United Kingdom. Educational materials was developed for the structure and function of eye of life field in the 10th science. It was learner-directed and interactive educational material using the Web-based and desktop VR. The result showed a meaningful improvement on the achievement. Using 3D VR shows the potential of available education media in the next generation as science teaching-aided materials, which especially was efficient in the understanding and perception of abstract or difficult to direct experience learning contents.

• 통합자연과학논문집
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• 제1권2호
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• pp.160-179
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• 2008

Field classes are necessary to grow the ability of and an attitude toward exploring nature and to shape the basic concept of natural science. I tried to develop a site for field classes and the old road Naori's hill is an ideal place with convenient traffic and established youth camps. As a result the vegetation was divided into five associations and communities. The vegetation units obtained in the present study were as follow: Quercus acutissima community, Pinus densiflora community, Pinus densiflora-Quercus acutissima community, Quercus acutissima-Pinus densiflora community, and Quercus mongolica community. In all survey areas 100 family 336 genus 587 species of palants was found. Furthermore, it provides lots of plants throughout the seasons. Not only the flora but also flowering phenology, variety of floral color and growth habits can be used as teaching items. Incorporation of diverse knowledge of plants at the old road Naori's hill into biology teaching will give students academic stimuli and teachers an opportunity of retraining. With a combination of use of visual instruments, the purpose of conceptual and exploring biology is more easily achieved.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4103-4107
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• 2015

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Transarterial chemoembolisation (TACE) is the standardized therapy for intermediate stage HCC. However, the prognosis for HCC patients treated by TACE greatly varies. Thus, there is a critical need for finding biomarkers to predict the prognosis of HCC patients. The amino acid transporter-2 (ASCT2) is involved in tumorigenesis and progression of many malignancies. This study aimed to evaluate the predictive role of two single nuclear polymorphisms (SNPs, rs3826793 and rs2070246) in the ASCT2 gene in HCC patients treated by TACE. Materials and Methods: Two functional SNPs (rs3826793 and rs2070246) in the ASCT2 gene were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 448 unresectable Chinese HCC patients treated by TACE. Univariate and multivariate Cox proportional hazards models and Kaplan-Meier curves were used for the prognosis analyses. Results: There was no significant association between two SNPs (rs3826793 and rs2070246) in the ASCT2 gene and overall survival of TACE treated HCC patients. However, we demonstrated that patients with early stage HCC carrying T genotype in rs2070246 showed better OS than those carrying CC genotype (P=0.023). Conclusions: We demonstrated that patients with early stage HCC carrying T genotype in rs2070246 showed better OS than those carrying CC genotype.

• 한국과학교육학회지
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• 제18권4호
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• pp.539-544
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• 1998

교육 목표 영역으로 설정된 부분이 실제 각 단원, 소단원 그리고 수업 차시 목표에 균형있게 반영되었는지를 확인하기 위해 제 6차 과학과 교육과정에 의해 개발된 초등학교 자연과 생물 영역의 수업 목표를 교사용 지도서를 중심으로 분석하였다. 교육목표설정 영역은 인지적 영역, 탐구과정 영역, 수공적 기능 영역, 창의성 영역, 정의적 영역과 STS 영역 등 6개이다. 인지적 영역의 교육목표가 가장 많았으나, 창의성 영역에 해당하는 것은 하나도 없었다. 단원 목표와 소단원 목표에서는 인지적 영역, 탐구과정 영역, 정의 영역, 수공적 기능 영역, STS 영역 순으로 비중이 높았으나, 차시 수업 목표에서는 인지적 영역과 탐구 과정 영역이 대부분이었다. 목표 영역 중에서 인지적 영역과 탐구과정 영역을 제외하고는 대체로 단원, 소단원과 차시의 수업 목표의 연계성이 부족하였으며, 특히 정의적 영역에서는 대단원, 소단원, 차시 수준으로 갈수록 그 비중이 급속하게 낮아지는 것으로 나타났다. 교육 목표 설정 영역의 형식적인 구분보다는 교과서의 개발시 목표 영역의 일관성 있고, 균형 있는 반영을 고려해야 하며, 또한 목표 설정 영역의 특성을 고려한 적절한 안배가 요구된다.

• Genomics & Informatics
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• 제20권2호
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• pp.18.1-18.7
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• 2022

According to long-term projections, by 2030, the world's population is predicted to reach 7.5 billion individuals, and there will be roughly 27 million new cancer cases diagnosed. The global burden of breast cancer (BC) is expected to rise. According to the Ministry of Health-Iraqi Cancer Registry, cancer is the second largest cause of death after cardiovascular disease. This study investigated the interleukin-18 (IL18) single-nucleotide polymorphisms (SNPs) -607C/A rs1946518 and -137G/C rs187238 using the sequence-specific amplification-polymerase chain reaction approach. Regarding the position -607C/A, there was a highly significant difference between the observed and expected frequencies in patients and controls (χ² = 3.16 and χ² = 16.5), respectively. The AA and CA genotypes were associated with significantly increased BC risk (odds ratio [OR], 3.68; p = 0.004 and OR, 2.83; p = 0.04, respectively). Women with the A allele had a 5.03-fold increased susceptibility to BC. The C allele may be a protective allele against BC (OR, 0.19). Although position -137G/C showed no significant differences in the CC genotype distribution (p = 0.18), the frequency of the CC genotype was significantly higher in patients than in controls. In contrast, patients had a significantly higher frequency of GC genotypes than controls (p = 0.04), which was associated with an increased risk of developing BC (OR, 2.63). The G allele frequency was significantly lower in patients than in controls (55.0% vs. 76.2%, respectively). This SNP may be considered a common genotype in the Iraqi population, with the wild-type G allele having a protective function (OR, 0.19) and the mutant C allele having an environmental effect (OR, 2.63).

• 분석과학
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• 제35권4호
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• pp.161-168
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• 2022

Wheat is rich in sources of fiber, oligosaccharides, and resistant starch, simple carbohydrates which may have a protective role against carcinoma. Additionally, Whole wheat/bran as well includes contains phytochemicals such as flavonoids, lignans, folate, phytosterols, phenolic acids, and tocols. The above phytochemicals suitable forms antioxidant and cholesterol-reducing activities. Phytoestrogens are regarded as especially essential in the preventative measures of hormonally dependent malignancies such as breast cancer (BC). In this study lowered BC risk has been associated with whole grain/bran consumption with an odds ratio (OR=0.24 and 95 %CI=0.10-0.56). Wheat/bran appears to have a reliable protective impact against BC. While intake of white bread has been associated with a high risk of BC (OR=2.63 and CI 95 %=1.07-6.48). Also, the E-Selectin (SELE) Single nucleotide polymorphisms (SNPs) rs5353 A/G and rs932307 C/T were investigated using the sanger sequences approach. There was a positive association between genotypes (rs5353 GG+AG) and (rs932307 TT+CT) with rate consumption of wheat-white/bread and these genotypes were more frequent in patients had BC in comparison with a significant difference (P=0.03) (P=0.01), respectively. The genotypes (GG+AG) frequency of the rs5353 polymorphism and (TT+CT) genotypes of the rs932307 polymorphism in the present study had a high risk of cancer with (OR=3.05), (OR=4.17) respectively. While these genotypes showed no significant association with the rate of whole grain consumption in patients and control. Therefore, the type of wheat may associate with increased incidence of disease-related with type of Polymorphism because some present genotypes of SNPs showed high (OR) which may refer to their positive associated with disease, the white wheat consumption may active the risky association between SNPs and BC.

• Genomics & Informatics
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• 제20권4호
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• pp.42.1-42.11
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• 2022

Breast cancer (BC) is a significant threat to female health, with both modifiable and non-modifiable risk factors. It is essential to monitor patients regularly and to raise population awareness. Increasing research also suggests that E-selectin (SELE) may increase tumor angiogenesis and the development of cancer. This study investigated SELE single-nucleotide polymorphisms (SNPs) in the following positions: rs5367T/C, rs5368C/T, rs5362T/G, and rs5362T/C. Using polymerase chain reaction, significant differences in allele and genotype frequencies were found between BC patients and controls. Position rs5368 was associated with an increased risk of BC for the CT and TT genotypes, with odds ratios (ORs) of 16.3 and 6.90 (Fisher probability = 0.0001, p = 0.005). Women with the T allele had a 19.3-fold higher incidence of BC, while allele C may be a protective allele against BC (OR, 0.05). Heterozygous genotypes at rs5367, rs5362, and rs5362 were significantly more common in BC patients, with ORs of 5.70, 4.50, and 3.80, respectively. These SNPs may be associated with the risk of BC, because the frequency of mutant alleles was significantly higher in patients (OR: 4.26, 3.83, and 4.30, respectively) than in controls (OR: 0.23, 0.30, and 0.20, respectively). These SNPs may be considered a common genotype in the Iraqi population, with the wild-type allele having a protective fraction and the mutant allele having an environmental fraction. The results also revealed a 2-fold increase in gene expression in BC patients compared to controls, with a significant effect (p = 0.017). This study's findings confirm the importance of SELE polymorphisms in cancer risk prediction.