• Journal of Pharmaceutical Investigation
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• 제30권2호
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• pp.73-83
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• 2000

Polyethylene glycol (PEG) is a water soluble, biocompatible, non-toxic polymer and PEGylation is a well established technique for the modification of therapeutic proteins and peptides. PEG-protein drugs have been extensively studies in relation to therapies for various diseases: cancer, inflammation and others. The covalent attachment of PEG to proteins and peptides prolonged plasma half-life, reduced antigenicity and immunogenicity, increased thermal and mechanical stability, and prevented degradation by enzymes. Several chemical groups for general and site specific conjugation have been exploited to activate PEG for amino group, carboxyl group, and cysteine groups. PEGylation of many proteins and peptides have been studied to enhance their properties for the potential uses. Also, the different positional isomers in several PEG-proteins have shown the difference in vivo stability and biological indicating that the site of PEG molecule attachment is one of the important factor to develop PEG-proteins as potential therapeutic agents.

• 대한의용생체공학회:의공학회지
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• 제15권2호
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• pp.209-216
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• 1994

The objective of the research reported in this paper is to design locomotion system of the motorized wheelchair, to develope the wall following algorithm. The indoor navigation of a motorized wheelchair can be based on the wall following techniques. In this paper, it is proposed to enhance stability and efficiency using the 3 ultrasonic sensors arranged at a same perpendicular pivot. Using this method, the angle between the motorized wheelchair and the wall is detected and the range of control commands has been increased. For the better stability, the calculated slope of a wall using LSLF algorithm was fed back to the control part. By adapting the suggested algorithm and method, the motorized wheelchair could follow a wall in 4 seconds, for a change of distance between the wheelchair and wall from 30 to 100cm.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.323-326
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• 1996

Dental implant is increasingly used to recover the mastication function of tooth. Several types of implant were designed to give an optimal stress distribution in surrounding bony regions. In this study, six types of implant were investigated using finite element method and it was studied i) how the variation of cortical bone thickness affects the stress distribution in surrounding bony regions depending upon implant types, ii) which type gives the best characteristics in the sence of stress distribution and stability. The hybrid-type implant with cylinder and screw gave the optimum properties in view of stability and response to the variation of cortical bone thickness.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.239-239
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• 2013

For more than four decades, ion-sensitive field-effect transistor (ISFET) sensors that respond to the change of surface potential on a membrane have been intensively investigated in the chemical, environmental, and biological spheres, because of their potential, in particular their compatibility with CMOS manufacturing technology. Here, we demonstrate a new type of ISFET with dual-gate (DG) structure fabricated on ultra-thin body (UTB), which highly boosts sensitivity, as well as enhancing chemical stability. The classic ion-sensitive field-effect transistor (ISFET) has been confronted with chronic problems; the Nernstian response, and detection limit with in the Debye length. The super-coupling effects imposed on the ultra thin film serve to not only maximize sensitivity of the DG ISFET, but also to strongly suppress its leakage currents, leading to a better chemical stability. This geometry will allow the ISFET based biosensor platform to continue enhancement into the next decade.

• Journal of applied mathematics & informatics
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• 제40권5_6호
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• pp.1199-1215
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• 2022

This article aims to study the dynamical behaviours of a two species model in which non-selective harvesting of a prey-predator system by using a reasonable catch-rate function instead of usual catch-per-unit-effort hypothesis is used. A system of two ordinary differential equations(ODE's) has been proposed and analyzed with the predator functional response to prey density is considered as Hassell-Varley type functional responses to study the dynamics of the system. Positivity and boundedness of the system are studied. We have discussed the existence of different equilibrium points and stability of the system at these equilibrium points. We also analysed the system undergoes a Hopf-bifurcation around interior equilibrium point for a various parametric values which has very significant ecological impacts in this work. Computer simulation are carried out to validate our analytical findings. The biological implications of analytical and numerical findings are discussed critically.

• 대한수학회지
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• 제59권3호
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• pp.519-548
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• 2022

In this paper, a stabilized-penalized collocated finite volume (SPCFV) scheme is developed and studied for the stationary generalized Navier-Stokes equations with mixed Dirichlet-traction boundary conditions modelling an incompressible biological fluid flow. This method is based on the lowest order approximation (piecewise constants) for both velocity and pressure unknowns. The stabilization-penalization is performed by adding discrete pressure terms to the approximate formulation. These simultaneously involve discrete jump pressures through the interior volume-boundaries and discrete pressures of volumes on the domain boundary. Stability, existence and uniqueness of discrete solutions are established. Moreover, a convergence analysis of the nonlinear solver is also provided. Numerical results from model tests are performed to demonstrate the stability, optimal convergence in the usual L² and discrete H¹ norms as well as robustness of the proposed scheme with respect to the choice of the given traction vector.

• Journal of applied mathematics & informatics
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• 제41권1호
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• pp.107-121
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• 2023

An epidemic infectious disease model consists of six compartments viz. Susceptible, Exposed, Infected, Quarantine, Recovered, and Virus with nonlinear saturation incidence rate is proposed to know the viral disease dynamics. There exist two biological equilibrium points for the model system. The system's local and global stability is done through Lyapunov's direct method about equilibrium points. The sensitivity analysis has been performed for the basic reproduction number and equilibrium points through the normalized forward sensitivity index. Sensitivity analysis shows that virus growth and quarantine rates are more sensitive parameters. In support of mathematical conclusions, numerical experimentation has been shown.

• 분석과학
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• 제30권3호
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• pp.138-145
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• 2017

Microwave-assisted organic synthesis has gained a remarkable interest over the past years because of its advantages - (i) rapid energy transfer and superheating, (ii) higher yield and rapid reaction, (iii) cleaner reactions. Ionic liquids are well known for their unique properties such as negligible vapor pressure and high thermal stability. With these properties, ionic liquids have gained increasing attention as green, multi-use reaction media. Recently, ionic liquids have been applied as reaction media for biocatalysis. Lipase-catalyzed reactions in ionic liquids provide high activity and yield compared to conventional organic solvents or solvent free system. Since polar molecules are generally good absorbent to microwave radiation, ionic liquids were investigated as reaction media to improve activity and productivity. In this study, therefore, the effect of microwave irradiation in ionic liquids was investigated on lipase catalyzed reactions such as benzyl acetate synthesis and caffeic acid phenethyl ester synthesis. Comparing to conventional heating, microwave heating showed almost the same final conversion but increased initial reaction rate (3.03 mM/min) compared to 2.11 mM/min in conventional heating at $50^{\circ}C$.

• 한국환경과학회지
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• 제16권2호
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• pp.227-232
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• 2007

Water pollution in enclosed water bodies such as lake and river has become a serious problem over the world. Domestic wastewater is responsible for more than 60 % pollution load in public water area in Korea. Effluent of the treated domestic wastewater at low removal level is abundantly fed rivers and lakes and thus be an serious cause of lake pollution. Therefore, effective implement of domestic wastewater treatment in basin of lake and river must be prepared. The septic tank is one of the effective domestic wastewater treatment equipment and used in individual treatment for a unit of household, The purpose of septic tank as biological treatment system is simultaneously to remove BOD, T-N, T-P and reduce turbidity from influent. Accordingly, the appropriate control of functional microorganisms is important subject for the establishment of stability and economy of the biological treatment method. Especially, microanimals as a high-ranked microorganisms of food-chain are important, because microanimals control the other microorganisms especially various bacteria and effect on function of treatment. Therefore, it is necessary that functional predator like rotifers are attached in wastewater treatment process. In this study, the methods for attachment high density the rotifer to and improvement of transparency in the effluence by a dense rotifer was examined using laboratory scale biological treatment reactor simulated septic tank and real one.

• BMB Reports
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• 제42권12호
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• pp.812-816
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• 2009

To screen chaperone proteins from Schizosaccharomyce pombe (S. pombe), we prepared recombinant citrate synthase of the fission yeast as a substrate of anti-aggregation assay. Purified recombinant citrate synthase showed citrate synthase activity and was suitable for the substrate of chaperone assay. Several heat stable proteins including aspartyl aminopeptidase (AAP) for candidates of chaperone were screened from the supernatant fraction of heat-treated crude extract of S. pombe. The purified AAP migrated as a single band of 47 kDa on SDS-polyacrylamide gel electrophoresis. The native size of AAP was estimated as 200 kDa by a HPLC gel permeation chromatography. This enzyme can remove the aspartyl residue at N-terminus of angiotensin I. In addition, AAP showed the heat stability and protected the aggregation of citrate synthase caused by thermal denaturation. This study showed that S. pombe AAP is a moonlight protein that has aspartyl aminopeptidase and chaperone activities.