• YAKHAK HOEJI
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• v.46 no.3
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• pp.192-196
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• 2002

To investigate the effect of intravenous ethanol administration on pancreatic exocrine secretion, we measured volume and protein amount in pancreatic juice and assayed amylase activity and phospholipase $A_2$ activity in pancreatic fragments and serum. Acute pancreatitis induced by obstruction of common bile-pancreatic duct (CBPD) and caerulein infusion (5 $\mu\textrm{g}$/kg/hr) showed typical characteristics, such as hyperamylasemia and pancreatic edema and increase of phospholipase $A_2$ activity in pancreatic fragments and serum. Intravenous ethanol infusion (50 mg/kg/hr) significantly stimulated pancreatic exocrine secretion, but such a stimulatory effect of ethanol disappeared at dose of 100 mg/kg/hr without typical symptoms of acute pancreatitis. In microscopic examination, there were no typical changes of edematous pancreatitis in ethanol administrated rats. These results suggest that acute ethanol administration has dual effect on exocrine pancreatic secretion: low dose of ethanol (50 mg/kg/hr) stimulates pancreatic exocrine secretion, whereas high dose of ethanol (100 mg/kg/hr) does not without typical changes of edematous pancreatitis.

• Korean Journal of Veterinary Pathology
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• v.5 no.2
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• pp.43-48
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• 2001

Ducklings collected from three farms, having history of rapid onset and spread of nerve signs including kick spasmodically with legs and opisthotonos, were pathologically, barteriologically, virologically examined. Grossly, multiple petechial to ecchymotic hemorrhages were detected in the swollen liver. Histopathologically, diffuse coagulative necrosis of hepatocytes was characteristic in acute cases. Chronic cases revealed marked bile duct hyperplasia rather than hepatocyte necrosis. Some of these cases exhibited multiple granulomas consisting of macrophages, heterophil, fibrin and necrotic cell debri. Filtered homogenate of livers sampled from ducklings caused embryo death with marked hemorrhage and swollen of liver after inoculation into chorioallantoic membrane. Three strains of Salmonella app.,S montevideo, S hadar, and S give, which were biochemically and serologically identified, weir isolated from ducklings of three farms, respectively. From these results, these ducklings were concurrently infected with duck hepatitis virus and Salmonella spp.

• Korean Journal of Veterinary Research
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• v.25 no.2
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• pp.171-174
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• 1985

An outbreak of duck virus hepatitis was confirmed for the first time in Korea from ducklings having up to 40~65% mortality in less than 15-day-old ducklings of two farms located in the vicinity of Kwangju city. The infected ducks showed sudden death and opisthotonus position. The predominant gross lesions were found in the liver, showing enlargement and petechial or ecchymotic hemorrhages. The microscopic findings were consisted of fatty changes and necrosis of the hepatic cells, and proliferation of the bile duct epithelium. The presence of the virus was detected by electron microscopy of the sera and livers of infected ducks. The duck embryo and the ducks inoculated with the liver materials from the infected ducks showed the same lesions with those of the naturally infected ducks.

• Korean Journal of Veterinary Research
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• v.7 no.2
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• pp.42-45
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• 1967

From April to May 1967 3,275 Korean native cattle slaughtered at Taegu public slaughter house were investigated for infection rate of faciola and 222 adult fasciola species taken from the bile duct, of the patients were examined for morphological study. The results were as follows: 1. Among 3,275 Cattle 1,099 Cattle (32.5%) were infected with fasciola species. 2. Seasonal changes of infection rate were 34.7%(Winter). 33.2%(Spring), 30.9%(fall) and 29.1%(Summer). 3. Three different species(large, small and intermediate type) of fasciola were detected from the patients. These large, small and intermediate types were identified morphologically with fasciola gigantica, fasciola hepatica and fasciold indica respectivelly. Distribution of these three kind, were 52.4%(intermediate type), 28.4%(Small type) and 19.0%(large type).

• The Korean Journal of Applied Statistics
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• v.25 no.6
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• pp.947-958
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• 2012

When modeling event times in biomedical studies, the outcome might be incompletely observed. In this paper, we assume that the outcome is recorded as current status failure time data. Despite well-developed literature the routine practical use of many current status data modeling methods remains infrequent due to the lack of specialized statistical software, the difficulty to assess model goodness-of-fit, as well as the possible loss of information caused by covariate grouping or discretization. We propose a model based on pseudo-observations that is convenient to implement and that allows for flexibility in the choice of the outcome. Parameter estimates are obtained based on generalized estimating equations. Examples from studies in bile duct hyperplasia and breast cancer in conjunction with simulated data illustrate the practical advantages of this model.

• Biomolecules & Therapeutics
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• v.6 no.2
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• pp.119-129
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• 1998

The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was inves-tigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 mg/kg b.wt. in $CCl_4$-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 mg/kg b.wt. in $CCl_4$-induced chronic liver disease, 30 mg/tg b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.

• Korean Journal of Head & Neck Oncology
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• v.13 no.1
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• pp.58-61
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• 1997

Multiple primary cancer is defined as the discrete primary cancers in an individual originating in different sites or tissues. Billroth, in 1869, first reported the occurrence of different primary malignant cancers in the same patient. Because early diagnosis and treatment are key to good survival and cure rates, clinicians should be more aware of the possibility of multiple primary cancers in an individual patient with malignant tumor. The authors recently experienced a case of fifth primary cancer, their sites of origin were lung, glottis, lymph node, supraglottis, common bile duct. We report this case with a brief review of literatures.

• Archives of Pharmacal Research
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• v.6 no.1
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• pp.7-16
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• 1983

A methadone-diazepam interaction study in rats was performed in which conjugated metabolites of methadone were analyzed using deuterated biosynthetic internal standards. Diazepam (5mg/kg) was given to rats through a cannulate djugular vein and a subcutaneous dose of methadone (10mg/kg) was given. Bile was collecte through the cannulate dbile duct over a period of 24 hours. The deuterium label of the internal standards was found to be stable under conditions of the prolonged incubation. There was no significant difference in the excretion of the metabolites between the control and the diazepam treated rats. Feasibility of using biosynthetic internal standards with selected ion monitoring was established for the drug metabolism and kinetic studies.

• Journal of Digestive Cancer Research
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• v.10 no.2
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• pp.92-98
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• 2022

Self-expandable metal stent (SEMS) is effective for biliary drainage, especially in pancreaticobiliary cancer. The mechanical properties, material, and design of SEMS are important in preventing recurrent biliary obstruction and complication. Radial and chronic expansion forces play roles in preventing stent migration and collapse. Complications, such as stent impaction, cholecystitis, and pancreatitis, were related to the axial force. The nickel-titanium alloy shows more flexibility, conformability, and optimal axial force compared to previously used stainless steel. Additionally, the stent structure affected the mechanical properties of SEMS. Therefore, understanding the mechanical properties, material, and design of SEMS will provide the best outcome for biliary drainage, as well as better SEMS development.

• Journal of Digestive Cancer Research
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• v.3 no.2
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• pp.101-104
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• 2015

A 55-year-old man was admitted to the hospital for jaundice. Computed tomography (CT) scans showed a diffuse mass in the pancreas and peripancreatic area, with infiltration to of the whole pancreas, and overall reduced enhancement compared to normal pancreas. Esophagogastroduodenoscopy revealed elevated mucosal lesion covered hyperemic mucosa at duodenal bulb and ulcerative lesion at body of stomach. Endoscopic ultrasonography revealed an irregular mass with unclear boundaries was observed within the pancreas. Abrupt narrowing of mid to distal common bile duct was seen and the stricture was caused by compression of pancreatic mass. Plastic stent was inserted and clinical improvement was achieved including resolution of jaundice. The patient is currently being treated with combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone. We report a case of primary pancreatic lymphoma presenting with obstructive jaundice.