• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 2003.06a
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• pp.170-170
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• 2003

• Proceedings of the KSCN Conference
• /
• 2003.05a
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• pp.139-140
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• 2003

베타-사이클로덱스트린은 7개의 글루코스 단위가 $\alpha$-1,4 결합으로 연결된 환상고리형 올리고당으로서 전분을 효소처리하여 추출한 물질이다. 베타-사이클로덱스트린은 혈액내 지질 함량을 현저하게 떨어뜨릴 수 있는 hypolipdemic, hypotriacylglyceridemic 그리고 hypocholesterolemic 효과를 가지므로 비만을 예방하는데 도움이 될 수 있다. 본 연구의 목적은 베타-사이클로덱스트린을 이용하여 조제된 펠렛 형태의 식이가 비만인의 체중, 체지방, 복부비만 감소 및 혈액 지질함량 감소에 미치는 효과를 조사하는 것이었다. (중략)

• Bulletin of the Korean Chemical Society
• /
• v.31 no.10
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• pp.3035-3037
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• 2010

• Bulletin of the Korean Chemical Society
• /
• v.27 no.1
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• pp.137-139
• /
• 2006

• Proceedings of the Korean Society of Dyers and Finishers Conference
• /
• 2007.11a
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• pp.143-144
• /
• 2007

• Proceedings of the Korean Magnetic Resonance Society Conference
• /
• 2002.08a
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• pp.78-78
• /
• 2002

• Proceedings of the Korean Society of Fisheries Technology Conference
• /
• 2001.05a
• /
• pp.193-194
• /
• 2001

Cyclodextrin(CD)의 산업화에 필요한 응용기술의 개발에 대해서는 주로 식품과 의약품 관련 산업에서 활발히 진행되고 있다. 실 예로 밀감 쥬스 시럽의 경우, 밀감 성분중 hesperidin이라는 flavonoid 배당체가 석출되어 시럽을 혼탁 시키는 원인이 된다. 시럽 혼탁을 방지하기 위해 $\beta$-CD를 첨가하여 난용성물질인 hesperidin을 포집하여 용해도를 증가시키므로 제품의 질을 개량하고 있다. (중략)

• Proceedings of the PSK Conference
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• 2002.04a
• /
• pp.215.1-215.1
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• 2002

• KSBB Journal
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• v.24 no.6
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• pp.570-578
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• 2009

In vitro biological activities such as antioxidant, whitening, anti-hangover and anticancer activities were evaluated. The antioxidant activities of astaxanthin and H. pluvialis extract were significantly higher than that of $\alpha$-tocopherol when the antioxidant activities were determined as xanthine oxidase inhibition, hydroxyl radical scavenging and DPPH radical scavenging. The whitening effect of H. pluvialis extract was about two times as kojic acid. H. pluvialis extract indicated an anticancer activity on a cervical cancer cell line. Astaxanthin showed anti-hangover effect of 1.5 times as jiguja extract. The anti-hangover effect of the inclusion complex (As-$\beta$-CD) was about 1.2 times of jiguja extract. And, the inclusion complex of Haematococcus pluvialis (H.p.-$\beta$-CD) showed almost the same whitening effect as kojic acid.

• Journal of Pharmaceutical Investigation
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• v.26 no.1
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• pp.1-11
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• 1996

Biphenyldimethyldicarboxylate (PMC), which has been used to treat hepatitis, is insoluble in water, therefore it has low bioavailability after oral administration. For the purpose of increasing the dissolution rate of PMC, the physical mixtures and inclusion complexes of PMC and $dimethyl-{\beta}-cyclodextrin\;(DM\;{\beta}CD)\;or\;hydroxypropyl-{\beta}-cyclodextrin\;(HP{\beta}CD)$ in molar ratio of 1 : 1 and 1 : 2 were prepared by solvent evaporation method. Mixed micelles of PMC were prepared by reacting PMC with bile salts [sodium cholate(NaC), sodium glycocholate (NaGC)] and oleic acid (OA) or palmitoylcarnitine chloride(PCC). Chloroform/water partition coefficient (PC) of PMC was 36.14 in artificial gastric juice (AGJ) and 33.47 in artificial intestinal juice (AIJ), respectively, on the other hand octanol/water PC was 63.36. PMC formulation was prepared by reacting PMC with PEG400-glycerin system(95 : 5, 90 : 10, respectively) and PEG400-PEG4000-glycerin system (70 : 25 : 5, 65 : 25 : 10, respectively). Dissolution test was performed in AGJ and AIJ by paddle method at $37{\pm}0.5^{\circ}C$. The dissolution rates of PMC tablets on the market were 5.74% and 8.26% at AGJ and AIJ, respectively and marketed PMC capsules were 22.14% and 28.64% at AGJ and AIJ, respectively. The dissolution rates of inclusion complexes of PMC with $DM{\beta}CD$ and $HP{\beta}CD$ in a molar ratio of 1 : 1 were more fast than those of corresponding physical mixtures. The decreasing order of dissolution rates was as follows; PMC-PEG400-PEG4000-glycerin formulation > PMC-PEG400-glycerin formulation > mixed micelles > CD inclusion complexes. The dissolution rates of PMC-PEG400-glycerin and PMC-PEG400-PEG4000-glycerin formulation were most fast and the percentage of dissolution was almost 100% within 20 minutes. And their dissolution rates after 120 minutes were markedly increased as compared with capsules on the market (4.0-fold and 3.2-fold in PMC-PEG400-glycerin formulation at AGJ and AIJ, respectively, and 4.8-fold and 3.7-fold in PMC-PEG400-PEG4000-glycerin formulation at AGJ and AIJ, respectively).