• 한국응용과학기술학회지
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• 제36권1호
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• pp.84-89
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• 2019

대장균 효소 ${\beta}$-gal를 이용하여 합성된 BzO-gal의 분자구조를 NMR ($^1H$-와 $^{13}C$-)과 고성능 mass spectrometry를 이용하여 분석하였다. BzO-gal은 $^1H$ NMR에서 14개의 proton으로부터 12개의 피크를 나타내었다. 방향족 고리에서 오는 5개의 proton 피크와 벤질기의 $CH_2$에서 오는 2개의 proton 피크는 벤질알코올이 존재함을 나타낸다. 지방족 사슬 영역인 ${\delta}_H$ 4.32 ~ 3.46 ppm에서 나타나는 7개의 proton 피크로부터 단당류가 도입되었음을 확인할 수 있었다. $^{13}C$ NMR 스팩트럼에서 나타난 11개의 carbon 피크도 또한 벤질알코올에 단당이 도입되었음을 나타낸다. BzO-gal의 분자량을 확인하기 위하여 mass spectrometry 로 분석한 결과 m/z가 293.0994인 BzO-gal의 sodium adduct ion($[M+Na]^+$)을 확인할 수 있었다. 이러한 결과를 바탕으로 세포독성이 감소된 첨가물 개발을 기대하고 있으며, 추가적인 후속연구를 진행할 예정이다.

• 한국식품영양과학회지
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• 제16권4호
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• pp.333-336
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• 1987

한국산 양송이버섯의 생것과 가열한 것의 향기성분을 GC, GC-MS를 이용하여 분석한 결과는 다음과 같다. 1) 생양송이에서는 향기성분 13종을 동정하였으며 이들중 1-octen-3-ol이 73.13%로 가장 많았고 2-octenol 7.44%, 3-octanone 3.09%, 3-octanol 1.42%로 전체의 85.08%를 차지하였다. 2) 가열중인 것에서도 13종을 동정할 수 있었으며 역시 1-octen-3-ol이 68.86%로 가장 많았으며 2-octenol이 8.42%, 3-octanone 3.75%, Benzyl alcohol 3.23%, 3-octanol 1.97%로 전체의 86.23%를 함유하였다.

• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.299-303
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• 2002

The oral bioavailability of itraconazole is variable and low in fasting state. This is mainly due to the low solubility of this drug. Bioavailability can be improved by changing the formulation and it is general that the liquid preparations show greater bioavailability than the solid dosage forms such as tablets and capsules do. Benzyl alcohol-water binary mixture showed the excellent solubilizing capacity for itraconazole but the release of the drug from the preparation needs to be enhanced. In this study, various nonionic surfactants and hydrophilic polymers, poloxamers, were screened to investigate their effects on the releasε of itraconazole from the liquid preparations. Poloxamer 407 showed the most enhancing effect on the drug release and the release rate was proportional to thε amount of poloxamer 407 added. A liquid preparation of itraconazole, consisting of benzyl alcohol/water/poloxamer 407 ternary solvent system, releasεd more than 80% of the total drug amount at 5 min and showεd the possibility of a new formulation development.

• 생약학회지
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• 제33권3호통권130호
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• pp.219-223
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• 2002

In order to screen new radical scavenging principle which is expected to be antiaging drug lead, we have isolated 160 strains of the marine-derived fungi and investigated 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity for their acetone extracts. The significant activities (>50% Inhibition) were observed in 8 strains of fungi (MFA006, MFA0l4, MFA040, MFA133, MFA139, MFA143, MFA148, MFA153), and among them, MFA153 (Aspergillus parasiticus) showed the most significant radical scavenging activity. The active components were purified by assay-guided isolation to yield two known benzyl alcohols, l53B3 (1) and l53B4 (2), and their structures were determined by physicochemical evidence. Two compounds (1,2) showed the significant radical scavenging activity with $IC_{50}$ values of 0.6 and $1.4{\mu}M$ against DPPH, respectively.

• 한국응용과학기술학회지
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• 제20권2호
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• pp.118-124
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• 2003

Silver nanoparticles was synthesized by the method of W/O microemulsions with AOT (bis(2-ethylhexyl) sodium sulfosuccinate). The nucleation particle growth and aggregation was controlled by the droplet exchange process. The intermicellar exchange reaction is varied by changing the AOT and the $H_2O$ concentration. The synthesized W/O microemulsions was found to give the nanoparticles, which was confirmed by SEM, TEM, particle-size-analyzer, and UV-spectrometer. The most stable particles was obtained at 0.056 mole AOT solution, and the particle size distribution was found in the range from 27 to 31 nm. The mean particle size was reduced by adding Tween 20 significantly, and distribution was found from 14 to 16 nm. And, It's size was reduced by cosurfactants as toluene and benzyl alcohol. In case of toluene and benzyl alcohol, the range of particle size was found 7${\sim}$11 nm and 8${\sim}$12 nm.

• 대한화학회지
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• 제54권1호
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• pp.131-136
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• 2010

다양한 철 원소의 조성을 갖는 인산알루미늄 철을 합성하여 표면 성질과 벌크 성질을 조사하였다. 벤질 알코올과 디에틸 말론산의 transesterification반응에 의해 촉매 특성을 결정 하였다. 에틸 벤질 말론산과 디벤질 말론산을 유일한 생성물로 얻었다. 철 성분이 0.025 몰 퍼센트인 FeAlP의 경우에 특이한 촉매 특성과 조직상의 특성이 나타난다. 디에스터의 형성은 중간 정도 크기의 산성 자리에서 이루어진다. 물질 안에 수화된 알루미나와 polycondensed인산이 존재할 경우에는 에스터교환 반응에서 인산 알루미늄 철의 촉매 특성이 감소하게 된다.

• 한국연초학회지
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• 제7권1호
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• pp.39-47
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• 1985

Normally cultured aromatic tobaccos, KA 101 and KA 103, were primed progressively in three-leaf segments, either 7 days before bud, bud, or early flower stage with 7 days interval, respectively, The cured leaves were weighed for yield, graded, analyzed for quality-related constituents including volatile aroma components. Also the cured leaves were manufactured and smoked by panelists. Yield and quality by price decreased with advancing ripeness. Reducing sugar, total nitrogen, protein nitrogen decreased with successive ripeness, but reverse in this trends with nicotine, petroleum ether extracts and volatile acids components. Among volatile neutral components, furfural, furfuryl alcohol, benzyl alcohol, penethyl alcohol and p-cresol decreased, but solanone increased with delayed harvest. Neophytadiene, oxysolanone, furfuryl aceton was highest at mid harvest, which was judged to be best by panelists. Mid harvest, first primed at bud stage when leaf color comes to pale green to yellow green, seems to be highly recommendable.

• 한국연초학회지
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• 제6권1호
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• pp.25-31
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• 1984

The volatile aroma components were isolated from Korean flue-cured tobacco (N.C. 2326) by using a vacuum steam distillation method. Individual aroma components were identified by GCIMS and comparison of gas chromatowaphic retention time with those of the authentic samples. Sensory analysis showed that a vacuum steam-distilled product of Flue-cured tobacco had a typical haylike, floral and fruity aroma. Among 62 compounds identified, major compounds included neophytadiene, benzyl alcohol, ethyl acetate, phenyl ethyl alcohol, ethyl alcohol, ethyl formate, acetic acid, solanone, 2-acetyl pyrrole, $\beta$-ionone epoxide, 2, 4-heptadienal (2 isomers), megastigmatrienone (4 isomers), furfural and total amounts of 13 compounds were about 80%.

• 자연과학논문집
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• 제9권1호
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• pp.169-175
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• 1997

효과적인 캐리어로 알려진 벤질알콜, 벤즈알데히드, 아세트 페놀을 사용하여 PET섬유를 분산염료로 염색함에 있어 캐리어 종류에 따른 염색성 특히 혼합용매의 효과를 평가하고 아울러 일광견뢰도, 세탁견뢰도, 인장강도와 같은 염색후의 물성변화에 대해 연구 검토하였다. 실험결과 벤즈알데히드와 아세트페놀의 혼합용매에서 가장 우수한 염색성을 보였으며 효과적인 캐리어 작용은 일광견뢰도 및 인장강도와 같은 물성을 크게 떨어뜨리는 결과를 가져왔다.

• 한국산업보건학회지
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• 제4권1호
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• pp.25-32
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• 1994

Arylmethyl halides(benzyl chloride, BZYC; benzal chloride, BZYA; benzotrichloride, BZTC) and related compounds(benzyl alcohol, BZYA; benzoyl chloride, BZOC) were determined by GC using capillary column. Detailed results are as follows. 1. Stability In methanol benzotrichloride slowly transferred to benzoyl chloride by hydrolysis(ca. 7.5% for 5 days), but the others were stable. Therefore, benzotrichloride solution should be prepared just before analysis. 2. GC analysis Tenax-GC was used to absorbent and desorption solvents were $CCl_4$ and MeOH. Arylmethyl halides were analyzed within 7.5min without interference with related compounds. The calibration curve(ca. 15-80 ppm in soln), repeatability(n=10) and the desorption efficiency were good. Limit of detection by NIOSH method was about 0.003 ppm for arylmethyl halide, respectively. To analyze arylmethyl halides and related compounds in working places GC using capillary column is anticipated to be used effectively.