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Screening of Radical Scavenging Activity from the Marine-Derived Fungus  

Li, Xi Feng (Department of Chemistry, Pukyong National University)
Li, Yong (Department of Chemistry, Pukyong National University)
Nam, Ki-Wan (Department of Marine Biology, Pukyong National University)
Kim, Dong-Soo (Department of Food Science and Technology, Kyungsung University)
Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.3, 2002 , pp. 219-223 More about this Journal
Abstract
In order to screen new radical scavenging principle which is expected to be antiaging drug lead, we have isolated 160 strains of the marine-derived fungi and investigated 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity for their acetone extracts. The significant activities (>50% Inhibition) were observed in 8 strains of fungi (MFA006, MFA0l4, MFA040, MFA133, MFA139, MFA143, MFA148, MFA153), and among them, MFA153 (Aspergillus parasiticus) showed the most significant radical scavenging activity. The active components were purified by assay-guided isolation to yield two known benzyl alcohols, l53B3 (1) and l53B4 (2), and their structures were determined by physicochemical evidence. Two compounds (1,2) showed the significant radical scavenging activity with $IC_{50}$ values of 0.6 and $1.4{\mu}M$ against DPPH, respectively.
Keywords
Marine-derived fungus; Aspergillus parasiticus; Radical scavenging activity; DPPH; Benzyl alcohol; Gentisyl alcohol;
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1 Son, B. W., Choi, J. S., Kim, J. C., Nam, K. W., Kim, D. S.,Chung, H. Y. and Choi, H. D. (2002) Parasitenone, a new epoxycyclohexenone related to gabosine from a marine-derived fungus Aspergillus parasiticus. J. Nat. Prod. 65(5):794-795   DOI   ScienceOn
2 Tubaki, K. (1992) Marine Microorganism as Drug Resour-ces. In Yajima, H., Shioiri, T, and Ohizumi, Y. (ed.), Marine Resources for Drug Discovery, 313-334. Hirokawa Publi-shing Co. Tokyo, Japan
3 Neilson, A, H., Allard, A. -S., Hynning, P. -A. and Rem-berger, M. (1988) Appl. Environ. Microbiol. 54: 2226-2236
4 Dreyfuss, M. M. and Chapela, I. H. (1994) In Gullo, V P. (ed.), The Discovery of Natural Products with Therapeutic Potential, Butterworth-Heinemaim: Boston, MA
5 Henkel, T, Brunne, R. M., Muller, H. and Reichel, F. (1999) Angew. Chem., Int. Ed. 38: 643-647   DOI   ScienceOn