• 대한물리의학회지
• /
• 제19권2호
• /
• pp.1-16
• /
• 2024

PURPOSE: This study examined the effects of four weeks of gaze stabilization exercises and balance training on the static and dynamic balance functions. METHODS: The study was an assessor-blinded randomized controlled trial conducted at Daegu University in South Korea. Thirty subjects who fulfilled the inclusion criteria were selected and divided randomly into three groups containing ten each. The first group received balance exercises with gaze stabilizing exercises (BGG). The second group received a balance exercise (BEG), and the third group received gaze-stabilizing exercise (GEG). Each group exercised for 40 minutes, three times a week for four weeks. The subjects were asked to complete the following static balance test: 1) one-leg standing test, 2) sharpened Romberg test, dynamic balance test, 3) Y-balance test, and 4) single-leg stand-squat-stand test. The static and dynamic balance were measured before and after four weeks to determine the effect of exercise on balance. RESULTS: The static (OLS and SRT) and dynamic (YBT and SST) balance tests showed significant differences in the surface and length of the three groups (p < .05), and the y-balance score effect size, 11.477 (p < .05), was improved significantly. On the other hand, the change in BGG value was larger than those of BEG and GEG, and the improvements in balance control were the most significant. CONCLUSION: After four weeks of exercise, BGG showed the best improvement in static and dynamic balance, suggesting that this specific type of gaze stabilization exercise with balance exercise may benefit healthy young adults.

• Biomolecules & Therapeutics
• /
• 제32권2호
• /
• pp.249-260
• /
• 2024

New supplements with preventive effects against skin photodamage are receiving increasing attention. This study evaluated the anti-photoaging effects of salmon nasal cartilage proteoglycan (SPG), acting as a functional material for skin health. We administered SPG to in vitro and in vivo models exposed to ultraviolet B (UVB) radiation and assessed its moisturizing and anti-wrinkle effects on dorsal mouse skin and keratinocytes and dermal fibroblasts cell lines. These results showed that SPG restored the levels of filaggrin, involucrin, and AQP3 in the epidermis of UVB-irradiated dorsal skin and keratinocytes, thereby enhancing the keratinization process and water flow. Additionally, SPG treatment increased the levels of hyaluronan and skin ceramide, the major components of intercellular lipids in the epidermis. Furthermore, SPG treatment significantly increased the levels of collagen and procollagen type 1 by down-regulating matrix metalloproteinase 1, which play a crucial role in skin fibroblasts, in both in vitro and in vivo models. In addition, SPG strongly inhibited mitogen-activated protein kinase (MAPKs) signaling, the including extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK), and p38. These findings suggest that dietary SPG may be an attractive functional food for preventing UVB-induced photoaging. And this SPG product may provide its best benefit when treating several signs of skin photoaging.

• Journal of Yeungnam Medical Science
• /
• 제41권1호
• /
• pp.48-52
• /
• 2024

While simultaneous bilateral partial nephrectomy with a conventional multiport robot has been consistently reported since the 2010s, the introduction of the DaVinci SP system (Intuitive Surgical, Sunnyvale, CA, USA) could provide a novel way to perform surgery on bilateral kidneys while innovatively reducing the number of incisions. In our first report worldwide, the patient with bilateral small renal mass (2.0 cm for the left and 1.5 cm for the right side) and preoperative normal renal function was placed in the lateral decubitus position on an inverted bed. After tilting the bed to be as horizontal as possible, a 4-cm incision was made in the lower part of the umbilicus for the floating trocar technique. The partial nephrectomy was performed reliably as with the conventional transperitoneal approach, and then the patient could be repositioned to the contralateral side for the same procedure, maintaining all trocars. Total operation time (skin to skin), total console time, and the left- and right-side warm ischemic times were 260, 164, 27, and 23 minutes, respectively, without applying the early declamping technique. The estimated blood loss was 200 mL. The serum creatinine right after the operation, on the first day, 3 days, and 90 days after surgery were 0.92, 0.77, 0.79, and 0.81 mg/dL, respectively. For 90 days after the procedure, no complications or radiologic recurrence were observed. Further clinical studies will reveal the advantages of using the DaVinci SP device for this procedure over traditional multiport surgery, maximizing the benefit of a single port-based approach.

• Hip & pelvis
• /
• 제35권1호
• /
• pp.32-39
• /
• 2023

Purpose: A staged revision with placement of a temporary antibiotic-loaded cement spacer after removal of the implant is the "gold standard" for treatment of chronic prosthetic joint infection (PJI). It enables local delivery of antibiotics, maintenance of limb-length and mobility, easier reimplantation. However, bacterial colonization of spacers and mechanical complications can also occur. The aim of this study is to evaluate functional results and infection control in two-stage treatment of total hip arthroplasty (THA) PJI with and without a spacer. Materials and Methods: A retrospective review of 64 consecutive patients was conducted: 34 underwent two-stage revision using a cement spacer (group A), 30 underwent two-stage revision without a spacer (group B). At the final follow-up, functional evaluation of patients with a THA in site, without PJI recurrence, was performed using the Harris hip score (HHS). Measurement of limb-length and off-set discrepancies was performed using anteroposterior pelvic X-rays. Results: Most patients in group B were older with more comorbidities preoperatively. Thirty-three patients (97.1%) in group A underwent THA reimplantation versus 22 patients (73.3%) in group B (P<0.001). No significant differences in limb-length and off-set were observed. The results of functional evaluation performed during the final follow-up (mean, 41 months) showed better function in patients in group A (mean HHS, 76.3 vs. 55.9; P<0.001). Conclusion: The use of antibiotic-loaded cement spacer seems superior in terms of functional outcomes and reimplantation rate. Resection arthroplasty might be reserved as a first-stage procedure in patients who are unfit, who might benefit from a definitive procedure.

• 자원ㆍ환경경제연구
• /
• 제23권4호
• /
• pp.719-746
• /
• 2014

본 연구는 수질오염물질에 대한 가상적 배출권거래시장을 상정하여 균형배출권가격을 도출함으로써 수질개선에 따른 편익을 추정하려고 시도하였다. 우리나라에서는 낙동강수계를 비롯하여 주요 수계에 수질오염물질 총량관리제도가 실시되고 있다. 사회적으로 바람직스러운 배출총량을 결정함으로써 국민과 정부는 암묵적으로 수질오염물질의 경제적 가치를 결정한 것과 같다고 할 수 있다. 각 지자체별로 수질오염물질 배출상의 제약으로 인하여 희생된 경제적 기회비용이 발생할 것이며 이 기회비용의 크기가 수질오염물질의 경제적 가치이기 때문이다. 이 가상적 배출권거래시장에서의 균형가격을 수질 총량제하의 수계전체의 배출총량과 지자체별 할당에 의하여 암묵적으로 결정된 수질오염물질 배출의 단위당 가치라고 해석할 수 있다. 배출량과 편익의 관계로부터 한계순편익함수를 도출하고 지자체별 배출허용총량을 이용하여 개별배출권 초과수요함수를 구성하여 균형배출권가격을 도출하였다. 추정 결과 배출권시장의 균형배출권가격이 1,409.3원/$kg{\cdot}BOD$으로 추산되었다. 이는 외국의 사례와 비교하여 적정한 수준이라 평가되며 이러한 배출권가격은 수질 오염물질의 단위당 경제적 가치를 산정하여 수질변화를 수반하는 사업의 B/C분석에 직접적으로 이용할 수 있을 것으로 기대된다.

• 한국토양비료학회지
• /
• 제31권2호
• /
• pp.85-94
• /
• 1998

물의 높은 유전율을 이용하여 토양 수분함량을 검정하고저 피복 절연 철봉을 토양에 박아 두 극으로 하는 토양 매질 콘덴서에 RC발진회로를 적용하여 주기를 조사하거나 또는 10 mega Herz Pulse 투여시 최대 저장(貯藏) 전압을 검정하는 방식으로 수분 변화에 따른 토양의 유전율을 조사하였다. 주기식 쎈서에선 토양 콘덴서의 용량이 영점 조정후 표준 콘덴서에 비교된 백분율로 출력되었는데 쎈서봉을 물에 담근 깊이와 선형적 관계에 있었다. 여러 개의 쎈서를 가까운 거리에 설치하면 쎈서봉이 안테나 역할을 하여 RC 발진에 교란이 있었으며 변온에 따른 출력 보정 함수를 제시했다. 토양 수분 함량과 출력사이에 높은 상관성이 있으나 쎈서 붕이 설치된 깊이 및 방향에 따라 출력반응이 변화하므로 사용자가 설치후 출력을 토양수분으로 변환하는 함수를 구하여야 한다. 전압식 쎈서에선 출력이 토양수분 함량과 역함수적 관계에 있어 토양 수분 정밀 계측용으론 적합치 않으나 구성 부품이 적고 노화가 느리어 토양 수분의 간이 검정에 적합하고 출력 전압에 따라 relay를 개폐하되 개폐 전압을 사용자가 설정할 수 있는 회로를 첨부하여 수위 조절 또는 토양수분에 따른 관개 line개폐에 활용한 결과 재현성이 우수하였다.

• 한국작물학회지
• /
• 제41권spc1호
• /
• pp.25-45
• /
• 1996

Soyfoods have potential roles in the prevention and treatment of chronic diseases, most notably cancer, osteoporosis, and heart disease. There is evidence that carcinogenesis are supressed by isolated soybean derived products in vivo such as a protease inhibitor, phytic acid, saponins and isoflavones. It is believed that supplementation of human diets with soybean products markedly reduces human cancer mortality rates. Especially, recent papers recognize the potential benefit of soybean isoflavone components for reducing the risk of various cancers. Isoflavones exhibit a multitude of medicinal effects that influence cell growth and regulation, which may have potential value in the prevention and treatment of cancer. In addition to potential biological effects, soybean isoflavones have the important physiological functions such as the induction of Bradyrizobium japonicum nod genes and the responses of soybean tissues to infection by Phytophthora megasperma as well as biochemical activities such as antifungal and antibacterial actions. Genistin, daidzin, glycitin and their aglycone (genistein, daidzein, glycitein) are the principal isoflavones found in soybean. Malonyl and acetyl forms have also been detected but they are thermally unstable and are usually transformed during the processing in glucoside form. Most soy products, with the exception of soy sauce, alcohol-extracted soy protein concentrate, and soy protein isolate, have total isoflavone concentrations similar to those in the whole soybean. Soybean-containing diets inhibit mammary tumorigenesis in animal models of breast cancer, therefore, it is possible that dietary isoflavones are an important factor accounting for the lower incidence and mortality from breast cancer. Of the total soybean seed isoflavones, $80\~90\%$ were located in cotyledons, with the remainder in the hypocotyls. The hypocotyls had a higher concentrations of isoflavones on a weight basis compared with cotyledons. Isoflavone contents were influenced by genetics, crop years, and growth locations. The effect of crop year had a greater impact on the isoflavone contents than that of location. The climate condition might be the attribution factor to variation in isoflavone contents. Also, while the isoflavone content of cotyledons exhibited large variations in response to high temperature during seed development, hypocotyls showed high concentration in isoflavone content. So, it is concluded that one of the factors affecting isoflavone content in soybean seeds is temperature during seed development. High temperature, especially in maturity stage, causes lower isoflavone content in soybean seed. It is also suggested that there may exist a different mechanism to maintain isoflavone contents between cotyledon and seed hypocotyls. In a conclusion, soy foods may be able to have a significant beneficial impact on public health.

• Journal of Preventive Medicine and Public Health
• /
• 제28권3호
• /
• pp.640-650
• /
• 1995

After the introduction of National Medical Insurance in 1989, the medical demand has rapidly increased. The impact of increased medical demand was followed by an increase in the number of claims in need of review. We studied a new, fair method for reducing the number of claims reviewed. We analysed 90,583 outpatient claims submitted between September and October; claims were made for services given August of 1994. We finally suggested a screening system for claims review using a statistical method of discriminant analysis of the medical costs. The results were as follows. 1. In the cut-off group, age, days of medication, number of hospital or clinic visits, and total charge were significantly high. The cut-off rates according to the hospital-type and existence of accompanied disease were significantly different 2. According to ICD, the cut-off rate was highest in peripheral enthesopathies and allied syndromes(20.76%), lowest in acute sinusitis(0.93%). The mean charges were significantly different according to ICD and existence of cut-off. 3. We build discriminant functions by ICD with such discriminant variables as patient age, sex, existence of accompanied disease, number of hospital or clinic visits, and 9 detailed hospital or clinic charges included in claim. 4. We applied the discriminant function for screening those claims that were expected to be cut-off. The sensitivities comprised from 40% to 70%, and specificities from 70% to 95% by ICD. Acute rhinitis had highest sensitivity(100.00%) and other local infections of skin and subcutaneous tissue had highest specificity(98.45%). The expected number of cut-off was 17,762(19.61%). The total sensitivity was 49.62%, the total specificity was 82.57% and the error rate was 19.66%. We lacked economic analysis such as cost-benefit analysis. But, if the new method of screening claims using discriminant analysis were applied, the number of claims in need of review will reduce considerably.

• 대한한방내과학회지
• /
• 제26권2호
• /
• pp.353-359
• /
• 2005

Objectives: Dysphagia is a common in stroke patients. Dysphagia often affects the rehabilitation of stroke patients by increasing the risk of nutritional deficits and aspiration pneumonia. Despite the proliferation of physical therapies including swallowing training, much controversy remains regarding the application and benefit of them. Therefore, in this study, the clinical effect of moxibustion at Chonjung(CV17, Shanzhong) on post-stroke dysphagia were assessed using Swallowing Provocation Test(SPT). Methods: Dysphagia subjects were selected by Dysphagia Screening Test. Swallowing function was tested by Swallowing Provocation Test(sec). Direct moxibustion was applied to the acupoint, Chonjung, five times and Swallowing Provocation Test was performed before and after 30 minute. The Latency Time of Swallowing Reflex (LTSR) was checked by SPT. To find factors related with improving swallowing function, Cold-Heat and Excess-Deficiency Diagnosis were considered. Results: A total of 42 patient were included, but two of them were excluded due to severe coughing. Overall, the swallowing reflex improved significantly. In subgroup analysis on brain lesion, non-brain stem lesion patients significantly improved. Moxibustion was more effective in the cold group than in the heat group, but there were no differences between the Excess and the Deficiency groups. Conclusions: The result of this clinical study suggest that moxibustion at Chonjung(CV17, Shanzhong) is an effective treatment for the dysphagia patients after stroke, especially in non-brain stem lesion and the cold diagnosed patients.

• 자원ㆍ환경경제연구
• /
• 제20권3호
• /
• pp.595-628
• /
• 2011

본 연구는 한국개발연구원의 예비타당성조사에서 문화 과학 시설 등의 비정형 사업에 대한 편익 평가의 기법으로 활용도가 커지고 있는 CVM의 분석체계를 고찰하고 개선과제를 제시하였다. CVM의 설계에서 시장영역, 즉 목표모집단의 설정, 소득세라는 지불수단, 5년간 연단위로 한정하는 지불 방법, 저항응답의 사유 등에 대해서는 추가적인 논의가 필요하고, CVM의 설계에서 편의를 줄일 수 있는 전문가 검토, 표적집단조사, 사전조사, 본조사가 운영되도록 하여야 한다. 한편 CVM의 지불의사 유도 방법으로 활용되고 있는 단일 및 이중 양분선택형 질문방식에 의한 지불의사 유도 방법이 일반적이지만, 이 모형들과 관련된 쟁점에 대한 검토와 더불어 이외의 모형에 대해서도 검토하는 작업이 필요하다. WTP 함수 추정에 가정하고 있는 특정 분포 가정을 다양화하여 WTP의 변동성을 검토하고, 모수적 분포 이외에 비모수적 기법을 활용하여 WTP 함수를 추정하는 연구가 필요한 시점이다. 아울러 0의 지불의사 문제와 저항응답을 처리하기 위한 다양한 시도가 필요하며, 지불거부여부를 제시금액 이전에 제시하는 등의 질문 순서의 변화 등을 통한 지불거부자 파악 과정에서 발생하는 편의를 회피하는 노력 등도 검토되어야 한다.