• Journal of the Korean Geographical Society
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• v.36 no.4
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• pp.434-443
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• 2001

Differing from the existing method to optimize the statistical proximity, the new optimization method was developed to maximize the spatial proximity among the unit areas of choropleth map. 25 choropleth maps were made using 5 classification methods(maximum BEI, maximum TEI, equal interval, natural break, n-tile) for 5 classes(3∼7) and were analyzed to elucidate the effectiveness of classification methods on the basis of 3 evaluation indeces (TEI, BEI, $C_{F}$). The results from the maximum TEI and maximum BEI were evaluated as relatively stable and effective compared to those from other classification methods. But they showed the opposite trends owing to the trade-off relationships. Meanwhile, the resets from the natural break method got higher marks, which was also identified through the analysis using a new $alpha$-index.x.

• Journal of the Chungcheong Mathematical Society
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• v.19 no.2
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• pp.123-131
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• 2006

In this paper, a numerical programming for Liapunov index of differential equations with periodic coefficients depending on parameters is given. The associated equations are given at first, then existence of periodic solutions to the associated equations is proved in this paper. And we compute periodic solution u(t) of the associated equations. Finally, we give the error of approximate calculation.

• Journal of the Korean Data and Information Science Society
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• v.24 no.6
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• pp.1231-1239
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• 2013

Recently, successful management of the brand is more important than anything else to enhance the competitiveness of enterprises and increase customer loyalty. Most customers evaluate value and image of an enterprise in accordance with their experience of its goods and service. This study focused on the Fisheries Cooperative Association representative brand for the marketing point of view and attitude shall establish a scheme that can identify. We suggest a model that can measure the brand equity index (BEI) for equity. Based on the survey, we intended to provide the strategic direction and derive important factors for improving brand equity.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.200.1-200.1
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• 2003

The purpose of this study is to examine whether an brain to blood efflux system for taurine is present on the blood-brain barrier (BBB) or not and this efflux transport system is regulated by CNS cell damage with oxidative stress agent such as diethyl maleate (DEM) or tumor necrosis factor-a (TNF-${\alpha}$), by using the brain efflux index (BEI) method. The brain efflux index value is defined as the relative amount of test compound efflux from cerebrum compared with that of a reference compound, [$\^$14/C] carboxyinulin, which has limited BBB permeability. (omitted)

• YAKHAK HOEJI
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• v.47 no.4
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• pp.224-229
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• 2003

We have investigated the transport characteristics of synthetic antioxidant and free radical scavenger, $\alpha$-phenyl-n-tert-butyl nitrone (PBN) at the blood-brain barrier (BBB) by in vitro uptake study in conditionally immortalized rat brain capillary endothelial cell line (TR-BBB). Also, the efflux of PBN from brain to blood is estimated using the brain efflux index (BEI) method. Choline is a charged organic cation, including nitrogen-methyl group and shows the carrier-mediated distribution to the brain. [$^3$H]Choline uptake by TR-BBB cells was significantly inhibited by PBN with $IC_{50}$/ of 1.2 mM, which appears to be due to similar structures between choline and PBN. And, PBN was microinjected into Par2 of the rat brain by BEI method, and was eliminated from the brain with an apparent elimination half-life of about 2 min. Also, [$^3$H]choline efflux was significantly inhibited by PBN using BEI method. In conclusion, the efflux transport of PBN takes place across the BBB and PBN may be transported into the brain and eliminated from the brain by BBB choline transporter.

• Korean Journal of Radiology
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• v.23 no.10
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• pp.986-997
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• 2022

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent ¹⁸F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called "individual contribution index" were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUV_mean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) × 10^-3 and (0.0967 ± 0.0545) × 10^-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785-0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUV_mean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

• Journal of Environmental Health Sciences
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• v.27 no.3
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• pp.71-80
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• 2001

Blood and urine mercury level of three workers were monitored during 60~80 days after high exposure to mercury at the silver refining plant. Mercury was used to form silver-mercury amalgam from plating sludge. Workers were exposed to mercury about 70 days at the several processes, such as hand held weaving, vibration table, and heating from the furnace. mercury was analysed by atomic absorption spectroscopy-vapor generation technique. Recovery from the biological sample was 95.51% and pooled standard deviation was 0.033. At the time of study, there was no work at the workplace. So, airborne mercury concentration was measured with area sampling 5 days after the work, ranged from 0.1459 to 1.2351 mg/㎥(Arithmatic mean 0.4711 mg/㎥, Geometric mean 0.3566 mg/㎥) at the inside of the plant, that is far above the ACGIH's TLV(0.025 mg/㎥) and ranged from 0.0073 to 0.0330 mg/㎥ at the outdoor. Blood mercury levels at the beginning of the monitoring were 4~14 times greater than the American Conference of Governmental Industrial Hygienists Biological Exposure Index(ACGIH BEI, 15 ug/L). Blood mercury levels were decreased logarithmically, that is, rapidly at the high level and slowly at the low level but sustained above the level of the ACGIH BEI 60~80 days after the work. Urine mercury levels at the beginning of the monitoring were 8~16 times greater than the ACGIH BEI(35 ug/g creatinine). Urine mercury levels were decreased logarithmically, but correlation between urine level and off-days were lower than those of blood. Decreasing pattern of blood mercury levels were little affected than that of urine levels when the chelating agent, D-penicillamine, was administered. There was correlation between blood mercury level and urine mercury level(0.81~0.83) but it didn\`t mean that the highest blood mercury level corresponded the highest urine mercury level. In our study, Case 1 always shows the highest level in urine but case 3 always shows the highest level in blood. Creatinine correction represented better correlations between urine mercury levels and blood levels, and between urine levels and off-days rather than by urine volume. Spot urine sampling had a wide variation than that of whole day urine sampling. So, We recommend spot urine sampling for screening and whole day urine sampling for exact diagnosis.

• Journal of Korean Society of Forest Science
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• v.28 no.1
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• pp.1-20
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• 1975

F$\ddot{u}$r die Erforschllng der Variationen bei der Naturpopulationen der Pinus densifiora wurden drei Populationen aus Chuwangsan (Kyong-buk), Anmyondo (Chung-nam) und Odaesan (Kangwon) Ausgewiiblt. Bei je 20 Individuen jeder Population wurden die Variationen von der Eigenschaft der $\ddot{a}$usseren Gestalt, von der anatomischen und morphologischen Eigenschaft der Kiefernadel und von der Holzqualit$\ddot{a}$t an Bohrsp$\ddot{a}$nen untersucht. Das Ergebnis der Untersuchung konnte in den folgenden sechs Punkten formuliert werden. 1. Von den Eigenschaften der $\ddot{a}$usseren Gestalt ist die Geradheit des Baumstamms, der Durchmesser der Zweige und der Winkel der Verzweigung in der Odaesan Population wlinschenswerter als in anderen Populationen. 2. Es wird festgestellt, dass sich die drei Nadelmerkmale, Anzahl der Z$\ddot{a}$hne je 0.5 cm, Anzahl der Stomata-Reihen und Anzahl der Harzkan$\ddot{a}$le, sowohl zwischen den Populationen als auch zwischen den Individuen signignifikant unterscheiden. 3. Bei der Betrachtung des Harzkanal Index, der Schichtanzahl der Hypodermis und der Entfernung der Fibrovasalb$\ddot{u}$ndel wird aufgezeigt, dass sich alle drei gepr$\ddot{u}$ften Populationen geringf$\ddot{u}$gig von der normalen Kiefer unterscheiden. 4. Zwischen den Populationen ergibt sich ein Unterschied im Prozentanteil des Spatho lzes und im spezifischen Geswicht, jedoch zeigt die Breite der Jahresrings und die Tracheidenl$\ddot{a}$nge keinen Unterschied. Das spezifische Gewicht und die Tracheidenl$\ddot{a}$nge der Individuen jeder Population ist signifikant verschieden. 5. Bei dem Alter 11-20 ist der Prozentanteil des sp$\ddot{a}$tholzes am gr$\ddot{o}$ssten und wird aber danach immer geringer bis zum Alter 30; sp$\ddot{a}$ter zeigt sich dann keine sichtbare Ver$\ddot{a}$nderung mehr. Das spezifische Gewicht sich vergr$\ddot{o}$ssert bei der Zunahme des Jahresrings, nimmt aber dann in Anmyondo und Odaesan Populationen beim Alter 21-30 wieder ab. Die Tracheidenl$\ddot{a}$nge der drei Populationen besitzen die Neigung, sich nach der zunahme der Jahresringe zu vermehren. 6. Mit diesen hier behandelten Charakteren werden ganz allgemeinen die Unterschiede der drei Kiefer populationen festgestellt. Diese Ergebnisse sind sehr bemerkenswert betrachtet vom genetischen Gesichtspunkt der waldbaumpopulation.

• Biomolecules & Therapeutics
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• v.14 no.1
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• pp.45-49
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• 2006

The purpose of this study was to clarify the efflux transport system of choline from brain to blood across the blood-brain barrier (BBB) in rats using the brain efflux index (BEI) method. $[^3H]$Choline was micro-injected into parietal cortex area 2 (Par2) of the rat brain, and was eliminated from the brain with elimination halflife of 45 min. The BBB efflux clearance of $[^3H]$choline was about 124 mL/min/g brain, which was determined from combination of an elimination rate constant $(1.54X10^{-2}min^{-1})$ and the distribution volume in the brain (8.05 mL/g brain). The efflux of $[^3H]$choline was inhibited by unlabeled choline in a dose-dependent manner and was significantly inhibited by cationic substrates, such as hemicholinium-3 and tetraethylammonium (TEA). These results suggest that the BBB may act as an efflux pump for choline to reduce the excessive choline concentration in the brain interstitial fluid.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.3
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• pp.35-55
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• 2001

In der Semiotik ist es sehr wichtig, den Rahmenbereich des Zeichens festzustellen, weil der Bereich des Zeichens je nach Wissenschaftler unterschiedlich ist. Dementsprechend muss jedes Forschungsergebnis in der Semiotik hinterfragt werden, um sichergehen zu $k\"{o}nnen$, ob es zur Semiotik $geh\"{o}rt$ oder nicht. Daher besteht $zun\"{a}chst$ die Notwendigkeit, zu bestimmen, was ein Zeichen ist. In diesem Zusammenhang versuchten wir in diesem Aufsatz, damit wir den Begriff 'Zeichen' besser erfassen $k\"{o}nnen$. das Zeichen von C. S. Peirce mit dem van W. v. Humboldt zu vergleichen. Zu Beginn dieses Aufsatzes stellten wir dar, was ein Zeichen ist. Dieser Vorgang ist notwendig, damit mit Hilfe des allgemeinen Begriffes des Zeichens ein Vergleich zwischen Peirce und Humboldt angestellt werden kann. Danach stellten wir die Zeichentheorie von Peirce vor. Nach Peirce ist die Sprache eine Untergattung von drei Zeichensorten, die Ikon, Index und Symbol genannt werden. Nach ihm gehbrt das Symbol zur Sprache. $F\"{u}r$ ihn ist der Interpretant im Zeichenbegriff am wichtigsten, weil ein Zeichen immer eines Interpretantes bedarf, der das Zeichen interpretiert. Aber der Interpretant ist kein Individuum, sondern ein interpretierendes $Bewu{\ss}tsein$, also eine traditionelle Gesellschaft, die ein Muster zum Interpretieren bietet. $Anschlie{\ss}end\;besch\"{a}ftigten$ wir uns mit der Theorie von Humboldt. Er benutzt verschiedene Zeichenbegriffe wie z.B. Schriftzeichen, Lautzeichen, Sprachzeichen, grammatische Zeichen, $h\"{o}rbare$ Zeichen, zeitliche Zeichen und $r\"{a}umliche$ Zeichen. Bei ihm ist die Unterscheidung zwischen Wort und Zeichen besonders wichtig, weil das Wort nicht zum Zeichen $geh\"{o}rt$, wie wir es normalerweise annehmen. Er behauptet, dass das Wort beim Produzieren motiviert ist. Daher ist nach ihm das Wort transsemiotisch. $Dar\"{u}ber$ hinaus muss das Zeichen und das Wort im Zusammenhang zwischen Sprache und Denken betrachtet werden. Wenn man das Wort als Zeichen betrachtet, ist das Wort ein Zwischending zwischen dem Sprechenden und dem Ding. Damit $k\"{o}nnen$ wir schlussfolgern; 1) Bei Humboldt ist das Zeichen em Mittel zum Denken, das sich vom transsemiotischen Wort unterscheidet. 2) Nach Peirce besteht ein Zeichen aus Ikon, Index und Symbol. Im Zeichen, das aus Reprasentamen, Interpretant und Objekt besteht, ist der Interpretant am wichtigsten, denn ein Zeichen, dass keinen Interpretant hat, ist kein Zeichen mehr, das interpretierbar ist.