• Korean Journal of Biological Psychiatry
• /
• v.18 no.2
• /
• pp.61-71
• /
• 2011

Substance addiction is a chronically relapsing disorder that has been characterized by a vicious cycle composed of intoxication, craving/anticipation, withdrawal, and response inhibition/bingeing. Here we summarize the findings from neuroimaging studies in addiction according to these behavioral components and suggest the integrated neurobiological model of drug addiction and related brain correlates. The roles of various prefrontal regions, thalamus, memory circuit, anterior cingulated, and insula were also suggested in addition to those of classical mesolimbic dopaminergic system and its responsivity. Limited studies of behavioral addiction demonstrated a similarity with substance addiction on the neurobiological basis. Based on the current understanding of neurobiology of addiction, further researches on interactions of behavioral components and their brain correlates, behavioral addiction, and therapeutic applications will be desired.

• BMB Reports
• /
• v.55 no.12
• /
• pp.621-626
• /
• 2022

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the degeneration of motor neurons in the spinal cord. Main symptoms are manifested as weakness, muscle loss, and muscle atrophy. Some studies have reported that alterations in sphingolipid metabolism may be intimately related to neurodegenerative diseases, including ALS. Acid sphingomyelinase (ASM), a sphingolipid-metabolizing enzyme, is considered an important mediator of neurodegenerative diseases. Herein, we show that ASM activity increases in samples from patients with ALS and in a mouse model. Moreover, genetic inhibition of ASM improves motor function impairment and spinal neuronal loss in an ALS mouse model. Therefore, these results suggest the role of ASM as a potentially effective target and ASM inhibition may be a possible therapeutic approach for ALS.

• 대한불안의학회:학술대회논문집
• /
• 2005.05a
• /
• pp.14-24
• /
• 2005

o 기질적 행동억제(behavioral inhibition)은 조건 및 비조건 공포의 기저 기전의 신경계와 관련이 있다. o 환경적 영향이 행동 억제에 영향을 미친다. o인지과정이 행동 억제의 표현에 영향을 줄 수 있다. o 행동 억제는 정신병리의 위험 인자이다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 2004.11a
• /
• pp.29-29
• /
• 2004

• Journal of Science Education
• /
• v.35 no.1
• /
• pp.59-67
• /
• 2011

The purpose of this study was to analyze on the relations of motivation system about science learning and science achievement. TIMSS 2007 was selected and translated for science achievement test. After that, fourth-grade 496 students and eighth-grade 425 students were required to accomplish the questionnaire on behavioral inhibition/activation system about science learning(SL-BIS/BAS) and science achievement. There were negative correlation with SL-BIS and science achievement, and positive correlation with SL-BAS and science achievement. In addition, two systems account for 12% of science achievement. These results would be helpful for teachers to understand the difference about motivation by students' variables and to make a plan for the appropriate strategies for learners.

• The Korean Journal of Pharmacology
• /
• v.11 no.1 s.17
• /
• pp.55-60
• /
• 1975

An animal which is placed in a new environment displays a complex behavioral pattern consisting of locomotion, grooming and rearing. This behavioral pattern is influenced by endogenous and exogenous stimuli, such as hormonal secretion, level of neurohumoral transmitters, drugs and light. It is widely known that the most tranquilizers depressed spontaneous motor activity although their mechanisms of action were different, while antidepressants stimulated except imipramine which showed various action. Until the present time, the hole-board apparatus, which gives rather subjective data, has been used extensively to study the effects of drugs on general activity and exploratory behavior in mice. Recently a new apparatus for mobility measurements, called a 'Selective Activity Meter' has been introduced. This instrument supposedly produces more objective data on activity and behavior. The purpose of the present experiment was to study the influence of psychotropics on motor activity using the Selective Activity Meter. In the experiment, various psychotropic agents such as major tranquilizers(chlorpromazine, haloperidol); minor tranquilizers(meprobamate, diazepam); and antidepressants(amphetamine, imipramine) were used. In each experiment, the drug was administered to five mice and their activity was recorded. Each experiment was run five or more times and the results are based on the mean of each trial. The results are summarized as follows: 1. The group of mice treated with chlorpromazine showed markedly inhibited motor activity in comparison with controls and the inhibitory action of chlorpromazine was shown to be more intense than any of the other drugs used in the test. Haloperidol administration yielded similar results until 60 minutes, but mice showed less inhibition of motor activity than with chlorpromazine after 90 minutes. 2. In the group treated with diazepam, there was strong inhibition of motor activity until 30 minutes, but after 60 minutes the mice showed less inhibition than with chlorpromazine. In the meprobamate group, motor activity was inhibited in a manner similar to that of other tranquilizers, but the inhibition was less than that of diazepam. 3. In the group treated with imipramine, the inhibition developed gradually after ten minutes. 4. The effects of amphetamine did not appear until 30 minutes after administration, but then there was a significant increase in the motor activity.

• Korean Journal of Cognitive Science
• /
• v.20 no.3
• /
• pp.357-381
• /
• 2009

Although it is known that there are personality characteristic variances in the sensitivity to environmental feedback, the trait individual difference has scarcely been explored in the context of recognition memory decision. The present study investigated this issue by examining the relationship between the feedback-based adaptive flexibility of recognition criterion positioning and personality differences in general sensitivity to non-laboratory outcomes. Experiment 1 demonstrated that veridical feedback itself had little effect on the recognition decision criterion whereas Experiment 2 demonstrated that biased feedback manipulations selectively restricted to high confidence errors, induced shifts even in the overall Old/New category criterion. Critically, individual differences in stable personality characteristic linked to reward seeking(Behavioral Activation System-BAS) and anxiety avoidance (Behavioral Inhibition System-BIS) has been shown to predict the sensitivity of subjects to this form of feedback-induced criterion learning. This data further support the idea that incremental reinforcement-based learning mechanism not often considered important during explicit recognition decisions may play a key role in criterion setting.

• Korean Journal of Health Education and Promotion
• /
• v.26 no.2
• /
• pp.63-73
• /
• 2009

Objectives: The purpose of this study was to identify the degree of internet addiction and factors affecting internet addiction in elementary school students. Methods: A cross-sectional survey design was employed in this study. The subjects were 378 students who were recruited from 5th and 6th grade in five elementary schools in J city, Korea. Data were collected through a structured questionnaire. The data were analyzed using the SPSS Win 10.1 program. Results: Of the children, 51.9% reported being average online users, 45.5%, heavy online users, and 2.6%, internet addicted. The level of internet addiction of subjects correlated significantly with the behavioral activation system, behavioral inhibition system, family cohesion, and learned self-concept, but not family adaptability. Significant predictors influencing internet addiction were the behavioral activation system, learned self-concept, and family cohesion. These predictors accounted for 22% of variance in internet addiction. Conclusion: This study found that the behavioral activation system in personality aspects, family cohesion in the family system, and learned self-concept are primary factors that explain internet addiction among elementary students. We suggest these results be used to develop an online addiction prevention or treatment program.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.2
• /
• pp.342-348
• /
• 2017

This study examined the difference between parents' and teachers' recognition about problem behaviors of children. The findings showed that there was a distinct difference between parents' and teachers' recognition about all problem behaviors of children. Especially, teachers had more recognition about problem behaviors of children than parents. And the reactive interaction and the actual prevention in educational institutions were preferred in the difference between parents' and teachers' recognition about a teaching strategy for children, such that teachers had significantly higher recognition about a teaching strategy for children than parents did, while there was no significant difference in the strategy for social emotion. This means that teachers should originally control and manage various problem behaviors based on the common teaching strategy, which is socio-emotionally recognized, rather than the biased teaching strategy. But the teaching strategy of reactive interaction is preferred in accordance with the type of problem behaviors between teachers and children and the children who show problem behaviors. Especially, teaching strategies of reactive interaction and actual prevention focused on the inhibition and prevention of children's problem behaviors are preferred in light of children's characteristics of many unexpected problem behaviors.

• Journal of Sasang Constitutional Medicine
• /
• v.31 no.1
• /
• pp.36-64
• /
• 2019

Introduction The purpose of this study was to review thirty years of studies on psychological characteristics of Sasang types to delineate generalizable psychological theories pertaining Sasang typology. Methods Research articles providing psychometric characteristics of each Sasang types were extracted from five database written in Korean and English. Demographic features of the participants, clinical methods for the Sasang type classification, and psychological characteristics of each Sasang types were reviewed and summarized. Results A total of 59 peer-reviewed research articles were found to be published from 1991 to 2018, and the So-Yang and So-Eum Sasang type showed distinctive and contrasting psychological features. The overlap between Eastern and Western psychology in Behavioral Activation and Inhibition System was highlighted as for personality studies, but the anxiety as a pathological factor was not found distinguishable between Sasang types. Discussion The present systematic review provided insight on psychological perspectives of Sasang typology, and would be useful for establishing unique construct of Korean Psychology.