• 생물정신의학
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• 제18권2호
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• pp.61-71
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• 2011

Substance addiction is a chronically relapsing disorder that has been characterized by a vicious cycle composed of intoxication, craving/anticipation, withdrawal, and response inhibition/bingeing. Here we summarize the findings from neuroimaging studies in addiction according to these behavioral components and suggest the integrated neurobiological model of drug addiction and related brain correlates. The roles of various prefrontal regions, thalamus, memory circuit, anterior cingulated, and insula were also suggested in addition to those of classical mesolimbic dopaminergic system and its responsivity. Limited studies of behavioral addiction demonstrated a similarity with substance addiction on the neurobiological basis. Based on the current understanding of neurobiology of addiction, further researches on interactions of behavioral components and their brain correlates, behavioral addiction, and therapeutic applications will be desired.

• BMB Reports
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• 제55권12호
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• pp.621-626
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• 2022

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the degeneration of motor neurons in the spinal cord. Main symptoms are manifested as weakness, muscle loss, and muscle atrophy. Some studies have reported that alterations in sphingolipid metabolism may be intimately related to neurodegenerative diseases, including ALS. Acid sphingomyelinase (ASM), a sphingolipid-metabolizing enzyme, is considered an important mediator of neurodegenerative diseases. Herein, we show that ASM activity increases in samples from patients with ALS and in a mouse model. Moreover, genetic inhibition of ASM improves motor function impairment and spinal neuronal loss in an ALS mouse model. Therefore, these results suggest the role of ASM as a potentially effective target and ASM inhibition may be a possible therapeutic approach for ALS.

• 대한불안의학회:학술대회논문집
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• 대한불안의학회 2005년도 춘계학술대회
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• pp.14-24
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• 2005

o 기질적 행동억제(behavioral inhibition)은 조건 및 비조건 공포의 기저 기전의 신경계와 관련이 있다. o 환경적 영향이 행동 억제에 영향을 미친다. o인지과정이 행동 억제의 표현에 영향을 줄 수 있다. o 행동 억제는 정신병리의 위험 인자이다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2004년도 추계학술대회 논문집
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• pp.29-29
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• 2004

• 과학교육연구지
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• 제35권1호
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• pp.59-67
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• 2011

이 연구의 목적은 과학학습 동기체계와 과학 성취도의 관계를 분석하는 것이다. 과학 성취도 검사를 위해 TIMSS 2007을 선정하고 번역하였다. 이후, 초등학교 4학년 496명, 중학교 2학년 425명이 과학학습행동억제/활성화체계(SL-BIS/BAS)와 과학 성취도 검사지를 수행하였다. 연구 결과, 과학 성취도는 SL-BIS와 부적상관이 있으며, SL-BAS와 정적상관이 있었다. 또한 과학 성취도에 대한 두 체계의 설명력은 12%로 유의미하였다. 본 연구에서 SL-BIS/BAS의 분석을 통해 동기와 관련변인을 근본적으로 이해하여, 학습자에게 적합한 지도 계획을 세우기 위한 기초자료로 활용할 수 있을 것이다.

• 대한약리학회지
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• 제11권1호
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• pp.55-60
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• 1975

An animal which is placed in a new environment displays a complex behavioral pattern consisting of locomotion, grooming and rearing. This behavioral pattern is influenced by endogenous and exogenous stimuli, such as hormonal secretion, level of neurohumoral transmitters, drugs and light. It is widely known that the most tranquilizers depressed spontaneous motor activity although their mechanisms of action were different, while antidepressants stimulated except imipramine which showed various action. Until the present time, the hole-board apparatus, which gives rather subjective data, has been used extensively to study the effects of drugs on general activity and exploratory behavior in mice. Recently a new apparatus for mobility measurements, called a 'Selective Activity Meter' has been introduced. This instrument supposedly produces more objective data on activity and behavior. The purpose of the present experiment was to study the influence of psychotropics on motor activity using the Selective Activity Meter. In the experiment, various psychotropic agents such as major tranquilizers(chlorpromazine, haloperidol); minor tranquilizers(meprobamate, diazepam); and antidepressants(amphetamine, imipramine) were used. In each experiment, the drug was administered to five mice and their activity was recorded. Each experiment was run five or more times and the results are based on the mean of each trial. The results are summarized as follows: 1. The group of mice treated with chlorpromazine showed markedly inhibited motor activity in comparison with controls and the inhibitory action of chlorpromazine was shown to be more intense than any of the other drugs used in the test. Haloperidol administration yielded similar results until 60 minutes, but mice showed less inhibition of motor activity than with chlorpromazine after 90 minutes. 2. In the group treated with diazepam, there was strong inhibition of motor activity until 30 minutes, but after 60 minutes the mice showed less inhibition than with chlorpromazine. In the meprobamate group, motor activity was inhibited in a manner similar to that of other tranquilizers, but the inhibition was less than that of diazepam. 3. In the group treated with imipramine, the inhibition developed gradually after ten minutes. 4. The effects of amphetamine did not appear until 30 minutes after administration, but then there was a significant increase in the motor activity.

• 인지과학
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• 제20권3호
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• pp.357-381
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• 2009

이전의 연구들이 외부 피드백 정보에 대한 반응민감도에 성격특성적 개인차가 반영된다는 사실을 밝힌바 있지만, 재인기억과 관련한 의사결정에서 이러한 기질 혹은 특성적 개인차가 어떻게 관여하는지는 아직 알려진 바가 없다. 본 연구는 재인기억 과제에서 피드백에 근거한 의사결정 준거의 순응적 변화정도와 피드백에 대한 일반적 반응민감도의 개인차간 관계를 살펴보았다. 통제 조건인 실험 1에서는 올바른 피드백 조건이 의사결정 준거의 유동성에 영향을 미치지 않음을 보인 반면 피드백 조작이 이루어진 실험 2에서는 확신도가 높은 오기억 반응에만 선택적으로 편향된 피드백이 주어졌음에도 전반적인 Old/New 반응 범주의 결정준거 또한 순응적으로 이동함이 나타났다. 보다 중요하게 이 피드백에 근거한 의사결정 준거 학습에 나타나는 개별 피험자들의 반응민감도 차이가 강화 추구 혹은 불안 회피와 밀접하게 관련된 안정적 성격(Behavioral Activation System-BAS 혹은Behavioral Inhibition System-BIS)의 개인차에 의해 유의미하게 예측될 수 있음이 나타났다. 이러한 결과는 그동안 외현적인 재인 기억 의사 결정에 있어서 중요하게 여기지 않았던 점증적 강화학습 기제가 결정 준거의 설정에 관여할 수 있음을 보여준다는 데에서 중요한 의미를 찾을 수 있다.

• 보건교육건강증진학회지
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• 제26권2호
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• pp.63-73
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• 2009

Objectives: The purpose of this study was to identify the degree of internet addiction and factors affecting internet addiction in elementary school students. Methods: A cross-sectional survey design was employed in this study. The subjects were 378 students who were recruited from 5th and 6th grade in five elementary schools in J city, Korea. Data were collected through a structured questionnaire. The data were analyzed using the SPSS Win 10.1 program. Results: Of the children, 51.9% reported being average online users, 45.5%, heavy online users, and 2.6%, internet addicted. The level of internet addiction of subjects correlated significantly with the behavioral activation system, behavioral inhibition system, family cohesion, and learned self-concept, but not family adaptability. Significant predictors influencing internet addiction were the behavioral activation system, learned self-concept, and family cohesion. These predictors accounted for 22% of variance in internet addiction. Conclusion: This study found that the behavioral activation system in personality aspects, family cohesion in the family system, and learned self-concept are primary factors that explain internet addiction among elementary students. We suggest these results be used to develop an online addiction prevention or treatment program.

• 한국산학기술학회논문지
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• 제18권2호
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• pp.342-348
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• 2017

본 연구는 유아의 문제행동에 대한 부모와 교사의 인식차이 연구로 유아의 문제행동에 대해 부모와 교사 간 인식차이 분석 결과 유아의 모든 문제행동 유형에 대하여 부모와 교사 간의 인식 차이가 뚜렷한 것으로 나타나고 특히 부모보다 교사들이 문제행동에 대해서 비교적 문제가 있다고 인식하고 있는 것으로 나타났다. 그리고 유아 지도전략에 대한 부모와 교사의 인식 차이에 있어서도 유아의 지도전략에 대해 부모와 교사의 인식에 있어, 반응적 상호작용과 교육기관에서의 예방실제가 선호되는 것으로 나타나 이는 부모보다 교사가 통계적으로 유의미하게 높은 것으로 나타난 반면 사회정서 전략에 있어서는 유의미한 차이가 없는 것으로 나타났다. 이 같은 결과는 원래 유아들의 다양한 문제행동을 통제관리 해야 하는 교사의 입장에서 편중된 지도전략보다 사회 정서적으로 인식되고 있는 공통적 지도전략에 바탕을 두되 교사 유아 간 발생되는 문제행동 유형과 대상유아에 따라 반응적 상호작용하는 지도전략이 선호되고 특히 돌출문제 행동이 많이 발생하는 유아의 행동 특성을 고려할 때 돌출문제 유아의 행동억제와 예방에 중점을 둔 반응적 상호작용 전략과 예방실제 지도전략이 선호되고 있음을 시사한 것으로 평가 할 수 있다.

• 사상체질의학회지
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• 제31권1호
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• pp.36-64
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• 2019

Introduction The purpose of this study was to review thirty years of studies on psychological characteristics of Sasang types to delineate generalizable psychological theories pertaining Sasang typology. Methods Research articles providing psychometric characteristics of each Sasang types were extracted from five database written in Korean and English. Demographic features of the participants, clinical methods for the Sasang type classification, and psychological characteristics of each Sasang types were reviewed and summarized. Results A total of 59 peer-reviewed research articles were found to be published from 1991 to 2018, and the So-Yang and So-Eum Sasang type showed distinctive and contrasting psychological features. The overlap between Eastern and Western psychology in Behavioral Activation and Inhibition System was highlighted as for personality studies, but the anxiety as a pathological factor was not found distinguishable between Sasang types. Discussion The present systematic review provided insight on psychological perspectives of Sasang typology, and would be useful for establishing unique construct of Korean Psychology.