• 대한약침학회지
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• 제10권3호
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• pp.5-19
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• 2007

Objectives The purpose of this study was to investigate the effects of Bee Venom and Sweet Bee Venom to the primary cultured preadipocyte, adipocytes, and localized fat tissue. Methods Decreased preadipocyte proliferation and decreased lipogenesis are mechanisms to reduce obesity. So, preadipocytes and adipocytes were performed on cell cultures using Sprague-Dawley Rats and treated with 0.01-1mg/ml Bee Venom and Sweet Bee Venom. And porcine skin including fat tissue after treated Bee Venom and Sweet Bee Venom according to the dosage dependent variation are investigated the histologic changes after injection of these Pharmacopuncture. Result Following results were obtained from the preadipocyte proliferation and lipolysis of adipocyte and histologic investigation of fat tissue. 1. Bee Venom and Sweet Bee Venom showed the effect of decreased preadipocyte proliferation depend on concentration. 2. Bee Venom and Sweet Bee Venom showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) significantly. 3. Bee Venom was not showed the effect of lipolysis, but Sweet Bee Venom was increased in low dosage and decreased in high dosage. 4. Investigated the histologic changes in porcine fat tissue after treated Bee Venom and Sweet Bee Venom, we knew that these Pharmacopuncture was activated nonspecific lysis of cell membranes depend on concentration. Conclusion These results suggest that Bee Venom and Sweet Bee Venom efficiently induces decreased proliferation of preadipocyte and lipolysis in adipose tissue.

• 한국산학기술학회논문지
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• 제13권11호
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• pp.5479-5486
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• 2012

본 논문에서는 Wi-Fi 환경에서 ZigBee 통신 시 채널별 특성 및 링크 품질을 나타내는 PRR, RSSI, LQI를 측정하고 평가하였다. Wi-Fi의 간섭에 의하여 Wi-Fi와 ZigBee의 겹치는 채널과 겹치지 않는 채널에서의 RSSI와 LQI 값이 PRR과 어떠한 관계가 있는지를 확인하기 위해 Wi-Fi 껐을 때와 켰을 때, 그리고 Wi-Fi를 이용하여 파일 다운로드 시 세 가지 경우에 대하여 실험하였다. Wi-Fi 간섭 환경에서 ZigBee 채널 특성 및 링크 품질 측정을 위해서 Wi-Fi와 ZigBee 수신단을 고정한 상태에서 ZigBee 수신단과 송신단 사이의 거리를 변화시켜가며 실험하였다. ZigBee 송신단은 ZigBee 수신단으로 매초 256 bits의 패킷을 보낸다. Wi-Fi 송신단과 ZigBee 수신단 위치에 따른 PRR값을 채널별로 측정하였고, ZigBee의 송, 수신단의 위치에 따른 RSSI와 PRR, LQI와 PRR을 역시 앞에서의 세 가지 경우에 대하여 측정하였다. 그 결과 Wi-Fi의 영향이 없을 때는 PRR 및 RSSI, LQI가 채널에 관계없이 비슷하였고, Wi-Fi의 영향이 커질수록 PRR의 값이 ZigBee와 겹치는 채널에서는 감소하였지만, 겹치지 않는 채널에서는 비슷하였다. 또한, RSSI와 LQI의 값은 Wi-Fi의 영향과 채널에 관계없이 비슷함을 확인하였다. 따라서 Wi-Fi 환경에서 ZigBee 통신의 간섭 탐지를 위해서 RSSI와 LQI의 사용은 적절하지 않으며, PRR을 이용해야 함을 알 수 있다.

• Journal of Acupuncture Research
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• 제20권6호
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• pp.13-26
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• 2003

Background and Objectives: Bee venom therapy is a new acupuncture theraphy using both acupuncture effect and a medical effect that the biochemical peculiar material affects body. The bee venom theraphy is efficacious of injecting region of disease and acupoint with extracting bee venom from bee and processing it. There have been more than 20 dissertations in Korea about bee venom and the bee venom research has actively been carrying done in other countries such as US, China, Russia, Northern Europe since 1980s. This paper is to understand the trend of arthritis and bee venom, and will be contributed to further bee venom study by analyzing local and international theses. Material and Method: This paper is reported by analyzing the dissertations regarding arthritis and bee venom of Korea and other countries and referencing PubMed. The reference terminology is as follows. bee venom, bee venom therapy, apitoxin, apitherapy, bee sting, bee sing therapy, arthritis, rheumatoid, rheumatic arthritis and so on. Results and Conclusions: The following result have been obtained. 1. Bee venom has an effect on both in vivio and in vitro of arthritisthis with suppressing inflammation, fever and pain. 2. Occasionally bee venom may induce either pain or inflammation. 3. Bee venom induces acute pain in healthy condition, while it suppresses inflammation and pain in regional inflammation state. 4. Bee venom may either induce or suppress pain and inflammation according to the used dosage.

• 한국지능시스템학회논문지
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• 제17권3호
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• pp.417-422
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• 2007

A new evolution method termed queen-bee and mutant-bee evolution is based on the previous queen-bee evolution [1]. Even though the queen-bee evolution has shown very good performances, two parameters for strong mutation are added to the genetic algorithms. This makes the application of genetic algorithms with queen-bee evolution difficult because the values of the two parameters are empirically decided by a trial-and-error method without a systematic method. The queen- bee and mutant-bee evolution has no this problem because it does not need additional parameters for strong mutation. Experimental results with typical problems showed that the queen-bee and mutant-bee evolution produced nearly similar results to the best ones of queen-bee evolution even though it didn't need to select proper values of additional parameters.

• 정보보호학회논문지
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• 제23권3호
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• pp.405-416
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• 2013

ZigBee는 WBAN이나 스마트 그리드를 위한 차세대 표준 인프라로 인정받는 무선네트워크 통신프로토콜이다. 보안은 몇몇의 ZigBee 어플리케이션에서 중요한 역할을 한다. 특히, ZigBee안에서 멤버가 가입이나 탈퇴를 하는 상황에서는 엄격한 멤버관리가 필요하다. 본 논문에서, 우리는 현재 ZigBee에서 사용 중인 탈퇴 과정의 보안 취약점에 대하여 조사하고, 문제 해결을 위한 새로운 보안 스키마를 제시하고 그것의 보안능력 및 성능을 분석한다.

• 대한약침학회지
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• 제9권3호통권21호
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• pp.97-104
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• 2006

Objectives : This study was conducted to compare antibacterial activities and free radical scavenging activity between the Bee Venom and Sweet Bee Venom in which the allergy-causing enzyme is removed. Methods : To evaluate antibacterial activities of the test samples, gram negative E. coli and gram positive St. aureus were compared using the paper disc method. For comparison of the antioxidant effects, DPPH(1,1-diphenyl-2picrylhydrazyl) free radical scavenging assay and Thiobarbituric Acid Reactive Substances(TBARS) assay were conducted. Results : 1. Antibacterial activity against gram negative E. coli was greater in the Sweet Bee Venom group than the Bee Venom group. 2. Antibacterial activity against gram positive St. aureus was similar between the Bee Venom and Sweet Bee Venom groups. 3. DPPH free radical scavenging activity of the Bee Venom group showed 2.8 times stronger than that of the Sweet Bee Venom group. 4. Inhibition of lipid peroxidation of the Bee Venom group showed 782 times greater than that of the Sweet Bee Venom group. Conclusions : The Bee Venom group showed outstanding antibacterial activity against gram positive St. aureus, and allergen-removed Sweet Bee Venom group showed outstanding antibacterial activity against both gram negative E. coli and gram positive St. aureus. For antioxidant effects, the Bee Venom was superior over the Sweet Bee Venom and the superiority was far more apparent for lipid peroxidation.

• 대한약침학회지
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• 제9권3호통권21호
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• pp.61-77
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• 2006

Objectives : Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom in which the allergy causing enzyme is removed. Methods : 95 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of bee venom pharmacopuncture and Sweet BV pharmacopuncture was equally at 0.1mg/ml and the experiment was conducted as the double blind test. Experiment groups were classified into low dosage groups(0.1ml for both bee venom pharmacopuncture and Sweet BV) and high dosage groups where 0.4ml of respective administrations were rendered made observations for allergic responses. Results : Participants of the study was comprised of 71 men and 24 women with the average age of 29.0 years. According to results of the low dosage groups, Sweet BV group showed significant reduction in pain after 4 hours and 24 hours compared to the bee venom pharmacopuncture group. Other allergic responses were insignificant between the groups. For the high dosage groups, Sweet bee venom group showed reduction in pain after 30 minutes and 4 hours. Other allergic responses such as edema, itchiness, dizziness from hypersensitivity, and fatigue were significantly lower in the Sweet bee venom administered group after 30 minutes. Conclusions : As a result of removed allergen, Sweet bee venom significantly inhibits allergic responses both locally and throughout the body. This indicates wider and easier application of Sweet bee venom for the symptoms applicable to the bee venom pharmacopuncture. Further comparative studies should be conducted to yield more objective verification.

• 대한약침학회지
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• 제4권3호
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• pp.93-99
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• 2001

Objective : This study was performed to examine the Herbal Acupuncture decrease the side effect of Bee Venom. Methods: We treated Bee Venom and various Herbal Acupuncture mixed Bee Venom using double blind test to 70th health youth, and checked pain, edema size, CBC, Serum biochemistry and Thermography. Results: 1. Herbal Acupuncture made by Morus bombycis Koidzumi showed good results to decrease the side effect of Bee Venom than any other Herbal Acupuncture. 2. We examined CBC, ESR and Serum biochemistry before and after treated. Special change was not showed. 3. We observed the pain and edema after treated Bee Venom and Morus bombycis Koidzumi Herbal Acupuncture mixed Bee Venom. We knew that Morus bombycis Koidzumi Herbal Acupuncture was decrease the pain and edema due to Bee Venom. 4. According to these clinical studies, Morns bombycis Koidzumi Herbal Acupuncture has a possibility to be a good partner of Bee Venom.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2007년도 춘계학술대회 학술발표 논문집 제17권 제1호
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• pp.233-236
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• 2007

A new evolution method for strong exploration and strong exploitation termed queen-bee and mutant-bee evolution is proposed based on the previous queen-bee evolution [1]. Even though the queen-bee evolution has shown very good performances, two parameters for strong mutation are added to the genetic algorithms. This makes the application of genetic algorithms with queen-bee evolution difficult because the values of the two parameters are empirically decided by a trial-and-error method without a systematic method. The queen-bee and mutant-bee evolution has no this problem because it does not need additional parameters for strong mutation. Experimental results with typical problems showed that the queen-bee and mutant-bee evolution produced nearly similar results to the best ones of queen-bee evolution even though it didn't need to select proper values of additional parameters.

• 대한약침학회지
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• 제10권3호
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• pp.85-89
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• 2007

Objective The aim of this study is to investigate if Sweet Bee Venom therapy has the equal effect in comparison with Bee Venom Therapy on Low back pain with Radiation pain. Methods Clinical studies were done 24 patients who were treated low back pain with radiation pain to Dept. of Acupuncture & Moxibusition, of Oriental Medicine Se-Myung University from April 1, 2007 to September 30, 2007. Subjects were randomly divided into two groups ; Bee Venom treated group(Group A, n=10), Sweet Bee Venom treatred group(Group B, n=14). In Bee Venom treated group(Group A), we treated patients with dry needle acupuncture and Bee Venom therapy. In Sweet Bee Venom treatred group(Group B), we treated patients with dry needle acupuncture and Sweet Bee Venom therapy. All process of treatment were performed by double blinding method. To estimate the efficacy of controlling pain. we checked Visual Analog Scale(VAS). For evaluating functional change of patients, Straight Leg Raising Test(S.L.R.T) was measured. Results 1. In controlling pain, Sweet Bee Venom treatred group(Group B) had similar ability in comparison with Bee Venom treated group(Group A). 2. In promoting function, Sweet Bee Venom treatred group(Group B) had similar ability in comparison with Bee Venom treated group(Group A). Conclusions It may be equal effects as compared with using Bee Venom to treat low back pain with radiation pain using Sweet Bee Venom. We can try to treat other disease known to have effect with Bee Venom.