• 환경영향평가
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• 제28권2호
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• pp.113-128
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• 2019

2018년 가을철(9월 5일~10일, 6일간) 수도권대기오염집중측정소에서 미세먼지와 함께 블랙카본(BC, black carbon)의 농도 및 코팅두께를 파악하였다. 가을철 $PM_{10}$은 $23{\pm}12.6{\mu}g/m^3$, $PM_{2.5}$는 $12{\pm}5.8{\mu}g/m^3$으로 다른 계절보다 낮은 수준이었다. Aethalometer로 측정한 BC는 $0.73{\pm}0.43{\mu}g/m^3$, SOCEC로 측정한 EC(elemental carbon)는 $0.34{\pm}0.18{\mu}g/m^3$, SP2로 측정한 rBC(refractory-BC)는 $0.32{\pm}0.18{\mu}g/m^3$으로 측정방법에 따른 농도차이를 보여주었으나, 시계열 분포와 일 변동은 동일한 경향을 나타내었다. 수도권대기오염집중측정소에서 측정된 블랙카본은 자동차와 같은 일차오염원의 영향을 강하게 받았고, 주간과 야간의 출퇴근으로 인한 교통 혼잡 시간대에 높은 특징을 보였다. SP2로 측정한 $PM_{1.0}$ 단일입자에 대한 블랙카본의 개수농도는 84 nm에서 최고치로 관측되었으며, 코팅두께는 43 nm로 산정되었다. 특히 블랙카본 입자의 직경이 작을수록 코팅두께는 증가하였고, 입자의 직경이 증가할수록 코팅두께는 작아지는 특성을 나타내었다.

• Journal of the Optical Society of Korea
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• 제12권4호
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• pp.351-354
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• 2008

We demonstrate an ultra-dense wavelength-division- multiplexed (UD-WDM) passive optical network (PON) where 12.5-GHz spaced 1 GbE ${\times}$ 256 optical channels are distributed using 12.5- and 200-GHz arrayed waveguide gratings in series. For the generation of upstream signals, we use reflective semiconductor optical amplifiers. We use two optical fiber amplifiers at the optical line terminal to amplify downstream and upstream channels.

• 한국자기공명학회논문지
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• 제23권1호
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• pp.26-32
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• 2019

${\alpha}B$-crystallin (${\alpha}BC$) is a member of a small heat-shock protein (sHSP) superfamily and plays a predominant role in cellular protein homeostasis network by rescuing misfolded proteins from irreversible aggregation. ${\alpha}BC$ assembles into dynamic and polydisperse high molecular weight complexes containing 12 to 48 monomers; this variable stereochemistry of ${\alpha}BC$ has been linked to quaternary subunit exchange and its chaperone activity. The chaperone activity of ${\alpha}BC$ poses great potential as therapeutic agents for various neurodegenerative diseases. In this mini-review, we briefly outline the recent advancement in structural characterization of ${\alpha}BCs$ and its potential role to inhibit protein misfolding and aggregation in various human diseases. In particular, nuclear magnetic resonance (NMR) spectroscopy and its complimentary techniques have contributed much to elucidate highly-dynamic nature of ${\alpha}BCs$, among which notable advancements are discussed in detail. We highlight the importance of resolving the structural details of various ${\alpha}BC$ oligomers, their quaternary dynamics, and structural heterogeneity.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제9권1호
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• pp.47-53
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• 1998

이 연구에서는 세 가지 치료조건을 조성하여 각 치료조건간의 반향어 발생률과 치료효과를 비교하였다. 치료조건1(A)은 치료사가 아동에게 쉽고 짧은 질문을 하는 ‘대화조건’ 이고, 치료조건2(B)는 아동이 치료사가 하라는 지시에 따라 쉬운 과제를 수행하는 ‘과제수행조건’ 이고, 치료조건3(C)은 보상과 통제를 사용하는 ‘강화의 조건’ 이다. 연구설계는 A-B-A-B-BC-B-BC를 사용하였다. 이 연구는 발달연령이 3~4세 수준인 2명의 남아(11세, 12세)에게 실시되었는데, 반향어 치료는 1회기에 15분씩, 하루에 5~6회를 2주간 실시하였다. 반향어 치료를 위한 개입은 즉각 반향어에만 적용했고, 지연 반향어는 치료 개입없이 관찰만 하였다. 아동1의 즉각 반향어 치료결과(평균 비율)는 A(99%)-B(65%)-A(95%)-B(10%)-BC(7%)-B(6%)-BC(7%)로 나왔고, 아동2의 치료결과는 A(67%)-B(62%)-A(63%)-B(35%)-BC(8%)-B(4%)-BC(0%)로 나왔다. 아동1의 지연 반향어는 치료 개입 전후를 통해 3% 수준으로 큰 차이없이 낮은수준을 유지했고, 아동2의 지연 반향어는 강화의 조건 병행 전에는 $35{\sim}57%$ 수준이던 것이 강화의 조건 개입 후에는 $5{\sim}9%$ 수준으로 감소하였다. 이 연구의 결론은 대화상황에서 아동의 반향어를 교정하기보다는 아동에게 쉬운 과제를 수행하는 학습환경을 조성해주는 것이 반향어를 감소시키는데 도움이 되고, 과제수행 학습환경에서 과제수행 행동을 보상하고, 반향어 행동을 통제하는 방법을 사용하면, 반향어 감소는 물론 반향어 치료효과가 아동의 전반적인 언어발달에도 긍정적인 영향을 줄 수 있음을 말해주고 있다.

• 대한전자공학회논문지TC
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• 제41권10호
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• pp.109-117
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• 2004

본 논문에서는 VCDRO, GaAs MESFET, 반사기 등을 이용하여 주파수 체배기 형테로 구성한 K-대역 국부발진기를 설계하고 제작하여 특성을 실험하였다. VCDRO은 위상잡음특성을 개선하기 위하여 저잡음 특성을 가지며 플리커 잡음이 적은 MESFET를 선택하였으며 Q값이 큰 유전체 공진기를 사용하여 선택도를 높였다. 특히, 제안된 주파수 체배기는 반사기와 대역저지필터를 사용함으로써, 일반적인 체배기에 비해 회로의 크기를 줄이고, 고조파 억압특성을 개선했을 뿐만 아니라 더 좋은 변환이득을 얻었다. 제작된 VCDRO의 특성을 측정한 결과, 중심 주파수 12.05 Uh에서 5.8 dRm의 출력 전력과 -37.98 dBc의 고조파 억압, 100 Khz offest 주파수에서 -114 dBc의 위상잡음 특성을 얻을 수 있었으며, 주파수 체배기의 특성을 측정한 결과, 5.8 dBm의 입력신호에 대해 출력 주파수인 24.10 GHz에서 출력 전력은 1.755 dBm이고, 변환이득은 1.482 dB, 고조파 억압은 -33.09 dBc, 100 kHz offset 주파수에서 -98.23dBc의 위상잡음 특성을 얻었다. 주파수 체배 기법을 이용하여 제작된 발진기는 K-대역에서 국부발진기로 이용될 수 있음을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4839-4842
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• 2014

Background: Although the Cox's proportional hazard model is the popular approach for survival analysis to investigate significant risk factors of cancer patient survival, it is not appropriate in the case of log-term disease free survival. Recently, cure rate models have been introduced to distinguish between clinical determinants of cure and variables associated with the time to event of interest. The aim of this study was to use a cure rate model to determine the clinical associated factors for cure rates of patients with breast cancer (BC). Materials and Methods: This prospective cohort study covered 305 patients with BC, admitted at Shahid Faiazbakhsh Hospital, Tehran, during 2006 to 2008 and followed until April 2012. Cases of patient death were confirmed by telephone contact. For data analysis, a non-mixed cure rate model with Poisson distribution and negative binomial distribution were employed. All analyses were carried out using a developed Macro in WinBugs. Deviance information criteria (DIC) were employed to find the best model. Results: The overall 1-year, 3-year and 5-year relative survival rates were 97%, 89% and 74%. Metastasis and stage of BC were the significant factors, but age was significant only in negative binomial model. The DIC also showed that the negative binomial model had a better fit. Conclusions: This study indicated that, metastasis and stage of BC were identified as the clinical criteria for cure rates. There are limited studies on BC survival which employed these cure rate models to identify the clinical factors associated with cure. These models are better than Cox, in the case of long-term survival.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5537-5540
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• 2015

Purpose: To research the association between pre-treatment elevated platelet count and clinicopathologic characteristics in breast cancer (BC), as well as explore the relationship between pre-treatment elevated platelet count and HER2 status and prognosis of BC patients. Materials and Methods: A retrospective cohort of BC patients who were newly diagnosed or treated by surgery only and had pathological detection results and platelet values in the Department of Oncology, the First Affiliated Hospital of Liaoning Medical College were enrolled from 1/1/2008 until 31/12/2009, and followed up until 31/12/2014. Age, thrombocyte parameters before chemotherapy and/or radiotherapy, immunohistochemical (IHM) indexes, and regional lymph node (LN) involvement and progression-free survival (PFS) were recorded. Results: A total of 447 eligible subjects were included in this research. As we analyzed, for HER2, positive and negative, the incidence rates of elevated platelet count were 25.8% and 14.7% (P<0.05). In the Cox proportional hazards model both variables were independent risk factors for BC (for HER2, OR, 0.592, 95% confidence interval, CI, 0.355 to 0.985, P=0.044;f or PLT, OR, 0.998, 95% CI, 0.996 to 1.000, P=0.042). For ER, PR, Ki67 and LN involvement, the differences were not statistically significant (P>0.05). Conclusions: In this research, pre-treatment elevated level of platelet count demostrated a significantrelationship with HER2 amplification/overexpression, and both variables significantly influenced the prognosis of BC. However, elevated platelet count did not exhibit any association with ER, PR, Ki67 and LN involvement.

• 스마트미디어저널
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• 제12권2호
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• pp.42-55
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• 2023

본 논문에서는 블록체인(Blockchain, BC), 인공지능 (Arificial Interlligence, AI), 양자 컴퓨팅 (Quantum Computing, QC) 및 사물 인터넷 (Internet of Things, IoT)의 결합이 의료, 물류 및 금융을 비롯한 다양한 산업 및 분야를 변화시킬 수 있는 가능성을 다룹니다. 이에 대해 기술들이 통합되는 경향과 발전, 그리고 이러한 기술들과 함께하는 잠재적 이점과 도전 과제를 분석합니다. 본 논문에서는 BC, AI, QC 및 IoT를 통합하기 위한 개념적 프레임워크를 제시하고, 제시한 프레임워크의 주요 특징과 도전 과제에 대해서 논의합니다. 또한 이러한 기술들을 통합하는 최신 연구와 개발, 그리고 이러한 기술들과 함께하는 주요 도전 과제와 기회를 살펴봅니다. 본 논문의 분석은 기술들을 통합하는 잠재적 이점을 강조하며, 보안성, 개인 정보 보호 및 효율성의 증대에 초점을 맞추어 이러한 기술들의 미래에 대한 인사이트를 제공합니다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2879-2886
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• 2012

In order to thoroughly analyze risk factors of breast cancer (BC) in premenopausal Uruguayan women, a case-control study was carried out at the Pereira Rossell Women's Hospital, Montevideo, where 253 incident BC cases and 497 frequency-matched healthy controls were interviewed on menstrual and reproductive story, were administered a short food frequency questionnaire and undertook a series of body measurements necessary to calculate body composition and somatotype. Odds ratio (OR) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Among the classical risk factors, only the family history of BC in first degree relatives was significantly associated with risk of premenopausal BC (OR=2.20, 95% CI 1.33-3.62). Interestingly, this risk factor was found to be stronger in women of ages >40 (OR=4.05, 95% CI 2.10-7.81), late menarche (OR= 2.39, 95% CI 1.18-4.85), early age for their first delivery (OR=3.02, 95% CI 1.26-7.22), short time between menarche and first delivery (OR=3.22, 95% CI 1.29-8.07), and with high parity (OR=4.10, 95% CI 1.79-9.36), although heterogeneity was detected only for age and parity. High consumption of red meat was positively associated with the disease risk (OR=2.20, 95% CI 1.35-3.60), in the same way as fried foods (OR=1.79, 95% CI 1.12-2.84). Conversely, a high intake of plant foods displayed a protective effect (OR=0.41, 95% CI 0.26-0.65). Except for hypertension (OR=1.55, 95% CI 1.03-2.35), none of the analyzed components of metabolic syndrome were associated to BC risk. Particular increases of risk for premenopausal BC were found for family history in first degree relatives in certain subsets derived from the menstrual-reproductive history. Preventive strategies could broaden their scope if new studies confirm the present results, in view of the limited prevention measures that premenopausal BC currently has.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2759-2763
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• 2013

Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, $67.4{\pm}12$ years) and forty age-sex matched healthy persons (mean age $56.0{\pm}1.7$ years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj- IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.