• Archives of Pharmacal Research
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• v.21 no.4
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• pp.465-469
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• 1998

The search for platinum (II)-based compounds with improved therapeutic properties was prompted to design and synthesize a new family of water-soluble, third generation cis-diaminedichloroplatinum (II) complexes linked to uracil and uridine. Six heretofore unreported uracil and uridine-platinum (II) complexes are; [N-(uracil-5-yl-methyl)ethane-1,2-di-amine]dichloroplatinum (II) (3a), [N-(uracil-6-yl-methyl)ethane-1,2-diaminel dichloroplatinum (II) (3b), t[N-($2^1$, $3^1$,$5^1$-tri-O-acetyl)uridine-5-yl-methyl] ethane-1,2-diamineldichloroplatinum (II) (6a), {[N-($2^1$,$3^1$, $5^1$-tri-O-acetyl) uridine-6-yl-methyl]ethane-1,2-diamine)dichloroplatinum (II) (6b),[N-(uridine- 5-yl-methyl)ethane-1,2-diamine]dichloroplatinum (II) (7a), [N-(uridine-6-yl- methyl)ethane-1,2-diamine]dichloroplatinum (II) (7b). These analogues were prepared from the key starting materials, 5-chloromethyluracil (1a) and 6-chloromethyluracil (1b) which were reacted with ethylenediamine to afford the respective 5-[(2-aminoethyl)aminol methyluracil (2a) and 6-[(2-aminoethyl)amino]methyluracil (2b). The cis-platin complexes 3a and 3b were obtained through the reaction of the respective 2a and 2b with potassium tetrachloroplatinate (II). The heterocyclic nucleic acid bases 1a and 1b were efficiently introduced on the .betha.-D-ribose ring via a Vorbruggen-type nucleoside coupling procedure with hexamethyldisilazane, trimethylchlorosilane and stannic chloride under anhydrous acetonitrile to yield the stereospecific .betha.-anomeric 5-chloromethyl- $2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4a) and 6-chloromethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4b), respectively. The nucleosides 4a and 4b were coupled with ethylenediamine to provide the respective 5-[(amino-ethyl)aminolmethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5a) and 6-[(aminoethyl)amino] methyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5b). The diamino-uridines 5a and 5b were reacted with potassium tetrachloroplatinate (II) to give the novel nucleoside complexes, 6a and 6b, respectively which were deacetylated into the free nucleosides, 7a and 7b by the treatment with CH$_{3}$ONa. The cytotoxic activities were evaluated against three cell lines (FM-3A, P-388 and J-82) and none of the synthesized compounds showed any significant activity.

• Korean Journal of Food Science and Technology
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• v.31 no.6
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• pp.1458-1464
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• 1999

The whole body of three species of fishes, raw anchovy (Engraulis japonica), big eyed herring (Harengula zunasi), and northern sand lance (Ammodytes personatus) catched at the south adjacent coast of Korea, were analyzed for extractive nitrogen, free amino acids, combined amino acids, ATP and its related compounds quaternary ammonium bases, and guanidino compounds using specimens collected in May and July 1991, and the composition of these nitrogenous components were compared with each other. The contents of extractive nitrogen in anchovy, big eyed herring, and northern sand lance were 633 mg, 601 mg, and 455 mg/100 g, respectively. Thirty-one or thirty-two kinds of free amino acids were found in the extracts of the three species of fishes. Histidine, taurine, alanine, leucine, carnosine, glutamic acid, and lysine were the major free amino acids in every sample. The composition of the major extractive components such as free amino acids, combined amino acids, ATP and its related compounds, TMAO, and creatine in the extracts were similar to each other, but their contents were some different individually.

• Journal of Life Science
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• v.17 no.6 s.86
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• pp.741-747
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• 2007

In the azoospermic patients, there are many of undiagnosed factors related to genetic bases. Among them, Klinefelter's syndrome (47,XXY; KS) and Y-chromosomal microdeletion with normal karyotype(46,XY; YMNK) are the most frequent causes of male infertility. This research focused on the comparative analysis of YMNK (n = 66) and K5 (n = 30) patients suffered from male infertility in Korean population. We used the polymerase chain reaction (PCR) approach including 19 pairs of sequence-tagged site (STS) primers for detecting the Y-chromosomal microdeletion on AZFa, b, c regions, indicating that Y chromosomal microdeletions were almost evenly occurred in AZF all regions in Korean population. Comparative analysis indicated that 34.9% YMNK and 73.4% KS patients harbored the microdeleted Y-chromosome. It seems to be high instability of Y-chromosome in KS patients than that of YMNK infertility patients. Taken together, genome instability containing microdeletion could bring male infertility with the disturbance of normal spermatogenesis.

• Journal of Korean Home Economics Education Association
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• v.32 no.1
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• pp.35-50
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• 2020

This study analyzed the images of father and mother featured in the illustrations of the middle and high school textbooks, paying attention to the roles of the school education for the effective gender equality. The purpose of this study was to examine whether the middle and high school textbooks would serve for a balanced gender role through their illustrations. To this end, this study sampled a total of 36 middle and high school textbooks: for the middle schoolers, and for high schoolers, and thereby, selected their illustrations of parents, and then, analyzed them in terms of their external aspects and contents. Summing up, it could be confirmed through the middle and high school textbooks that most of their illustrations show gender-equal roles, while some of them reflect a fixed conception of the gender roles. Since the homes are the bases for socialization of the children about the gender roles, it is required of our middle and high schools to implement a gender-equal education. As seen in the results of this study, some illustrations of our middle and high school 'technology and home Education' textbooks feature the mothers as housekeeper and the fathers as family heads creating the goods and services. Hence, it is urgent to correct such conception of the patriarchal gender roles.

• Journal of Environmental Health Sciences
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• v.19 no.4
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• pp.51-58
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• 1993

The integrated solid waste management for Seoul Metropolitan city can be established on the basis of the following hierarchy of priorities: 1. Efforts for source reduction should be propelled by both government and citizens to achieve the effects of resource conservation. The adequate production and consumption which are environmentally amenable and sustainable can be induced by the reasonable imposition of deposit money for waste treatment to one-time use products. To accomplish source reduction effectively, the induction of legal and institutional regulation of producer and consumer participation is requisite. 2. For resource recovery, wastes generated should be recycled as far as practicable. Community residents are responsible to separate discharge, the authorities concerned have responsibility of separate collection, and recycling industry should be assissted through tax reduction and financing. Resource separation facilities can be constructed at Kimpo Metropolitan landfill site for wastes not separately collected due to some unavoidable circumstances. 3. Garbage should be composted. Garbage is uneconomical for incineration, because it has high moisture content and low calorie, thus there is no reason for the incineration of garbage even though garbage is classified into combustibles. Composting facilities can be located at sites which are not densely populated and easily accessible to transportation, for example, Kimpo Metropolitan landfill site. Compost produced can be managed by the authorities for the use of fertilizer to a green tract of suburban land and farms. 4. Nonhazardous combustible wastes not recyclable can be utilized for thermal recovery at the incinerators which are completely equipped with pollution control devices. According to the trend of local autonomy and the equity principle of local autonomous entities, incineration facilities of minimal capacity required can be constructed at each districts of Seoul Metropolitan city which have organized local assembly. In case of Yangcheon district, the economically combustible waste quantity is about 260 tons/day which exceeds 150 tons/day, the incineration capacity of existing facility. But, from now on, waste quantity can be reduced substantially by the intensive efforts of citizens for source reduction and recycling and the institutional support of administrative organizations. Especially, it is indispensable for the government to constitute institutional and technological bases that can recycle paper and plastics form 43% of waste generated. A good time for constructing of incineration facilities for municipal solid waste can be postponed to the time that pollution control technologies of domestic enterprises are fully developed to satisfy the standards of air pollution prevention, because the life expectancy of Kimpo Metropolitan landfill site is about 25 years. Within this period, institutional improvements and technological advancements can be attained, while the air qual. ity of Seoul Metropolitan city can be ameliorated to the level to afford incineration facilities. 5. For final disposal, incombustibles and ash are landfilled sanitarily at Kimpo Metropolitan landfill site.

• Journal of Bio-Environment Control
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• v.21 no.4
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• pp.459-465
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• 2012

This study analyzed the effect of semi-rigid rafter-purlin cross-linking connection and driven steel pipe base on the static behavior of plastic greenhouse (PG). To promote the time and cost efficiency of the assembly process, each cross-linking connections of space arch type grid that consists of rafter and purlin is linked with steel-wire buckles, and each end of the rafters was driven directly to the ground to support the PG structure. However, in the design process, cross-linking connections and bases are idealized by being categorized as fully rigid or frictionless pinned, which does not appropriately reflect actual conditions. This study takes a full-scale loading test of PG and analyzes the effect of member cross-linking connections and driven steel pipe base on the behavior of a structure. The analysis provided a basis for determining the rigidity factor of member cross-linking nodes needed for finite element analysis, and the reliability of the result regarding the static behavior of PG.

• Archives of design research
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• v.17 no.4
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• pp.201-210
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• 2004

This study is to analyze the present situation of Incheon design and to research Incheon industrial design with the special character of the city. Next, the final purpose is to apply this study for the Incheon International Design Competition event that will be held first time sponsored by Incheon Metropolitan. Incheon is Metropolitan which has 2.6 million people and the entrance of seoul Metropolitan which is the center of export industry and one of the greatest industrial city. It is growing the hub of International trade city of the twenty-first centry due to the opening of Incheon International Airport and the new development of Song-do city. The industrial structure of Incheon is mostly consist of small industry centered which has a lack of design development capacity, and it has a little insufficient design-related institutes which can educate the design personnel. It has only two universities and six junior colleges. Especially, design-related academics and exhibitions are rare nearby Seoul area. I will contribute the study which makes the industrial character and the necessity of design that can be possible through the Incheon International Design Exhibition, and it will promote the backward design industry and economy of Incheon that compared to other regions of Korea. And, I am going to utilize as basic data bases for exercising advanced Incheon Industrial Design Competition. Furthermore, I would like to contribute the image improvement of new International Incheon Metropolitan through the training of excellent design experts and finding design-related personnels which can be accomplished the cooperation among local autonomy, industries and schools.

• Korean Journal of Food Science and Technology
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• v.30 no.6
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• pp.1345-1349
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• 1998

The flavor constituents and functionality of small kingfish were studied as affected by two stage enzyme hydrolysis (TSEH). Total free amino acid contents in water extract, autolytic extract and TSEH of small kingfish were 541.3 mg%, 8,245.3 mg% and 6,636.6 mg%, respectively. Major free amino acids in TSEH were hydroxyproline, glutamic acid, proline, leucine, phenylalanine, lysine, arginine. As for nucleotides and other bases, IMP, TMAO and total creatinine were principal components in TSEH. And the major inorganic ions in TSEH were Na, K, P, Cl and $PO_{4}$. Also TSEH of small kingfish revealed very higher Angiotensin-I converting enzyme inhibition effect than those of water and autolytic extract.

• Environmental Mutagens and Carcinogens
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• v.26 no.4
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• pp.125-132
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• 2006

Previous studies showed that epigallocatechin gallate(EGCG) have substantial effects of suppressing the N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)-initiated cell transformation process on the bases of foci formation frequency and loss of anchorage dependency. In this study we tried to clarify the molecular mechanism of suppressing the cell transformation process. Mouse cell line balb/c 3T3 A31-1-1 was exposed 2 days to MNNG followed by 15 days 12-O-tetradecanoylphorbol-13-acetate(TPA) treatment for our transformation process. EGCG was added after the time point of 24 hours exposure to TPA and incubated for 19 days. 2029 genes were selected in our transformation process that showed fold change value of 1.5 or more in the microarray gene expression analysis covering the mouse full genome. These genes were found to be involved mainly in the cell cycle pathway, focal adhesion, adherens junction, TGE-$\beta$ signaling, apoptosis, lysine degradation, insulin signaling, ECM-receptor interaction. Among the genes, we focused on the 631 genes(FC>0.5) reciprocally affected by EGCG treatment. Our study suggest that EGCG down-regulate the gene expressions of up stream signaling factors such as nemo like kinase with MAPK activity and PI3-Kinase, Ras GTPase and down stream factors such as cyclin D1, D2, H, T2, cdk6.

• The Journal of Korean Academy of Prosthodontics
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• v.34 no.3
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• pp.415-430
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• 1996

The purpose of this study was to evaluate the stress distributions in the surrounding tissues of the teeth seated by indirect retainers in three different teeth of unilateral distal extension partial denture when the dislodging forces were applied on denture bases. Three dimensional photoelastic models were made. The teeth on which indirect retainers were seated were mandibular left lateral incisor (Model I), canine (Model II), and first premolar (Model III). The dislodging force with 860mg at $45^{\circ}$ angulation to occlusal plane was applied to each model. Three dimensional photoelastic stress analysis was done, and the records were diagramed and analysed. The results were as follows : The compressive stresses were shown the most on neck portions of buccal, mesial, and distal sides in all three models. Slight tensile stresses were shown on neck portions of lingual sides in all three models. The compressive stresses on buccal side were shown in strength in such order as model I, model II, and model III. The compressive stresses were shown on neck portion of mesial and distal sides of model I and mode II, with model I more than Model II. The compressive stresses were shown only on neck portion of mesial side on Model III. The general overall magnitude of compressive stresses were shown in strength in such order as Model I, Model II, and Model III.