• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2011년도 한국컴퓨터종합학술대회논문집 Vol.38 No.1(B)
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• pp.377-380
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• 2011

음악은 인류의 대표적인 예술로서 오랜 세월동안 사랑을 받아왔다. 그 오래된 세월만큼이나 인류가 만들어온 음악의 수는 방대하다. 방대한 음악이 IT기술의 발달과 인터넷의 확산을 통하여 온라인 음악시장을 형성하였고 음악은 디지털 음원으로 관리되게 되었다. 이러한 디지털 음원을 효과적으로 검색하기 위한 방법은 많이 연구되었다. 그리고 검색을 도와줄 대량의 디지털 음원 자료들을 저장하고 관리하는 기법에 관한 연구가 필요하다. 본 논문에서는 대용량 자료를 처리하는 기술로 관심 받고 있는 하둡을 통하여 이 문제를 연구하였다. 하둡의 맵리듀스, HDFS 그리고 HBase를 이용하여 음악 내용기반검색을 설계하였다. 본 시스템은 음악 검색 시스템을 관리하고 유지하는데 있어서 컴퓨팅자원을 절약함으로써 비용을 절감 효과를 얻을 수 있다.

• 대한두경부종양학회지
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• 제27권1호
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• pp.66-69
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• 2011

Skull base osteoradionecrosis(ORN)is a rare complication of radiotherapy for nasopharyngeal carcinoma, but is one of the most severe and possibly fatal condition followed by radiotherapy. However, the treatment of skull base ORN has seldom been thoroughly described yet. Here we report a case of skull base ORN that was successfully treated with hyperbaric oxygen therapy(HBO). A 52-year-old man visited our department complaining of trismus and foul odor. He was diagnosed with nasopharyngeal cancer with multiple lymph node metastasis one year ago and underwent concurrent chemoradiotherapy. On the physical examination, mucopus and crusts with exposed necrotic bone was seen in the right nasopharynx. On the paranasal sinus magnetic resonance imaging, osteoradionecrosis which was extending from the right nasopharynx to the clivus, petrous apex, and cavernous sinus was noted. Nasopharynx biopsy resulted of ulcer with no malignant cells. HBO therapy was performed with debridement of nasopharynx for 3 months. There was no sign of recurrence or residual ORN 18 months after HBO therapy.

• 융합신호처리학회논문지
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• 제9권3호
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• pp.224-229
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• 2008

In the paper, a new Constraint algorithm is proposed to solve the fan-in problem occurred in the encoding circuitry of an ADC. The Flash ADC architecture uses a Double-Base Number System(DBNS). The DBNS has been known to represent the Multidimensional Logarithmic Number System (MDLNS) used for implementing the multiplier accumulator architecture of FIR filter in Digital Signal Processing (DSP) applications. The authors use the DBNS with the base 2 and 3 in designing ADC encoder circuits, which is called as Double Base Integer Encoder(DBIE). A symmetric map is analyzed first, and then asymmetric map is followed to provide addition ready DBNS for DSP circuitry. The simulation results of the DBIE circuits in 6-bit and 8-bit ADC show the effectiveness of the Constraint algorithm with $0.18{\mu}m$ CMOS technology. The DBIE yields faster processing speed compared to the speed of Fat Tree Encoder (FAT) circuits by 17% at more power consumption by 39%.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권9호
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• pp.2314-2333
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• 2023

It is significant to predict the performance degradation of complex electromechanical systems. Among the existing performance degradation prediction models, belief rule base (BRB) is a model that deal with quantitative data and qualitative information with uncertainty. However, when analyzing dynamic systems where observable indicators change frequently over time and working conditions, the traditional belief rule base (BRB) can not adapt to frequent changes in working conditions, such as the prediction of aeroengine performance degradation considering working condition. For the sake of settling this problem, this paper puts forward a new hidden belief rule base (HBRB) prediction method, in which the performance of aeroengines is regarded as hidden behavior, and operating conditions are used as observable indicators of the HBRB model to describe the hidden behavior to solve the problem of performance degradation prediction under different times and operating conditions. The performance degradation prediction case study of turbofan aeroengine simulation experiments proves the advantages of HBRB model, and the results testify the effectiveness and practicability of this method. Furthermore, it is compared with other advanced forecasting methods. The results testify this model can generate better predictions in aspects of accuracy and interpretability.

• BMB Reports
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• 제54권2호
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• pp.98-105
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• 2021

The clustered regularly interspaced short palindromic repeats (CRISPR) system is a family of DNA sequences originally discovered as a type of acquired immunity in prokaryotes such as bacteria and archaea. In many CRISPR systems, the functional ribonucleoproteins (RNPs) are composed of CRISPR protein and guide RNAs. They selectively bind and cleave specific target DNAs or RNAs, based on sequences complementary to the guide RNA. The specific targeted cleavage of the nucleic acids by CRISPR has been broadly utilized in genome editing methods. In the process of genome editing of eukaryotic cells, CRISPR-mediated DNA double-strand breaks (DSB) at specific genomic loci activate the endogenous DNA repair systems and induce mutations at the target sites with high efficiencies. Two of the major endogenous DNA repair machineries are non-homologous end joining (NHEJ) and homology-directed repair (HDR). In case of DSB, the two repair pathways operate in competition, resulting in several possible outcomes including deletions, insertions, and substitutions. Due to the inherent stochasticity of DSB-based genome editing methods, it was difficult to achieve defined single-base changes without unanticipated random mutation patterns. In order to overcome the heterogeneity in DSB-mediated genome editing, novel methods have been developed to incorporate precise single-base level changes without inducing DSB. The approaches utilized catalytically compromised CRISPR in conjunction with base-modifying enzymes and DNA polymerases, to accomplish highly efficient and precise genome editing of single and multiple bases. In this review, we introduce some of the advances in single-base level CRISPR genome editing methods and their applications.

• 한국문헌정보학회지
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• 제42권4호
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• pp.223-241
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• 2008

본고는 문헌정보학과 교육학의 통합 연구를 기반으로 문헌정보교육학의 학문적 생성 담론을 다룬다. 학교도서관과 사서교사의 역할이 학교 교육 속에서 정착되기 위한 기초로, 문헌정보교육학의 연구 영역과 과제를 논의하고 방향을 제시한다. 이를 통해 학교도서관 연구의 질적 향상에 기여한다. 학교도서관의 연구 영역은 문헌정보학적 측면과 교육학적 측면에서 분석하고 통합한다. 학교도서관의 연구 추세는 국내 학회지의 논문 게재 빈도의 측면에서 분석하고 통합 연구의 방향을 제시한다. 문헌정보교육학의 정립 이론은 도서관기반교육론과도서관기반학습, 연결거점론, 통합거점론, Top456접근법, 교육과정기반접근법, 관점접근법, 정보와 도서관 교과교육학 등을 제시한다. 연구 논점은 학교도서관의 교육적 기초, 운영, 전자도서관 구축, 교육 활동의 측면에서 논의한다. 결론적으로, 본고는 우리나라 학교도서관과 사서교사의 현실을 진단하고 해결책을 문헌정보교육학의 관점에서 제공한다.

• International Journal of Stem Cells
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• 제16권2호
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• pp.202-214
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• 2023

Background and Objectives: To investigate the role of exosomes from periodontal ligament cells (PDLCs) in bone marrow mesenchymal stem cell (BMSC) migration. Methods and Results: Human PDLCs were applied cyclic tension stretching. Exosomes were extracted from cultured PDLCs by ultracentrifugation, then characterized for their size, morphology and protein markers by NTA, TEM and western blotting. The process that PKH26-labeled exosomes taken up by BMSCs was assessed by confocal microscope. BMSC migration was examined by Transwell assay. Exosomes derived from PDLCs were identified. Cyclic tension stretch application on PDLCs can enhance the migration ability of BMSCs through exosomes. The exosomal miRNA expression profiles of unstretched and stretched PDLCs were tested by miRNA microarray. Four miRNAs (miR-4633-5p, miR-30c-5p, miR-371a-3p and let-7b-3p) were upregulated and six (miR-4689, miR-8485, miR-4655-3p, miR-4672, miR-3180-5p and miR-4476) were downregulated in the exosomes after stretching. Sixteen hub proteins were found in the miRNA-mRNA network. Gene Ontology and KEGG pathway analyses demonstrated that the target genes of differentially expressed exosomal miRNAs closely related to the PI3K pathway and vesicle transmission. Conclusions: The exosomes derived from cyclic tension-stretched PDLCs can promote the migration of BMSCs. Alternation of microRNA profiles provides a basis for further research on the regulatory function of the exosomal miRNAs of PDLCs during orthodontic tooth movement.

• 대한소아치과학회지
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• 제51권3호
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• pp.220-228
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• 2024

In clinical pediatric dentistry, a base material with optical properties, including transparency, that can mask the color of the material used for root canal-filling is preferred. This study aimed to examine the optical properties of various base materials by thickness. The disk-shaped specimens were photopolymerized and fabricated using Ionosit (IN), TheraCal LC (TL), TheraCal PT (PT), and A2 shade of Filtek^TM Supreme Flowable Restorative (FZ), Fuji II LC (FL), and Ketac^TM Fil (KF) with 1 and 2 mm thickness. The color parameters of these specimens were measured using a spectrophotometer on a black and white background and were measured using the same method on a mold containing Vitapex^® and gutta-percha. The translucency parameter (TP) and color difference were calculated for each group. The Kruskal-Wallis and Bonferroni tests were used in the statistical analyses. The TP decreased when the thickness was 2 mm compared with 1 mm. The TP values of TL and PT were the lowest at all thicknesses. The TP values of 2 mm thickness in all molds filled with Vitapex^® and gutta-percha were the lowest for TL, PT, KF, and IN. In TL and PT, the color difference before and after the application of the canal-filling material was the smallest, regardless of material thickness. Within the limits of this in vitro study, TL, PT, KF, and IN demonstrated better masking of the color of canal-filling material.

• 대한치과마취과학회지
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• 제14권4호
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• pp.227-232
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• 2014

The indication for submandibular intubation is the requirement for intraoperative maxillomandibular fixation (MMF) in the presence of injuries that preclude nasotracheal intubation. Thus, We reported 2 cased of endotracheal intubations via submandibular approach that is applicable in patients with skull base fractures for a reliable general anesthesia. Endotracheal intubation via submandibular approach was applied during general anesthetic procedures for open reduction in three patients with Le Fort II, III or nasoorbitoethmoid (NOE) fractures. No complications due to submandibular intubation, such as infection, postoperative scarring, nerve injury, hematoma, bleeding, or orocutaneous fistula, were observed following submandibular intubation. Endotracheal intubation via submandibular approach is effective in patients with skull base fractures. In our method, the tube connector is removed in orotracheal intubation in order to avoiding the tube removal or displacement. The advantages of this method are very simple, safe, and to provide the good operation field.

• 대한치과보철학회지
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• 제45권5호
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• pp.621-632
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• 2007

Statement of problem: The failure of adhesion between the resilient denture liner and the denture base is a serious problem in clinic. Purpose: The purpose of this study was to evaluate the effect of denture base resin surface pretreatments (mechanical and/or chemical) on the tensile bond strength between a resilient liner and processed denture resin. Material and method. Acrylic-based resilient liners (Soft liner; GC co., Japan & Coe-Soft; GC America Inc. USA) and silicone-based resilient liners (Mucosoft, Parkell Inc., USA & Dentusil; Bosworth co., USA) were used. Specimens in each soft lining material were divided two groups with or without mechanical pretreatment. Each denture base specimen received 1 of 4 chemical pretreatments including: (1) no treatment, (2) 30-s acetone treatment, (3) 15-s methylene chloride treatment, (4) 180-s methyl methacrylate treatment. All specimens were thermocycled and placed under tension until failure in a universal testing machine. Results: 1. Silicone-based resilient liners exhibited significantly higher tensile bond strengths than acrylic-based resilient liners (P<.05). 2. Grinding the denture base resin improved tensile bond strengths of silicone-based resilient liners, but reduced tensile bond strengths of acrylic-based resilient liners (P<.05). 3. In acrylic-based resilient liners, treating with acetone significantly increased the bond strength of Soft liner and treating with methyl methacrylate significantly increased the bond strength of Coe-Soft (P<.05). However they were not effective compared to silicone-based resilient liner. 4. In silicone-based resilient liners, treating with all chemical etchants significantly increased the bond strength of Mucosoft to denture base, and treating with methylene chloride and methyl methacrylate increased the bond strength of Dentusil to denture base (P<.05). Conclusion: Although chemical and mechanical pretreatments were not effective on tensile bond strength of acrylic-based resilent liner to denture base, treating the denture base resin surface with appropriate chemical etchants after mechanical pretreatment significantly increased the tensile bond strength of silicone-based resilient liner to denture base.