• Proceedings of the Korean Society for Bioinformatics Conference
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• 2004.11a
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• pp.39-49
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• 2004

When there is a lack of detailed kinetic information, dFBA(dynamic flux balance analysis) has correctly predicted cellular behavior under given environmental conditions with FBA and different ial equations. However, until now, dFBA has centered on substrate concentration, cell growth, and gene on/off, but a detailed hierarchical structure of a regulatory network has not been taken into account. For this reason, the dFBA has limited the represen tation of interactions between specific regulatory proteins and genes and the whole transcriptional regulation mechanism with environmental change. Moreover, to calculate optimal metabolic flux distribution which maximizes the growth flux and predict the b ehavior of cell system, linear programming package(LINDO) and spreadsheet package(EXCEL) have been used simultaneously. thses two software package have limited in the visual representation of simulation results and it can be difficult for a user to look at the effects of changing inputs to the models. Here, we descirbes the construction of hierarchical regulatory network with defined symbolsand the development of an integrated system that can predict the total control mechanism of regulatory elements (opero ns, genes, effectors, etc.), substrate concentration, growth rate, and optimal flux distribution with time. All programming procedures were accoplished in a visual programming environment (LabVIEW).

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.12A
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• pp.1160-1170
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• 2010

Existing multipath routing mechanism has much overhead to maintain the state of nodes on the multipath route and does not guarantees completely disjoint multipath construction from source to destination. In this paper, we propose an Explicit Disjoint Multipath (EDM) routing algorithm to enhance energy efficiency through removing the flooding mechanism for route discovery process, minimizing the number of nodes participating in route update and balancing the traffic load for entire network. EDM constructs logical pipelines which can create disjoint multipaths in logical way. Then it physically performs anchor node based geographic routing along the logical pipeline in order to build multipath to the destination. EDM can provide the distribution effect of traffic load over the network, help to balance the energy consumption and therefore extend the network lifetime.

• Archives of Pharmacal Research
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• v.29 no.2
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• pp.165-171
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• 2006

Osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to overproduction under undesirable physiological conditions. Phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as Ecklonia and Eisenia families. Phlorotanninrich extracts of Ecklonia cava including LAD103 showed significant antioxidant activities such as DPPH radical scavenging, ferric ion reduction, peroxynitrite scavenging, and inhibition of LDL oxidation, indicating their possible antioxidative interference both in onset and downstream consequences of osteoarthritis. LAD103 also showed significant down regulation of $PGE_2$ generation in LPS-treated RAW 246.7 cells, and significant inhibition of human recombinant interleukin-$1{\alpha}$-induced proteoglycan degradation, indicating its beneficial involvement in pathophysiological consequences of osteoarthritis, the mechanism of which needs further investigation. Since LAD103 showed strong therapeutic potentials in arthritic treatment through several in vitro experiments, it is highly encouraged to perform further mechanistic and efficacy studies.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.150.2-150.2
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• 2013

We elucidate the mechanism of the self-assembled organic layer formation at the organic/metal interface of hexaaza-triphenylene-hexacarbonitrile (HATCN)/Au(111) by first-principles calculations and Lowtemperature scanning tunneling microscope (STM). In this work, we used HATCN to deposit organic material which is well known as an efficient OLED charge generation material. Low-temperature STM measurements revealed that self-assembled hexagonal porous structure is formed at terraces of Au(111). We also found that the hexagonal porous structure has chirality and forms only small (<1000 $nm^2$) phaseseparated chiral domains that can easily change their chiral phase in subsequence STM images at 80 K. To explain the mechanism of these observation, we calculated the molecular-molecular and molecule-surface interaction energies by using density functional theory method. We found that the change of their chiral phase resulted from the competition between the two energies. These results have not only verified our experimental observations, but also revealed the delicate balance between different interactions that caused the self-assembed structures at the surface.

• Journal of TMJ Balancing Medicine
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• v.8 no.1
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• pp.6-10
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• 2018

In order to propose a fundamental and appliable theories for balancing therapy of temporomandibular joint (TMBT), evolutionary proofs and up-down theories in evolutionary biology and Korean medicine were investigated. Balancing therapy of temporomandibular joint treats disorder and diseases of the whole body through straightening of the abnormal linking between temporomandibular joint and axis. Although the mechanism of this therapy contains many merits like multicellular integrity and coadjustment, ease of balance and alert forward mobility by the bipedal stepping and evolution to Homo sapiens, increasing disadvantages of balancing pressure of right and left in the lengthened perpendicular axis and the balancing load of temporomandibular joint and axis following the reactional change of dental occlusion are deeply related and considered in this therapy. As for up-down theory, crossing of heavenly qi and earth qi centering on cervical joint is presented as the first mechanism for TMBT, and the other ones like in-out and up-down qi activity of tripple energizer, up-down of essence-qi-spirit in the three backbone barrier and three cinnabar field, up-down of yin-yang-water-fire of viscera and bowels can be related too.

• IMMUNE NETWORK
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• v.23 no.2
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• pp.12.1-12.17
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• 2023

Ssu72, a dual-specificity protein phosphatase, not only participates in transcription biogenesis, but also affects pathophysiological functions in a tissue-specific manner. Recently, it has been shown that Ssu72 is required for T cell differentiation and function by controlling multiple immune receptor-mediated signals, including TCR and several cytokine receptor signaling pathways. Ssu72 deficiency in T cells is associated with impaired fine-tuning of receptor-mediated signaling and a defect in CD4⁺ T cell homeostasis, resulting in immune-mediated diseases. However, the mechanism by which Ssu72 in T cells integrates the pathophysiology of multiple immune-mediated diseases is still poorly elucidated. In this review, we will focus on the immunoregulatory mechanism of Ssu72 phosphatase in CD4⁺ T cell differentiation, activation, and phenotypic function. We will also discuss the current understanding of the correlation between Ssu72 in T cells and pathological functions which suggests that Ssu72 might be a therapeutic target in autoimmune disorders and other diseases.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.9
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• pp.875-882
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• 2011

In the present study, the imbalance in the axial-thrust and variation in the volumetric efficiency that occurred during the trimming of impeller diameter were investigated. The present study was focused on low-specific-speed multistage centrifugal pumps with a balancing piston as the balancing mechanism. The effects of impeller trimming on the axial-thrust balance in multistage pumps with horizontal and vertical axes were compared. The results showed that impeller trimming resulted in an additional axial-thrust acting in direction of pump inlet. The axial-thrust imbalance due to impeller trimming was more severe in the vertical-axis pumps than in the horizontal-axis pumps. The rate of increase in the diameter of the balancing piston, which was proportional to the rate of impeller trimming, was evaluated to maintain the axial-thrust balance. Furthermore, a simultaneous increase in the piston length and piston diameter was more effective for reducing the axial-thrust imbalance along with the volumetric efficiency drop.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.8
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• pp.3626-3635
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• 2011

The modular robots are a kind of system that was developed to overcome the limitation of the movement for the mobile robot with wheels or legs. In legs type mobile robot case, they are limited for velocity and balance during moving at the uneven terrain. In wheeled mobile robot case, they are also limited to overcome dump, stair and so on. The modular robots can overcome moving limitation because of their transforming ability. However, they are researched not only driving mechanism but also combination mechanism. In this paper we proposed four kinds of unique structure for the combination and separation and also its algorithm. The effectiveness of the structure is verified with building the real structure and taking experiments to the designed modular robot

• Journal of Internet Computing and Services
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• v.10 no.4
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• pp.199-211
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• 2009

Recent advancements in wireless networks have enabled support for mobile applications to transfer data over heterogeneous wireless paths in parallel using data striping technique [2]. Traditionally, high performance data transfer requires tuning of multiple TCP sockets, at sender's end, based on bandwidth delay product (BDP). Moreover, traditional techniques like Automatic TCP Buffer Tuning (ATBT), which balance memory and fulfill network demand, is designed for wired infrastructure assuming single flow on a single socket. Hence, in this paper we propose a buffer tuning technique at senders end designed to ensure high performance data transfer by striping data at transport layer across heterogeneous wireless paths. Our mechanism has the capability to become a resource management system for transport layer connections running on multi-homed mobile host supporting features for wireless link i.e. mobility, bandwidth fluctuations, link level losses. We show that our proposed mechanism performs better than ATBT, in efficiently utilizing memory and achieving aggregate throughput.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.645-650
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• 2019

Brown adipocytes have an important role in the regulation of energy balance through uncoupling protein-1 (UCP-1)-mediated nonshivering thermogenesis. Although brown adipocytes have been highlighted as a new therapeutic target for the treatment of metabolic diseases, such as obesity and type II diabetes in adult humans, the molecular mechanism underlying brown adipogenesis is not fully understood. We recently found that protein tyrosine phosphatase receptor type B (PTPRB) expression dramatically decreased during brown adipogenic differentiation. In this study, we investigated the functional roles of PTPRB and its regulatory mechanism during brown adipocyte differentiation. Ectopic expression of PTPRB led to a reduced brown adipocyte differentiation by suppressing the tyrosine phosphorylation of VEGFR2, whereas a catalytic inactive PTPRB mutant showed no effects on differentiation and phosphorylation. Consistently, the expression of brown adipocyte-related genes, such as UCP-1, $PGC-1{\alpha}$, PRDM16, $PPAR-{\gamma}$, and CIDEA, were significantly inhibited by PTPRB overexpression. Overall, these results suggest that PTPRB functions as a negative regulator of brown adipocyte differentiation through its phosphatase activity-dependent mechanism and may be used as a target protein for the regulation of obesity and type II diabetes.