• 한국지하수토양환경학회지:지하수토양환경
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• 제26권6호
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• pp.1-17
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• 2021

Self-potential (SP) surveys measure naturally occurring differences in electrical potential in the absence of artificial sources and have been applied to various fields since the first application in mineral explorations. Among various causes of SP occurrences, streaming potential is generated by the flow of groundwater, and makes SP surveys suitable for the exploration of groundwater table fluctuation, fractures, sinkholes and landslide occurrences. Recently, there has been many studies that applied SP surveys to monitor water leakage through dikes and embankments. In this review paper, we first review the characteristics and theoretical backgrounds of streaming potential in saturated or unsaturated porous media to introduce it in the embankment among various application field. After the review of the background theory, we review the past cases of field SP surveys on dikes and embankments and also the characteristics of field streaming potential data in the surveys. Further, by analyzing past studies of qualitative as well as quantitative interpretation of SP survey data, we show the possibility of quantitative interpretation of streaming potential data obtained on dikes and embankments. Consequently, it is hope that this review paper helps researches on SP surveys on dikes and embankments, and provides basis for interpretation methods of the SP data to identify leaked area and further leakage rate (or permeability).

• Journal of Radiation Protection and Research
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• 제46권3호
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• pp.106-111
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• 2021

Background: Crookes tube is utilized in junior high and high schools in Japan to study the character of electrons and current, and not for radiological education. There is no official guideline or regulation for these radiation source to the public. Therefore, most teachers have no information about the leakage of X-rays from Crookes tube. The peak energy of X-rays is approximately 20 keV, and it is impossible to measure using conventional survey meters. Materials and Methods: Each leakage dose of low energy X-rays from 38 Crookes tube in the education field, such as junior and senior high schools in Japan, was explored by the teachers in the school using radio-photoluminescence (RPL) dosimeters. Before and after the measurements, the dosimeters were sent by postal mails. Results and Discussion: At the exploration in this study, it was estimated that the 70 ㎛ dose equivalent, H_p(0.07) of X-rays from 31 Crookes tubes were smaller than 100 µSv in 10 minutes, at the distance of 1 m, where the Crookes tube was usually observed. However, the highest dose was estimated as 0.69 mSv by an equipment with the full power. Furthermore, one Crookes tube exhibited 0.62 mSv with minimum output power of the induction coil. This relatively large dose was reduced by the shorter distance of discharge electrodes of the induction coil. Conclusion: The leakage dose of low energy X-rays from 38 Crookes tube was explored using RPL dosimeters. It was estimated that the H_p(0.07) of X-rays from 31 Crookes tubes were smaller than 100 µSv in 10 minutes at the distance of 1 m, while some equipment radiated a higher dose. With this study, the provisional guideline for the safety operation of Crookes tube is established.

• Journal of Rhinology
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• 제25권2호
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• pp.123-129
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• 2018

Background and Objectives: Endoscopic repair of cerebrospinal fluid (CSF) leak can avoid morbidity of open approaches and has shown a favorable success rate. Free mucosal graft is a good method, and multi-layered repair is more favorable. The inferior turbinate has been commonly utilized for the free mucosal graft, but we newly designed it as a bone-periosteal-mucosal composite graft for multilayered reconstruction. Subjects and Method: Four subjects with a skull base defect were treated with this method. The inferior turbinate was partially resected including the conchal bone and was trimmed according to defect size. Both bony parts and periosteum were preserved on the basolateral side of the mucosa as a composite graft. The graft was applied to the defect site using an overlay technique. Results: All cases were successfully repaired without any complications. Three of them had a defect size greater than 10-12 mm, and the graft stably repaired the CSF leakage. Conclusion: Endoscopic repair of CSF leakage using inferior turbinate composite graft is a simple and easy method and would be favorable for defect sizes greater than 10 mm.

• The Korean Journal of Pain
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• 제35권2호
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• pp.224-230
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• 2022

Background: An epidural blood patch (EBP) is a procedure to treat intracranial hypotension that does not respond to conservative treatment. EBPs are commonly repeated when the symptoms persist. In this study, we used a large single-center retrospective cohort and evaluated the factors associated with repeated EBPs. Methods: From January 2010 to December 2020, a total of 596 patients were treated with EBPs for intracranial hypotension. We evaluated the factors associated with repeated EBPs in the entire population, in patients with spontaneous intracranial hypotension (SIH), and in those with available myelographies. Results: In a total of 596 patients, 125 (21.1%) patients required repeated EBPs, and 96/278 (34.5%) in SIH and 29/314 (9.2%) in iatrogenic population. In patients with SIH, international normalized ratio (INR) and cerebrospinal fluid (CSF) leakage on myelographies consistently exhibited significant associations (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.02-1.87; P = 0.043 and OR, 2.18; 95% CI, 1.28-3.69; P = 0.004). In patients with iatrogenic injury, INR and CSF leakage on myelogram did not show difference in repeated EBPs. Conclusions: Repeated EBPs may be more frequently required in patients with SIH. Prolonged INR and CSF leakage were associated with repeated EBPs in patient with SIH. Further studies are needed to determine factors associated with repeated EBP requirements.

• Safety and Health at Work
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• 제14권2호
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• pp.237-242
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• 2023

Background: This study evaluated occupational exposure levels of doxorubicin in healthcare workers performing rotational intraperitoneal pressurized aerosol chemotherapy (PIPAC) procedures. Methods: All samples were collected during PIPAC procedures applying doxorubicin to an experimental animal model (pigs). All procedures were applied to seven pigs, each for approximately 44 min. Surface samples (n = 51) were obtained from substances contaminating the PIPAC devices, surrounding objects, and protective equipment. Airborne samples were also collected around the operating table (n = 39). All samples were analyzed using ultra-high performance liquid chromatography-mass spectrometry. Results: Among the surface samples, doxorubicin was detected in only five samples (9.8%) that were directly exposed to antineoplastic drug aerosols in the abdominal cavity originating from PIPAC devices. The telescopes showed concentrations of 0.48-5.44 ng/cm² and the trocar showed 0.98 ng/cm² in the region where the spraying nozzles were inserted. The syringe line connector showed a maximum concentration of 181.07 ng/cm², following a leakage. Contamination was not detected on the surgeons' gloves or shoes. Objects surrounding the operating table, including tables, operating lights, entrance doors, and trocar holders, were found to be uncontaminated. All air samples collected at locations where healthcare workers performed procedures were found to be uncontaminated. Conclusions: Most air and surface samples were uncontaminated or showed very low doxorubicin concentrations during PIPAC procedures. However, there remains a potential for leakage, in which case dermal exposure may occur. Safety protocols related to leakage accidents, selection of appropriate protective equipment, and the use of disposable devices are necessary to prevent occupational exposure.

• Nutrition Research and Practice
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• 제17권5호
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• pp.827-843
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• 2023

BACKGROUND/OBJECTIVES: Mitochondrial DNA leakage leads to inflammatory responses via endosome activation. This study aims to evaluate whether the perennial grass water extract (Pogonatherum panicum) ameliorate mitochondrial DNA (mtDNA) leakage. MATERIALS/METHODS: The major bioactive constituents of P. paniceum (PPW) were investigated by high-performance liquid chromatography, after which their antioxidant activities were assessed. In addition, RAW 264.7 macrophages were stimulated with lipopolysaccharide, resulting in mitochondrial damage. Quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to examine the gene expression and cytokines. RESULTS: Our results showed that PPW extract-treated activated cells significantly decrease reactive oxygen species and nitric oxide levels by reducing the p2^phox and iNOS expression and lowering cytokine-encoding genes, including IL-6, TNF-α, IL-1β, PG-E2 and IFN-γ relative to the lipopolysaccharide (LPS)-activated macrophages. Furthermore, we observed that LPS enhanced the mtDNA leaked into the cytoplasm, increasing the transcription of Tlr9 and signaling both MyD88/Irf7-dependent interferon and MyD88/NF-κb p65-dependent inflammatory cytokine mRNA expression but which was alleviated in the presence of PPW extract. CONCLUSIONS: Our data show that PPW extract has antioxidant and anti-inflammatory activities by facilitating mtDNA leakage and lowering the Tlr9 expression and signaling activation.

• Safety and Health at Work
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• 제15권1호
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• pp.42-52
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• 2024

Background: The lack of headforms that accurately reflect the head characteristics of Koreans and the demographic composition of the Korean population can lead to inadequate FFR testing and reduced effectiveness of FFRs. Method: Direct measurements of 5,110 individuals and 3D measurements of 2,044 individuals, aged between 9 and 69 years, were sampled from the data pool of Size Korea surveys based on the age and gender ratios of the Korean resident demographics. Seven head dimensions were selected based on the ISO 16976-2, availability of Size Korea measurements, and their relevance to the fit performance of FFRs. A principal component analysis (PCA) was performed using the direct measurements to extract the main factors explaining the head characteristics and then the main factors were standardized and remapped to 3D measurements, creating five size categories representing Korean head shapes. Lastly, representative 3D headforms were constructed by averaging five head shapes for each size category. Results: The study identified two main factors explaining Korean head characteristics by the PCA procedure specified in ISO 16976-2 and developed five representative headforms reflecting the anthropometric features of Korean heads: medium, small, large, short & wide, and long & narrow. Conclusion: This study developed representative headforms tailored to the Korean population for conducting total inward leakage (TIL) tests on filtering facepiece respirators (FFRs). The representative headforms can be used for TIL testing by employing robotic headforms to enhance the performance of FFRs for the Korean target population.

• 한국지하수토양환경학회지:지하수토양환경
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• 제20권1호
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• pp.41-55
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• 2015

Monitoring of $CO_2$ release through the ground surface is essential to confirm the safety of carbon storage projects. We conducted a feasibility study of the multi-channel surface-soil $CO_2$-concentration monitoring (SCM) system as a soil $CO_2$ monitoring tool with a small scale injection test. The background concentrations showed the distinct diurnal variation. The negative relation of $CO_2$ with temperature and the low $CO_2$ concentrations during the day imply that surface-soil $CO_2$ depends on photosynthesis and respiration. After 4.2 kg of $CO_2$ injection (1 m depth for 29 minutes), surface-soil $CO_2$ concentrations increased in the all five chambers, which were located less than 2.8 m of distance from each other. The $CO_2$ concentrations seem to be recovered to the background around 4 hours after the injection ended. To determine the leakage, the data from Chamber 2 and 5 with low increase rates were used for statistical analyses. Coefficient of variation for 30 minutes ($CV_{30min}$.) is efficient to determine a leakage signal, with reflecting the fast change in $CO_2$ concentrations. Consequently, SCM and $CV_{30min}$ could be applied for an efficient monitoring tool to detect $CO_2$ release through the ground surface. Also, this study provides ideas for establishing action steps after leakage detection.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권11호
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• pp.5731-5754
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• 2019

In this paper, we redesign, implement, and evaluate ShareSafe (Based on SecGraph), an open-source secure graph data sharing/publishing platform. Within ShareSafe, we propose De-anonymization Quantification Module and Recommendation Module. Besides, we model the attackers' background knowledge and evaluate the relation between graph data privacy and the structure of the graph. To the best of our knowledge, ShareSafe is the first platform that enables users to perform data perturbation, utility evaluation, De-A evaluation, and Privacy Quantification. Leveraging ShareSafe, we conduct a more comprehensive and advanced utility and privacy evaluation. The results demonstrate that (1) The risk of privacy leakage of anonymized graph increases with the attackers' background knowledge. (2) For a successful de-anonymization attack, the seed mapping, even relatively small, plays a much more important role than the auxiliary graph. (3) The structure of graph has a fundamental and significant effect on the utility and privacy of the graph. (4) There is no optimal anonymization/de-anonymization algorithm. For different environment, the performance of each algorithm varies from each other.

• 품질경영학회지
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• 제46권2호
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• pp.301-310
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• 2018

Purpose: The purpose of this study is to investigate the effect of work intensity on fit factor and affective quality of the dustproof Background: Among the victims who suffer pneumoconiosis due to the inhalation of toxic substances or the lack of oxygen during the work, the proportion of the victims is larger than the other causes. Wearing a respirator may prevent pneumoconiosis, but it can be hazardous to workers because of the leakage through filters, cartridges, exhaust valves, broken parts, and face-to-face contact. Despite leakage through the contact area between the mask and the face has various causes such as the wearer's activity, sweat accumulation, facial shape, etc., There is a lack of relevant research and regulation compared to developed countries that have already institutionalized the law 30 years ago and give the right to sell through a test Method: The work intensity was adjusted by walking or running at 6km/h and 11km/h on the treadmill, and tasks were defined with reference to the test procedure and the exercise sequence applied in the face leakage test of the dustproof mask. And fit factor was measured objectively using 'Respirator Fit Tester 8038' which measures fit factor calculated by dividing the number of dust present outside the mask by inside the mask. In addition, affective quality was classified by the ease of use, ease of breathing, and ease of wearing, and was measured using the 5-point likert scale questionnaire. Results: There was a significant difference in fit factor, ease of breathing, and wearing convenience according to work intensity and no significant difference in ease of use(${\alpha}=0.01$). And when the work intensity was high, fit factor, ease of breathing, and wearing convenience were all lower than when the work intensity was low. Conclusion: In Korea, it is necessary to consider consideration of the work intensity when testing the leakage rate of the face part for safety certification of the respiratory protective equipment, When developing a mask, it should be possible to maintain high adhesion even under intense, active situation and high temperature conditions by selecting materials, improving the wearing style, and expanding the adjustable range.