• 한국임상수의학회지
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• 제26권1호
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• pp.23-28
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• 2009

복막투석은 정상적인 생리적 상태의 장애를 야기하는 체내의 독성물질을 치료적으로 제거하는 임상적 방법이다. 본 연구에서는 신부전으로 내원한 환자에게 복막투석을 적용한 20증례의 임상적 결과와 합병증을 후향적으로 평가하였다. 복막투석을 실시하는 동안 적혈구수, 혈구용적, 신기능과 관련된 혈액 화학적 수치 및 전해질 등의 혈액학적 분석과 합병증, 임상적 결과 등을 기록하였다. 복막투석의 결과로 19마리의 개에서 혈중 요소 질산 농도가 유의하게 감소하였고 (p<0.05), 17마리의 개에서 혈중 크레아티닌의 농도가 유의하게 감소하였다 (p<0.05). 복막투석의 부작용으로는 저알부민혈증(12/20, 60%), 빈혈(10/20, 50%), 투석액의 피하 누출(9/20, 45%), 세균성 복막염 (6/20, 30%), 투석액의 저류 (5/20, 25%)와 사지의 부종(4/20, 20%)이 나타났다. 본 증례고찰을 통하여 복막투석은 신부전(특히 급성기)에 이환된 개에서 질소혈증을 개선하는데 효과적임을 알 수 있었다.

• 대한한의학회지
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• 제18권2호
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• pp.283-315
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• 1997

The effects of Geumguesingitang and Dohongsamultang on rats with nephrosis induced by a single tail-intravenous injection of puromycin aminonucleoside(PAN), 2.5mg/l00g of body weight were evaluated in the present study. The effects of Geumguesingitang and Dohongsamultang on PAN nephrosis were evaluated by measuring (1)the concentrations of albumin, total protein, total lipid, cholesterol, triglyceride, creatinine, blood urea nitrogen(BUN) and uric acid in the serum, (2)the concentrations of protein, creatinine, glucose, occult blood and volume of the 24 hours urine and (3)the volume of intake water. The results are summerized as follows; 1. In the Control group as compared to the Normal. the amount of protein of 24 hours urine was significantly increased, the concentrations of albumin and total protein were significantly decreased. Total lipid, cholesterol and triglyceride in the serum were significantly increased. The concentrations of creatinine, BUN, uric acid in the serum, the amount of glucose and occult blood of 24 hours urine were also increased significantly. 2. In the Geumguesingitang group as compared to the Control, the increase in the amount of urinary protein during 24 hours induced by PAN was significantly suppressed, and the concentrations of total protein and albumin in the serum were significantly increased. The concentrations of total lipid, cholesterol and triglyceride in the serum were significantly inhibited. The decrease of the concentrations of creatinine and uric acid in the serum were also observed significantly. 3. In the Dohongsamultang group as compared to the Control, the increase of the amount of protein and glucose of the 24 hours urine induced by PAN were significantly inhibited, and the concentrations of total protein and albumin in the serum were increased significantly. The concentrations of total lipid, cholesterol and triglyceride in the serum were decreased significantly. The decrease of the concentrations of creatinine and uric acid in the serum were observed significantly. It can be inferred that Geumguesingitang has effects on improving proteinuria, hypoproteinemia effectively. It has an effect on hyperlipidemia significantly relieved. And relieving azotemia when nephrotic syndrome is accompanied by the acute renal failure. It can be inferred that Dohongsamultang improves hyperlipidemia effectively. It has effects on proteinuria, hypoproteinemia in nephrotic syndrome significantly relieved. And relieving azotemia when nephrotic syndrome is accompanied by the acute renal failure.

• 한국임상수의학회지
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• 제20권4호
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• pp.431-436
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• 2003

이 연구의 목적은 실험적으로 유발한 면역매개성 사구체 질환이 신증후군으로 진행하는 과정과 치유과정에서 단백뇨 배설에 근거한 조기진단 및 치유과정의 감시에 대한 평가를 하는 것이다. 두당 endotoxin 1 $\mu$g과 native bovine serum albumin 5mg 을 9두의 건강한 개에 정맥주사하여 감작시키고, 그 후 1주일부터 양이온화한 bovine serum albumin 120mg을 주 5회 반복 정맥주사한 결과 5두에서 면역매개성 사구체신염과 신증후군이 발생하였다. 사구체신염이 발생한 실험동물에서는 요단백질/ 크레아티닌 비의 증가 (>1.0), 저알부민혈증 (< g/이), BUN 증가 (>40 mg/dl), 부종 등이 나타났다. 이것은 임상병리학적으로 평가 가능한 면역매개성 사구체시염 및 신증후군 모델견이 제작되었음을 제시하는 것이었다. 사구체신염의 유발과 신증후군의 진행과정에 요단백질/크레아티닌 비의 증가가 저알부민혈증, BUN 증가, 고콜레스테롤혈증보다 1-4주 먼저 출현하였다. 사구체신염에 의해 신증후군이 유발된 실험동물 모두에서 prednisolone 을 2.2 mg/kg씩 1일 2회 경구투여한 결과 혈중 알부민 농도의 증가와 콜레스테롤 농도의 감소가 먼저 일어나고, 그 후 1-4 주에 요단백질/크레아티닌 비가 감소하기 시작하였다. 종합적으로 볼때, 면역매개성 사구체신염성 신증후군의 조기진단에는 요 단백질/크레아티닌 비가 유리한 지표로, 그리고 초기 치유과정의 감시에는 혈청 알부민, 콜레스테롤이 더 유리한 임상 지표로 이용될 수 있음을 확인하였다.

• 사상체질의학회지
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• 제15권2호
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• pp.129-136
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• 2003

Diabetic nephropathy is defined that renal glomeruluses are damaged by diabetes melitus and proteins that are not excreted to urine normally are exhausted, or do not excrete waste matter to urine, so-called chronic renal failure state. Clinical stage is explained divided 5. If reached 4 or 5 stage, overt proteinuria is occurred to clinical nephropathy, and hypoalbuminemia, azotemia, hypertension, and edema become serious. Concept about edema is differing comprehension about mechanism of a disease, and treatment methodaccording to Sasang Constitution in Sasang Constitutional Medicine. I treated edemtous Soyangin(少陽人) patient with Dojeokgangkitang(導赤降氣湯) who diagnosed as diabetic nephropathy and wrongly treated in Soeumin. I have got good results, so I do case study.

• Childhood Kidney Diseases
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• 제9권2호
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• pp.251-254
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• 2005

저자들은 핍뇨를 주소로 내원한 12세 남아에서 임상 소견 및 검사 소견 상 전신적 강직성 경련으로 유발뇐 횡문근융해증에 의해 초래된 급성신부전으로 진단하고 충분한 수액공급 소변의 알칼리화, 이뇨제 투여와 함께 항경련제의 사용으로 경련을 조절함으로써 급성신부전이 호전된 1례를 경험하였기에 보고하는 바이다.

• 대한수의학회지
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• 제48권2호
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• pp.215-218
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• 2008

A 2-year-old, female, Maltese dog (3.2 kg of body weight) was referred to the Veterinary Medical Teaching Hospital, Chungnam National University with vomiting, anorexia and depression. Twelve hours prior to the onset of clinical signs, the dog ingested some grape skins (about 60 g). Physical examination at the time of presentation showed peripheral edema and mucous pallor. Blood and blood chemical analysis revealed anemia and moderate azotemia with elevated blood urea nitrogen (107.2 mg/dl), creatinine (6.3 mg/dl) and hyperphosphatemia (11.3 mg/dl). Echogenicity of renal cortex were observred by ultrasonography. The dog was diagnosed as acute renal failure occurred by grape skin toxicosis. The dog was treated with supportive care such as fluid therapy, diuretics (furosemide) and phosphorus binder (almagate). A normal condition of blood and blood chemical findings and clinical signs was observed at five days after treatment, and prognosis is good to date.

• 한국임상수의학회지
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• 제26권2호
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• pp.170-175
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• 2009

7년생 중성화하지 않은 수컷 포메라니언(체중 2.2 kg)이 지속적인 식욕부진과 다음/다뇨, 심한 질소혈증 및 심잡음을 주증으로 내원하였다. 진단적 검사 결과 중증의 고혈압과 비대성 심근증을 동반한 만성 신장 질환이 확인 되었다. 2일 동안 복막투석과 수혈, 그리고 amlodipine을 이용한 항고혈압 치료를 실시하였고 동시에 만성신부전에 대한 보존 치료요법을 적용하였다. 본 증례는 만성 신장질환이 있는 개에서 병발한 고혈압성 심근증인 희귀 증례이다.

• 대한수의학회지
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• 제53권3호
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• pp.177-180
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• 2013

Two dogs were presented with melena, vomiting and depression after accidental swallowing of candy form of Strepsils (flurbiprofen), which is one of non-steroidal anti-inflammatory drugs used in human medicine for controlling a sore throat. These dogs had common signs of anemia induced by gastrointestinal ulceration and hemorrhage with azotemia and leukocytosis. The dogs were treated with blood transfusion, fluid therapy, proton-pump inhibitor, antiemetics, mucus protectant and antibiotic. Although most of clinical signs of two dogs were resolved, azotemic problem with evidence of renal injury have remained.

• Tuberculosis and Respiratory Diseases
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• 제53권2호
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• pp.202-208
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• 2002

A diffuse alveolar hemorrhage is a rare manifestation in microscopic polyangiitis. Recently we experienced a case of diffuse alveolar hemorrhage associated with microscopic polyangiitis, which was diagnosed with the typical clinical manifestations, ANCA and a renal biopsy. A 71 year old female was admitted complaining of coughing and dyspnea. A chest X-ray, HRCT and BAL revealed a diffuse alveolar hemorrhage. A diffuse alveolar hemorrhage was noted during a bronchoscopy. She also had proteinuria, microscopic hematuria and mild azotemia. The renal biopsy showed necrotic glomerulonephritis without immune complex deposits or granuloma. Under the diagnosis of microscopic polyangiitis, she was treated with steroid pulse therapy, and prednisolone with cyclophosphamide subsequently. She showed marked improvement in the clinical manifestations.

• 한국임상수의학회지
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• 제25권6호
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• pp.553-556
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• 2008

The urinary bladder retroflexion, flipped over backwards into the pelvic canal, by trauma has been rarely reported in dogs. This paper describes clinical and radiological features of urinary bladder retroflexion in two dogs with a history of traffic accident. The main clinical signs were hind limb lameness, severe pain and dysuria. Radiography and ultrasonography were performed to evaluate the patient's damages. No remarkable findings were observed except pelvic fracture on survey radiograph. On cystourethrography, caudal displacement and retroflexion of the bladders were identified. Cystopexy was performed and the bladders were repositioned. After surgery one dog with severe azotemia and bilateral hydroureteronephrosis was deteriorated noticeably and euthanized by request of the owner, while the other dog was recovered no recurrence of the problem by 12 months post-surgery. It should be considered that contrast study and serial assessment in urinary tract be important to demonstrate the evidence of bladder retroflexion and evaluate the prognosis in dogs with severe trauma.