• Journal of Ginseng Research
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• 제46권1호
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• pp.1-10
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• 2022

Ginseng has been well-known as a medicinal plant for thousands of years. Bacterial endophytes ubiquitously colonize the inside tissues of ginseng without any disease symptoms. The identification of bacterial endophytes is conducted through either the internal transcribed spacer region combined with ribosomal sequences or metagenomics. Bacterial endophyte communities differ in their diversity and composition profile, depending on the geographical location, cultivation condition, and tissue, age, and species of ginseng. Bacterial endophytes have a significant effect on the growth of ginseng through indole-3-acetic acid (IAA) and siderophore production, phosphate solubilization, and nitrogen fixation. Moreover, bacterial endophytes can protect ginseng by acting as biocontrol agents. Interestingly, bacterial endophytes isolated from Panax species have the potential to produce ginsenosides and bioactive metabolites, which can be used in the production of food and medicine. The ability of bacterial endophytes to transform major ginsenosides into minor ginsenosides using β-glucosidase is gaining increasing attention as a promising biotechnology. Recently, metabolic engineering has accelerated the possibilities for potential applications of bacterial endophytes in producing beneficial secondary metabolites.

• 공업화학
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• 제33권2호
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• pp.145-150
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• 2022

Microalgae are attracting attention as a resource for the production of biofuels, food nutrients, biochemicals, and bioplastics. Among a wide range of sources of the biomass, microalgae have been highlighted due to relatively easy cultivation, ability to eliminate carbon dioxide, and low culturing cost. Despite the great potential of microalgal biomass as a biological material, the complexity and relatively expensive downstream processes have inhibited the commercial use of microalgae. In this study, we reviewed recent techniques for microalgal drying for the production of microalgal based products. As drying processes comprise the largest portion of microalgae processing cost, an efficient drying technique is key to the utilization of microalgal biomass.

• Asia Marketing Journal
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• 제24권4호
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• pp.152-160
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• 2023

A great deal of attention has been paid to entrepreneurship and social enterprises that help improve societies' ability to solve social problems and develop new ways of thinking (Drucker 1995). Dong Wha Pharm, founded in 1897, was the first social enterprise in South Korea. The purpose of this study is to provide meaningful insights into the theoretical development of social entrepreneurship and how to achieve social innovation by fostering social entrepreneurship. Drawing on the five critical elements of social entrepreneurship developed by Dees (1998), we explore social entrepreneurship by investigating the first Korean social entrepreneur, Kang Min, the founder of Dong Wha, a 125-year-old company in South Korea. The findings offer meaningful and valuable insights to the literature on social entrepreneurship and to current and potential social entrepreneurs wanting to find new ways to achieve social improvement and move society forward.

• BMB Reports
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• 제56권1호
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• pp.43-48
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• 2023

Pre-clinical models are critical in gaining mechanistic and biological insights into disease progression. Recently, patient-derived organoid models have been developed to facilitate our understanding of disease development and to improve the discovery of therapeutic options by faithfully recapitulating in vivo tissues or organs. As technological developments of organoid models are rapidly growing, computational methods are gaining attention in organoid researchers to improve the ability to systematically analyze experimental results. In this review, we summarize the recent advances in organoid models to recapitulate human diseases and computational advancements to analyze experimental results from organoids.

• The Journal of Asian Finance, Economics and Business
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• 제9권3호
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• pp.113-121
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• 2022

The study aimed to assess the availability of intellectual capital in Kuwaiti private universities in terms of its three dimensions (human capital, structural capital, and relational capital), as well as its role in crisis management (crisis preparedness, crisis mitigation, confrontation, and response to the crisis, and learning from the crisis) during the COVID-19 pandemic. Members of the boards of trustees, university presidents, their deputies, and deans of the colleges were chosen as respondents to this study from a sample of (8) private universities in Kuwait, with the sampling unit consisting of leaders in these universities. The study revealed that all dimensions of intellectual capital play a statistically significant impact in executing crisis management during the COVID-19 pandemic at Kuwaiti private universities after conducting the data analysis process. The study concluded that universities should pay attention to intellectual capital in all its dimensions (human capital, structural capital, and relational capital) because of its role in improving their ability to implement crisis management strategies and strive to improve their capabilities to face crises by implementing crisis management strategies.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 춘계학술발표대회
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• pp.397-400
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• 2021

To solve the problem that existing computing methods cannot adequately represent the semantic features of sentences, Siamese TRAT, a semantic feature extraction model based on Transformer encoder is proposed. The transformer model is used to fully extract the semantic information within sentences and carry out deep semantic coding for sentences. In addition, the interactive attention mechanism is introduced to extract the similar features of the association between two sentences, which makes the model better at capturing the important semantic information inside the sentence. As a result, it improves the semantic understanding and generalization ability of the model. The experimental results show that the proposed model can improve the accuracy significantly for the semantic similarity calculation task of English and Chinese, and is more effective than the existing methods.

• 센서학회지
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• 제31권3호
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• pp.139-144
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• 2022

Advanced tactile sensors are receiving significant attention in various industries such as extended reality, electronic skin, organic user interfaces, and robotics. The capabilities of advanced tactile sensors require a variety of functions, including position sensing, pressure sensing, and material recognition. Moreover, they should comsume less power and be bio-friendly with human contact. Recently, a tactile sensor based on the triboelectrification effect was developed. Triboelectric tactile sensors have the advantages of wide material availability, simple structure, and low manufacturing cost. Because they generate electricity by contact, they have low power consumption compared to conventional tactile sensors such as capacitive and piezoresistive. Furthermore, they have the ability to recognize the contact material as well as execute position and pressure sensing functions using the triboelectrification effect. The aim of this study is to introduce the progress of research on triboelectrification-based tactile sensors with various functions such as position sensing, pressure sensing and contact material recognition.

• Mass Spectrometry Letters
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• 제14권3호
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• pp.79-90
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• 2023

Natural goods, especially therapeutic plants, are abundant in the World. Because they have the ability to provide all humanity with countless advantages as a source of medicines, medicinal plants are presently receiving more attention than ever. These plants' therapeutic efficacy is based on bioactive phytochemical components that have clear physiological effects on the human body. The drying process is crucial for the preparation of plant materials prior to extraction since freshly harvested plant materials include active enzymes that create active components, intermediates, and metabolic processes. Many of the phytoconstituents may be extracted using the semi-polar solvent methanol. The goal of the current work is to use the GC-MS gas chromatography- mass spectrometry technology to identify the phytochemicals and review their biological activity. In methanol leaf extract, 5 phytocompounds were found in Ricinus communis, 5 phytocompounds in Pongamia pinnata, 12 phytocompounds in Datura metal, 7 phytocompounds in Azadirachta indica, 11 phytocompounds in Acalypha indica.

• 핵의학기술
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• 제28권1호
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• pp.1-11
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• 2024

Hypoxia, defined as the deficiency of oxygen, is a significant hallmark of cancers presenting in the majority of solid tumors. Detection of tumor hypoxia is essential in cancer diagnosis to prevent cancer progression, metastasis, and resistance to cancer therapies in clinical practices. Single-photon emission computed tomography (SPECT) is one of the methods studied and applied for hypoxia detection with the use of radiolabeled imaging agents in which ^99mTc is the common radioisotope used for radiolabeling. Nitroimidazoles are the hypoxia-targeting moieties presenting in numerous ^99mTc-radiolabeled imaging agents due to their bio-reducible ability in hypoxic environments. Recently, in addition to ^99mTc-labeled radiopharmaceuticals containing one nitroimidazole unit, there has been considerable attention given to ^99mTc-radiopharmaceuticals bearing two or more nitroimidazole units. This review summarizes the synthesis of hypoxia-targeting chelators and radiolabeling processes to produce these ^99mTc-radiopharmaceuticals for SPECT imaging.

• 방송공학회논문지
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• 제25권1호
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• pp.1-12
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• 2020

의료분야에서 질환별 유병률 차이로 인한 데이터 수적 불균형은 흔하게 발생되는 문제로 인공지능 학습 성능을 저하시켜 개발의 어려움을 초래한다. 최근 이러한 데이터 수적 불균형문제를 해결하기 위한 한 방법으로 적대적 생성 신경망(GAN) 기술이 도입되었고 다양한 분야에 성공적으로 적용되어왔다. 그러나 수적 불균형에 의해 저하된 성능 문제를 해결하는데 있어서 기존 연구들의 영상 해상도가 아직 충분하지 않고 영상 내 구조가 전역적으로 일관성 있게 모델링 되지 않아 좋은 결과를 얻기 어렵다. 본 논문에서는, 흉부 X선 영상 데이터의 수적 불균형문제를 해결하기 위하여 고해상도 영상을 생성할 수 있는 주목 메커니즘 기반 멀티 스케일 조건부 적대적 생성 네트워크를 제안한다. 해당 네트워크는 질환제어 조건변수에 의해 하나의 네트워크만으로 다양한 질환 영상을 생성할 수 있어 각 클래스별로 학습을 하는 비효율성을 줄였고, 자기 주목 메커니즘을 통해 영상 내 장거리 종속성 문제를 해결하였다.