• The Korean Journal of Pesticide Science
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• v.7 no.4
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• pp.271-279
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• 2003

To investigate the toxicological effects of technical of IAP-3006, we performed subchronic oral toxicity study in Sprague-Dawley (SD) rats. In the subchronic dietary study, rats of both sexes were fed diets containing technical of IAP-3006 at concentrations of 0, 1000, 10,000, or 15,000 ppm for 90 days. No clinical signs and mortality were observed in animals treated with technical of IAP-3006 throughout the experimental period. There were also no significant changes in body weights, feed consumption, and any gross or histopathological lesions. Although there were statistically significant differences between the control and treated groups in some relative and absolute organ weights, and hematological and biochemical analyses, the data were in biologically normal ranges and did not show a dose-dependent manner. From these results, it is suggested that subchronic oral toxicity NOEL of technical of IAP-3006 in rats may be over 15,000 ppm.

• Journal of Advanced Navigation Technology
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• v.20 no.2
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• pp.148-154
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• 2016

Safety assessment is necessary to develop safety related CNS/ATM system. It includes functional hazard assessment (FHA), effects eliciting system safety requirement that mitigates system's hazardous event. This paper performs a case study for functional hazard assessment of A-SMGCS. To do this, related A-SMGCS studies from Eurocontrol and EMMA are surveyed, and assessment schemes of functional hazard from Eurocontrol and EMMA are combined. Not only FHA scope but also several assumptions for FHA are defined for Incheon airport. 29 hazards are identified and their severities are assessed. And exposures and safety objectives from hazards are analyzed using event tree analysis method. Differences between result of this study and result of EMMA are analysed, and assessment results in this study are also reviewed.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.1255-1263
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• 2008

A Safety Case is an railway organization's formal arrangement, through the provision of policies, resources and processes, to ensure the safety of its work activity within safety management system. An effective system helps the organization to identify and manage risks effectively. It allows an organization to demonstrate its capability in achieving its safety objectives and in meeting regulatory requirements. The purpose of this research is to give how to the risk assessments are described within Railway Safety Cases can be prepared and maintained to meet the criteria specified by the upcoming railway regulations. Through this research, we propose the elements of safety management system that include arrangements for the ongoing identification of hazards, assessment of risks and the implementation of necessary control measures.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.22 no.3
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• pp.175-183
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• 2012

Objectives: This study developed a harmonized method for risk assessment based on the Hazard & Risk Evaluation of Chemicals (HREC) according to the Industrial Safety and Health Act (ISHA). Methods: Three preliminary studies, performed during 2010 and 2011 by the Occupational Safety and Health Research Institute and three academic research groups, were compared. The differences in risk assessment, especially in the dose-response assessment method, were analyzed. A new harmonized method for dose-response assessment was suggested and its applicability for the HREC was examined. Results: Considering the various steps of each dose-response assessment, the equivalent steps in quantitative correction, uncertainty factor 2 (UF2) for intra-species uncertainty, and UF3 for the experimental period in the uncertainty correction were relatively high. Using our new method, the total correction values (quantitative correction plus uncertainty correction) ranged from 72~15,789 to 30~60, and the ratio of the threshold limit value (TLV) to the reference concentration decreased from 12.8~1900 to 5.4~11.8. Furthermore, when we performed risk characterization by our new method, hazard quotient (HQ) values for chloroethylene, epichlorohydrin, and barium sulfate became 3.0, 14.1, and 1.13 respectively, whereas three previous studies reported HQ values of 7.1, 4580, and 87.3 considering reasonable maximum exposure (RME) conditions. HQs of the three chemicals were calculated to be 0.6, 2.4, and 0.1 respectively, when compared to their TLVs. Conclusions: Our new method could be applicable for the HREC because the total correction values and the ratio of TLVs were within reasonable ranges. It is also recommended that additional risk management measures be applied for epichlorohydrin, for which the HQ values were greater than 1 when compared with both reference values and the TLV. Our proposed method could be used to harmonize dose-response assessment methods for the implementation of risk assessment based on the HREC according to ISHA.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1669-1679
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• 2010

Related to the on-going "Train Control System Project of Pilot Line Construction for Urban MAGLEV Train", activities by each phase shall be conducted to achieve SIL4 level and obtain safety certification from the Independent Safety Assessment(ISA), based on the IEC standards((IEC 62278/62279 and IEC 62425) for the first time in Korea. This thesis describes the introduction of IEC standards, system assurance activities (such as plan, analysis, test, verification and validation) in compliance with requirements management and project life-cycle and relations with the safety assessment activities; and certification activities (such as document reviews and audits) through system RAMS activities, software quality assurance activities and safety assessment, for the purpose of achieving a successful safety certification at the time of completing the project as system assurance activities including software and safety certification activities in order to acquire the safety certification for train control system which does not exist at all in domestic cases. It is believed that overall system safety assurance activities in this project will contribute to develop more upgraded products of the domestic train control system on the quality and safety point of view, find overseas markets and establish a bridgehead in the future.

• Journal of the Korean Society for Railway
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• v.20 no.4
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• pp.550-557
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• 2017

Owing to the established international standards for reliability and safety management of railways and the third-part conformity assessment implementation, quantitative risk assessment focusing on communication system related to railway safety has being implemented. The quantitative risk assessment starts from the establishment of quantitative RAMS requirements; the risk has to be maintained under an acceptable safety level. This paper introduces the risk assessment process based on international standards ; risk assessment was conducted using failure data for railway facilities for about 5.5 years. In addition, based on the results, a scientific risk management method for railway facilities is suggested.

• Journal of the Korean Society of Safety
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• v.17 no.1
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• pp.68-71
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• 2002

A research on accident loss calculation for polyol process without safety management activities, and safety cost estimation using process risk assessment has been implemented. In order to estimate a magnitude of loss, accident scenarios were made by combining result made from HAZOP Study method with accident possibility analysis results implemented with FTA. Also effect assessment was implement for accident consequence of each scenario. And minimum possible loss cost has been calculated when safety investment do or not. Result from cost-benefit analysis was shown as approximately \335 billion(=USS44,000 billion), as cost after subtracting safety management cost from minimum possible loss cost.

• Korean Journal of Computational Design and Engineering
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• v.10 no.5
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• pp.356-364
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• 2005

As a ritual of modern people is getting higher, the safety assessment of the structure related to people has become the most important part in the process of the design. Especially, in the case of a ship, as regulations about the safety of passengers and the pollution in the ocean are strictly reinforcing, the safety assessment has become the most important part in the process of the design. However, because the established safety assessment is mostly depend on the experienced theory, it is so difficult to assess the safety considering a lot of situations such as various ocean environments, the mistake of sailors and emergency situations. As the way to solve this problem, lately the study of the simulation using a computer has been processed. In this paper, we suggested network-based simulation system framework using HLA (High Level Architecture) among many kind of simulations to assess the safety of the ship. Because HLA has already become a standard of the future simulation system in the U.S. DoD(Department of Defense) and Korea army, we expect to raise the possibility in the future. In addition, because HLA makes a standard of documents and a reused component(Federate) of simulation(Federation) by OMT(Object Model Template) and RTI(Runtime Infrastructure), we expect that this study will be developing the safety assessment of ship as well as operation in warship and cooperation with another applications.

• Journal of the Korean Society of Safety
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• v.24 no.5
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• pp.13-20
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• 2009

The risk assessment of thermal hazard to identify chemical or process hazard during early process developments have been considered. The early identification of thermal hazards associated with a process, such as rapid heats of reaction, exothermic decompositions, and the potential for thermal runaways before any large scale operations are undertaken. This paper presents to evaluate the safe operating parameters/envelope for exist plant operations. The assessment of thermal hazard with operating conditions such as amount of process materials, inhibitor, and catalyst on esterification process in manufacture of concrete mixture agents are described. The experiments were performed by a sort of calorimetry with the Multimax reactor system as a screening tool. The aim of the study was to evaluate the thermal risk of process material and mixture in terms of safety security to be practical applications in esterification process. It suggested that we should provide the thermal hazard of reaction materials to present safe operating conditions with cause of accident through this study.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.1097-1098
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• 2005