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Subchronic oral toxicity study of Technical of IAP-3006 in Rats  

Seo, Dong-Seok (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Kim, Jae-Young (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Jeong, Jae-Hwang (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Bark, Hak-Soo (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Yu, Wook-Joon (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Go, Sang-Beom (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Kim, Jeong-Heon (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Jang, Dong-Hyouk (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Seo, Mu-Yeb (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Cho, Bin-Haing (Jang Yu Industry)
Sung, Ha-Jung (Safety Assessment Center, Korea Testing and Research Institute for Chemical)
Publication Information
The Korean Journal of Pesticide Science / v.7, no.4, 2003 , pp. 271-279 More about this Journal
Abstract
To investigate the toxicological effects of technical of IAP-3006, we performed subchronic oral toxicity study in Sprague-Dawley (SD) rats. In the subchronic dietary study, rats of both sexes were fed diets containing technical of IAP-3006 at concentrations of 0, 1000, 10,000, or 15,000 ppm for 90 days. No clinical signs and mortality were observed in animals treated with technical of IAP-3006 throughout the experimental period. There were also no significant changes in body weights, feed consumption, and any gross or histopathological lesions. Although there were statistically significant differences between the control and treated groups in some relative and absolute organ weights, and hematological and biochemical analyses, the data were in biologically normal ranges and did not show a dose-dependent manner. From these results, it is suggested that subchronic oral toxicity NOEL of technical of IAP-3006 in rats may be over 15,000 ppm.
Keywords
Gibberellic acid; technical of IAP- 3006; subchronic toxicity; rats;
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