• Interdisciplinary Bio Central
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• v.2 no.2
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• pp.3.1-3.4
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• 2010

In the present research, we assessed the utility of the structural information of drugs for predicting human in vivo intrinsic clearance from in vitro intrinsic clearance data obtained by human hepatic microsome experiment. To compare with the observed intrinsic clearance, human intrinsic clearance values for 51 drugs were estimated by the classical methods using in vivo-in vitro scale-up and by the new methods using the in vitro experimental data and selected molecular descriptors of drugs by the forward selection technique together. The results showed that taking consideration of molecular descriptors into prediction from in vitro experimental data could improve the prediction accuracy. The in vitro experiment is very useful when the data can estimate in vivo data accurately since it can reduce the cost of drug development. Improvement of prediction accuracy in the present approach can enhance the utility of in vitro data.

• Journal of computational fluids engineering
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• v.9 no.3
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• pp.1-7
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• 2004

A kinetic theory analysis is made of low-speed rarefied gas flows around a flat plate. The Boltzmann equation simplified by a collision model is solved by means of a finite difference approximation with the discrete ordinate method. The method does not suffer from statistical noise which is common in particle based methods and requires much less amount of computational effort. Calculations are made for flows around a micro-scale flat plate with a finite length of 20 microns. The method is assessed by comparing the results with those from several different methods and available experimental data.

• Journal of Korean Neurosurgical Society
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• v.40 no.4
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• pp.304-308
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• 2006

Statistical analyses used in clinical articles published on the Journal of Korean Neurosurgical Society were identified and appropriateness of statistical aspects in reporting results was assessed. Forty seven clinical articles were selected in this study, which were published from February, 2005 to February, 2006 on the journal. The frequency of statistical analysis was as follows : descriptive statistics only 24 [51.1%]. one type of statistical method 10 [21.3%], two or more methods 13 [27.6%]. An assessment of statistical aspects was performed in 24 clinical articles reporting inferential statistics. Ten articles [41.7%] did not adequately describe or reference all statistical methods used. There were six articles [25.0%] not reporting the confidence level used as the critical criteria of the statistical significance. In thirteen articles [54.2%] it seems more appropriate to implement multivariate analyses in addition to univariate analyses. We recommend that the journal readers should concentrate on improving their knowledge of basic statistics and statistical review for manuscripts submitted should be sought from professionals in the fields of biostatistics and epidemiology.

• Steel and Composite Structures
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• v.24 no.3
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• pp.351-358
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• 2017

Due to the increasing competition, automotive manufacturers have to manufacture highly safe and light vehicles. The parts which make up the body of the vehicle and absorb the energy in case of a crash, are usually manufactured with sheet metal forming methods such as deep drawing, bending, trimming and spinning. The part may get thinner, thicker, folded, teared, wrinkled and spring back based on the manufacturing conditions during manufacturing and the type of application methods. Transferring these effects which originate from the forming process to the crash simulations that are performed for vehicle safety simulations, makes accurate and reliable results possible. As a part of this study, firstly, the one-step and incremental sheet metal forming analysis (deep drawing + trimming + spring back) of vehicle front bumper beam and crash boxes were conducted. Then, crash performances for cases with and without the effects of sheet metal forming were assessed in the crash analysis of vehicle front bumper beam and crash box. It was detected that the parts absorbed 12.89% more energy in total in cases where the effect of the forming process was included. It was revealed that forming history has a significant effect on the crash performance of the vehicle parts.

• Korean Journal of Bronchoesophagology
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• v.9 no.1
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• pp.83-86
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• 2003

Background and Objectives : Paradoxical vocal cord movement is a series of paroxysmal adduction of the anterior two-thirds of the vocal cords during respiration or during phonation. The choking, stridor, and wheezing in this condition occur primarily on inhalation, rather than on exhalation. The two pathognomonic diagnostic criterias that need to be assessed during an acute presentation are laryngoscopy with direct visualization of paradoxical adduction of the vocal cords and pulmonary function testing. Materials and Methods : A retrospective review of 3 patients who were referred to otolaryngologist from pulmonology department, and were confirmed by typical laryngoscopic findings with paradoxical adduction of the vocal cords was conducted. Results The patients were misdiagnosed as exercised-induced asthma, and unresponsive to corticosteroid and bronchodilators. Improvement was achieved only by diagnosis with paradoxial vocal cord movement. Biofeed back therapy, voice therapy, treatment for reflux laryngitis improved symptoms. Conclusion The etiology of paradoxical vocal cord movement is unknown. It may be functional or emotional. The functional factors that were proposed are neurologic deficit and gastroesophageal reflux. Management methods of this condition consist of psychological counselling, voice therapy, and antireflux medication.

• Smart Structures and Systems
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• v.13 no.1
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• pp.111-135
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• 2014

Based on the Reissner mixed variational theorem (RMVT), finite rectangular layer methods (FRLMs) are developed for the three-dimensional (3D) linear buckling analysis of simply-supported, fiber-reinforced composite material (FRCM) and functionally graded material (FGM) sandwich plates subjected to bi-axial compressive loads. In this work, the material properties of the FGM layers are assumed to obey the power-law distributions of the volume fractions of the constituents through the thickness, and the plate is divided into a number of finite rectangular layers, in which the trigonometric functions and Lagrange polynomials are used to interpolate the in- and out-of-plane variations of the field variables of each individual layer, respectively, and an h-refinement process is adopted to yield the convergent solutions. The accuracy and convergence of the RMVT-based FRLMs with various orders used for expansions of each field variables through the thickness are assessed by comparing their solutions with the exact 3D and accurate two-dimensional ones available in the literature.

• Journal of East-West Nursing Research
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• v.14 no.2
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• pp.8-15
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• 2008

Purpose: Yangsaeng is a traditional health care regimen that incorporates specific principles and methods to promote health and prevent illness, with the aim of improving the health and longevity of life. The present study assessed Yangsaeng and quality of life (QOL-BREF) in Korea. Methods: Data from 346 adults and elderly Koreans was collected by using a self-reported questionnaire. Analysis of the data included descriptive statistics, Pearson's correlation, t-test, ANOVA and Cronbach's ${\alpha}$. Results: Statistically significant differences in QOL-BREF were evident according to the age, job, religion, education level, economic status and positive thinking. Statistically significant differences were evident in Yangsaeng according to religion, education, economic status and positive thinking. Total QOL-BREF positively related to total Yangsaeng. Morality Yangsaeng, exercise Yangsaeng and sleep Yangsaeng were positively related to all QOL-BREF sub-domains. Conclusions: The Yangsaeng oriental health care regimen can improve QOL, and should be recommended as a means of health promotion and QOL in the Korean culture.

• Journal of the Korean Home Economics Association
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• v.44 no.6 s.220
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• pp.129-140
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• 2006

In this study, the various financial management systems practiced by modem dual-income families were assessed by in-depth interviews with 6 people, 3 practicing integrated financial management and 3 practicing individual financial management. The results indicated significant differences between the two financial management methods regarding family structure, individual values, and family finances. Families that practiced individual financial management consisted of weekend couples without children who showed an individual-centered value tendency and seemed to take a positive attitude towards their future economic situation due to possession of their on stabilized financial assets. Based on these results, we can expect more families to adopt methods of individual financial management and show a wider variety in their financial planning tools which will require adequate and efficient countermeasures and strategies suitable for each financial management practice.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.508-515
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• 2003

There are various methods to assess to company's outcome. Among them, the customers satisfaction, which is assessed by customers, is the most important. If the customers satisfaction is measured by the CSI based on the proper reliability and validity, you can apply the result for various marketing methods. Therefore, this study develops a model to assess CSI for an industry, specifically, local automotive industry based on the SEM that is already proven valid through assessing models such as ACSI, KCSI and NCSI. Moreover, this research can be utilized for marketing strategy helping customers to decide as an AHP model, one of the decision making method.

• Proceedings of the Korea Concrete Institute Conference
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• 2000.04a
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• pp.491-496
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• 2000

This paper presents the evaluation of behavior and the prediction of tensile capacity of anchors that fail concrete, as the design basis for anchorage. Tests of cast-in-place headed anchors, domestically manufactured and installed in uncracked, unreinforced concrete are performed to investigate the behavior of single anchors and multiple anchors with the consideration of various embedment lengths and edge distances. The failure mode and the load-deformation response of these anchors are discussed and the concrete failure dta are then compared with capacity predictions by the two existing methods : the 45 degree cone method of ACI 349, 318 and the concrete capacity design (CCD) method. Discrepancies between the test results and these two prediction methods, FEM analysis are assessed.