• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2759-2764
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• 2014

Aim: This study aims to investigate the manifestation of CT, MRI and dynamic enhanced scans for primary hepatic neuroendocrine cell carcinoma. Methods: CT or MRI arterial and venous phase scan images of 19 cases of pathologically confirmed PHNEC were retrospectively analyzed. Results: 14 cases (73.68%) with single lesion, 5 cases (26.3%) with multiple lesions, with an average diameter of 13.2 cm. Some 12 cases (63.16%) showed inhomogeneous enhancement, seven cases (36.8%) showed homogeneous enhancement, 13 cases (68.4%) demonstrated significant enhancement in the arterial phase, 13 cases (68.4%) had significantly enhanced portal venous phase including 7 cases (36.8 %) with portal venous phase density or signal above the arterial phase and 5 cases (26.3%) with the portal vein density or signal below the arterial phase. Seven cases (36.8%) had continued strengthened separate shadows in the center of the lesion. Thrombosis were not seen in portal veins. Conclusion: CT and MRI images of liver cell neuroendocrine carcinoma have certain characteristics that can provide valuable information for diagnosis and differential diagnosis.

• 대한기계학회논문집B
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• 제26권1호
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• pp.39-44
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• 2002

The arterial stenosis related to the intimal thickening of the arterial wall is the main cause of many diseases in human cardiovascular system. Hemodynamic behavior of the blood flow is influenced by the presence of the arterial stenosis. In this study, effects of the pulsatile flow, caused by the periodic motion of the heart, on the blood flow and its interaction with the arterial stenosis are analyzed by the FEM-based computational fluid dynamics. As a result, it was found that the characteristics of the pulsatile flow in the artery with stenosis are quite different from those of the steady flow. And, the pulsatile flow condition affects the wall shear stress, which is one of the most important physiological parameters in the hemodynamics.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권6호
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• pp.408-411
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• 2013

After radical excision of a tumor in the maxillofacial area, functional and esthetic reconstruction is needed, including flap surgery. Among the many etiologies of flap failure, venous thrombosis is one of the most frequent. Heparin is used routinely in the effort to avoid development of venous thrombosis. In rare cases, heparin-induced thrombocytopenia (HIT) type II occurs due to exposure to heparin. Heparin attached to platelet factor 4 forms a PF4/heparin-immunoglobulin G immune complex on platelet surfaces. This complex activates platelets, which leads to multiple coagulation in venous and arterial blood. We report here on a rare occurrence of HIT type II following fibula free flap surgery.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1273-1277
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• 1992

Percutaneous Transluminal Angioplasty[PTA] was introduced by Dotter and JudKins [1964], using coaxial catheters of increasing diameter. The remarkable advances in vascular catheter technology over the past several decades have permitted the development. But the application of the balloon catheters carries with it the risk of arterial injury, thrombosis, embolism, and loss of life or limb. A 53-year-old man was admitted to other hospital due to a intermittent claudication in his right leg for 10 years. and PTA was performed at that hospital. Thereafter he was transferred to our hospital because of coldness, pulselessness, rest pain, ischemic ulcer, and progressing gangrene at the anterior aspect of left lower leg. The left lower extremity was salvaged by left ilio-femoral bypass and later saphenous in situ femoro-popliteal bypass.

• Journal of Chest Surgery
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• 제48권2호
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• pp.134-138
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• 2015

Thoracoabdominal aortic aneurysm accompanied by Leriche syndrome is an extremely rare combination of aortic diseases, the surgical management of which has not been described to date. We report the successful treatment of one such case through open surgical repair of the thoracoabdominal aorta.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.33-33
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• 1993

Among the Glycosaminoglycans (GAGs), Heparin and its fractions or fragments, obtained by several different processes, are of considerable interest .In these last few years, the goal of the researchers in this field has been finding molecular species having selective action, like for instance species having only antithrombotic activity disjointed from any anticoagulant effect, and assessing the effects of these GAGs and of other GAGs, like dermatan sulphate, not only in the field of venous or arterial thrombosis but also on cell factors like smooth muscle cell proliferation and even on aspects of antiinflammatory activity.

• 대한골관절종양학회지
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• 제12권1호
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• pp.83-88
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• 2006

골연골종은 가장 흔한 양성 골 종양으로, 주변 골단판 연골의 골막하 전위에 의한 과증식성 골 병변이며, 대개 골단판이 닫히면서 성장이 끝나는 것으로 알려져 있다. 이러한 골연골종이 혈관계 합병증을 유발하는 경우는 드물지만, 종괴 효과로 주변의 동맥이나 정맥을 눌러 허혈이나 정맥염이 생기거나, 연골모가 골화되면서 생기는 날카로운 말단에 의해 동맥벽의 천공이 생길 수 있다. 이러한 혈관계 합병증은 대부분 젊은 남자의 동맥에서 발생하며, 정맥에 생기는 경우는 드문 것으로 알려져 있다. 저자들은 원위 대퇴골 골연골종으로 인해 심부 정맥 혈전증이 발생한 21세 남자 환자에서 골연골종의 제거 후 정맥 절제술 및 복재 정맥 이식술로 치료한 경험을 보고하고자 한다.

• Journal of Yeungnam Medical Science
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• 제34권2호
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• pp.279-284
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• 2017

Pulmonary artery sarcoma (PAS) is a rare and fatal disease that often mimics chronic thromboembolic pulmonary hypertension (CTEPH); therefore, diagnosis of PAS is often delayed. Herein, a healthy 74-year-old man was presented with a 4-month history of dyspnea. Chest computed tomography showed wall thickening and stenosis in the main pulmonary artery as well as in both proximal pulmonary arteries. In order to differentiate between unusual CTEPH, vasculitis, and PAS, we performed right heart catheterization and pulmonary angiography. The mean pulmonary arterial pressure was 21 mmHg, and there was severe pulmonary artery stenosis. Thrombi on the pulmonary arterial wall lesions were observed in intravascular ultrasound and optical coherence tomography. Furthermore, the patient had a history of deep vein thrombosis. Therefore, we diagnosed unusual CTEPH. After 6 months of rivaroxaban anticoagulation therapy, a chest X-ray revealed a left lower lobe lung mass, and a positron emission tomography later showed hypermetabolic lesions in the main pulmonary artery wall, in both pulmonary arteries walls, in the lung parenchyma, and in the bones. A biopsy of the right proximal humerus lesion revealed undifferentiated intimal sarcoma. Pulmonary sarcoma is rare, but should be considered when differentially diagnosing main pulmonary artery wall thickening and stenosis. A positron emission tomography may aid in this diagnosis.

• Journal of Ginseng Research
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• 제46권5호
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• pp.683-689
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• 2022

Background: Since ginsenosides exert an anti-thrombotic activity, blood flow-improving effects of DK-MGAR101, an extract of mountain ginseng adventitious roots (MGAR) containing various ginsenosides, were investigated in comparison with an extract of Korean Red Ginseng (ERG). Methods: In Sprague-Dawley rats orally administered with DK-MGAR101 or ERG, oxidative carotid arterial thrombosis was induced with FeCl₃ (35%), and their blood flow and occlusion time were measured. To elucidate underlying mechanisms, the cytoprotective activities on rat aortic endothelial cells (RAOECs) exposed to hydrogen peroxide (H₂O₂) were confirmed. In addition, the inhibitory activities of DK-MGAR101 and ERG on agonist-induced platelet aggregation, thromboxane B₂ production, and ATP granule release from stimulated platelets as well as blood coagulation were analyzed. Results: DK-MGAR101 containing high concentrations of Rb1, Rg1, Rg3, Rg5, and Rk1 ginsenosides (55.07 mg/g) was more effective than ERG (ginsenosides 8.45 mg/g) in protecting RAOECs against H₂O₂ cytotoxicity. DK-MGAR101 was superior to ERG not only in suppressing platelet aggregation, thromboxane B₂ production, and granule release, but also in delaying blood coagulation, FeCl₃-induced arterial occlusion, and thrombus formation. Conclusions: The results indicate that DK-MGAR101 prevents blood vessel occlusion by suppressing platelet aggregation, thrombosis, and blood coagulation, in addition to endothelial cell injury.

• Journal of Chest Surgery
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• 제41권2호
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• pp.149-159
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• 2008

배경: 최근 관상동맥우회술 및 말초 혈관 수술의 증가로 동종 이식편 혹은 합성 도관의 필요성이 제기되고 있으나, 만족스럽지 못한 장기 개존율로 널리 사용되지 못하고 있다. 최근 냉동보존된 동종 판막의 생육성 유지의 잠재력이 밝혀지면서, 냉장보존 및 냉동보존된 동종 동맥 혹은 정맥이식편의 실험적인 연구와 임상 적용이 시도되고 있다. 대상 및 방법 : $4^{\circ}C$ 냉장보존과 $-170^{\circ}C$ 냉동보존된 한국산 잡견의 대퇴 동맥 및 대복재 정맥을 수여견의 대퇴 동맥에 이식하여, 냉장보존 및 냉동보존된 동맥과 정맥의 개존율의 차이와 생육성에 따른 내피세포의 기능을 시간대별로 관찰하였다. 결과: RPMI-1640을 배양액으로 하는 3일간의 $4^{\circ}C$냉장보존법과 10% DMSO${\cdot}$RPMI-1640 을 배양액으로 하는 2주간의 $-170^{\circ}C$의 냉동보존법은 혈류량(개존율)(p=0.264), 혈전의 발생 정도(p=0.264)와 내피의 존재 정도(p=0.587), 트롬보모듈린(thrombomodulin) 면역조직화학 염색에도 차이가 없었다(p=0.657). 동맥 이식편과 정맥 이식편은 보존방법에 관계없이 동맥 이식편이 정맥 이식편보다 혈류가 좋았고(p=0.030), 혈전의 발생 정도가 낮았다(p=0.030). 혈전의 정도 및 내피의 존재 유무와 트롬보모듈린의 면역조직화학적 염색의 상관관계를 보았을 때, 혈전의 정도와 면역조직화학적 염색 정도와의 상관관계 계수는 0.654였으며(p=0.006), 내피의 존재와 면역조직화학적 염색 정도와의 상관관계 계수는 0.520 이었다.(p=0.0049). 이식편을 수여견에 이식 후 적출한 이식편을 기간별로 내피의 존재 여부와 면역조직화학적 염색 정도와의 상관관계를 살펴보면 2주일 전에는 상관관계가 없었으나(p=0.306), 1개윌 후에는 상관관계 계수가 0.931 이었다(p=0.0008). 결론: RPMI를 배양액으로 하는 3 일간의 $4^{\circ}C$냉장보존과 10% DMSO${\cdot}$RPMI-1640을 배양액으로 하는 2주간의 $-170^{\circ}C$의 냉동보존은 최소한 같은 정도의 생육성이 유지된 혈관 보존을 할 수 있었다. 보존방법에 관계없이 동맥 이식편은 정맥 이식편 보다 혈전의 발생률이 적었으며, 혈류량으로 평가한 개존율이 우수하였다. 트롬보모율련의 역할을 고려할 때, 이식 후 2주일 전에 적출된 이식편에는 내피가 존재하더라도 광학현미경상의 형태만 갖고 있고, 항응고 기능은 없었으나, 이식 후 1개월 이후에 적출된 이식편에서는 내피가 존재하는 경우 항응고 기능이 있는 것을 알 수 있었다.