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http://dx.doi.org/10.1016/j.jgr.2022.01.001

DK-MGAR101, an extract of adventitious roots of mountain ginseng, improves blood circulation by inhibiting endothelial cell injury, platelet aggregation, and thrombus formation  

Seong, Hye Rim (College of Veterinary Medicine, Chungbuk National University)
Wang, Cuicui (College of Veterinary Medicine, Chungbuk National University)
Irfan, Muhammad (College of Veterinary Medicine, Kyungpook National University)
Kim, Young Eun (Pharmaceutical Technology Institute, Dongkook Pharmaceutical Co., Ltd.)
Jung, Gooyoung (Pharmaceutical Technology Institute, Dongkook Pharmaceutical Co., Ltd.)
Park, Sung Kyeong (Department of Beauty Care, Daejeon Health Institute of Technology)
Kim, Tae Myoung (College of Veterinary Medicine, Chungbuk National University)
Choi, Ehn-Kyoung (College of Veterinary Medicine, Chungbuk National University)
Rhee, Man Hee (College of Veterinary Medicine, Kyungpook National University)
Kim, Yun-Bae (College of Veterinary Medicine, Chungbuk National University)
Publication Information
Journal of Ginseng Research / v.46, no.5, 2022 , pp. 683-689 More about this Journal
Abstract
Background: Since ginsenosides exert an anti-thrombotic activity, blood flow-improving effects of DK-MGAR101, an extract of mountain ginseng adventitious roots (MGAR) containing various ginsenosides, were investigated in comparison with an extract of Korean Red Ginseng (ERG). Methods: In Sprague-Dawley rats orally administered with DK-MGAR101 or ERG, oxidative carotid arterial thrombosis was induced with FeCl3 (35%), and their blood flow and occlusion time were measured. To elucidate underlying mechanisms, the cytoprotective activities on rat aortic endothelial cells (RAOECs) exposed to hydrogen peroxide (H2O2) were confirmed. In addition, the inhibitory activities of DK-MGAR101 and ERG on agonist-induced platelet aggregation, thromboxane B2 production, and ATP granule release from stimulated platelets as well as blood coagulation were analyzed. Results: DK-MGAR101 containing high concentrations of Rb1, Rg1, Rg3, Rg5, and Rk1 ginsenosides (55.07 mg/g) was more effective than ERG (ginsenosides 8.45 mg/g) in protecting RAOECs against H2O2 cytotoxicity. DK-MGAR101 was superior to ERG not only in suppressing platelet aggregation, thromboxane B2 production, and granule release, but also in delaying blood coagulation, FeCl3-induced arterial occlusion, and thrombus formation. Conclusions: The results indicate that DK-MGAR101 prevents blood vessel occlusion by suppressing platelet aggregation, thrombosis, and blood coagulation, in addition to endothelial cell injury.
Keywords
Adventitious root; Blood circulation; Ginsenoside; Mountain ginseng; Platelet aggregation;
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Times Cited By KSCI : 4  (Citation Analysis)
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