• 대한약침학회지
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• 제5권1호
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• pp.171-180
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• 2002

Objective: The purpose of this study is to develop and activate the methods of using the arsenic compounds as the anti-cancer medicine. Methods: We investigated some literatures on the using methods, the effects for anti-cancer, and the toxicity of the arsenic compounds. Results: The results are summarized as follows. 1. As is the one of the nitrogen familIy(5A familly). 2. The Arsenic compounds which have been used as the one of the oriental medicine are the Arsenicum Sulbimatum($As_2O_3$) and the Realgar(AsS). 3. As+ 3 is more toxic than the other arsenic compounds. The fatal amount is 100-300 mg. So, it is used 1-5 mg/day as a medicine. 4. The Arsenicwn Sulbimatum($As_2O_3$) and the Realgar(AsS) are used after the heat treatment or the boiling with the acetic acid. 5. The gastrointestinal tract, vessel, and respiration are affected by the acute toxicity of the arsenic compounds. 6. The arsenic compounds are good for the dermatosis and the malignant cancer, especially the acute promyelocytic leukcrnia(APL). we should study the reason of these and the different effect in concentration, also develop new methods of using the the arsenic compounds as getting rid of their toxicity.

• 한국물환경학회지
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• 제29권2호
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• pp.176-183
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• 2013

The variation of the stable region of arsenic compounds in aqueous environment with temperature has been investigated by constructing the Pourbaix diagram of arsenic at different temperatures. The standard potential corresponding to the boundary between arsenic compounds with different charge valence was estimated to be decreased with temperature, which means the stability of arsenic compound with +5 charge valence increases. The distribution diagram of the most highly oxidized arsenic compound showed that arsenic acid is formed at higher pH and arsenate is generated at lower pH as temperature rises. The aquatic toxicity due to arsenic compounds was considered to be decreased with temperature in the neutral pH condition based on the $LD_T$ value defined in this study.

• 한국물환경학회지
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• 제21권6호
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• pp.659-663
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• 2005

Many studies have been conducted to develop new technologies for arsenic removal and to reveal the levels of arsenic and other chemicals in rivers, lakes and ground waters. However, there are few studies dealing with such compounds in the total water system of the city, and the way of management of these compounds in the water system. Because the occurrence of these hazardous compounds, which are geological origins, is almost impossible to control, it is very important to manage these compounds in the water system. In this research, it was revealed that the risk of arsenic in the water treatment system of S city in Japan. As a results, the parameters such as Q in river and E260 in drinking water treatment plant is proposed as a new indicator with simple and rapid method for controling arsenic level.

• 동의생리병리학회지
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• 제19권4호
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• pp.1050-1054
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• 2005

Recently, arsenic compounds were considered as novel agents for treatment of acute promyelocytic leukemia and malignant tumors. However, it showed severe toxicity effect on normal tissue at the same time. In this study, to investigate the possible molecular mechanism (s) of arsenic compounds as candidate of anti-cancer drugs, we compared the abilities of two arsenic compounds, tetraarsenic oxide $(AS_4O_6)$ and arsenic trioxide (diarsenic oxide, $As_2O_3$), to induce cell growth inhibition as well as apoptosis induction in A549 human non-small cell lung cancer cells. Both $As_4O_6\;and\;As_2O_3$ treatment declined the cell growth and viability of A549 cells in a concentration-dependent manner, which was associated with induction of G1 arrest of the cell cycle and apoptotic cell death. However, $As_4O_6$ induced growth inhibition and apoptosis in A549 cells at much lower concentrations than $As_2O_3.\;As_4O_6$ down-regulated the levels of anti-apoptotic Bcl-2 protein, however, the levels of Bax, a pro-apoptotic protein, were up-regulated in a dose-dependent manner. In conclusion, $As_4O_6$ might be a new arsenic compound which may induce apoptosis in A549 cells by modulation the Bcl-2 family and deserves further evaluation.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2004년도 임시총회 및 추계학술발표회
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• pp.350-353
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• 2004

in order to develop a new technique for the removal of arsenic compoundsfrom acidified water, the removal of arsenic compounds by an acidophilic moss, Jungermannia vulcanicola Steph. was investigated in this study. The result of vial tests for arsenic removal is dependent on the biological activity of moss. The presence of phosphate inhibited the arsenic removal. And the acclimatization of moss by the media containing arsenic increased the its capability of arsenic remova.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.163.1-163.1
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• 2003

Arsenic is a ubiquitous element that ranks 20th in abundance in the earth's crust, 14th in the sea water, and is a component of several hundred minerals. Arsenic and its compounds are mobile in the environment. Groundwater contamination by arsenic is a serious threat to mankind all over the world and it can also enter food chain. Humans are exposed to this toxic arsenic from air, food and water. (omitted)

• Environmental Analysis Health and Toxicology
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• 제13권3_4호
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• pp.95-104
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• 1998

확률론적 해석방법은 환경독성물질에 의한 인체위해도 평가시 사용된 각 입력인자들의 불확실성까지 고려하는 방법론이다. 기존의 위해도 평가방법은 불확실성을 고려하지 않고 단순히 결과치의 포인트 값만을 제공하는데 비해 이러한 확률론적 해석방법은 입력인자들의 불확실성이 고려되고 결과치에 대한 이들의 중요도가 산출될 수 있는 등 더 많은 정보를 제공하므로써 환경위해도를 기반으로 한 환경정책 결정시 용이하게 사용될 수 있다. 본 논문은 현재 미국에서 음용수 기준설정시 논란이 많은 무기비소에 대해 확률론적 평가방법론을 적용하였다. 우선 인체위해도평가에 필요한 무기비소의 각종 자료들을 수집, 정리하고 이를 바탕으로 각 인자들의 불확실성을 계산하였다. 최종적으로 이들로부터 무기비소가 포함된 음용수를 마신 일반인의 피부암 위해도를 확률적으로 계산하였다. 또한 계산된 결과치와 여러 위해도기준치를 비교하여 정책결정에 필요한 의사결정에 대해서도 살펴보았다. 계산결과에 의하면 다수의 일반인들이 무기비소를 함유한 음용수섭취를 통해 현재 위해도설정치(10$^{-6}$)보다 높은 ] 피부암 위해를 입고 있는 것으로 나타나 이에 대한 규제가 필요하다고 본다.

• 한국토양환경학회지
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• 제4권3호
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• pp.67-75
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• 1999

비소는 자연적인 환경 하에서 음이온적인 거동을 하며 조건의 변화에 따라 다양한 형태로 전환되는 물질이기 때문에 적당한 처리방법이 없는 형편이다. 본 연구의 처리방법은 광미에 과산화수소를 첨가하여 비산철로 불용화 하는 방법으로 실제 구봉광산의 광미를 이용하여 실험한 결과 비소와 철의 용출농도가 각각 84%와 93%가량이 감소되는 것으로 나타났으며, 순수한 황철광과 비소표준용액을 이용하여 과산화수소를 첨가하는 실험에서는 과산화수소의 첨가량에 따라 비소의 농도가 직선적으로 감소하는 것으로 나타났다. 재용출 실험에서는 철은 약 80%, 비소는 약 90%가 용출이 억제되어 장기적 안정성면에서도 우수한 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4185-4197
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• 2016

Chronic arsenicosis is a major environmental health hazard throughout the world, including India. Animals and human beings are affected due to drinking of arsenic contaminated ground water, due to natural mineral deposits, arsenical pesticides or improperly disposed arsenical chemicals. Arsenic causes cancer with production of free radicals and reactive oxygen species (ROS) that are neutralized by an elaborate antioxidant defense system consisting of enzymes and numerous non-enzymatic antioxidants. Dietary antioxidant supplements are useful to counteract the carcinogenesis effects of arsenic. Oyster mushroom lectins can be regarded as ingredients of popular foods with biopharmaceutical properties. A variety of compounds have been isolated from mushrooms, which include polysaccharides and polysaccharopeptides with immune-enhancing effects. Lectins are beneficial in reducing arsenic toxicity due to anticarcinogenetic roles and may have therapeutic application in people suffering from chronic exposure to arsenic from natural sources, a global problem that is especially relevant to millions of people on the Indian subcontinent.

• 한국토양비료학회지
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• 제47권2호
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• pp.113-119
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• 2014

Arsenic and its compounds which is one of the most toxic elements that can be found naturally on earth in small concentrations are used in the production of pesticides, herbicides, and insecticides. Most arsenic that cannot be mobilized easily when it is immobile is also found in conjunction with sulfur in minerals such as arsenopyrite (AsFeS), realgar, orpiment and enargite. In this investigation we observed the leaching of arsenic in soils amended with several levels of gravel size of arsenopyrite collected from a road construction site. Soil and gravel size of arsenopyrite were characterized by chemical and mineralogical analyses. Results of XRF analysis of arsenopyrite indicated that the proportion of arsenate was 0.075% (wt $wt^{-1}$) while the maximum amount of arsenic in soil samples was 251.3 mg $kg^{-1}$. Cumulative amounts of effluent collected from the bottom of the soil column for different mixing rate of the gravel were gradually increased where proportion of the gravel mixed was greater than 70% whereas the effluent was stabilized to the maximum after approximately 45 pore volumes of effluent or greater were collected. The arsenic in the effluent was recovered from the soil columns in which the proportion of arsenopyrite gravel was 60% or greater. The total amount of arsenic recovered as effluent was increased with increasing proportion of gravel in a soil, indicating that the arsenic in the effluent was closely related with gravel fraction of arsenopyrite.