• 응용통계연구
• /
• 제23권6호
• /
• pp.1225-1234
• /
• 2010

구속영장 기각시 그 기각사유로 단순히 도주 및 증거인멸 우려가 없다고만 기재되는 경우가 대부분이다. 이로 인해 사건의 어떤 측면이 구속영장발부에 영향을 미쳤는지 전혀 알 수 없고, 구속영장을 발부하는 정확한 기준이 무엇인지에 대해 끊임없이 제기되고 있다. 본 연구에서는 창원지방검찰청 진주지청에서 2006-2008년의 3개년도 영장청구자료를 범죄 유형에 따라 7가지로 분류하고 각 범죄별로 구속영장 기각 여부를 결정하는 변수를 알아보고자 한다. 7대 범주별 교차분석을 통하여 구속영장 기각 여부에 대한 통계모형을 다루었다.

• Journal of Chest Surgery
• /
• 제29권1호
• /
• pp.14-23
• /
• 1996

Circulatory arrest under deep hypothermia is an important auxiliary means for cardiac surgery, especially useful in pediatric patients. However, its clinical safety, particularly with regard to the neurologic outcome after long duration of circulatory arrest, is still not established. This study is a review of the eight years'clinical experience of hypothermic circulatory arrest at the Seoul national University Children's Hospital. During an eight-year period from January 1986 through December 1993, a total of 589 consecutive cardiac operations were done using circulatory arrest under deep hypothermia. Among them, 434 consecutive patients, in whom the duration of arrest was 20 minutes or more, are the subject of this study. The duration of arrest ranged from 20 minutes to 82 minutes (mean = 38.7 minutes) under rectal temperature in the range from 12.5$^{\circ}C$ to 25.8$^{\circ}C$. Early neurologic abnormalities occurred in 47 patients : seizure attacks in 28 patients, motor paralyses with or w thout seizure in 12, blindness in 2, and no recovery of consciousness in 5 patients. The rate of incidence of early neurologic abnormalities was calculated at 15.7%. 25 patients showed late neuropsychologic sequelae, such as motor paralysis (9 patients), recurrent seizures (6), developmental delay (8), and definitely low intelligence (2). The rate of incidence of late neurologic sequelae was 8.5%, By statistical analysis, the following factors were identified as the risk factors for post-arrest neurologic abnormalities ; 1) long duration of circulatory arrest, 2) lower-than-ideal body weight, 3) preexisting neurological abnormalities, 4) associated non-cardiovascular congenital anouialies, and 5) low blood pressure during the early post-arrest period. It is concluded that circulatory arrest under deep hypothermia is a relatively safe means for pediatric cardiac surgery with acceptable risk. However, to warrant maximal safety, it is desirable to limit the duration of arrest to less th n 40 minutes. In addition, it is our contention that the early post-arrest period is a very critical period during which maintenance of adequate perfusion pressure in important for the neurologic outcome.

• Journal of Pharmaceutical Investigation
• /
• 제33권2호
• /
• pp.105-112
• /
• 2003

Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at $1\;{\mu}M$ after 24 hr exposure. Forty ${\mu}M$ and $50\;{\mu}M$ of ce1ecoxib induced $G_1$ arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

• Journal of Chest Surgery
• /
• 제57권3호
• /
• pp.272-280
• /
• 2024

Background: The phenomenon known as the "weekend effect" impacts various medical disciplines. We compared outcomes between regular hours and off hours to investigate the presence of the weekend effect in extracorporeal cardiopulmonary resuscitation (ECPR). Methods: Between January 2018 and December 2020, 159 patients at our center were treated with veno-arterial extracorporeal membrane oxygenation (ECMO) for cardiac arrest. We assessed the time required for ECMO preparation, the rate of successful weaning, and the rate of in-hospital mortality. These factors were compared among regular hours ("daytime": weekdays from 7:00 AM-7:00 PM), off hours on weekdays ("nighttime": weekdays from 7:00 PM-7:00 AM), and off hours on weekends and holidays ("weekend": Fridays at 7:00 PM to Mondays at 7:00 AM). Results: The time from the recognition of cardiac arrest to the arrival of the ECMO team was shortest for the daytime group and longest for those treated over the weekend (daytime, 10.0 minutes; nighttime, 12.5 minutes; weekend, 15.0 minutes; p=0.064). The time from the ECMO team's arrival to ECMO initiation was shortest for the daytime and longest for the nighttime group (daytime, 13.0 minutes; nighttime, 18.5 minutes; weekend, 14.0 minutes; p=0.028). No significant difference was observed in the rate of successful ECMO weaning (daytime, 48.3%; nighttime, 39.5%; weekend, 36.1%; p=0.375). Conclusion: In situations involving CPR, the time to arrival of the ECMO team was longer during off hours. Furthermore, ECMO insertion required more time at night than during the other periods. These findings warrant specific training in decision-making and emergent ECMO insertion.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권2호
• /
• pp.563-567
• /
• 2012

In our era there has been several anti-cancer drugs which have undergone both experimental and clinical trials; however, due to their poor solubilities, numerous side effects, insufficient bioavailability and poor compliance, many have resulted into poor outcomes. Therefore, our aim was to investigate the effects of novel hydrophilic taxanes analogues CQMU-0517 and CQMU-0519 on growth of A549 lung, SKVO3 ovary and MCF7 breast carcinoma cell lines. Different concentrations of original paclitaxel, CQMU-0517, original docetaxel and CQMU-0519 were utilized on three cell lines, where cell growth was assessed using cell culture kit-8 and flow cytometry analysis. The results unveiled that CQMU-0517 and CQMU-0519 suppressed cell growth in the three particular cell lines, cell cycle arrest being evident in the G2/M phase. Hence, the results showed that these new taxane analogues have potential and warrant future clinical trials.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제8권1호
• /
• pp.70-82
• /
• 1997

본 연구는 비행청소년의 사회심리적 특성을 파악하고 비행을 직접적으로 유발시키는 요소를 알아보고자 실시되었다. 청소년 병동에 입원한 환자 중 정신증 진단을 제외한 210명을 비행의 정도에 따라 경찰체포후 훈방된군(60명), 재판 판결을 받은군(35명), 이러한 사실이 없는 정서적으로 혼란된 비교군(105명)으로 나누어 인지-학습, 감정상태, 자살사고, 성격특성, 가족구조, 생활사건 영역에 관한 표준화된 검사를 실시하고 그 결과를 비교분석하였다. 공유진단을 파악하고자 이중 무작위로 60명은 구조화된 면담을 실시하였다. 연구결과 비행청소년은 비교군에 비해 1) 입양, 성생활의 문란, 가출, 정신과 입원력이 높았으며, 2) 언어성 지능지수 및 학습능력이 떨어지고, 3) 성격구조상 충동적이고 사회순응도가 낮으며, 강압적이며, 4) 가족단위의 여가활동이 적고, 낮은 종교 도덕관을 가진 가족의 특성을 보였으며, 5) 부정적 생활 경험이 많았고, 6) 품행자애, 반항장애, 주의력 결핍 과잉행동장애 진단율이 높았다. 우울, 불안, 자살사고는 3군중 훈방된군에서 가장 낮게 나왔다. 따라서 비행청소년을 다룰 때 비행에 관여하는 인지학습측면, 충동적인 성격구조, 가족구조, 부정적 생활경험, 파탄적 행동장애 측면에 관한 보다 집중적인 대처방안이 강구되어져야 하겠다.