• Journal of Pharmaceutical Investigation
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• v.24 no.1
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• pp.11-16
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• 1994

In order to reduce the systemic side effects and gastrointestinal irritation of ketoprofen after its oral administration, it was formulated as a 3% ketoprofen gel (ID-GEL) with Pluronic F-127. The pharmacokinetic characteristics of ID-GEL was evaluated following its transdermal application on the dorsal skin of rats at the dose of 9 mg/kg in reference to those of existing 3% ketoprofen gels. Even though the maximum concentration of 810 ng/ml was reached at 6 hrs postdose, the plasma concentration was kept almost constant until 24 hrs postdose, which suggested that ketoprofen was released continuously from the gel during this period. The bioavailability of ID-GEL was two times higher than those of existing 3% ketoprofen gels, based on the calculated area under the plasma concentration-time curves after the percutaneous administration.

• YAKHAK HOEJI
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• v.45 no.6
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• pp.664-669
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• 2001

Acebutolol is almost absorbed after oral administration, but its bioavailability is reduced because of considerable first-pass metabolism through the gastrointestinal tract and liver. The purpose of this study was to report the pharmacokinetic changes of acebutolol (15 mg/kg,oral) and its main metabolite, diacetolol in rabbits pretreated (15 mg/kg, oral) and coadministered (15 mg/kg, S. C., bid for 3 days) with diltiazem. The plasma concentration and area under the plasma concentration-time curves (AUC) of acebutolol and diacetolol were significantly increased in rabbits pretreated and coadministered with diltazem. The elimination rate constant ( $K_{el}$ ) and total body clearances (CL $_{t}$) of acebutolol and diacetolol were significantly decreased and half-life of those were significantly prolonged in the rabbit. Metabolite percentage rate of diacetolol to the plasma concentration of total acebutolol in rabbits pretreated and coadministered with diltiazem were significantly decreased. The results suggest that the dosage of acebutolol should be adjusted when the drug would be administered chronically with diltiazem in a clinical situation.n.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.4
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• pp.614-622
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• 2003

In this paper, the stress-strain curves of bearing steels at hot working conditions are obtained by hot compression test with a computer controlled servo-hydraulic Gleeble 3800 testing machine and elongations and reductions of area of the bearing steels are also obtained by hot tensile test with a Gleeble 1500 testing machine. Experiments are conducted under the various strain-rates and temperatures and their results are used to obtain the flow stress information. A rigid thermo-viscoplastic finite element method is applied to the multi-stage hot forging process in order to predict temperature distribution of workpiece. The experimental results and the analysis results are used to obtain an optimal hot forging condition.

• Journal of Korean Neurosurgical Society
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• v.57 no.6
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• pp.432-435
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• 2015

Moyamoya disease is a unique cerebrovascular disorder characterized by idiopathic progressive stenosis at the terminal portion of the internal carotid artery (ICA) and fine vascular network. The aim of this review is to present the clinical application of quantitative digital subtraction angiography (QDSA) in pediatric moyamoya disease. Using conventional angiographic data and postprocessing software, QDSA provides time-contrast intensity curves and then displays the peak time ($T_{max}$) and area under the curve (AUC). These parameters of QDSA can be used as surrogate markers for the hemodynamic evaluation of disease severity and quantification of postoperative neovascularization in moyamoya disease.

• Proceedings of the IEEK Conference
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• 2009.05a
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• pp.132-134
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• 2009

Hemorrhagic shock is a common cause of death in emergency rooms. Since the symptoms of hemorrhagic shock occur after shock has considerably progressed, it is difficult to diagnose shock early. The purpose of this study was to improve early diagnosis of hemorrhagic shock using a survival prediction model in rats. We measured ECG, blood pressure, respiration and temperature in 45 Sprague-Dawley rats, and then obtained a logistic regression equation predicting survival rates. Area under the ROC curves was 0.99. The Hosmer-Lemeshow goodness-of-fit chi-square was 0.86(degree of freedom=8, p=0.999). Applying the determined optimal boundary value of 0.25, the accuracy of survival prediction was 94.7%

• Structural Engineering and Mechanics
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• v.77 no.3
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• pp.407-416
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• 2021

Seismic isolation is one of the best-advanced methods for controlling seismic vibrations in buildings, bridges and nuclear facilities. A new Friction Multi-Layer Elastomeric Seismic Isolator (FMESI) has been modeled, analyzed and investigated by ABAQUS finite element analysis software and then, compared to real models. A number of friction cores have been used instead of the lead core therefore, some of the previous isolator problems have been almost resolved. Moreover, Studies show that the proposed isolator provides suitable initial stiffness and acceptable hysteresis behavior under different vertical and horizontal loading conditions and also internal stresses in different layers are acceptable. Also, as a result, the initial stiffness and overall area of the curves increase, as friction coefficients of the cores increase, although the frictional coefficients must be within a certain range.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.159-163
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• 2013

Background: This study used Surveillance, Epidemiology and End Results (SEER) pancreatic cancer data to identify predictive models and potential socio-economic disparities in pancreatic cancer outcome. Materials and Methods: For risk modeling, Kaplan Meier method was used for cause specific survival analysis. The Kolmogorov-Smirnov's test was used to compare survival curves. The Cox proportional hazard method was applied for multivariate analysis. The area under the ROC curve was computed for predictors of absolute risk of death, optimized to improve efficiency. Results: This study included 58,747 patients. The mean follow up time (S.D.) was 7.6 (10.6) months. SEER stage and grade were strongly predictive univariates. Sex, race, and three socio-economic factors (county level family income, rural-urban residence status, and county level education attainment) were independent multivariate predictors. Racial and socio-economic factors were associated with about 2% difference in absolute cause specific survival. Conclusions: This study s found significant effects of socio-economic factors on pancreas cancer outcome. These data may generate hypotheses for trials to eliminate these outcome disparities.

• Journal of Pharmaceutical Investigation
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• v.21 no.2
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• pp.103-110
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• 1991

Two new prodrugs of lonazolac, lonazolac acetic acid ester and lonazolac argininate, were prepared and examined for physicochemical properties and biopharmaceutical characteristics. The prodrugs were stable in solid state and lonazolac argininate showed higher dissolution rate than lonazolacca in both artificial gastric and intestinal juices. These prodrugs have higher analgegic effect than that of lonazolac-Ca in mice, and increased anti-inflammatory activities in rats. In addition, ulcerogenic effects and acute toxicity of these prodrugs were lower than those of lonaaolac-Ca. Lonazolac acetic acid ester showed larger area under the plasma concentration-time curves (AUC) than that of lonazolac. Therefore, it was suggested that these prodrugs of lonazolac have advantages over lonzolac-Ca for not only enhanced bioavailability but also decreased ulcerogenic and toxic effects.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.22 no.4
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• pp.32-40
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• 1986

A model experiment of purse seine by the circulating water tank was carried out on the changes of net shape and the tension of purseline under operation in two layer current. In the circular tank, the two layer current was made by cutting off the current of upper layer and producing the bottom current by the equipment shown in Fig. 1. The model experiment of purse sein was made on a reduced scale 1 :400, and the experiment was carried out according to the Tauti's model law. When the bottom current of O. 5 knot flows to lower part of three-eighths of net, following results are derived. The depth of sinkerline reached only about 80% of that of no current set. The horizontal shift of sinker line caused by the bottom current is maximized in tight set. The enclosed area by the floatIine immediately after the completion of set net is 61. 5% in tight set, 50. 0 % in loose set and 54. 1 % in lateral set of those in the case of no current. In the first half period of pursing, the tension of the purseline is enhenced by the bottom current and the pattern of increasing is irregular in the tension curves.

• Corrosion Science and Technology
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• v.6 no.3
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• pp.112-119
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• 2007

This paper presents the importance of corrosion control and protection technology with a real case study of heater tube rupture damaged by High temperature H2S-H2 corrosion in the refinery. The heater was operated at the Hydrocracking unit and the operation temperature and pressure was $340^{\circ}C$ and $18kg/cm^{3}$ respectively. Top side of the convection tube was thinned by high temperature hydrogen sulfide and hydrogen gas as a uniform corrosion and finally ruptured under operation pressure. Damaged area (Convection tube zone) was blocked by protection wall, so it was impossible to inspect with conventional nondestructive examination. Instead the elbow area which is out of the protection wall was inspected regularly to evaluate the corrosion rate of convection tube indirectly. However the operation temperature and the phase of the process stream was different between inside the chamber and outside the chamber. As a result, it caused severe corrosion to the horizontal convection tube inside the chamber comparing to the elbow outside the chamber. Finally convection tube was corroded more rapidly than the elbow and ruptured after 13 years operation. Because of the rupture, the heater was totally burned and the operation was stopped for 3 months until it has been reconstructed. To prevent this kind of corrosion problem and accident, corrosion control should be strengthened and protection technology should be improved.