Journal of Pharmaceutical Investigation
- 제24권1호
- /
- Pages.11-16
- /
- 1994
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
케토프로펜 겔제제로부터 약물의 경피흡수
Percutaneous Absorption of Ketoprofen from Gel Preparations
- Tan, Hyun-Kwang (Central Research Laboratories, Il Dong Pharmaceutical Co., Ltd.) ;
- Chi, Sang-Cheul (College of Pharmacy, Sung Kyun Kwan University) ;
- Jun, H.Won (College of Pharmacy, University of Georgia, Athens)
- 발행 : 1994.03.20
초록
In order to reduce the systemic side effects and gastrointestinal irritation of ketoprofen after its oral administration, it was formulated as a 3% ketoprofen gel (ID-GEL) with Pluronic F-127. The pharmacokinetic characteristics of ID-GEL was evaluated following its transdermal application on the dorsal skin of rats at the dose of 9 mg/kg in reference to those of existing 3% ketoprofen gels. Even though the maximum concentration of 810 ng/ml was reached at 6 hrs postdose, the plasma concentration was kept almost constant until 24 hrs postdose, which suggested that ketoprofen was released continuously from the gel during this period. The bioavailability of ID-GEL was two times higher than those of existing 3% ketoprofen gels, based on the calculated area under the plasma concentration-time curves after the percutaneous administration.