• 말소리와 음성과학
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• 제6권3호
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• pp.33-40
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• 2014

The purpose of the study was to examine alternating motion rate and its variability in children with childhood apraxia of speech (CAS) compared to typically developing children. Six children with CAS aged 9-12 years old and 10 children who were age-matched participated in the study. This study measured tokens per second and variabilities of the rates during the production of /$p^*$ a/, /$t^*$ a/, and /$k^*$ a/. For variability measures of the rates, each participant was asked to repeat speech tasks three times and the average value of the rates and its standard deviation were obtained. The results revealed that the CAS group showed slower rate only at /$k^*$ a/ than the control group. The CAS group exhibited greater variability of AMR at all the tasks than the control group. The results suggested that variability of AMR might be a more distinctive speech feature to children with CAS than the rate of the speech task.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.111-114
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• 2022

Many monogenic neurodevelopmental disorders have been newly identified in recent years owing to the rapid development of genetic sequencing technology. These include variants of the epigenetic machinery - up to 300 known epigenetic factors of which about 50 have been linked to specific clinical phenotypes. Chromodomain, helicase, DNA binding 1 (CHD1) is an ATP-dependent chromatin remodeler, known to be the causative gene of the autosomal dominant neurodevelopmental disorder Pilarowski-Bjornsson syndrome. Patients exhibit various degrees of global developmental delay, autism, speech apraxia, seizures, growth retardation, and craniofacial dysmorphism. We report the first case of Pilarowski-Bjornsson syndrome in Korea, due to a de novo missense variant of the CHD1 gene (c.862A>G, p.Thr288Ala) in a previously undiagnosed 17-year-old male. His infantile onset of severe global developmental delay, intellectual disability, speech apraxia, and failure to thrive are compatible with Pilarowski-Bjornsson syndrome. We also noted some features not previously reported in this syndrome such as skeletal dysplasia and ichthyosis. Further studies are needed to discover the specific phenotypes and pathogenic mechanisms behind this rare disorder.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2003년도 10월 학술대회지
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• pp.125-127
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• 2003

The aim of the paper is to analyze prosodic characteristics in apraxia of speech and establish the fundamental sources in diagnosis of motor speech disorders. The sentences consist of two different types (declarative and interrogative) with different numbers of constituents which are one to three. The stimuli were constructed to assess apraxics speech with articulation and humming skills. The features of speech patterns were examined such as utterance duration, boundary tones, and etc. The results of the analysis are as follow: 1) In the interrogative sentences, the rising boundary tones appeared only in the humming tasks 2) the utterance duration is relatively shorter in the humming tasks than the speech with articulation.

• 대한한방내과학회지
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• 제27권3호
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• pp.762-769
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• 2006

A callosal disconnection syndrome results in the functional independence of each hemisphere caused by ACA infarction, head injury or callosal operation for epilepsy. Clinical features are characterized by left unilateral tactile anomia, left unilateral agraphia, left unilateral apraxia, difficulty in copying drawings, dyscalculia and alien hand syndrome. Taeumchowe-tang(太陰調胃湯) is used to treat Taeumin(太陰人) Wewansuhanpyohanbyung(胃脘受寒表寒病). A 47 year-old man, following callosal infarction, was detected on MRI with left agraphia, dyscalculia and alien hand syndrome, but no left ideomotor apraxia or left apraxia. He was treated with Taeumchowe-tang. Significant improvement of clinical symptoms was seen, so it is here reported.

• 대한한방내과학회지
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• 제39권6호
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• pp.1313-1320
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• 2018

Objectives: This case study reports on the effects of Korean medicine on a corticobasal syndrome with apraxia. Methods: We used acupuncture, bee-venom, pharmaco-acupuncture and herbal medicine to treat a corticobasal syndrome patient during hospitalization for 32 days. We observed changes in the UPDRS score, hand movement by opening and closing of hands, the making of a tower with 10 blocks and writing. Results: The hand movement count was improved from 2 to 10. The time needed for making a tower with 10 blocks decreased from 68 to 50 sec, and the number of stroke when writing the Korean word '철' decreased. In addition, the UPDRS score was decreased after treatment from 27 to 24. Conclusion: This clinical case study suggests that Korean medicine treatment could be used in the treatment of corticobasal syndrome.

• 대한음성언어의학회:학술대회논문집
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• 대한음성언어의학회 2006년도 제25회 학술대회
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• pp.152-152
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• 2006

• 대한한방내과학회지
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• 제25권4호
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• pp.221-226
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• 2004

Objective : This study was designed to evaluate the effects of oriental medicine therapy on a normal pressure hydrocephalus patient Methods : The clinical data was analyzed on a patient with normal pressure hydrocephalus whose main symptoms were gait apraxia, dementia and urinary incontinence, The patient was admitted to the internal medicine department of KyungWon university In-cheon Oriental Medical Hospital, on April 19, 2004 and remained until Apri 30, 2004. He was treated with herbal medicine(Oryung-San), acupuncture and moxa therapy. Results : After treatment, improvement was seen in gait apraxia, dementia and urinary disturbance. Conclusion : The study suggests that oriental medicine therapy is significantly effective in the treatment of normal pressure hydrocephalus.

• 생물정신의학
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• 제15권1호
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• pp.46-53
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• 2008

Posterior cortical atrophy(PCA) is a presenile dementia that presents primarily with signs and symptoms of cortical visual dysfunction, while memory is relatively preserved until the late stage of the disease. We report a patient with PCA, confirmed by brain magnetic resonance imaging (MRI) and $F^{18}$-fluorodeoxyglucose positron emission tomography(FDG PET). A 58-year-old right-handed woman presented initially with visual dimness and difficulty finding things around her. She had partial Balint's syndrome, partial Gerstmann syndrome, and idiomotor apraxia. She also had a mild memory disturbance, but preserved insight of her disease. Neuropsychological evaluation showed decreased parietal and left temporal functions bilaterally. Brain MRI and $F^{18}$-FDG PET revealed typical bilateral occipitoparietal atrophy and hypometabolism, which were slightly worse on the right side. Cholinesterase inhibitor administration for 6 months improved the memory impairment slightly, but not the cortical visual dysfunction. This is a typical case of PCA, confirmed by neurologic signs and imaging findings.

• 혜화의학회지
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• 제16권1호
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• pp.181-189
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• 2007

Objectives : The purpose of this study is to search for more effective methods of diagnosis and treatment of Communication Disorder with Post-Stroke. Methods : Literature review on Communication Disorder with Post-Stroke in view of oriental and western medicine. Conclusions : Communication Disorder with Post-Stroke is relative with aphasia in western medicine, Sul-um(舌瘖) oriental medicine Aphasia, apraxia of speech, and dysarthria come after strock Each of them has its own mechanism. Yomchon(CV23), Amun(GV15), Chuldol(CV22), Tongni(HT5), Pungnyung(ST40), Pungbu(GV16), Chigu(TE6), Yongchon(KI1), Hapkok(L14), Peakoe(GV20), Kokchi(LI11), Puryu(KI7), Shinsu(BL23), Kumjin-okaek, and Chohea(KI6) was used on Communication Disorder with Post-Stroke treatment.

• 대한감각통합치료학회지
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• 제2권1호
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• pp.53-64
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• 2004

Objective : To identify the effect of intensive sensory integration therapy through 5 days camp programs for children with dyspraxia Methods : A comparison of quantitative date and qualitative description between before and after sensory integration therapy camp described adaptative response of children and individual home-based program was designed and therapist educated parents about it. Results : The problem of control and apraxia which children have was improved rather than before camp and adaptive response increased. Conclusion : Follow-up study is needed to observe and investigate the effect of continuous treatment after camp participation.