• Radiation Oncology Journal
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• 제35권2호
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• pp.121-128
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• 2017

Purpose: To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. Materials and Methods: Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A total of 55 patients with a minimum follow-up of 1 month after WBI were evaluated. Optically stimulated luminescence dosimeter (OSLD) detected radiation dose delivered to the skin during IORT. Acute toxicity was recorded according to the Common Terminology Criteria for Adverse Events v4.0. Clinical parameters were correlated with seroma formation and maximum skin dose. Results: Median follow-up after IORT was 25.9 weeks (range, 12.7 to 50.3 weeks). Prior to WBI, only one patient developed acute toxicity. Following WBI, 30 patients experienced grade 1 skin toxicity and three patients had grade 2 skin toxicity. Skin dose during IORT exceeded 5 Gy in two patients: with grade 2 complications around the surgical scar in one patient who received 8.42 Gy. Breast volume on preoperative images (p = 0.001), ratio of applicator diameter and breast volume (p = 0.002), and distance between skin and tumor (p = 0.003) showed significant correlations with maximum skin dose. Conclusions: IORT as a boost was well-tolerated among Korean women without severe acute complication. In vivo dosimetry with OSLD can help ensure safe delivery of IORT as a boost.

• 멤브레인
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• 제26권1호
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• pp.26-31
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• 2016

폴리카프로락톤(PCL)에 NaCl을 혼합한 용액을 블레이드법에 의하여 막형태로 제조한 후 NaCl을 추출하는 염출법을 이용하여 조직공학적으로 사용할 3차원 다공망을 갖는 멤브레인 형태의 지지체를 제조하였다. 본 연구에서는 성형된 멤브레인의 건조조건과, NaCl 입자의 크기, NaCl의 혼합량을 각각 다르게 하여 제조하였다. 별도로 제작한 고분자용액 공급장치를 이용하여 PCL/클로로포름($CHCl_3$) 용액에 NaCl 입자가 균일하게 혼합된 용액을 유리판에 분주하여 필름 어플리케이터를 사용하여 블레이드법에 의한 멤브레인을 제조하였다. 멤브레인 지지체에는 NaCl 입자에 의한 거대기공과 거대기공을 이루는 구조벽에서는 $CHCl_3$의 증발에 의한 미세기공이 함께 복합적으로 상호 연결되어 형성되었다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.150-153
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• 2002

High dose rate (HDR) brachytherapy in the treatment of cervix carcinoma has become popular, because it eliminated many of the problems with conventional brachytherapy. In order to improve clinical effectiveness with HDR brachytherapy, dose calculation algorithm, optimization procedures, and image registrations should be verified by comparing the dose distributions from a planning computer and those from a humanoid phantom irradiated. Therefore, the humanoid phantom should be designed such that the dose distributions could be quantitatively evaluated by utilizing the dosimeters with high spatial resolution. Therefore, the small size of thermoluminescent dosimeter (TLD) chips with the dimension of 1/8" and film dosimetry with spatial resolution of <1mm used to measure the radiation dosages in the phantom. The humanoid phantom called a pelvic phantom is made of water and tissue-equivalent acrylic plates. In order to firmly hold the HDR applicators in the water phantom, the applicators are inserted into the grooves of the applicator supporters. The dose distributions around the applicators, such as Point A and B, can be measured by placing a series of TLD chips (TLD-to- TLD distance: 5mm) in three TLD holders, and placing three verification films in orthogonal planes.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2003년도 International Symposium on Clean Environment
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• pp.15-18
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• 2003

Recently, some researches related to air pollution problems in large cities of the Islamic Republic of Iran have been done. Famous institutes and research centers in countries like Japan, Sweden and Germany have been in cooperation with Iranian institutes in implementing the results. Due to quick increase in the population because of peoples＇ migration from countryside to cities, and rate of growth in the early years after the revolution, air pollution was an important problem in I.R.Iran. Therefore, air pollution control is one of the main issues in major cities of I.R. Iran. It is the purpose of this study to investigate the control mechanisms for air pollution problems in the major industrial cities. The necessary action plans that were taken in recent years in some of the cities, which were also suggested to be taken in the other ones, are the other purpose of this study. From the results of studies it was obtained in Iran, lots of researches are important to mention. Amongst the main activities that are done in recent years are： establishing of the meteorological research centers and atmosphere sciences; three applicator meteorological research centers and more than 40 new stations in the country; installation of newest computer systems in metrological information, using of wall map and continuous radio-traffic to announce traffic news; completing of subway construction in Tehran; forbidding of industrial activities in a definite distance away from Tehran and transferring them to suitable places; building of highways and freeways; improving of public transportation and gasifying them; developing of fuels quality and removing lead from them; and gasifying of the heating systems in houses and buildings.

• Radiation Oncology Journal
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• 제8권1호
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• pp.133-136
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• 1990

자궁암치료에서 재발되거나 치료가 어려운 종양에 대하여 방사선과 온열요법을 병행함으로서 치료 성과를 다소 향상시킬 수 있었다. 더욱이 방사선 근접조사와 강내온열치료는 주위 건강조직의 피해를 줄이면서 종양에 집중손상을 줄 수 있었으며 강내방사선조사 기구를 공동으로 이용하므로서 시술이 간단하고 치료부위를 정확히 조준할 수 있었다. 그러나 강내조사용 안테나는 그 모양과 구성에 따라 온열 분포가 변하며 재래식 쌍극철심형 안테나는 끝부분 또는 연결부위의 가온이 급증하여 균등한 온열분포를 기대할 수 없었다. 저자들은 안테나의 길이를 마이크로파의 약수 즉 3, 6, 12 cm로 하여 공명이 잘 이루어지도록 하였으며 끝이 굵고 접촉 부위가 가느다란 꼬깔형 (conical) 안테나를 제작하여 사용한 결과 안테나 축에 따라 거의 일정하거나 약간 타원형의 온도분포를 이루었으며 가온 깊이도 $2\~3\;cm$로서 비교적 깊은 곳까지 가열할 수 있어 강내 치료효과를 향상시킬 수 있다고 생각된다.

• The Journal of Advanced Prosthodontics
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• 제4권1호
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• pp.1-6
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• 2012

PURPOSE. The aim of this study was to compare the flexural strength of polymethyl methacrylate (PMMA) and bis-acryl composite resin reinforced with polyethylene and glass fibers. MATERIALS AND METHODS. Three groups of rectangular test specimens (n = 15) of each of the two resin/fiber reinforcement were prepared for flexural strength test and unreinforced group served as the control. Specimens were loaded in a universal testing machine until fracture. The mean flexural strengths (MPa) was compared by one way ANOVA test, followed by Scheffe analysis, using a significance level of 0.05. Flexural strength between fiber-reinforced resin groups were compared by independent samples t-test. RESULTS. For control groups, the flexural strength for PMMA (215.53 MPa) was significantly lower than for bis-acryl composite resin (240.09 MPa). Glass fiber reinforcement produced significantly higher flexural strength for both PMMA (267.01 MPa) and bis-acryl composite resin (305.65 MPa), but the polyethylene fibers showed no significant difference (PMMA resin-218.55 MPa and bis-acryl composite resin-241.66 MPa). Among the reinforced groups, silane impregnated glass fibers showed highest flexural strength for bis-acryl composite resin (305.65 MPa). CONCLUSION. Of two fiber reinforcement methods evaluated, glass fiber reinforcement for the PMMA resin and bis-acryl composite resin materials produced highest flexural strength. Clinical implications. On the basis of this in-vitro study, the use of glass and polyethylene fibers may be an effective way to reinforce provisional restorative resins. When esthetics and space are of concern, glass fiber seems to be the most appropriate method for reinforcing provisional restorative resins.

• 폴리머
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• 제38권5호
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• pp.573-579
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• 2014

탄소나노튜브(CNT), 불소계 아크릴레이트 2,2,2-trifluoroethylmethacrylate(3FMA) 및 유-무기 조성비와 같은 합성조건을 달리하여 제조된 자외선 경화형 유-무기 하이브리드 코팅 막의 표면특성 및 내오존성에 대해 연구하였다. 코팅 막은 금속 알콕사이드 전구체인 tetraethoxysilane(TEOS)와 실란 커플링제인 methacryloyloxypropyltrimethoxysilane (MPTMS)로 구성된 유-무기 혼성 용액에 탄소나노튜브 및 3FMA와 자외선 경화를 위한 유기물을 첨가하여 제조된 코팅제를 자외선 경화시켜 제조하였다. 제조된 코팅 막의 내오존성 및 기재와의 접착력은 TEOS, 3FMA 및 CNT의 함량에 크게 영향을 받는다는 것을 확인하였다. 특히, 탄소나노튜브가 첨가된 코팅 막은 우수한 내오존성 및 접착력 뿐만 아니라 높은 표면경도를 나타내었다. TEOS의 경우, 함량이 증가할수록 표면경도 및 내오존성은 향상되었지만, 기재와의 접착력은 감소되었다. 불소아크릴레이트 3FMA의 경우, 함량이 증가할수록 내오존성은 향상되었지만 표면경도는 감소하였다.

• 한국전자파학회논문지
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• 제13권7호
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• pp.732-739
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• 2002

고온온열치료(Hyperthermia)용 안테나의 성능은 안테나의 임피던스 매칭과 안테나 주위 조직의 SAR 분포에 의해서 결정된다. 본 논문에서는 FDTD 해석법을 이용하여 coaxial-slot 안테나를 계단형(staircasing)으로 근사화하여 분석하였고, 가열 특성을 개선시킬 수 있는 Hyperthermia용 안테나를 설계하였다. 계단형과 구형(square) 모델로 근사화한 coaxial-slot 안테나에서 간에 유기되는 SAR 값을 분석하였고 두 모델의 SAR 값을 Saito의 측정결과와 비교해 보았으며 그 결과 계단형 모델이 구형 모델 보다 측정결과에 가까운 것을 확인할 수 있었다. 본 논문에서 제안하는 안테나에서 유기되는 SAR 값은 1g 평균 첨두치가 195 W/kg으로 Saito가 제안한 안테나의 SAR 값인 152.5 W/kg에 비해 대략 27.9 %도 증가한 값으로 나타났다.

• Journal of Oral Medicine and Pain
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• 제18권1호
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• pp.73-82
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• 1993

To investigate the changes in aerobic and facultative anaerobic oral microflora during remission-induction chemotherapy in patients with acute myeloid leukemia, 10 consecutive patients were studied during a period of 28 days. One day before, during and after the induction therapy, patients were given 10% Betadine solution for mouthrinses after breakfast and kept from eating and drinking. After 3 hours, paraffin-stimulated whole saliva was obtained for 2 minutes and transported to the laboratory. The samples were dispersed and homogenized by use of vortex mixer for 20 seconds. From these samples 10-fold serial dilutions (from 10-1 through 10-3) were prepared. Each dilution of 0.1 ml was plated on duplicate set of one nonselective medium (Blood agar) and four selective media (Sabourauds dextrose agar, Mannitol salt agar, Mac-Conkey agar, SF medium ) using applicator woods. All agar plate were incubated at 37$^{\circ}C$ for 48 hours. The total number of microorganisms was calculated and the percentage distribution of the various microorganisms from each specimen was drawn. 1. The salivary flow rate decreased by 66%, going from 5.38 ml/2min to 1.81 ml/2min over two days during the chemotherapy. 2. The total number of microorganisms in saliva increased by 22%, going from 4.88$\times$105/ml to 6.00$\times$105/ml over two days during the chemotherapy. 3. The salivary flow rate and the total number of microorganisms in saliva were recovered within 28 days after the chemotherapy. 4. The quantitative alteration in oral Enterobacteria, Enterococci, Staphylococci, Cndida during the chemotherapy had no statistical significance. 5. In saliva of the patients with acute myeloid leukemia who ahd intraoral ulcer, Enterobacteria was quantitatively predominent. Our study suggests that chemotherapy-induced transient xerostomia may induce acute oral infection. Consequently, the use of saliva substitute, the removal of intraoral infection source and the consistent oral hygiene care seem to be required to avoid the transmission of potential pathogenes in this group of patients.

• Korean Chemical Engineering Research
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• 제50권3호
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• pp.421-426
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• 2012

불소계 아크릴레이트 2,2,2-trifluoroethylmethacrylate을 사용한 자외선 경화형 유-무기 하이브리드 코팅 막에 있어서 무기물 및 사용되는 유기 단량체의 종류 및 조성이 내 오존성 및 표면 특성에 미치는 영향에 대해 연구하였다. 코팅액은 금속 알콕사이드인 tetraethoxysilane(TEOS)와 실란 커플링제인 methacryloyloxypropyltrimethoxysilane(MPTMS)로 구성된 유-무기 혼성 용액에 2,2,2-trifluoroethylmethacrylate와 자외선 경화를 위한 유기물을 첨가하여 제조되었다. 코팅막은 코팅액을 기재위에 바 코팅 한 후 자외선 경화를 통해 제조되었다. 제조된 코팅 막의 내 오존성은 TEOS의 함량이 증가할수록 내 오존성과 표면경도는 향상되었다. 또한, 불소 함량이 증가할수록 내 오존성은 향상되었지만 표면 경도는 다소 떨어졌다. 우레탄 아크릴레이트를 첨가한 코팅 막은 높은 연필경도를 나타내었다. 코팅 막의 투과도는 TEOS와 2,2,2-trifluoroethylmethacrylate의 함량에 큰 영향을 받지 않았다. 더욱이, 코팅 막은 90% 이상의 높은 투과도를 나타내었다.