• 제목/요약/키워드: apparent absorption

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HMDA 첨가에 따른 AMP 수용액의 이산화탄소 흡수특성 (Absorption Characteristics of Carbon Dioxide in Aqueous AMP Solution Adding HMDA)

  • 최원준;조기철;오광중
    • 한국대기환경학회지
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    • 제21권6호
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    • pp.605-612
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    • 2005
  • In this study, the possible use of HMDA (Hexamethylenediamine) as additive to enhance reaction between $CO_{2}$ and AMP (2-amino-2-methyl-1-propanol) which has higher absorption capacity than that of MEA (Monoethanolamine) was investigated. Also, the absorption capacity for $CO_{2}$ was compared with addition of HMDA, piperazine or MDEA (N-methyldiethanolamine) into $30\;wt\%$ AMP at $40^{circ}C$ and $CO_{2}$ partial pressure ranging from 0.5 to 120 kPa. Apparent rate constant ($K_{app}$) and absorption capacity with the addition of $5\∼20\;wt\%$ HMDA into AMP increased $214.2\∼276.3\%$ and $29.9\∼91.7\%$ than those of AMP alone. As a result, when $5\;wt\%$ HMDA added into AMP, the increasing rate of the absorption rate and the absorption capacity was found to be the highest. In addition, the absorption capacity increased $6.8\%,\;9.8\%,\;11.6\%$ with addition of MDEA, piperazine or HMDA respectively as compared to AMP alone at $CO_{2}$ partial pressure of 20 kPa. Consequently, HMDA as additive to improve absorption capacity of AMP was superior to other additives.

피페라실린의 공장 및 비점막흡수 촉진에 대한 혼합미셀의 효과 (Effect of Mixed Micelles on Jejunal and Nasal Absorption Enhancement of Piperacillin)

  • 박기배;이용석;노현구;이광표
    • Journal of Pharmaceutical Investigation
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    • 제23권2호
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    • pp.71-80
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    • 1993
  • The purpose of this study was to compare the intrinsic absorptivity of piperacillin in the jejunum and the nasal cavity, to investigate the effect of bile salts, fatty acids and their mixed micelles on the intestinal and nasal absorption of piperacilIin, to examine the reversibiIity of bile salt-fatty acid mixed micelles absorption promoting action and to design an effective intranasal drug delivery system for antibiotics. And absorption promoters used were bile salts [sodium cholate (NaC), sodium glycocholate (NaGC)], unsaturated fatty acids [oleic acid (OA), linoleic acid (LA)] and their mixed micelles (NaC-LA). The present study employed the in situ nasal and intestinal perfusion technique in rats. The apparent permeabilities $(P_{app})$ of piperacillin were $0.40{\pm}0.04{\times}10^{-5}cm/sec(mean{\pm}S.E)$ in the jejunum and $1.32{\pm}0.08{\times}10^{-5}\;cm/sec$ in the nasal cavity, which indicated that intrinsic absorptivity of piperacillin was greater in the nasal cavity than in the jejunum. When absorption promoters were used in the rat nasal cavity, the decreasing order of apparent piperacillin permeability $(P_{app},\;10^{-5}\;cm/sec)$, corrected for surface area of absorption, was NaC-LA $(4.62{\pm}0.16)$> NaC $(4.36{\pm}0.32)$>LA$(2.24{\pm}0.26)$ NaGC $(2.17{\pm}0.21)$>OA $(1.53{\pm}0.16)$. The increase in permeability of piperacillin was 3.5-fold in the rat nasal cavity and 1.5-fold in the rat jejunum for formulations containing NaC-LA mixed micelles as compared to those without absorption enhancer. The effect of NaC-LA mixed micellar solutions was synergistic and was greater than that with single adjuvant. The reversibility of nasal mucosal permeability was observed within approximately 2 hr after removal of NaCLA mixed micelles from the nasal cavity. These results suggest that NaC-LA mixed micelles can be used as nasal mucosal absorption promoters of poorly absorbed drugs.

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연고제(軟膏劑)의 경도(硬度)에 관(關)한 연구(硏究) 1. 약전수재연고제(藥典收載軟膏劑)의 외견상(外見上)의 대수경도(對數硬度) (The Study Concerned with the Hardness of Ointment 1. The Apparent Logarithmic Hardness of Ointment Registered on the Pharmacopeia of Korea)

  • 김종갑
    • Journal of Pharmaceutical Investigation
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    • 제1권1호
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    • pp.70-77
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    • 1971
  • The ointment, had discovered and used from the ancient, have not ever defined to qualitity as the hardness concerned with the absorned With the absorption of the effect of durg through the skin. Auther, for the first time, suggest the apparent logarithmic hardness against the penetration of ointment registered on the pharmacopeia of the Republic of Korea, the results are as the followings. 1. The speciality of this apparent logarithmic hardness ie in proportion for the solidity on the contrary to the penetration of oiniment, and the distribution range of it are between 1.68 to 3.53 for their ointments examined. 2. The specific gravity of the verious ointments according to the apparent logarithmic hardness may be ignore on the calculaiotn, the mean valve of the samples was 2.9303. 3. The determination of apparent logarithmic hardness(H) by the penetration method follows the under equation. $H=log_{10}({\frac{P-0.545h^3}{0.855h^2}})$ where, the h is the penetrate length described centimeter, and p is the weight of the cone.

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$C_4$-추잔물에서의 이오부틸렌 추출공정 - 파라톨루엔 설폰산에서 이오부틸렌의 흡수 및 반응 - (Extraction Process of Isobutylene from $C_4$-raffinate - Absorption and Reaction of Isobutylene in Para-Toluene Sulfonic Acid -)

  • 선용호;최대기이윤용
    • KSBB Journal
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    • 제6권1호
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    • pp.99-103
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    • 1991
  • 본 연구는 혼합 반응기에서 파라-톨루엔 설폰산(PTSA) 용액으로 이소부틸렌의 최적 흡수 속도론과 최적 흡수 조건을 연구하였다. 본 실험에서 행한 실험 조건은 온도 $20-80^{\circ}C$, 혼합속도 400-1000 rpm, 산농도 30-70 wt% 그리고 산부하(acid loading) 0.3-5 이었다. 결과적으로 최적 조건에서의 이소부틸렌의 흡수속도는 이소부틸렌 농도항에 대한 1차 반응이며 PTSA 농도항에 대해서는 반응 차수가 변한다. 그때의 겉보기 활성에너지는 13Kcal/mol 이었다.

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Study on the Interaction between Curcumin and Ethylamines by Absorption and Fluorescence Spectroscopic Techniques

  • Kim, Sung Hoon;Gwon, Seon Yeong;Lee, Eun-Mi;Bae, Jin-Seok
    • 한국염색가공학회지
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    • 제27권4호
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    • pp.340-344
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    • 2015
  • The interaction between curcumin(1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) and ethylamines was studied in DMSO:$H_2O$(5:1, v/v) using absorption and fluorescence measurements. The association constant, $K_{ass}$, and the Stern-Volmer constants were calculated by the Benesi-Hildebrand and Stern-Volmer equation, respectively. Curcumin displayed marked UV-Vis absorption changes and highly responsive fluorescence quenching in the presence of ethylamine and the quenching ability was enhanced almost linearly with the concentration of ethylamines. The apparent Stern-Volmer constant measured for the ethylamine-curcumin system was about 1000-fold greater than that of the triethylamine-curcumin system, indicating considerably greater quenching efficiency of ethylamines.

Comparison of the Efficiency of Absorbed Nitrogen Use from Different Protein Sources in Diets Having Similar Amino Acid Balance

  • Lee, K.U.;Boyd, R.D.;Austic, R.E.;Ross, D.A.;Han, In K.
    • Asian-Australasian Journal of Animal Sciences
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    • 제11권6호
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    • pp.725-731
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    • 1998
  • Nine crossbred female pigs fitted with the bladder catheters were used to investigate the effects of dietary protein form on the efficiency of absorbed nitrogen for nitrogen retention in growing pigs. Combinations of the main protein sources were corn-soybean meal (CSM; slow + slow absorption rate form), corn-hydrolyzed casein (CAS; slow + rapid absorption rate form) and corn-porcine plasma (CPL; slow + intermediate absorption rate form). All experimental diets were formulated to be isonitrogenous (CP 11%) and isocaloric (3.5 Mcal/kg) and synthetic amino acids were added to the diet as required to maintain an equivalent amino acid profile among diets. Fecal digestibility of nitrogen was not different among treatments (p > 0.10). Ingested nitrogen was absorbed with an apparent efficiency of 82% to 84%. Mean nitrogen retention in pigs fed the CSM diet was as high as for pigs fed the CPL diet (0.74 g N/kg $BW^{0.75}$ per d), which was higher than the N retention rate in pigs fed CAS diet (0.68 g/kg $BW^{0.75}$ per d; P < 0.05). Apparent biological values (ABV = 100 ${\times}$ N retention/absorbed nitrogen) were 63.3%, 58.0% and 61.6% for CSM, CAS, and CPL groups, respectively (p < 0.05). There was no difference in mean energy digestibility among treatments. The efficiency of absorbed lysine utilization was significantly different among treatments (p < 0.05). Pigs fed the CAS diet were inferior to counterparts on the other diets in utilizing absorbed lysine. The ratios of free (and small peptide-bound) to protein-bound amino acids in CSM diet differed considerably from the CAS diet. This may affect the efficiency of amino acids utilization for nitrogen retention if hydrolyzed and intact amino acid pools reach the blood at different times.

제주도 화산암의 물리・역학적 특성에 대한 비교연구 (Comparative Study on Physical and Mechanical Characteristics of Volcanic Rocks in Jeju Island)

  • 양순보
    • 한국지반공학회논문집
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    • 제30권11호
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    • pp.39-49
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    • 2014
  • 제주도의 화산암은 여러 환경적인 요인으로 인하여 크기와 분포가 다양한 기공이 많은 다공상 구조를 보이고 있으며, 지질학적 그리고 역학적 특성 또한 지역마다 차이를 나타내고 있다. 제주도 화산암에 대한 지질학적/화학적 특성에 대한 연구 및 물리적/역학적 특성에 대한 연구는 많은 연구자에 의해 활발히 이루어져 왔지만, 제주도 화산암의 물리적 및 역학적 특성에 대한 종합적인 비교 분석은 이루어져 있지 않다. 본 연구에서는 제주도 화산암에 대하여 기존에 발표된 연구논문 및 보고서를 통하여, 제주도 화산암에 대한 물리 역학적 특성의 상관관계를 종합적으로 비교 분석하였다. 그 결과 흡수율 및 공극률과 겉보기 비중과의 관계는 일반적으로 선형의 관계에 있으며, 여러 환경적 요인에 의해 제주도 화산암은 두 개의 서로 다른 선형근사로 대표시킬 수 있음을 알 수 있었다. 그리고 P파 속도와 S파 속도와의 관계와 흡수율 및 공극률과 건조 상태의 암석에 대한 일축압축강도와의 각각의 관계에 대하여 흡수율 및 공극률과 겉보기 비중과의 두 개의 서로 다른 선형근사 관계를 고려함으로서, P파 속도와 S파 속도와의 관계와 흡수율 및 공극률과 일축압축강도와의 관계를 명확하게 구분할 수 있음을 알 수 있었다.

유동층 CO2 회수공정을 위한 흡수제의 흡수 및 재생특성 (Absorption and Regeneration Characteristics of a Sorbent for Fluidized-Bed CO2 Removal Process)

  • 이창근;홍선욱;조성호;손재익;최정후
    • Korean Chemical Engineering Research
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    • 제43권2호
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    • pp.294-298
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    • 2005
  • 연소기체로부터 이산화탄소를 흡수하는 유동층 공정에 사용되는 흡수제의 흡수 및 재생 반응특성을 측정 및 고찰하였다. 유동층 공정을 위해서 제조된 흡수제 Sorb NH의 흡수 및 재생 반응속도는 순수한 $Na_2CO_3$보다 더 빨랐다. 흡수 반응에서 Sorb NH의 겉보기 활성화에너지는 -10,100 cal/g mol, 순수한 $Na_2CO_3$의 겉보기 활성화에너지는 -12,200cal/g mol이었다. 재생반응에서 Sorb NH의 겉보기 활성화에너지는 약 12,050 cal/g mol, 순수한 $Na_2CO_3$의 활성화에너지는 약 11,320 cal/g mol이었다.

Spectral Distribution and Spectral Absorption of Suspended particulates in Waters of Sanya Bay

  • Yang, Dingtian;Cao, Wenxi
    • 대한원격탐사학회:학술대회논문집
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    • 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume I
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    • pp.495-498
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    • 2006
  • Optical profile and spectral absorption of suspended solids in waters of Sanya bay was measured on August 8-14, 2003. Optical profile was taken by using MicroPro optical profile. Apparent optical indexes, vertical diffuse attenuation coefficient ($K_d$) and water leaving radiance (Lw), were calculated. $K_d$ at the blue end of the spectrum was greater than that at the red end of the spectrum in waters near Sanya River mouth, however, in waters near open sea, $K_d$ at the blue end of the spectrum was smaller than that at the red end of the spectrum. Distribution of water leaving radiance was relatively higher in waters near Sanya River mouth, but relatively weaker in near open sea water. Spectral absorption of suspended particulates was also measured. Results showed that the spectral absorption of chlorophyll a was greater in waters near Sanya river mouth, but relatively weaker in waters near open sea, which indicated higher concentration of phytoplankton in waters near Sanya river mouth. Except for water at the 5th sampling station, the ratio of spectral absorption of chlorophyll a to total suspended particulates in surface waters was greater than that in bottom waters at all stations.

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Effects of Fermented Soy Protein on Nitrogen Balance and Apparent Fecal and Ileal Digestibility in Weaned Pigs

  • Yoo, J.S.;Jang, H.D.;Cho, J.H.;Lee, J.H.;Kim, I.H.
    • Asian-Australasian Journal of Animal Sciences
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    • 제22권8호
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    • pp.1167-1173
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    • 2009
  • This study was conducted to evaluate the effects of providing fermented soy protein to weaned pigs on nitrogen balance and apparent fecal and apparent ileal digestibility (AID) of AA. Four weaned ((Yorkshire${\times}$Landrace)${\times}$Duroc) barrows (BW = 6.58${\pm}$0.98 kg), surgically fitted with a simple T-cannula approximately 15 cm prior to the ileo-cecal junction, were fed four diets according to 4${\times}$4 Latin square design. Diets were a basal diet supplemented with one of the following: 3% SDPP (spray dried plasma protein), 5% RBP (soy protein fermented by Lactobacillus spp.), 5% PSP (soy protein fermented by Aspergillus oryzae and Bacillus subtilis), and 2.5% RPP (2.5% RBP+2.5% PSP). No differences were observed in DM and N intakes among treatments. However, the level of urine excretion was greater in the RPP group than in the PSP group. Additionally, fecal DM excretion, fecal N concentration and fecal N excretion were increased in the RBP, PSP and RPP groups when compared with the SDPP group (p<0.05). Furthermore, total excretion was increased in the RPP group when compared with the PSP group (p<0.05). In addition, N absorption and the N absorption ratio were higher in the SDPP group than in the RPP group (p<0.05). Moreover, the DM and N digestibilities were lower in the RBP, PSP and RPP groups than in the SDPP group (p<0.05), and the ash and energy digestibilities were higher in the SDPP and RBP groups than in the PSP and RPP groups (p<0.05). However, no significant differences were observed in the DM, N, Ash, Ca, P or ileal digestibilities among treatments, although the energy digestibility was higher in the SDPP group than the RBP group (p<0.05). In addition, the apparent ileal digestibilities of essential amino acids (Arg, His, Iso, Leu, Lys, Phe, Thr, and Val) were significantly higher in the SDPP group than in the other groups (p<0.05), and the levels of Ala, Cys, Glu and Try were greater in the SDPP treatment group than the RBP, PSP and RPP groups (p<0.05). Additionally, the levels of Asp, Gly and Ser were higher in the SDPP group than the PSP and RPP groups, and the level of Pro was higher in the SDPP group than the RPP group (p<0.05). Finally, total non-essential amino acid and total amino acid digestibility were higher in the SDPP group than in the other treatments (p<0.05). Taken together, the results of this study indicate that animal protein is more bioavailable than plant protein. However, the N absorption ratio and ileal digestibility were found to be similar in the SDPP and RBP groups.