• Clinical and Experimental Reproductive Medicine
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• v.50 no.3
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• pp.177-184
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• 2023

Objective: Reconstructed oocytes after polar body genome transfer constitute a potential therapeutic option for patients with a history of embryo fragmentation and advanced maternal age. However, the rescue of genetic material from the first polar body (PB1) through introduction into the donor cytoplasm is not yet ready for clinical application. Methods: Eighty-five oocytes were obtained following in vitro maturation (IVM) and divided into two groups: PB1 nuclear transfer (PB1NT; n=54) and control (n=31). Following enucleation and PB1 genomic transfer, PB1 fusion was assessed. Subsequently, all fused oocytes underwent intracytoplasmic sperm injection (ICSI) and were cultured in an incubator under a time-lapse monitoring system to evaluate fertilization, embryonic morphokinetic parameters, and cleavage patterns. Results: Following enucleation and fusion, 77.14% of oocytes survived, and 92.59% of polar bodies (PBs) fused. However, the normal fertilization rate was lower in the PB1NT group than in the control group (56.41% vs. 92%, p=0.002). No significant differences were observed in embryo kinetics between the groups, but a significant difference was detected in embryo developmental arrest after the four-cell stage, along with abnormal cleavage division in the PB1NT group. This was followed by significant between-group differences in the implantation potential rate and euploidy status. Most embryos in the PB1NT group had at least one abnormal cleavage division (93.3%, p=0.001). Conclusion: Fresh PB1NT oocytes successfully produced normal zygotes following PB fusion and ICSI in IVM oocytes. However, this was accompanied by low efficiency in developing into cleavage embryos, along with an increase in abnormal cleavage patterns.

• Journal of the Korean Geotechnical Society
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• v.25 no.8
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• pp.5-21
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• 2009

Based on recent studies on rock socketed drilled shafts, it was found that the side resistance of rock socketed drilled shafts is affected by unconfined compressive strength of rock, socket roughness, rock types and joints, and initial normal stress. Especially, the socket roughness is affected by rock types and joints, drilling methods, and diameters. Since existing roughness measurement systems could be conducted only in the air, a new roughness measurement system, which can measure rock socket roughness in the air and also in the water, is needed. However, the development of new roughness measurement system fur civil engineers has been faced with difficulties of electrical applications. In this study, the laboratory verification system far BKS-LRPS (Backyoung-KyungSung Laser Roughness Profiling System) was developed, which can be applied both in the water and air. Based on the laboratory verification, it was found that the improved BKS-LRPS could define effective measurement distances for the conditions reflecting the apparatus and in-situ situations.

• Korean Journal of Acupuncture
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• v.40 no.4
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• pp.194-205
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• 2023

Objectives : This study investigated the current utilization status of thermotherapy devices in Korean medicine (KM) institutions and identified areas for improvement and further development, as perceived by KM doctors (KMDs). Methods : An online survey was conducted, targeting KMDs primarily engaged in clinical patient care. The questionnaire included items about respondents' clinical practices, the extent of thermotherapy device usage, their opinions on these devices, and perceived improvement needs. The collected data underwent quantitative analysis. Results : From the 1,025 respondents, data from 862 respondents who provided complete responses were analyzed. On average, respondents utilized thermotherapy treatments for 80% of their patients. Infrared (IR) phototherapy unit, electrical moxibustion apparatus, and heater-based thermotherapy devices were predominantly owned by respondents, with IR being the most frequently used. The average satisfaction score for current thermotherapy devices was 79. A significant concern raised was the necessity for improved health insurance coverage and efficacy evaluation. Conclusions : This research has confirmed that the extensive use of thermotherapy devices by KMDs in treating primarily musculoskeletal and gastrointestinal ailments - common conditions among patients in KM institutions. The main areas identified for improvement encompass safety, cost-effectiveness, and device efficacy. Future enhancements in thermotherapy devices should address these crucial aspects.

• Archives of design research
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• v.19 no.5 s.67
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• pp.129-138
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• 2006

It is expected that the typical lifestyle of the future will be transformed into an opulent and comfortable existence as the quality of life improves due to the increase in household income and reduction in working hours. In the meantime, as the standard of living becomes increasingly more comfortable and plentiful, the toll on physical health becomes magnified as a result of obesity and insufficient exercise caused by super nutrition and change in labor conditions (from physical labor to mental labor). This has instigated a deep awareness in fitness on the part of many people, forcing them to recognize the significance of daily exercise and physical activity. The high annual growth rate in the fitness and athletic apparatus market, which is more than 20%, is attributed to this phenomenon. The Elliptical Cross Trainer(ECT), which has drawn wide attention recently, is a non-impact athletic apparatus that not only promotes exercise of the upper body parts in such sports as skiing but also the exercise of lower parts of the body on a treadmill. It is a type of cross training athletic gear that has been developed for aerobic exercise throughout the entire body. It has already formed a market as big as that of the treadmill in Europe, America, etc. Recently, its demand is growing sharply in the Korean markets as well as those in Northeast Asian countries, Despite such demand increase and expansion, since most of the expensive ECTs are exclusively supplied by suppliers in only a few advanced countries, localization of the ECT is urgently required in order to enhance competitiveness of Korean manufacturers and to expand the market. This paper introduces the process and results of a design-engineering cooperative study that was peformed for the development of the ECT.

• The Korean Journal of Pesticide Science
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• v.20 no.4
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• pp.305-311
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• 2016

In cultivation environment, various pesticides are used and some of them could be volatilized into the air. This could affect farmer's health and also cause environmental pollution. This study was carried out to investigate the volatilization of pesticides, and use the reference data for preventing farmer's pesticide intoxication and securing worker safety. The experiment was conducted in a greenhouse using a lysimeter which was of $1m^2$ area and 1.5 m depth filled with upland soil. The pesticides treated in lysimeter soil were ethoprophos (5.0% GR), diazinon (34.0% EC), alachlor (43.7% EC), metolachlor (40.0% EC), chlorpyrifos (2.0% GR), pendimethalin (31.7% EC), carbaryl (50.0% WP), napropamide (50% WP), tebuconazole (25.0% WP) and imidacloprid (2.0% GR). Each pesticide was treated at a concentration of 770.5 mg based on A.I (%). The recovery of pesticide ranged from 77.4 to 99.3%. The volatilized pesticides in air were collected by personal air sampler with PUF tube at 4 l/min flow rate. In addition, temperature and humidity were measured. The collected samples were extracted using acetone in a soxhlet apparatus for 8 hours. The extracted pesticides were resoluted with acetonitrile and diluted 5 times. It was analyzed with LC-MS/MS. For 720 hours experiment, the largest vaporization amount of each pesticide in air was ethoprophos $15.24{\mu}g/m^3$, diazinon $5.14{\mu}g/m^3$, pendimethalin $2.70{\mu}g/m^3$, chlorpyrifos $1.76{\mu}g/m^3$, alachlor $1.40{\mu}g/m^3$, metolachlor $1.12{\mu}g/m^3$, carbaryl $0.27{\mu}g/m^3$, napropamide $0.22{\mu}g/m^3$, tebuconazole $0.11{\mu}g/m^3$ and imidacloprid $0.05{\mu}g/m^3$. The R value (coefficient of correlation) between volatilization and vapor pressure of pesticides is higher than 0.99. Therefore, there is high correlation between volatilization and vapor pressure of pesticides.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.28 no.2
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• pp.73-80
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• 2016

To reduce the mechanical energy loss and to get the high energy efficiency, an apparatus of wave power generation inducing a consistent one way rotating motion from the wave reciprocation motions was developed and the hydraulic experiments for the real electric power production were conducted and the results were discussed. In the experiments for the shape of the buoyant tank, the efficiency of the fixed 9 cm diameter type enduring the wave plate weight was 14.6% and this was the best result for all shapes. But although the free sliding type was expected to represent a high efficiency, the experiments did not show a good result as 8.5% efficiency. Therefore, the shape of buoyant tank was decided as the fixed 9 cm diameter type in the next all tests. In the experiments for the various incident waves, when the water depth was 90 cm, the average efficiencies were measured as 3.9% in the 2nd gear, 4.9% in the 3rd gear, 4.9% in the 4th gear, 12.0% in the 5th gear, 10.0% in the 6th gear, 3.1% in the 7th gear, and 3.0% in the 8th gear. Also, when the water depth was 80 cm, the average efficiency was shown as 15.0% with 5th gear condition. Therefore the high average efficiency as 13.5% was given with 80~90 cm water depth and the 5th gear in the model.

• Journal of Pharmaceutical Investigation
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• v.32 no.3
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• pp.223-229
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• 2002

Metformin is an oral antihyperglycemic agent used in the therapy of noninsulin-dependent diabetes mellitus and does not cause hypoglycemia at the therapeutic dose. Its mechanism of action may involve an increased binding of insulin to its receptors and glucose uptake at the post-receptor level. The purpose of the present study was to evaluate the bioequivalence of two metformin tablets, Glucophage (Daewoong Pharmaceutical Co., Ltd.) and Glycomin (Ilsung Pharmaceuticals Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The metformin release from the two metformin tablets in vitro was tested using KP VII Apparatus II method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $23.75{\pm}1.96$ years in age and $68.77{\pm}10.41\;kg$ in body weight, were divided into two groups with a randomized $2{\times}2$ cross-over study. After one tablet containing 500 mg as metformin was orally administered, blood was taken at predetermined time intervals and the concentrations of metformin in serum were determined using HPLC with UV detector. Besides, the dissolution profiles of two metformin tablets were very similar at 떠1 dissolution media. The pharmacokinetic parameters such as $AVC_t,\;C_{max}\;and\;T_{max}$ were calculated. The ANOVA test was performed for the statistical analysis of the logarithmically transformed $AVC_t\;and\;C_{max}$, untransformed $T_{max}$. The results showed that the differences in $AVC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the Glucophage were 0.09%, 6.09% and -8.22%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.94){\sim}log(1.09)\;and \;log(1.01){\sim}log(1.15)$\;for\;AVC_t\;and\;C_{max},\;respectively)$, indicating that Glycomin tablet is bioequivalent to Glucophage tablet.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.11
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• pp.949-956
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• 2016

There are a number of effects by solar radiation in many aerospace industrial fields, such as degradation of mechanical properties, sealing effect of sealants or decolorization. Because it takes long time to investigate these effects by using the light of natural state, new methods are developed for accelerating this phenomenon. In this paper, we developed an apparatus to simulate accelerated solar radiation phenomenon selecting irradiation intensity $1,120W/m^2$ as the designed environment. Epoxy polymer as the composite material was chosen and processed by ASTM-D638, a reference for tensile test of polymer and plastic. Total color shift was selected as the test category to evaluate acceleration of the test. We obtained acceleration factors and numerical model from test data and concluded it can shorten test periods by accelerated irradiation intensity of $1,120W/m^2$.

• YAKHAK HOEJI
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• v.57 no.3
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• pp.205-212
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• 2013

Dissolution test has been performed to control drug quality and to predict in vivo drug release profile of solid dosage forms, so there's a drift towards setting dissolution test instead of disintegration test. However, some solid dosage forms in Korea Pharmaceutical Codex (KPC) are not established the dissolution test yet, so these monographs are necessary to set the specification of dissolution test. In this study, we developed the specification and test method of dissolution test for itopride hydrochloride tablets and tiropramide hydrochloride tablets which are not established the dissolution test yet. According to the "Manual for Guideline Application for Validation of Analytical Procedures" and "Guidelines on Specification of Dissolution test for Oral dosage form" of Korean Pharmacopoeia (KP), we validated and established each development method. Based on the preliminary dissolution profile, we set the dissolution condition(paddle apparatus, pH 1.2 media, 50 rpm). For this condition, we performed the main dissolution test to determine the specification (45 min, 85%). Finally, we validated each analytical method by specificity, linearity, accuracy and precision. These developed methods will be included the next supplement of KPC and also contributed to the quality control of medicines.

• The Korean Journal of Applied Statistics
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• v.27 no.7
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• pp.1243-1255
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• 2014

This study is aimed at developing an index and indicator in the light of social factors by analyzing the basic materials on Korean working conditions survey to make it possible to grasp various working environment factors consequent on business type and to judge the industrial safety & health policy of the related area. For the purpose of developing an index, this study was conducted by benchmarking the OECD-suggested index development guidelines and overseas cases of index development. This study suggested indexes related to health by benchmarking OECD's press-state-response model. The press-state health-related indexes specified in Korean working condtions survey were found to consist of physical risk environment, working hours, business environment, and social environment, and its consequent 'state' items were comprised of mental health, physical health, absence from work due to health problems and work satisfaction as health-related items. As a result, it was found that the 'press-state index' for wage worker, regular employee, manager, clerks, expert & related personnel involved, and workers aged under 50 was relatively good; in contrast, the 'press-state index' for people aged over 50, owner-operator, daily job, skilled position in agriculture & fisheries, simple labor service, and apparatus & machines assembly worker was found to be relatively vulnerable.