• Plant Resources
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• v.1 no.1
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• pp.60-79
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• 1998

In this review we summarize the isolation, structural determination, antitumor activity of substances from higher plants which were collected in Asian region.

• Proceedings of the Plant Resources Society of Korea Conference
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• 1996.09a
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• pp.10-11
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• 1996

In this review, we summarize the isolation, structural determination, antitumor activity of substances from higher plants which were collected in Asian region.

• Korean Journal of Plant Resources
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• v.8 no.3
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• pp.341-364
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• 1995

In this review, we summarize the isolation, structural determination, antitumor activity of substances from higher plants which were collected in Asian region.

• Microbiology and Biotechnology Letters
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• v.26 no.6
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• pp.471-475
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• 1998

The aim of the present research program was to develop a strain of gastrointestinal bacteria containing antitumor substances. Fecal samples were collected from neonates and a number of gastrointestinal bacteria were isolated from the fecal samples by applying selective agar for intestinal bacteria. Among 127 isolates, a strain 2B4-1 containing an antitumor substance against stomach cancer, SNU-1, was selected. The strain 2B4-1 was identified as a strain similar to Enterococcus faecalis NCTC 775 with respect to morphological characteristics, growth temperature, salt and acid tolerance, growth under facultative anaerobic conditions and utilization of carbon sources such as arabinose and melibiose and so on. However, it showed some differences such as a negative reaction to hippurate hydrolysis and negative reaction to $\beta$-hemolysis. We assigned to the strain 2B4-1 to Enterococcus faecalis.

• Journal of Mushroom
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• v.6 no.1
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• pp.1-12
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• 2008

Mushroom is well known for a safe food for a long time and, what is more, has a lot of useful characteristics related on the pharmacological activities. It is expected to be one of the most important functional food due to its diverse bioactive compounds. Especially, medical potentiality on immunomodulator and antitumor continues to be focused. Recent research trend and commercialization of functional healthy food using mushroom and its bioactive compounds will be herein introduced. Industrialization of mushroom functional substances will be also discussed.

• Journal of Korea Foresty Energy
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• v.24 no.1
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• pp.1-12
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• 2005

• Proceedings of the Plant Resources Society of Korea Conference
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• 1993.08a
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• pp.24-30
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• 1993

• Korean Journal of Plant Resources
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• v.6 no.1
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• pp.45-51
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• 1993

Many plants collected at Japan, China, Korea, Imdonesia and South America were applied to antitumor and / or cytotoxic screening tests against Sarcoma 180 ascites in mice and / or V-79, KB, P388 cultured cells. On the course of these screening tests, alcoholic extracts of Forsythia viridissima (Oleaceae), Eurycoma longifolia(Simaroubaceae), Rubia cordifolia and R. akane(Rubiaceae), Cissampelos pareira and Abuta concolor (Menispermaceae), Nardostachys chinensis (Valerianacese), Mansoa alliaceae (Bignoniaceae), Casearia sylvestris (Flacourtiacear), Maytenus ilicifolia (Celastraceae), Hedychium coronarium (Zingiberaceae), Croton palanostigma(Euphorbiaceae), Cocculus trilobus(Menispermaceae), Ginkgo biloba(Ginkgoaceae), Alpinia galanga and Cucculus zanthorrhiza(Zingiberaceae), Evodia rutaecarpa(Rutaceae), and Periploca sepium(Asclepiadaceae) showed significant activity and their active principles were clarified. In this paper, a few antitumor substances in above plants are introduced.

• Biomolecules & Therapeutics
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• v.24 no.4
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• pp.347-362
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• 2016

Marine sponges have been considered as a drug treasure house with respect to great potential regarding their secondary metabolites. Most of the studies have been conducted on sponge's derived compounds to examine its pharmacological properties. Such compounds proved to have antibacterial, antiviral, antifungal, antimalarial, antitumor, immunosuppressive, and cardiovascular activity. Although, the mode of action of many compounds by which they interfere with human pathogenesis have not been clear till now, in this review not only the capability of the medicinal substances have been examined in vitro and in vivo against serious pathogenic microbes but, the mode of actions of medicinal compounds were explained with diagrammatic illustrations. This knowledge is one of the basic components to be known especially for transforming medicinal molecules to medicines. Sponges produce a different kind of chemical substances with numerous carbon skeletons, which have been found to be the main component interfering with human pathogenesis at different sites. The fact that different diseases have the capability to fight at different sites inside the body can increase the chances to produce targeted medicines.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4753-4758
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• 2014

In recent times, a number of studies have provided evidence that biotoxins present great potential as antitumor agents, such as snake venom, bee venom, some bacteria toxins and plant toxins, and thus could be used as chemotherapeutic agents against tumors. The biodiversity of venoms and toxins make them a unique source from which novel anticancer agent may be developed. Biotoxins, also known as natural toxins, include toxic substances produced by plants, animals and microorganisms. Here, we systematically list representative biological toxins that have antitumor properties, involving animal toxins, plant toxins, mycotoxins as well as bacterial toxins. In this review, we summarize the current knowledge involving biotoxins and the active compounds that have anti-cancer activity to induce cytotoxic, antitumor, immunomodulatory, and apoptotic effects in different tumor cells in vivo or in vitro. We also show insights into the molecular and functional evolution of biotoxins.