• International Journal of Oral Biology
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• 제32권2호
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• pp.75-78
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• 2007

The periodontal diseases and dental caries are major infectious diseases in oral cavity. Many of the preventive and therapeutic dental products contain the antimicrobial and anti-inflammatory components. But some of these antimicrobial have weak points such as coloration, burning sensation and insolubility in water. We have screened the therapeutic herbal extracts of the Plant Extract Bank for the antimicrobial activity on the major dental pathogens by growth inhibition assay. For the Porphyromonas gingivalis, 8 herbal extracts had an antimicrobial activity, 11 herbal extracts for the Prevotella intermedia, 43 herbal extracts for the Haemophilus actinomycetemcomitans and 61 herbal extracts for the Streptococcus mutans. Among these extracts, 6 herbal extracts had an antimicrobial activity for more than 3 species of dental pathogens. These extracts are Araliae Cordatae Radix, Crassirhizomae Rhizoma, Mori Radicis Cortex, Psoraleae Semen, Pini Ramulus and Sieges- beckiae Herba. All of effective extracts were CA group, ethanol extracts. Among these 6 herbal extracts, only Crassirhizomae is known to have a antibacterial effects. Therefore these herbal extracts have a possibility to be a candidate for a major antibacterial components in dental products.

• 한국지역사회생활과학회지
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• 제15권1호
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• pp.85-90
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• 2004

To classify the physiological activity by habitat and part of Dandelion (Taraxacum officinale), antioxidative and antimicrobial activities were investigated from methanol extracts of Dandelion. Dandelion was taken from Uiryeong (in Kyungnam province) and from Seoul, and antioxidative and antimicrobial activities were measured for three different parts of the dandelion: the flower, leaf and root. Antioxidative activities of methanol extracts from Dandelion were examined by a DPPH test, and antimicrobial activities were examined against 5 microorganisms: Bacillus subtilis and Bacillus cereus as G(+) microorganisms, and Salmonella typhimurium, Staphylococcus aureus and Eschrichia coli as G(-) microorganisms. No significant differences were found in terms of antioxidative and antimicrobial activities between the dandelions in Uiryeong and the dandelions in Seoul. Antioxidative activity, however, was higher in the flower of the dandelion, irrespective of habitat. Further research with other physiological factors (besides antioxidative and antimicrobial activities) is necessary to shed light on dandelion physiological function and to enhance the utilization of dandelion.

• Bulletin of the Korean Chemical Society
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• 제35권12호
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• pp.3632-3636
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• 2014

In this study we designed and synthesized several heptapeptides that are enforced to form an amphipathic helix using all-hydrocarbon stapling system and evaluated their antimicrobial and hemolytic activities. The antimicrobial activity showed clear structure-activity relationships, confirming the importance of helicity and amphipathicity. Some stapled heptapeptides displayed a moderate antimicrobial activity along with a low hemolytic activity. To our best knowledge, although not highly potent, these stapled peptides represent the shortest helical amphipathic antimicrobial peptides reported to date. The preliminary data obtained in this work would serve as a good starting point for further developing short analogs of amphipathic helical antimicrobial peptides.

• 대한의생명과학회지
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• 제13권3호
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• pp.189-195
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• 2007

This study was carried out to examine antimicrobial substances from medicinal plants, the ethanol extracts of 38 medicinal plants were tested for the antimicrobial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant Staphylococcus aureus ATCC 43300. The extracts of Glycyrrhiza uralensis, Sophora flavescens, Dryopteris crassirhizoma, and Pinas densiflora showed significant antimicrobial activities against both S. aureus ATCC 25923 and methicillin-resistant S. aureus ATCC 43300. The extract of Dryopteris crassirhizoma among these medical plants showed the highest antimicrobial activity. These results suggested that the extracts from Dryopteris crassirhizoma, Sophora flavescens, Pinas densiflora, and Glycyrrhiza uralensis could be the potential source of antimicrobial agents against methicillin-resistant S. aureus and S. aureus.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 추계종합학술대회 B
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• pp.865-869
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• 2008

This study was carried out to research antimicrobial agents from medicinal plants, Pueraria thunbergiana, Sophora flavescens, Lonicera japonica, Pinellia ternata, Dictamnus dasycarpus, Paeonia lactiflora, Angelica dahurica, Spirodela polyrhiza, Cryptotympana pustulata, Pinus densiflora, Cimicifuga heracleifolia, Bupleurum falcatum, Magnolia kobus, Artemisia princeps, Houttuynia cordata, Forsythia koreana, Arctium lappa, Castanea crenata, Aster tataricus, Citrus unshiu, Gardenia jasminoides, Ledebouriella seseloides, Hovenia dulcis, Prunus sargentii. The ethanol extracts of 24 medicinal plants were tested for the antimicrobial activity against Streptococcus mutans. The extracts of Sophora flavescens, Pinus densiflora, Cimicifuga heracleifolia, Gardenia jasminoides and Ledebouriella seseloides showed antimicrobial activity against Streptococcus mutans. The extracts of Pinus densiflora and Sophora flavescens among these medical plants showed significant antimicrobial activity against Streptcoccus mutans. These results suggested that the extracts from Pinus densiflora and Sophora flavescens could be the potential source of antimicrobial agents against S. mutans.

• Journal of Microbiology and Biotechnology
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• 제26권12호
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• pp.2036-2042
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• 2016

We evaluated the potentials of 10 isothiocyanates (ITCs) from cruciferous vegetables and radish root hydrolysate for inhibiting the growth of oral pathogens, with an emphasis on assessing any structure-function relationship. Structural differences in ITCs impacted their antimicrobial activities against oral pathogens differently. The indolyl ITC (indol-3-carbinol) was the most potent inhibitor of the growth of oral pathogens, followed by aromatic ITCs (benzyl ITC (BITC) and phenylethyl ITC (PEITC)) and aliphatic ITCs (erucin, iberin, and sulforaphene). Sulforaphene, which is similar in structure, but has one double bond, showed higher antimicrobial activity than sulforaphane. Erucin, which has a thiol group, showed higher antimicrobial activity than sulforaphane, which has a sulfinyl group. BITC and iberin with a short chain exhibited higher antimicrobial potential than PEITC and sulforaphane with a longer chain, respectively. ITCs have strong antimicrobial activities and may be useful in the prevention and management of dental caries.

• 공업화학
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• 제23권5호
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• pp.429-432
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• 2012

최근 항생제에 대한 내성이 빠르게 확산됨에 따라 이를 극복하기 위해 새로운 항생제들을 찾기 위한 노력이 많은 연구자들에 의해 이루어지고 있다. 미생물의 외부공격에 대해 모든 생명체들은 방어물질을 분비하거나 내재하고 있는 데 그 중 하나가 항균 펩타이드이며, 전 세계적으로 활발한 연구가 이루어지고 있고 새로운 차세대 항생제로써 인식 되어진다. 이에 본 총설에서는 항균 펩타이드의 미생물에 대한 항생활성, 작용기작과 개발현황에 대해 고찰하고자 한다.

• Journal of Microbiology and Biotechnology
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• 제21권3호
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• pp.229-235
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• 2011

Antimicrobial peptides exhibit high levels of antimicrobial activity against a broad range of spoilage and pathogenic microorganisms. Compared with bacteriocins produced by lactic acid bacteria, antimicrobial peptides from the genus Bacillus have been relatively less recognized despite their broad antimicrobial spectra. These peptides can be classified into two different groups based on whether they are ribosomally (bacteriocins) or nonribosomally (polymyxins and iturins) synthesized. Because of their broad spectra and high activity, antimicrobial peptides from Bacillus spp. may have great potential for applications in the food, agricultural, and pharmaceutical industries to prevent or control spoilage and pathogenic microorganisms. In this review, we introduce ribosomally synthesized antimicrobial peptides, the lantibiotic bacteriocins produced by members of Bacillus. In addition, the biosynthesis, genetic organization, mode of action, and regulation of subtilin, a well-investigated lantibiotic from Bacillus subtilis, are discussed.

• 한국응용과학기술학회지
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• 제21권4호
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• pp.327-334
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• 2004

Cysteine-silver complexes were prepared and investigated the antimicrobial activity on rubber mat manufactured with waste rubber. We are exposed to harmful bacteria and fungi all the time. We manufactured antimicrobial mat to be imposed to mats that it can prevent generation of bacteria and microorganisms, and restrict their reproduction. Infection of medical devices causes significant morbidity and mortality. For aim of this study, we measured the antimicrobial mat manufactured with cysteine-Ag complex by CCD, FT-IR and NMR. The effect of mole ratio of cysteine-Ag complex on antimicrobial activity to bacteria and fungi is investigated. Reduction rate is evaluated using the Quinn method. Antimicrobial activity of complex on mole ratio 1:4 was effectively inhibited. The complexes had a better antibacterial activity than antifungal activity on rubber mat.

• Restorative Dentistry and Endodontics
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• 제12권1호
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• pp.77-84
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• 1986

This study was designed to compare the antimicrobial effect of the several root canal cements and to determine the duration of their activity. After Strep. sanguis 9811 was streaked on the surface of BHI agar and Plain agar, PVC tubes filled with root canal cements were applied and cultured for 48 hours, aerobically. Following results were obtained, 1. All of the examined root canal cements had antimicrobial activity with varying degree. 2. The antimicrobial activity of N2 was larger than any other root canal cements. Nogenol and Tubliseal showed the lowest activity. ZOE, AH26, Procosol and PCA cement showed the moderate antimicrobial activity. (P>0.05) 3. At one day after mixing the root canal cements, all of the root canal cements except N2 and PCA cement showed greatly reduced antimicrobial activity. 4. At three days after mixing, PCA cement showed the reduced antimicrobial activity. N2 showed the reduced activity at 7 days after mixing.