• Progress in Medical Physics
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• v.21 no.4
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• pp.348-353
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• 2010

The purpose of this study was to explore the potentials of a clinical 3T MRI in mouse brains and technical adaptation and optimization. T1-weighted images (T1WI), T2-weighted images (T2WI), FLAIR (Fluid Attenuated Inversion Recovery) images, Gadolinium enhanced T1-weighted images (Gd-T1WI), Diffusion weighted images (DWI) were acquired in brain of 2 mice (weight 20~25 g) with cerebral infarction by occlusion of right middle cerebral artery, 1 hour, 24 hours, 72 hours after infarction and 1 normal mouse brain using clinical 3T MRI scanner. We analyzed differentiation of striatum, ventricle, cerebral cortex, and possibility of detection of acute cerebral infarction. We could differentiate the striatum, ventricle, cerebral cortex on T2WI and on DWI, FLAIR, T1WI, the differentiation of each anatomy of brain was not definite, but acute cerebral infarction was detected on DWI of 1 hour, 24 hours, 72 hours after infarction and on T2WI, FLAIR of 24 hours, 72 hours after infarction. Clinical 3T MRI can be used in differentiation of anatomy of mouse brains and DWI can be helpul in detection of acute cerebral infarction in acute phase. With technical adaptation and optimization clinical 3T MRI can be useful tool for provide preclinical and clinical small animal studies.

• Journal of Veterinary Clinics
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• v.23 no.3
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• pp.263-266
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• 2006

The purpose of this study was to assess the usefulness of radiographic examination of the splenomegaly associated with drug-induced splenic congestion and to establish the standard goal of the splenomegaly in dogs. Radiographic images of spleen in normal dogs were collected to determine the maximum diameter prior to, and 15 minutes after, administration of acepromazine, ketamine/diazepam combination, or propofol. Significant splenic enlargement was seen after administration of acepromazine, but statistical signalficant was found in a ventrodorsal view only. Splenic size tended to decrease after administration of ketamine/diazepam combination. Significant splenic enlargement was not found after administration of propofol. These results suggest that measurable splenomegaly can be detected by radiographic examination after some kind of drug administration and the evaluation of splenomegaly is more useful at ventrodorsal view than lateral view.

• Proceedings of the Korean Environmental Health Society Conference
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• 2005.06a
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• pp.105-139
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• 2005

Increased signal in T1-weighted images was observed in the experimental manganese (Mn) poisoning of the non-human primate and a patient with Mn neurointoxication. However, our study showed that the increased signals in magnetic resonance images (MRI) were highly prevalent (41.6%) in Mn-exposed workers. Blood Mn concentration correlated with pallidal index. These changes in MRI tend to disappear following the withdrawal from the source of Mn accumulation, despite permanent neurological damage. Thus increased signal intensities on a T1-weighted image reflect exposure to Mn, but not necessarily manganism. Our study also showed that the concentration of Mn required to produce increased signal intensities on MRI is much lower than the threshold necessary to result in overt clinical signs of manganism. Increased signal intensities in the globus pallidus were determined by manganese accumulation in the animal experiment. Reanalysis of the previous data with the structural equation model revealed that pallidal index (Pl) on MRI reflects target organ dose of occupational Mn exposure

• Journal of Veterinary Clinics
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• v.9 no.2
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• pp.473-481
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• 1992

To elucidate the applicability of the wide latitude X-ray film for radiographic diagnosis and treatment of diseases in small animals, the quality of the wide latitude film was compared with that of the standard latitude film which is commonly used in veterinary clinic. The images of head, neck, thorax, abdomen, extremities and joints were radiographed with the wide latitude and standard latitude film in fourteen dogs. In soft tissues such as abdominal organs, lung, skin, mammary glands, the clearer and higher contrast of the image was observed on the wide latitude film. And these advantages were more apparent in pneumoeritoneography. Therefore. it can be suggested that the wide latitude film is practically useful for the evaluation of the images of soft tissues, and also can be used on hard tissue radiography with the same quality as the standard latitude film.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.469-473
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• 2001

A 12-year-old bitch, Yorkshire terrier, was admitted to the Chungbuk National University animal hospital with draining from mammary masses in the left and right mammary glands. She was involved in the mammary masses, suffering bilateral inguinal hernia. Physical examination during the hospitalization demonstrated the masses in right (3 cm) and left (1.5 cm) mammary glands. Blood pool images didn\`t show the subtle increase in blood flow to the inguinal hernia, and the increase of radionuclide distribution to the mammary gland on the soft tissue phase. However, delayed bone images showed a very focal lesion in the right mammary gland. These findings were confirmed on a subsequent biopsy, which also revealed adenocarcinoma with areas of malignant new bone formation. We present a case of primary mammary adenocarcinoma with $^{99m}Tc-MDP$ activity relative to normal bone. Tumor in the bitch demonstrates malignant new bone formation as the likely mechanism for the marked radiotracer avidity.

• Journal of Biomedical Engineering Research
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• v.42 no.3
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• pp.116-124
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• 2021

It is important to differentiate between the target tissue (or organ) and the rest of the tissue before incision during surgery. And when it is necessary to preserve the differentiated tissues, the blood vessels connected to the tissue must be preserved together. Various non-invasive medical imaging methods have been developed for this purpose. We aimed to develop a medical imaging system that can simultaneously apply fluorescence imaging using indocyanine green (ICG) and laser speckle contrast imaging (LSCI) using laser speckle patterns. We designed to collect images directed to the two cameras on a co-axial optical path and to compensate equal optical path length for two optical designs. The light source used for fluorescence and LSCI the same 785 nm wavelength. This system outputs real-time images and is designed to intuitively distinguish target tissues or blood vessels. This system outputs LSCI images up to 37 fps through parallel processing. Fluorescence for ICG and blood flow in animal models were observed throughout the experiment.

• Journal of Biosystems Engineering
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• v.37 no.4
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• pp.271-278
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• 2012

Worldwide trends in animal welfare have resulted in an increased interest in individual management of sows housed in groups within hog barns. Estrus detection has been shown to be one of the greatest determinants of sow productivity. Purpose: We conducted this study to develop a method that can automatically detect the estrus state of a sow by selecting optimal texture parameters from images of a sow's pudendum and by optimizing the number of neurons in the hidden layer of an artificial neural network. Methods: Texture parameters were analyzed according to changes in a sow's pudendum in estrus such as mucus secretion and expansion. Of the texture parameters, eight gray level co-occurrence matrix (GLCM) parameters were used for image analysis. The image states were classified into ten grades for each GLCM parameter, and an artificial neural network was formed using the values for each grade as inputs to discriminate the estrus state of sows. The number of hidden layer neurons in the artificial neural network is an important parameter in neural network design. Therefore, we determined the optimal number of hidden layer units using a trial and error method while increasing the number of neurons. Results: Fifteen hidden layers were determined to be optimal for use in the artificial neural network designed in this study. Thirty images of 10 sows were used for learning, and then 30 different images of 10 sows were used for verification. Conclusions: For learning, the back propagation neural network (BPN) algorithm was used to successful estimate six texture parameters (homogeneity, angular second moment, energy, maximum probability, entropy, and GLCM correlation). Based on the verification results, homogeneity was determined to be the most important texture parameter, and resulted in an estrus detection rate of 70%.

• Journal of Science of Art and Design
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• v.4
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• pp.91-122
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• 2002

`Bio morphism` are constituted in paintings where the artists try to embody the elementary properties of living creature as of growth and durability. They are the most appropriate concept of painting to harmonize human being with nature closely. The formative ways of them attach great importance to both unconsciousness and desire , as well as variations or dynamics, by noticing a flow of natural senses and feelings of human being. In other words, the formative ways are based on a recognition of nature as the intrinsic force of life, with the result that aesthetics of incompleteness is embodied in images. Therefore they are clearly distinguished from that of functional, geometric images. A tendency of painting at that time, in a word, 'return to figure and expression', means a conversion into organic images like the incomplete, atypical, and biomorphic forms, while denying the mechanical or geometric. Elizabeth Murray are analyzed, for these works are remarkable in the characteristics of 'Bio morphism'. Consequently the features of organic images, that is, 'the formative acceptance of natural figures, or an informality' and 'the force of free will, or an incompleteness', could obviously be revealed. It is a type that obtains a motif out of natural figures like an animal, a plant, or the concrete figures of human being. In conclusion, this thesis is focused on not only emphasizing that 'Bio morphism' were a major tendency among the various trends of postmodern painting in the 20th century, but also analysing both the painterly formation of organic images and the structure of them. In addition to these points, it is a central aim to evoke that Bio morphism should accurately be evaluated and positioned in postmodern painting. A new recognition of 'Bio morphism' is a peculiarity of the times that reflects a cultural aspect of the present, hence it should be recognized as another way to approach the postmodern painting.

• Korean Journal of Veterinary Research
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• v.51 no.4
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• pp.319-323
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• 2011

A 12-year-old spayed female Yorkshire terrier dog was presented with two-weeks history of lethargy, mental dullness and polydipsia. Neurologic examination revealed proprioceptive defect of all limbs and loss of swallowing gag reflex. The dog revealed persistent dehydration, hypernatremia, hyperosmolarity and hyposthenuria. On magnetic resornance imaging (MRI), the mass were heterogeneous signality on T1 weighted images, hyperintense signality on T2 weighted image with contrast enhancement on hypothalamohypophyseal lesion. Based on these findings, the dog was suspected as having pituitary gland tumor. Through water deprivation test and response to desmopressin acetate (1-deamino-8-D-arginine, DDAVP), this case was diagnosed by central diabetes insipidus (CDI). This paper reports the clinical sign, MRI, response to the exogenous antidiuretic hormone of CDI due to suspected pituitary tumor in a dog and DDAVP administration was evaluated effective therapy to correct hypernatremia induced by CDI.

• Journal of Veterinary Clinics
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• v.25 no.6
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• pp.549-552
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• 2008

An eight-month-old, intact female Jindo, weighing 9 kg with a one-day history of acute bloody diarrhea was referred. Plain abdominal radiographic findings included evidence of a soft tissue tubular mass within the dilated colon. In ultrasonographs, a target-like mass was identified with multiple hyperechoic and hypoechoic parallel wall layers. A barium enema showed a large radiolucent filling defect within the colon and a completely occlusive lumen. On the basis of these images, ileocecocolic and colocolic intussusception was diagnosed. Surgical manual reduction, resection and anastomosis were performed. The patient recovered normally without any complications or recurrence.