• Clinical and Experimental Pediatrics
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• 제64권2호
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• pp.86-92
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• 2021

Background: Anemia is an important health problem affecting approximately 25% of the global population. Although its prevalence is decreasing worldwide, few studies have examined the prevalence of anemia in Korean adolescents. Purpose: This study aimed to determine the prevalence of anemia in Korean adolescents over the past 21 years using data from the Korea National Health and Nutrition Examination Survey. Methods: We investigated the prevalence of anemia in adolescents aged 10-18 years for the period 1998-2018 according to sex, age, residential area, and household income. The effects of menarche age and menstruation were examined in female adolescents for the period 2001-2018. Results: Among the total 11,782 participants, the weighted prevalence of anemia was 4.0%. The prevalence of anemia in male participants significantly decreased (from 3.0% to 0.5%, P<0.001), whereas that in female participants did not change significantly over time (from 7.9% to 8.5%, P=0.054). The average age at menarche was 12.4±0.0 years; the prevalence of anemia in females increased from age 13 years onward. Multivariate analysis revealed that anemia was more common in female than male participants (odds ratio [OR], 9.88; 95% confidence interval [CI], 7.19-13.57; P<0.001). In female adolescents, the prevalence of anemia increased with age (OR, 1.26; 95% CI, 1.15-1.38, P<0.001) and was 3.6 times higher after than before menarche (OR, 3.65; 95% CI, 2.21-6.05, P<0.001). Conclusion: Over the 21-year study period, the prevalence of anemia decreased among male adolescents but did not change in female adolescents. In female adolescents, age and menarche were identified as significant risk factors that require continued attention.

• 한국임상약학회지
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• 제30권4호
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• pp.264-269
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• 2020

Background: Inflammatory diseases can increase the prevalence of anemia. Recent studies confirmed that the prevalence of anemia is increased by atopic dermatitis (AD), a chronic inflammatory disease. Therefore, we aimed to elucidate the correlation between AD severity and prevalence of anemia. Methods: We used data of pediatric patients from the Health Insurance Review and Assessment Service (HIRA-PPS-2016). We included pediatric patients (<18 years) with AD diagnosis who were prescribed medications for AD. We applied a propensity score method with inverse probability of treatment weighting (IPTW) adjusting for differences in prevalence of confounders and performed IPTW logistic regression to evaluate associations between the anemia and severity of AD. Results: In total, 91,501 patients (mild AD: 47,054 patients; moderate-to-severe AD: 44,447 patients) <18 years who were prescribed drugs for AD were analyzed. Analysis of the probability of patients with mild AD and prevalence of anemia as a reference revealed an odds ratio (OR) of 1.159 (95% CI, 1.109-1.212; p<0.001) in moderate-to-severe AD patients, indicating a correlation between anemia prevalence and AD severity. Subgroup analysis according to gender, age group, and type of health insurance revealed there was an association between AD severity and anemia except in patients equal or older than 7 years. Conclusion: The prevalence of anemia increased with AD severity despite adjusting for confounding factors. Our results support the hypothesis that AD can cause anemia, and anemia prevalence could be increased in severe AD patients. Further studies are needed to establish a pathological basis.

• 식품보건융합연구
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• 제8권2호
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• pp.7-13
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• 2022

The purpose of this study was to compare the nutrient intake of elderly according to their cohabitation status and determine its effects on the prevalence of anemia. Data from the KNHANES were used for this study, including raw data on socioeconomic characteristics, nutrient intake, health status, and clinical laboratory findings. Study subjects aged 60 to 80 years were retrieved and analyzed. As a result, the prevalence of anemia was 12.0% (men, 11.6%; women, 12.3%). The prevalence rate increased with age, and odds ratio [OR] of anemia among those aged 75 to 80 years was 4.16 times higher in men (OR=4.16, 95% confidence interval [CI]=2.48-6.97) and 2.77 times higher in women (OR=2.77, 95% CI=1.86-4.14) compared to 60~64 years old. Socioeconomic factors (area of residence, education level, household income), including cohabitation Status (living alone VS living with other family members), and health behaviors (high-risk drinking, smoking, aerobic exercise) did not significantly effect on anemia. In addition, other than protein intake for men, nutrient intake did not have a significant effect on the prevalence rate of anemia. Hypertension, diabetes, and cancer significantly increased the risk of anemia. In Korea, the influencing factors of elderly anemia change over time, so periodic follow-up studies are needed.

• 중환자간호학회지
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• 제12권1호
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• pp.94-108
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• 2019

Purpose : Heart failure (HF) is considered an important medical burden with rehospitalization and mortality. Anemia is a major risk factor associated with the severity of HF. To improve the understanding of the impact of anemia in the population with HF, we explored the prevalence of anemia, its guidelines, relationship between anemia and mortality or rehospitalization, and limitation of reviewed papers of various populations with HF. Method: We used Whittemore and Knafl's integrative review methodology (2005), and thirty research papers were analyzed. PubMed, CINAHL, Cochrane, PsychInfo, Embase, Web of Science were searched for papers published between January 1960-June 2018. Results: Anemia in individuals with HF was primarily defined using the World Health Organization guideline. The prevalence of anemia in patients with HF varied from 9% to 56.7%. Moreover, such a condition significantly increases the prevalence of mortality or rehospitalization in patients with HF. The analyzed majority were non-prospective cohort study including secondary data analysis. Conclusion: Anemia in individuals with HF is a significant risk factor of mortality and rehospitalization. Prospective cohort studies should be designed to identify the optimal value for screening anemia and the impact of anemia on rehospitalization and mortality among HF patients.

• 한국산업보건학회지
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• 제33권2호
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• pp.126-133
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• 2023

Objectives: This study was conducted to find out the prevalence and risk factors of anemia according to shift work. Methods: Data from the Korean National Health and Nutrition Survey (2016-2020) were used. 9,787 workers were divided into shift workers and non-shift workers. The work type between 6AM-6PM was defined as day work, and other work types were defined as shift work. A chi-square test was used to indicate the distribution of risk factors expected to affect shift work in both frequency and percentage. Multiple logistic regression analysis was performed to find out the relationship between anemia prevalence and shift work. Results: As a result of analysis, multiple logistic regression analysis of anemia prevalence and shift work, the OR (95% CI) of male workers on shift work was 2.186 (1.139 to 4.194) and there was a statistically significant difference. Conclusions: In conclusion, anemia in male shift workers should be considered a possibility of health problems. In the future, research based on various data collection should be conducted for research to reveal various causes or diseases of anemia in the future.

• Nutrition Research and Practice
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• 제2권1호
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• pp.8-12
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• 2008

The objective of this study was to assess the prevalence and clinical characteristics of anemia and to define the risk factors for anemia in older Koreans in Asan. From January to February 2002, five hundred sixty two community-dwelling older adults aged over 60 years were selected from a cross sectional study. All subjects underwent laboratory tests, which included a complete blood cell count, reticulocyte, liver and renal functional tests, lipid profiles and iron status tests. The median age was 68.6 years (range, 60-92 years). The mean levels of hemoglobin were $14.4{\pm}1.3\;g/dL$ in men and $12.9{\pm}1.0\;g/dL$ in women, and the overall prevalence of anemia was 12.5% in all subjects, 10.8% in men and 13.6% in women. The prevalence of anemia was the lowest among age group of 60-69 (10.0%) followed by 70-79 (15.5%), and the highest among age over 80 (20.7%), but the difference was significant only for men. The age difference was more distinct in men than in women (p<0.05). The mean hemoglobin level was significantly lower in the subjects aged over 80 y than those in the 60-69 y group (p<0.05). According to a logistic regression analysis, lower albumin and higher creatinine levels were identified as independent risk factors of anemia among older adults in Asan. In conclusion, the overall prevalence of anemia in our study group was 12.5% and the highest (20.7%) among those aged over 80 y.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권2호
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• pp.152-161
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• 2019

Purpose: We examined the prevalence of anemia, annual screening for anemia, and treatment of anemia with iron among children with inflammatory bowel disease (IBD). Methods: A retrospective study of U.S. pediatric patients with IBD was performed in the MarketScan commercial claims database from 2010-2014. Children (ages 1-21) with at least two inpatient or outpatient encounters for IBD who had available lab and pharmacy data were included in the cohort. Anemia was defined using World Health Organization criteria. We used logistic regression to determine differences in screening, incident anemia, and treatment based on age at first IBD encounter and sex. Results: The cohort (n=2,446) included 1,560 Crohn's disease (CD) and 886 ulcerative colitis (UC). Approximately, 85% of CD and 81% of UC were screened for anemia. Among those screened, 51% with CD and 43% with UC had anemia. Only 24% of anemia patients with CD and 20% with UC were tested for iron deficiency; 85% were iron deficient. Intravenous (IV) iron was used to treat 4% of CD and 4% UC patients overall and 8% of those with anemia. Conclusion: At least 80% of children with IBD were screened for anemia, although most did not receive follow-up tests for iron deficiency. The 43%-50% prevalence of anemia was consistent with prior studies. Under-treatment with IV iron points to a potential target for quality improvement.

• 한국산학기술학회논문지
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• 제20권11호
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• pp.157-163
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• 2019

본 연구는 노인 인구에서 대조군과 만성폐쇄성폐질환 환자의 빈혈 유병률과 헤모글로빈 농도의 차이를 살펴보고자 시행되었다. 또한, 본 연구는 노인 인구에서 만성폐쇄성폐질환의 중증도에 따른 빈혈 유병률과 헤모글로빈 농도를 조사하였다. 제 7기 국민건강영양조사 1차 년도(2016) 조사에 참여한 8150명의 의무기록을 분석하여 총 694명이 연구에 포함되었다. 대상자를 만성폐쇄성폐질환군과 비질환 대조군으로 분류하였고, 헤모글로빈, 헤마토크리트, 적혈구 농도 및 빈혈 유병 유무를 조사하였다. 만성폐쇄성폐질환군은 중증도에 따라 하위그룹으로 나누어 동일한 분석을 시행하였다. 비질환 대조군과 만성폐쇄성폐질환군의 빈혈 유병률은 그룹 간에 차이가 없었다. 비질환 대조군에 비해 만성폐쇄성폐질환군의 헤모글로빈, 헤마토크리트 및 적혈구 농도가 통계적으로 유의하게 높았다. 통계적으로 유의하진 않았으나, 만성폐쇄성폐질환의 중증도가 심해짐에 따라 빈혈 유병률은 감소하고 헤모글로빈, 헤마토크리트 및 적혈구 농도는 증가하는 경향성을 보였다. 본 연구를 통해 노인 만성폐쇄성폐질환 환자의 빈혈 유병률 및 헤모글로빈 농도에 대한 구체적인 자료를 제시할 수 있었다. 노인 만성폐쇄성폐질환 환자에서 빈혈이 발생한다면 원인에 대한 추가적인 평가를 고려해 봐야 한다.

• 대한영양사협회학술지
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• 제23권1호
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• pp.54-63
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• 2017

Anemia, defined as a reduction in the hemoglobin concentration of blood, is common in diabetes mellitus (DM) patients, can be potentially caused by diabetes complications such as nephropathy. Recent research suggests that diabetes mellitus (DM) itself may be a major risk factor of anemia. However, there are few Korean studies on the relationship between diabetes mellitus (DM) and anemia. This study was performed to investigate the association between anemia and diabetes mellitus (DM) in Korean adults. A total of 10,151 Korean adults over aged 19 years (4,422 male, 5,729 female) were selected from the participants of the Korean National Health and Nutrition Examination Survey VI (KNHANES VI). Korean adults with anemia had a higher prevalence of diabetes mellitus (DM) than the normal adults (11.4% vs. 30.4% in male, 8.8% vs. 9.4% in female). The unadjusted odds ratio (OR) for anemia was greater in adults with DM than in normal male (OR=3.28; 95% CI: 2.27~4.73). After adjusting for other risk factors including age, education, family income, smoking, drinking, and menstrual status, anemia and diabetes were not associated (OR=1.33; 95% CI: 0.84~2.09). Similarly, there was no association between anemia and diabetes in female. In conclusion, this study shows that the prevalence of anemia is similar in diabetic and non-diabetic Korean adults after adjusting for multiple risk factors. Further research is required to elucidate the mechanism of anemia caused as a consequence of diabetes mellitus (DM).

• 한국식품영양학회지
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• 제5권2호
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• pp.99-103
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• 1992

Patterns in the outbreaks of senile diseases were investigated on 1, 264 workers by special examination among the 43, 210 industrial workers by the screening test performed in Kwang-ju and Chon-nam Branch of Korean Industrial Health Association from January 4 to December 31 in 1991. The results are summarized as follows : 1) Prevalence rate of senile diseases of industrial workers was 2.9%. And prevalence rate according to the kinds of senile diseases was observed in the order of hepatitis (0.9%), hypertension(0.7%), diabetes mellitus(0.5%), anemia(0.4%). 2) Prevalence rate of complicated senile diseases of industrial workers was 0.5%. And prevalence rate according to kinds of complicated senile diseases was observed in the order of others hypertension and arteriosclerosis (0.1%), HBV and others chronic hepatitis(0.1%), essential hypertension and arteriosclerosis(0.03%), iron deficiency anemia and leukopenia(0.03%).