• 대한본초학회지
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• 제29권1호
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• pp.35-43
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• 2014

Objectives : We investigated the effects of gambigyeongsinhwan(GGH)(1) on body weight and non-alcoholic fatty liver disease(NAFLD) examined whether blood total cholesterol, LDL-cholesterol, free fatty acid and triglyceride levels and hepatic lipid accumulation are inhibited by it in high fat diet-fed obese male mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, GGH(1)-1, GGH(1)-2 and GGH(1)-3. After mice were treated with GGH(1) for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma ALT, leptin and lipid levels. We also did histological analysis for liver and fat on the mice. Results : Compared with controls, GGH(1)-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in GGH(1)-3. Compared with controls, GGH(1)-treated mice had lower feeding efficiency ratio and blood leptin level, the magnitudes of which was prominent in GGH(1)-3. Compared with controls, GGH(1)-treated mice had lower blood plasma total cholesterol, LDL-cholesterol, free fatty acid and triglyceride levels. Compared with controls, GGH(1)-3 treated mice had lower blood plasma ALT concentration. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by GGH(1), whereas the adipocyte number per unit area was significantly increased, suggesting that GGH(1) decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by GGH(1). Conclusions : In conclusion, these results suggest that GGH(1) exhibits anti-obesity effects through the modulation of feeding efficiency ratio and plasma obesity parameters. Moreover, it seems that GGH(1) also contributes to improve NAFLD through the regulation of plasma ALT and hepatic triglyceride accumulation.

• 한국인터넷방송통신학회논문지
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• 제22권4호
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• pp.49-57
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• 2022

정부에서는 전국에 설치된 공공 CCTV를 이용하여 실종아동 등 범죄 예방을 위하여 많은 노력을 하고 있다. 하지만, 운용인력의 부족과 장시간 집중에 따른 집중력 약화 그리고 추적의 어려움 등이 나타나고 있다. 또한, 딥러닝 알고리즘을 통하여 실시간 객체 탐색 및 재인식 그리고 추적을 적용하는 것은 복잡한 신경망 분석의 사유로 파라미터가 증가하고 속도감소 메모리 부족이라는 현상을 나타냈다. 본 논문에서는 실시간 객체 인식이 가능한 Yolo의 적용과 Batch 및 TensorRT 기술 적용을 통하여 신경망을 경량화를 통하여 속도 개선 및 메모리 절약이 가능하도록 설계하였다. 이 논문에서는 이러한 발전된 알고리즘의 연구를 바탕으로 K-reciprocal nearest neighbor 알고리즘, Jaccard distance 비유사도 측정 알고리즘, 산출물 알고리즘 등을 개발하여 공공 CCTV 식별추적시스템 구축을 제시하였다. 그 결과, 비교분석을 통한 알고리즘 조합을 통해 공공 다중CCTV환경에서 실시간으로 객체를 인식하고 재식별하여 객체를 추적할 수 있는 한국형 공공 추적시스템을 제안하였다.

• Wind and Structures
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• 제34권1호
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• pp.127-136
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• 2022

In this work a multi-fidelity non-intrusive polynomial chaos (MF-NIPC) has been applied to a structural wind engineering problem in architectural design for the first time. In architectural design it is important to design structures that are safe in a range of wind directions and speeds. For this reason, the computational models used to design buildings and bridges must account for the uncertainties associated with the interaction between the structure and wind. In order to use the numerical simulations for the design, the numerical models must be validated by experi-mental data, and uncertainties contained in the experiments should also be taken into account. Uncertainty Quantifi-cation has been increasingly used for CFD simulations to consider such uncertainties. Typically, CFD simulations are computationally expensive, motivating the increased interest in multi-fidelity methods due to their ability to lev-erage limited data sets of high-fidelity data with evaluations of more computationally inexpensive models. Previous-ly, the multi-fidelity framework has been applied to CFD simulations for the purposes of optimization, rather than for the statistical assessment of candidate design. In this paper MF-NIPC method is applied to flow around a rectan-gular 5:1 cylinder, which has been thoroughly investigated for architectural design. The purpose of UQ is validation of numerical simulation results with experimental data, therefore the radius of curvature of the rectangular cylinder corners and the angle of attack are considered to be random variables, which are known to contain uncertainties when wind tunnel tests are carried out. Computational Fluid Dynamics (CFD) simulations are solved by a solver that employs the Finite Element Method (FEM) for two turbulence modeling approaches of the incompressible Navier-Stokes equations: Unsteady Reynolds Averaged Navier Stokes (URANS) and the Large Eddy simulation (LES). The results of the uncertainty analysis with CFD are compared to experimental data in terms of time-averaged pressure coefficients and bulk parameters. In addition, the accuracy and efficiency of the multi-fidelity framework is demonstrated through a comparison with the results of the high-fidelity model.

• 한국측량학회지
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• 제40권4호
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• pp.325-332
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• 2022

우주 측지 기술 사이의 상대적인 위치 관계를 설명하는 벡터를 결정하기 위해서는 VLBI IVP (Very Long Baseline Interferometry Invariant Point)의 위치를 정밀하게 계산하여야 한다. 이를 위해 일반적으로 VLBI 안테나에 반사 타겟을 부착한 후 필라들로부터 경사 거리, 수평각, 수직각을 관측한다. 그 다음 단계에서는 관측값과 미지수를 연결하는 수학 모델을 이용하여 조정 계산을 수행하게 된다. 따라서 계산된 미지수는 관측값의 정밀도에 영향을 받게 된다. 이때 특히 문제가 되는 것은 반사 타켓이 일반적인 측량 정밀도를 확보하기 어려운 곳에 위치하고 있다는 점이다. 즉, 반사 타겟의 방향을 조정하여 측량 기기에 정확하게 맞출 수 없다는 것이다. 따라서 이러한 부분은 관측 오차에 또 다른 형태로 나타날 것이며 조정 계산 시 오차 모델링에 오류를 발생시킬 수도 있다. 본 연구에서는 조정 계산 후 계산된 잔차의 특성에 대한 분석을 수행하였다. 먼저 관측 타입별 통계 분석을 통해 정규성을 검정하였으며 분산에 차이가 있는 지에 대한 검정도 실시하였다. 관측 타입별로 등분산 검정을 한 경우 분산이 서로 다른 것으로 나타났다. 각 필라에 대해 관측 타입별 등분산 검정을 했을 때 경사 거리와 수평 및 수직각 사이에는 분산에 차이가 있는 것으로 나타났다. 따라서 결합 측량으로부터 최적의 결과를 얻기 위해서는 관측 오차에 대해 보다 세분화된 모델링이 필요한 것으로 나타났다.

• 대한족부족관절학회지
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• 제25권4호
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• pp.157-164
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• 2021

Purpose: This study aimed to report the current trends in the management of the hallux valgus (HV) deformity over the last few decades through a survey of the Korean Foot and Ankle Society (KFAS) members. Materials and Methods: A web-based questionnaire containing 34 questions was sent to all KFAS members in September 2021. The questions were mainly related to the preferred techniques and clinical experience in correction in patients with an HV deformity. Answers with a prevalence of ≥50% of respondents were considered a tendency. Results: One hundred and nine (19.8%) of the 550 members responded to the survey. The most common symptom for determining surgical treatment was bunion pain (68.8%), and different surgical techniques were selected according to the following radiological parameters: HV angle 30 to 40 degrees and intermetatarsal angle 15 to 20 degrees. The two procedures most preferred by the respondents were distal chevron osteotomy (55.0%), and proximal chevron osteotomy (21.1%). In an average of 71.6% of respondents, Arkin osteotomy was performed simultaneously during HV surgery. HV accompanied by an overriding deformity of the second toe was most often addressed with a combination of second metatarsal osteotomy and soft tissue rebalancing procedure (35.8%). After HV surgery, the recurrence rate of HV deformity was found to be 12.2% on average and the surgeons who had performed minimally invasive surgery (MIS) for HV comprised 34.9% of the total respondents. Conclusion: This study provides updated information on the current trends in the management of the HV deformity in Korea. Both consensus and variation in the approach to patients with HV were identified by this survey study. Although MIS for HV has increased, it appears the consensus for selecting this method has not yet been established.

• 한국어병학회지
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• 제35권1호
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• pp.93-102
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• 2022

본 연구에서는 뱀장어에 대한 trichlorfon (TCF)의 잔류허용기준(maximum residue level, MRL) 설정을 위한 기초 자료를 얻기 위하여 뱀장어를 대상으로 하여 trichlorfon (TCF) 노출에 따른 체내 잔류량 및 약물동태학적 분석을 실시했다. 28℃와 18℃ 에서 각각 30 ppm 및 150 ppm의 TCF를 30분간 약욕하여 이에 따른 체내 약물잔류농도를 LC-MS/MS로 분석한 결과를 바탕으로 PK solver program 을 이용하여 혈청, 근육 및 간에서 TCF의 약동학 파라미터를 얻었다. 혈청, 근육 및 간에서 최고 농도(C_max)는 25.87-357.42, 129.91-1043.73 및 40.47-375.20였고, 최고 농도 도달시간(T_max)는 0.13-1.32 h, 1.17-3.34 h, 및 0.14-5.40 h이었으며, 배설 반감기 (T_1/2)는 2.13-3.92 h, 5.30-10.35 h, 및 0.65-13.81 h이었다. 30 mg/L농도 투여군에서는 약욕 후 96시간이 지난 뱀장어의 혈청에서 TCF가 검출되지 않았으며, 근육 및 간에서는 336시간이후 부터 검출 한계 이하로 나타났다. 반면에 150 mg/L농도 투여군에서는 약욕 후 336시간이 지난 뱀장어의 혈청에서 TCF가 검출되지 않았지만, 근육 및 간에서는 336시간에도 검출되었다. 결론적으로 본 연구를 통해 얻은 결과들은 향후 양식 뱀장어에 대한 trichlorfon (TCF)의 잔류허용기준(MRL) 설정에 유용한 기초 자료로 활용 될 것으로 기대한다.

• 한국전자통신학회논문지
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• 제17권4호
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• pp.555-562
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• 2022

4차 산업혁명시대에 반지하 실내 복도 환경에서 새로운 전파 수요를 발굴하기 위해 본 논문에서는 주파수 6, 10, 17 GHz의 전파 특성에 대한 측정 및 분석하였다. 측정한 실내 내부 환경은 3면의 강의실과 외면의 유리창으로 구성되어있는 일자형 복도이다. 본 연구는 이러한 환경에 맞게 측정 시나리오 개발과 측정 시스템을 구성하였다. 송신 안테나는 고정하고 수신 안테나 위치의 거리에 따라 가시선 환경에서 주파수 영역과 시간영역 전파 특성을 측정하여 분석 하였다. 주파수 영역은 FI(: Floating intercept) 경로 손실 모델의 매개변수와 R-squared 값의 0.5 이상에 대한 신뢰도를 얻었다. 또한, 시간 영역은 RMS(: Root mean square) 지연 확산과 K-factor의 누적 확률에서 6 GHz는 전파 전달도가 높고, 17 GHz는 전파 전달도가 낮은 결과를 얻었다. 이러한 연구 결과는 반지하 실내 복도 환경에서 WIFI 6 이상이나 5G 이상에 대해 초 연결과 초 지연 인공지능 서비스를 제공하는데 효과가 있을 것이다.

• 한국환경보건학회지
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• 제48권3호
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• pp.159-166
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• 2022

Background: A quantitative structure-activity relationship (QSAR) model was adopted in the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH, EU) regulations as well as the Act on Registration, Evaluation, etc. of Chemicals (AREC, Republic of Korea). It has been previously used in the registration of chemicals. Objectives: In this study, we investigated the correlation between the predicted data provided by three prediction programs using a QSAR model and actual experimental results (acute fish, daphnia magna toxicity). Through this approach, we aimed to effectively conjecture on the performance and determine the most applicable programs when designating toxic substances through the AREC. Methods: Chemicals that had been registered and evaluated in the Toxic Chemicals Control Act (TCCA, Republic of Korea) were selected for this study. Two prediction programs developed and operated by the U.S. EPA - the Ecological Structure-Activity Relationship (ECOSAR) and Toxicity Estimation Software Tool (T.E.S.T.) models - were utilized along with the TOPKAT (Toxicity Prediction by Komputer Assisted Technology) commercial program. The applicability of these three programs was evaluated according to three parameters: accuracy, sensitivity, and specificity. Results: The prediction analysis on fish and daphnia magna in the three programs showed that the TOPKAT program had better sensitivity than the others. Conclusions: Although the predictive performance of the TOPKAT program when using a single predictive program was found to perform well in toxic substance designation, using a single program involves many restrictions. It is necessary to validate the reliability of predictions by utilizing multiple methods when applying the prediction program to the regulation of chemicals.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1610-1610
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• 2001

Microbiological examination of silage is of little value in gauging the outcome of silage, and so chemical analysis is more reliable and meaningful indicator of quality. On the other hand chemical assessments of the principal fermentation products provide an unequivocal basis on which to judge quality. Livestock require energy, protein, minerals and vitamins from their food. While fresh forages provide these essential items, conserved forages on the other hand may be deficient in one or more of them. The aim of the conservation process is to preserve as many of the original nutrients as possible, particularly energy and protein components (Woolford, 1984). Silage fermentation is important to preservation of forage with respect of feeding value and animal performance. Chemical and bacteriological changes in the silo during the fermentation process can affect adversely nutrient yield and quality (Moe and Carr, 1984). Many of the important chemical components of silage must be assayed in fresh or by extraction of the fresh material, since drying either by heat or lyophilisation, volatilises components such as acids or nitrogenous components, or effects conversion to other compounds (Abrams et al., 1987). Maize silage dorms the basis of winter rations for the vast majority of dairy and beef cattle production in Uruguay. Since nutrient intake, particularly energy, from forages is influenced by both voluntary dry matter intake and digestibility; there is a need for a rapid technique for predicting these parameters in farm advisory systems. Near Infrared Reflectance Spectroscopy (NIRS) is increasingly used as a rapid, accurate method of evaluating chemical constituents in cereals and dried forages. For many years NIRS was applied to assess chemical composition in dry materials (Norris et al., 1976, Flinn et al., 1992; Murray, 1993, De Boever et al., 1996, De la Roza et al., 1998). The objectives of this study were (1) to determine the potential of NIRS to assess the chemical composition of dried maize samples and (2) to attempt calibrations on undried samples either for farm advisory systems or for animal nutrition research purposes in Uruguay. NIRS were used to assess the chemical composition of whole - plant maize silage samples (Zea mays, L). A representative population of samples (n = 350) covering a wide distribution in chemical characteristics were used. Samples were scanned at 2 nm intervals over the wavelength range 400-2500 nm in a NIRS 6500 (NIRSystems, Silver Spring, MD, USA) in reflectance mode. Cross validation was used to avoid overfitting of the equations. The optimum calibrations were selected on the basis of minimizing the standard error of cross validation (SECV). The calibration statistics were R$^2$ 0. 86 (SECV: 11.4), 0.90 (SECV: 5.7), 0.90 (SECV: 16.9) for dry matter (DM), crude protein (CP), acid detergent fiber (ADF) in g kg$\^$-1/ on dry matter, respectively for maize silage samples. This work demonstrates the potential of NIRS to analyse whole - maize silage in a wide range of chemical characteristics for both advisory farm and nutritive evaluation.

• 한국음향학회지
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• 제42권1호
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• pp.25-31
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• 2023

능동소나를 이용하여 수중물체의 속도를 추정하려면 Continuous Wave(CW) 펄스를 이용하는 것이 일반적이나, 수중물체의 속도가 느리고 근거리의 해양에서는 잔향음의 영향으로 수중물체의 속도 추정이 용이하지 않다. 2017년도에 Wang 연구진은 이를 극복하고자 수중물체의 속도에 의한 도플러 변이에 둔감한 광대역 신호인 Hyperbolic Frequency Modulation(HFM) 펄스 두 개를 상반된 스윕방향으로 이용하였다. 두 펄스 간 송신 시간간격과 탐지시간 차이의 변화를 통하여 수중물체 속도 추정이 가능하다는 것을 시뮬레이션으로 제시하였다. 하지만 동일한 대역을 이용하므로 상호상관성에 의해서 수중물체 탐지 성능이 영향을 받을 수 밖에 없다. 상호상관성에 의한 수중물체 탐지 성능저하를 방지하기 위하여 대역이 분리된 상반된 스윕방향의 두 HFM 펄스 이용을 제안한다. 본 논문에서는 상반된 스윕방향의 두 대역 HFM을 이용하여 수중물체의 시선속도 추정에 관한 이론을 도출하였고, 펄스길이와 대역폭이 1 s와 400 Hz인 HFM 펄스로 시뮬레이션을 수행하였다. 제안한 방법을 이용하여 수중물체의 시선속도를 추정하면 약 6 %의 오차로 표적 속도 추정이 가능하다는 것을 시뮬레이션을 통하여 확인하였다.