• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.320-326
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• 2003

Recently several studies have indicated that ubiquinone-l0 (CoQ-10) decrease with aging in various organs of the human body. The decrease of ubiquinone-10 in the aging process suggests the reduction of both energy production in mitochondria and anti-oxidation with aging. Based on these findings, Ubiquinone-10 is being focused at as an anti-aging agent in the cosmetic market.(omitted)

• Transactions of Materials Processing
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• v.5 no.4
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• pp.327-336
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• 1996

The effect of dynamic strain aging on high temperature deformation behaviour of the A-Mg alloy was investigated by strain rate change tests and stress relaxation tests between 20$0^{\circ}C$and 50$0^{\circ}C$. Yield point, short stress transient and periodic discontinuities on the stress-strain curve were considered as an evidence of the effect of dynamic strain aging. With this criterion two distinct strain rate-temperature regimes could be manifested. Dynamic strain aging was considered to be effective in the high temperature-low strain rate regime, whereas dynamic recovery was a dominant deformation mechanism in the low temperature-high strain rate regime. It was found that dynamic strain aging in the high temperature deformation was governed by the mechcanism of diffusion-controlled, viscous dislocation movement.

• BMB Reports
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• v.52 no.1
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• pp.64-69
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• 2019

The loss of skeletal muscle, called sarcopenia, is an inevitable event during the aging process, and significantly impacts quality of life. Autophagy is known to reduce muscle atrophy caused by dysfunctional organelles, even though the molecular mechanism remains unclear. Here, we have discuss the current understanding of exercise-induced autophagy activation in skeletal muscle regeneration and remodeling, leading to sarcopenia intervention. With aging, dysregulation of autophagy flux inhibits lysosomal storage processes involved in muscle biogenesis. AMPK-ULK1 and the $FoxO/PGC-1{\alpha}$ signaling pathways play a critical role in the induction of autophagy machinery in skeletal muscle, thus these pathways could be targets for therapeutics development. Autophagy has been also shown to be a critical regulator of stem cell fate, which determines satellite cell differentiation into muscle fiber, thereby increasing muscle mass. This review aims to provide a comprehensive understanding of the physiological role of autophagy in skeletal muscle aging and sarcopenia.

• Molecules and Cells
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• v.46 no.11
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• pp.664-671
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• 2023

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we review findings regarding the role of mRNA quality control in the aging and longevity of Caenorhabditis elegans, an outstanding model for aging research. We discuss the recently discovered functions of the proper regulation of nonsense-mediated mRNA decay, ribosome-associated quality control, and mRNA splicing in the aging of C. elegans. We describe how mRNA quality control contributes to longevity conferred by various regimens, including inhibition of insulin/insulin-like growth factor 1 (IGF-1) signaling, dietary restriction, and reduced mechanistic target of rapamycin signaling. This review provides valuable information regarding the relationship between the mRNA quality control and aging in C. elegans, which may lead to insights into healthy longevity in complex organisms, including humans.

• Korean Journal of Community Nutrition
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• v.6 no.5
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• pp.773-788
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• 2001

The purpose of this study was to investigate the difference in nutrient intake according to the level of self-perception of health status, aging status and life satisfaction of the rural elderly. The factors for the study were surveyed by interview method. The subjects were 270 people(71 male, 129 female) aged over 65 years(73.5 $\pm$ 5.6ys) in the Ham-an area. The obtained results as follows : By evaluation of self-perception of health status, 57.5% of subjects answered they are in a bad health condition. The 91.5% of subjects had diseases(rheumatitis & arthritis 31.4%, cardiovascular disease 20.2%, gastric disease 10.2%). The women had more diseases than the men(p < 0.01). The subjects took medical treatment in private hospital(40.5%) and public health centers(35.0%). The men showed better level of aging status(p < 0.001) and life satisfaction index(p < 0.01) than the worsen. Living with spouse influenced the aging status(p < 0.05) and the more pocket money influenced life satisfaction(p < 0.05) and aging status(p < 0.05). The elderly who eat regularly 3 times a day(p < 0.05) and have a good appetite(p < 0.001) appeared to have positive effect on the self perception of health status and aging status. An increasing level of the self-perception of health status and regular exercise worked to improve aging status(p < 0.001). The habits of smoking and alcohol drinking, however had no effect on any index. The self-perception of health status affected the nutrient intake, but only in female elderly. The aging status and the life satisfaction index related overall positively to the intake of nutrients. In conclusion, the study shows that gender did influence nutrient intake in the elderly. The women who live alone rated lowest in social resources and health condition therefore their nutrient intake was also extremely in deficit. For successful aging, a program for rural elderly is needed, i.e. actions to provide minimum economic life, food delivery and psychological/physical health care through regional public health centers.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.4
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• pp.523-530
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• 2019

Pavement distress and traffic accidents are caused by pot-hole. In addition, direct and indirect damages of road users are increasing, such as loss of life due to personal injury and damage to vehicles. Generally, the asphalt concrete pavements are continuously aging from the production process to the terminal performance period. Aging causes stripping due to cracks and moisture penetration and weakening the pavement structure to induce pot-hole. In this study, adhesion performance and moisture sensitivity were evaluated according to aging degree in order to investigate the effect of aging on asphalt pavement. As a result of the study, the viscosity of the asphalt binder was increased with aging and the bond strength of the aged was increased 2~3 times than that of the unaged. The results of accelerated aging test showed an increases in indirect tensile strength and the increase in the TSR (Tensile Strength Ratio) by 4.2~8.9 %. As a result, it is noted that the anti-stripping and adhesion performances of the aged asphalt concrete are improved compared to the unaged one under the aging conditions of asphalt binder coated on aggregates.

• Journal of Korean Academy of Nursing
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• v.18 no.3
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• pp.269-280
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• 1988

Although everyone grows old, perception about the aging process and aging as measured physiologically vary widely. Perecptions of aging have psychologically influence on physical aging. This study was to examine the relationships between, self-concept, perception of aging, and physical aging in the elderly and to contribute to the theory development which may direct nursing intervention to promote well-being of the aged. Subjects were 70 women residents of a nursing home for the elderly in Seoul. Data collection was done from May 15 to June 15, 1988 using interview schedules and mechanical instruments. The instruments were selected items from the Health Self Concept Scale developed by Jacox and Stewart for self concept, and Secord and Jourad's Body Cathexis Scale and Osgood's Semantic Differential Scale for perception of aging. Physical aging was measured by mechanical instruments, inspection, questions, and palpation. The data were analysed for mean, 1-test, ANOVA, and Pearson Correlation Coefficient using an S.P.S.S computerized program. The results of the analysis were as follows. 1. The mean level of self concept for the subject group was 16.97(SD＝$\pm$6.17)in a range from 6-30. The mean level of perception of aging was 39.6. (SD＝$\pm$6.51) in a range from 13-65. The mean level of physical aging was 14.09(SD＝$\pm$2.05)in a range from 8-40. 2. Relationships among self - concept, perception of aging, and physical aging. 1) There was a positive relationship between self-concept and perception of aging(r＝0.4461, p＝0.000). 2) There was a negative relationship between physical aging and perception of aging(r＝-0.2975, p＝0.006). 3) There was a tendancy toward a negative relationship between physical aging and self -concept, but not a significant relationship (r＝-0.1033, p＝0.197). 3. 1) No general charcteristic variables were related to self concept. 2) The general characteristic variable related to the level of perception of aging was religion (t＝4. 17, p＝0.001). 3) The general characteristic variable related to the level of physical aging was age (F＝12.008, p＝0.000). There was a significant relationship between self - cencept and perception of aging, and between physical aging and perception of aging. Therefore nursing intervention should focus on promoting a positive perception of aging and strengthening self- concept during the physical aging process.

• Korean Journal of Materials Research
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• v.24 no.11
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• pp.610-616
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• 2014

In this study, we investigated the precipitation behavior of the R-phase precipitated at the initial stage of aging and its effect on the pitting corrosion of 25%Cr-7%Ni-4%Mo super duplex stainless steel. The R-phase in super duplex stainless steel was mainly precipitated at the interface of ferrite/austenite phases and inside of the ferrite phase during the initial stage of aging, and it was transformed into the ${\sigma}$-phase with an increase in aging time. The ferrite phase was decomposed into a new austenite phase and ${\sigma}$-phase. The R phase was an intermetallic compound, which represented a lower Ni and higher Mo than the matrix, and also had a higher Mo and Cr concentration than the ${\sigma}$ phase. With an increasing aging time, the pitting potential $E_p$ was increased slowly by the precipitation of the R-phase, and it was then steeply decreased by the precipitation of the ${\sigma}$-phase. The R-phase was decreased the pitting potential, but its effect was smaller than effect of ${\sigma}$-phase.

• BMB Reports
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• v.53 no.2
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• pp.65-73
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• 2020

Life expectancy has dramatically increased around the world over the last few decades, and staying healthier longer, without chronic disease, has become an important issue. Although understanding aging is a grand challenge, our understanding of the mechanisms underlying the degeneration of cell and tissue functions with age and its contribution to chronic disease has greatly advanced during the past decade. As our immune system alters with aging, abnormal activation of immune cells leads to imbalance of innate and adaptive immunity and develops a persistent and mild systemic inflammation, inflammaging. With their unique therapeutic properties, such as immunomodulation and tissue regeneration, mesenchymal stem cells (MSCs) have been considered to be a promising source for treating autoimmune disease or as anti-aging therapy. Although direct evidence of the role of MSCs in inflammaging has not been thoroughly studied, features reported in senescent MSCs or the aging process of MSCs are associated with inflammaging; MSC niche-driven skewing of hematopoiesis toward the myeloid lineage or oncogenesis, production of pro-inflammatory cytokines, and weakening their modulative property on macrophage polarization, which plays a central role on inflammaging development. This review explores the role of senescent MSCs as an important regulator for onset and progression of inflammaging and as an effective target for anti-aging strategies.

• Journal of the East Asian Society of Dietary Life
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• v.18 no.3
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• pp.322-330
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• 2008

This study was performed to the possibility of developing anti-aging convenient food that is to Koreans' taste. Editor: this abstract appears to describe a study of public opinion and not related to the development of anti-aging convenient foods. In total, The 150 adults, living in Seoul (Korea), participated in this study in the capacity of subjects. Editor: You really have to mention the age-range of the subjects, as senility is an old age disease. In particular, you talk about the intention of subjects (discussed below) to buy anti-aging food products. This would be directly related to their age, as I assume that older people would be more concerned about senility that relatively younger subjects. They were randomly assigned to 25 groups. In result initial descriptive analysis revealed that, 82 percent of subjects awoke to were aware of senility, and the while 26.7 percent were seriously thought of it concerned. Furthermore, The 58.7 percent said that believed food has the possibility has a role in of controlling senility, and the while 64.0 percent said stated that senility may be controlled by eating constitutional foods. Further comparative analysis of In the case of the group of which members subjects have been who were trying to control senility revealed that their, the reliance on food general and constitutional food was significantly higher than those who have not tried to do so did nothing. The From the 61.3 percent have been of subject who were trying to control senility, from among them, the 74.0 percent and the 22.7 percent were relied on physical taking exercises and anti-aging foods, respectively. Likewise, it was ascertained When asked whether subjects intend to purchase anti-aging convenient food if it was is developed. The 67.3 percent and the 72.7 percent indicated their intentionded to purchase the normal product and constitutional products, respectively. Resultantly, anti-aging convenient food was in demand to some extent. Given that anti-aging products are in high demand, In such a case, senile severity (p<0.05), anti-aging possibility in constitutional foods (p<0.001) and anti-aging action (p<0.001) are regarded as variables in the purchase of the normal products. In the case of relation to constitutional products, anti-aging possibility in constitutional food (p<0.001) and anti-aging action (p<0.001) were regarded as variables.