• Earthquakes and Structures
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• v.12 no.6
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• pp.713-723
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• 2017

Steel plate shear walls (SPSWs) are effective lateral systems which have high initial stiffness, appropriate ductility and energy dissipation capability. Recently, steel plate shear walls with low yield point strength (LYP), were introduced and they attracted the attention of designers. Structures with this new system, besides using less steel, are more stable. In the present study, the effects of plates with low yield strength on the seismic design parameters of steel frames with steel plate shear walls are investigated. For this purpose, a variety of this kind of structures with different heights including the 2, 5, 10, 14 and 18-story buildings are designed based on the AISC seismic provisions. The structures are modeled using ANSYS finite element software and subjected to monotonic lateral loading. Parameters such as ductility (${\mu}$), ductility reduction ($R_{\mu}$), over-strength (${\Omega}_0$), displacement amplification ($C_d$) and behavior factor (R) of these structures are evaluated by carrying out the pushover analysis. Analysis results indicate that the ductility, over-strength and behavior factors decrease by increasing the number of stories. Also, the displacement amplification factor decreases by increasing the number of stories. Finally, the results were compared with the suggestions provided in the AISC code for steel plate shear walls. The results indicate that the values for over-strength, behavior and displacement amplification factors of LYP steel plate shear wall systems, are larger than those proposed by the AISC code for typical steel plate shear wall systems.

• Journal of the Earthquake Engineering Society of Korea
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• v.16 no.5
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• pp.33-40
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• 2012

To reduce the vulnerability of torsional irregular buildings caused by seismic loads, the torsional amplification factor was introduced by the seismic code. This factor has been applied differently in a variety of seismic codes. In this study, the final static eccentricity, and the lateral and torsional stiffness ratios of buildings designed with different design eccentricities were compared. The increment of the torsional amplification factor resulted in a decrement of the final static eccentricity of the building. However, after reaching the maximum value of this factor, the final static eccentricity of the building increased again. The final static eccentricity of the building designed by multiplying the sum of the inherent and accidental eccentricity by the torsional amplification factor was zero or had a minus value, depending to the position of the vertical element.

• Journal of Microbiology and Biotechnology
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• v.30 no.5
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• pp.662-667
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• 2020

Epidermal growth factor receptor (EGFR) mutations are not only genetic markers for diagnosis but also biomarkers of clinical-response against tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Among the EGFR mutations, the in-frame deletion mutation in EGFR exon 19 kinase domain (EGFR exon 19-del) is the most frequent mutation, accounting for about 45% of EGFR mutations in NSCLCs. Development of sensitive method for detecting the EGFR mutation is highly required to make a better screening for drug-response in the treatment of NSCLC patients. Here, we developed a fluorometric tandem gene amplification assay for sensitive detection of low-abundance EGFR exon 19-del mutant genomic DNA. The method consists of pre-amplification with PCR, thermal cycling of ligation by Taq ligase, and subsequent rolling circle amplification (RCA). PCR-amplified DNA from genomic DNA samples was used as splint DNA to conjugate both ends of linear padlock DNA, generating circular padlock DNA template for RCA. Long stretches of ssDNA harboring multiple copies of G-quadruplex structure was generated in RCA and detected by thioflavin T (ThT) fluorescence, which is specifically intercalated into the G-quadruplex, emitting strong fluorescence. Sensitivity of tandem gene amplification assay for detection of the EGFR exon 19-del from gDNA was as low as 3.6 pg, and mutant gDNA present in the pooled normal plasma was readily detected as low as 1% fraction. Hence, fluorometric detection of low-abundance EGFR exon 19 deletion mutation using tandem gene amplification may be applicable to clinical diagnosis of NSCLC patients with appropriate TKI treatment.

• Journal of Korean Society of Steel Construction
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• v.22 no.1
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• pp.87-97
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• 2010

The purpose of this study was to evaluate the validity of the second-order analysis for asymmetric unbraced frame using the load amplification factor suggested by design codes. For this purpose, the first-order analysis with the B1 and B2 factors suggested by KBC 2005 and the direct analysis with the load amplification factors suggested by KBC 2009 were performed for five story - two bay and five story - four bay asymmetric unbraced steel frames. The results of the analyses were compared with the results of the second-order inelastic analysis to evaluate the validity of the suggested methods. The main parameters of the analysis were the shape of the frame, the axial load ratio of the column, the methods of analysis and the location of column. The research results show that the asymmetric shape of the frame deteriorates the validity of the factor B2 and the suggested methods. The range of error is increased in case of irregular or inclined column.

• Journal of Korean Society of Steel Construction
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• v.21 no.6
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• pp.627-636
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• 2009

The purpose of this study was to evaluate the validity of the second-order analysis using the load amplification factor suggested by design codes. For this purpose, the first-order analysis with the B1 and B2 factors suggested by KBC 2005 and the direct analysis with the load amplification factor suggested by KBC 2009 (draft) were performed for three-story -one-bay and five-story-three-bay unbraced steel frames. The results of the analyses were compared with the results of the second-order inelastic analysis to evaluate the validity of the suggested methods. The main parameters of the analysis were the scale of the frame, the axial load ratio of the column, and the methods of analysis. The research results showedthat the method suggested by KBC 2005 does not properly consider the second-order effect under the high axial load ratio, but the direct analysis method suggested by KBC 2009 (draft) properly estimates the second-order effect without any serious problem.

• New Physics: Sae Mulli
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• v.68 no.12
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• pp.1378-1383
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• 2018

Multi-wavelength holography has a better axial range than single-wavelength holography, thus allowing unambiguous phase imaging. Noise amplification is the limiting factor in multi-wavelength holography as noise is amplified by a factor equivalent to the magnification of the wavelengths. Here, we propose a new algorithm to remove noise amplification in multi-wavelength holography. The proposed method does not use phase unwrapping and removes $2{\pi}$ ambiguities. Experiments and numerical simulations indicated that the proposed method is fast, has low noise, and is useful for measuring samples with arbitrary step heights.

• 전기의세계
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• v.30 no.9
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• pp.582-588
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• 1981

The laser parameters such as a population inversion density, a stimulated emission cross section and loss factor in the glass laser amplifier medium were experimentally determined in order to analyse the properties of laser amplification. Using these parameters, the rate equations were approximately solved and the properties of laser amplification were analysed. An experiment of two-stage amplifier of Q-switching laser pulse was performed and the maximum output power was 1.1 GW, 33J. The several problems such as a laser solarization and a laser coupling in laser amplification were resolved.

• Wind and Structures
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• v.38 no.3
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• pp.193-202
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• 2024

Modern high-rise tower designs incorporating recessed balcony cavity spaces can be prone to high-frequency and narrow-band Rossiter aerodynamic excitations under glancing incident winds that can harmonize and compete with recessed balcony volume acoustic Helmholtz modes and facade elastic responses. Resulting resonant inertial wind loading to balcony facades responding to these excitations is additive to the peak design wind pressures currently allowed for in wind codes and can present as excessive facade vibrations and sub-audible throbbing in the serviceability range of wind speeds. This paper presents a methodology to determine Cavity Amplification Factors to account for façade resonant inertial wind loads resulting from balcony cavity aero-acoustic-elastic resonances by drawing upon field observations and the results of full-scale monitoring and model-scale wind tunnel tests. Recessed balcony cavities with single orifice type openings and located within curved façade tower geometries appear particularly prone. A Cavity Amplification Factor of 1.8 is calculated in one example representing almost a doubling of local façade design wind pressures. Balcony façade and tower design recommendations to mitigate wind induced aero-acoustic-elastic resonances are provided.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2007.04a
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• pp.369-374
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• 2007

For a stability design of steel frames, AISC-LRFD specification recommend to use Alignment Chart and story-based methods in order to determine an effective budding length. Recently, elastic buckling analysis, which is the method that calculate the effective length of members using eigenvalue of the overall structure, has been widely used in practical design of steel frames because this method can be performed effectively and automatically by computers. However, it can in some cases lead to unexpectedly large effective length in column having small axial forces. Therefore, this paper propose a method using elastic buckling analysis, which estimate a proper effective buckling length for all members having a small axial force. For verification of proposed method, it is compared with system based approach and stiffness distribution factor method. As a result, proposed method can rationally solve a problem in some case of column having small axial force. Also, adoption range for proposed method is established.

• Journal of the Earthquake Engineering Society of Korea
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• v.18 no.6
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• pp.301-308
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• 2014

A suspension bridge is a type of bridge in which the beam is suspended by load-bearing cables. There are two classifications: the self-anchored suspension bridge has the main cable anchored to the bridge girders, and the earth-anchored suspension bridge has the main cable anchored to a large anchorage. Although a suspension bridge is structurally safe, it is prone to be damaged by various actions such as hurricanes, tsunamis and terrorist incidents because its cables are exposed. If damage to a cable eventually leads to the cable rupture, the bridge may collapse. To avoid these accidents, studies on the dynamic behavior of cable bridges due to the cable rupture have been carried out. Design codes specify that the calculated DAF (dynamic amplification factor) should not exceed a certain value. However, it has been difficult to determine DAFs effectively from dynamic analysis, and thus no systematic approach has been suggested. The current study provides a guideline to determine DAFs reliably from the dynamic analysis results and summarizes the results by applying the method to an earth-anchored suspension bridge. In the study, DAFs were calculated at the location of four structural parts, girders, pylons, main cable and hangers, with variations in the rupture time.