• Title/Summary/Keyword: alzheimer

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Alzheimer Disease detection and analysis using P300 componenet of ERP in Alzheimer type Dementia (사상관련전위 P300 요소를 이용한 알츠하이머형 치매의 탐지와 분석)

  • 박은혜;이영혁;임재환;김종우;황의완;김현택
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2002.11a
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    • pp.148-152
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    • 2002
  • This study is to develop the Alzheimers disease (AD) detection and analysis system using event-related potential (ERP) of AD patients. We recorded ERP in an auditory oddball paradigm in mild AD (n=25), severe AD (n=12), age-matched normal aged controls (n=17), and young controls (n=7). The amplitude and latency of target P300 components were compared among 4 groups. The relationship between P300 measures and neuro psychological test (K-DRS) scores were evaluated by correlations. The latency of P300 was prolonged in AD and the effects were correlated with the severity of dementia. The P300 amplitude was not affected significantly in AD. Theres no difference between normal aged group and young group. These results suggest that the P300 component is specifically affected by Alzheimer type dementia.

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A Case Report of Delirium and Cognitive Decline Caused by Traumatic Subarachnoid Hemorrhage in Soeumin Alzheimer Patient (소음인 알츠하이머 환자의 외상성 지주막하 출혈로 인한 섬망과 인지저하 치험 1례)

  • Park, Gyung-hun;Kim, Jong-Won;Jeon, Soo-Hyung
    • Journal of Sasang Constitutional Medicine
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    • v.31 no.4
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    • pp.57-64
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    • 2019
  • Objectives This study is to investigate the effect of sasang constitutional medicine on the delirium and cognitive decline caused by traumatic subarachnoid hemorrhage in a soeumin alzheimer patient Methods We have treated a 79-year-old Soeumin patient mainly with Doksampalmul-tang. She was already suffering from Alzheimer's disease. After traumatic subarachnoid hemorrhage, there were symptoms of delirium and cognitive decline. The degree of improvement was checked by K-MMSE and K-MOCA scores. Results The K-MMSE score improved from 0 to 11 and the K-MOCA score from 0 to 3. Conclusions Sasang constitutional medicine has been effective in the treatment of delirium and cognitive decline caused by traumatic subarachnoid hemorrhage.

Cognitive Improvement Effect of Resplex Alpha A in the Scopolamine-induced Mouse Model

  • Bong-geun Jang;Youngsun Kwon;Sunyoung Park;Gunwoo Lee;Hyeyeon Kang;Jeom-Yong Kim
    • CELLMED
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    • v.13 no.14
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    • pp.14.1-14.9
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    • 2023
  • Administration of Scopolamine can be considered a psychopharmacological model of Alzheimer's disease (AD). We made an animal model of Alzheimer's disease (AD) by administering Scopolamine to Blab/c mice. In this study, we investigated the effects of Resplex Alpha on memory impairment and cognitive function in mice in a mouse animal model of Scopolamine-induced memory impairment. Through Y-mazed and passive avoidance behavioral assays, we observed that Resplex Alpha recovered Scopolamine-induced short-term memory and cognitive functions. The results of our study imply that Resplex Alpha may be beneficial in the prevention of Alzheimer's disease (AD).

Development of Biochip Sensors for Blood Biomarkers Specific to Alzheimer's Disease Diagnostics (알츠하이머 질병 진단을 위한 혈액 바이오마커 검출용 바이오칩 센서 개발)

  • Kim, Suhee;Lee, Sang Hyuk;Lee, Hye Jin
    • Applied Chemistry for Engineering
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    • v.28 no.4
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    • pp.397-403
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    • 2017
  • The number of patients suffering from Alzheimer's disease is increasing year after year and almost approaching 15% of the total elderly population. Although it is critical to detect the early stage of Alzheimer's disease, which is a serious illness causing cognitive deficits, various existing diagnosis methods such as MRI, PET and CSF analysis could be the burdens for patients due to their high costs and long time to diagnosis. In order to tackle some of challenging issues for such existing diagnosis methods, extensive efforts have been made on developing fast and convenient biochip sensing methodologies for the diagnosis of Alzheimer's disease with a droplet of patient biofluids (e.g., blood). In this mini-review, we highlight some of the latest biochip sensing technologies that could qualitatively and quantitatively analyze blood biomarkers used for Alzheimer's disease diagnostics and discuss briefly related research trends and future aspects.

Antioxidant and Anti-Diabetic, Anti-Alzheimer Activities of Stem from Opuntia ficus-indica var. saboten Cultivated in Jeju at Harvest Time (채취시기별 보검선인장 줄기의 항산화, 항당뇨 및 항알츠하이머 활성평가)

  • Jeong, Yun Sook;Hwang, Byung Soon;Cho, Soo-Muk;Hwang, Kyung-A;Hwang, In Guk
    • The Korean Journal of Food And Nutrition
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    • v.30 no.6
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    • pp.1332-1340
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    • 2017
  • In this study, we assessed antioxidant, anti-diabetic, and anti-Alzheimer activities of Opuntia ficus-indica var. saboten (OFI) at harvest time. OFIs were cultivated December 2015~November 2016 in Jeju island. The 70% ethanol extracts of OFI were used to investigate total polyphenol and flavonoid contents, antioxidant(DPPH and ABTS radical scavenging assay), anti-diabetic(yeast ${\alpha}$-glucosidase and rat ${\alpha}$-glucosidase inhibition assay), and anti-Alzheimer(Acetylcholinesterase and butyrylcholinesterase inhibition assay) activities. Total polyphenol and flavonoid contents of OFIs were $17.40{\sim}23.11{\mu}g$ garlic acid/mg Ex and 2.17~6.22 ug (+)-catechine/mg Ex, respectively. DPPH and ABTS radical scavenging activity of OFIs were 131.98~184.90 mg ascorbic acid(AA) eq/100 g and 63.60~101.83 mg AA eq/100 g, respectively. In the anti-diabetic and anti-Alzheimer activities, 70% ethanol extracts of OFI exhibited moderate inhibition activity, compared to control (acarbose and beberine). Total polyphenol and flavonoid contents, antioxidant, anti-diabetic, and anti-Alzheimer activities were no significant differences by season, respectively. Therefore, information on comparative biological evaluations of OFI may be a beneficial in exploring functional food and drug development.

The Effect of Oral Administration of Herbal Medicines on Memory in Alzheimer's Disease Animal Models: A Review of Animal Study Reports Published in Korea (알츠하이머병 유발 동물모델에서 한약제재 경구투여가 기억에 미치는 영향에 대한 국내 연구보고 고찰)

  • Han, Da-Young;Park, Na-Eun;Kim, Sang-Ho;Chung, Dae-kyoo
    • Journal of Oriental Neuropsychiatry
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    • v.28 no.4
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    • pp.359-371
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    • 2017
  • Objectives: The objective of this study was to review the effect of oral administration of herbal medicines on the improvement of memory in Alzheimer's disease animal model reported in Korean domestic journals. Methods: The Korean databases (Koreantk, KISS) were searched with memory as a popular search term. During the searches, only animal study reports were reviewed. Data of animal models, intervention, observation methods of measuring indicators were extracted from the databases. Results: Typically, 36 articles were reviewed. Twenty-two studies used scopolamine to induce Alzheimer's disease, 24 studies used complex herbal medicines, and 12 studies used simple herbal medicines. Polygalae Radix and Acori Rhizoma were the most frequently used herbal medicines to improve memory in Alzheimer model. To evaluate the effect of herbal medicines, 36 studies used macroscopy, 16 studies used molecular biological analysis, 21 studies used biochemical analysis, 15 studies used histological analysis, and 11 studies used hematological analysis. Each study showed significant improvement with respect to memory indicators. Conclusions: Overall, the results suggest that treatment employing herbal medicines is an effective option to treat memory impairment in Alzheimer's disease.

A Voxel-Based Morphometry of Gray Matter Reduction in Patients with Dementia of the Alzheimer's Type (화소 기반 형태분석 방법을 이용한 알츠하이머 치매환자의 회백질 용적감소의 정량적 분석)

  • Lim, Hyun-Kook;Choi, Eun-Hyung;Lee, Chang-Uk
    • Korean Journal of Biological Psychiatry
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    • v.15 no.2
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    • pp.118-125
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    • 2008
  • Objectives : The purpose of this study was to find brain regions in which gray matter volume was reduced and to show the capability of voxel-based morphpmetry(VBM) analysis for lateralizing clinically significant brain regions in dementia of Alzheimer's type patients compared to healthy group. Methods : MR T1-weighted images of the 20 dementia of Alzheimer's type patients were compared with those of the 20 normal controls. Images were transformed to standard MNI space. In order to observe gray matter volume change. Gray matter was smoothed with a Gaussian kernel. After these preprocessing, statistical analysis was performed using statistical parametric mapping software(SPM2). Results : Gray matter volume was significantly reduced in the bilateral parahippocampal gyri, Lt. anterior cingulate gyrus, Lt. posterior cingulate gyrus, bilateral superior temporal gyri Lt. middle temporal gyrus, Lt. superior, bilateral middle, Rt. anterior frontal gyri and Rt. precuneus in dementia of Alzheimer's type patient group. Conclusions : These VBM results confirm previous findings of temporal lobe and limbic lobe atrophic changes in dementia of Alzheimer's type, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.

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The Effect of Reminiscence Therapy on Communication Ability of Elderly Patient With Alzheimer's Dementia (회상하기 프로그램이 알츠하이머 노인의 의사소통 능력에 미치는 영향)

  • Kim, Soo-Jung;Chang, Hyun-Jin
    • Therapeutic Science for Rehabilitation
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    • v.9 no.4
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    • pp.21-31
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    • 2020
  • Objective : Reminiscence program is a method to restore psychological stability for the elderly having dementia, and at the same time it makes the aged with dementia express themselves correctly by helping them to recollect their past life memories. The purpose of this study was to investigate the effects on communication ability in applying the reminiscence program to elderly patients with Alzheimer's dementia. Methods : The subject were 4 patients whose Alzheimer's dementia of moderate. This experiment was designed with pre-stage, treatment-stage, post-stage. The reminiscence therapy was compose of reminiscence activities of their live; in their childhood, adolescence, adulthood, and senescence. The therapy was delivered 30 times for 15 weeks. Results : The result of the study were as follows. First, after reminiscence therapy, recognition ability was improved. Second, after reminiscence therapy, emotional side was improved. Third, after reminiscence therapy, communication ability was improved. Conclusion : In this study, the reminiscence therapy had a positive effect on the improvement of communication skills among the elderly with Alzheimer's dementia. Based on the reminiscence therapy, it is thought to be very helpful in improving the communication ability of the elderly with dementia in the future.

Alzheimer's Disease-linked Swedish Amyloid Precursor Protein Mutation Induces Cell Death by Increasing Reactive Oxygen Species Generation

  • Kim Hye Sun;Lee Jun Ho;Kim Eun Mee;Lee Jean Pyo;Suh Yoo Hun
    • Environmental Mutagens and Carcinogens
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    • v.25 no.1
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    • pp.19-24
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    • 2005
  • The Swedish double mutation (KM670/671NL) of amyloid precursor protein (Swe-APP) is associated with early-onset familial Alzheimer's disease (FAD) and increases amyloid beta peptide production. Although APP/A/3 mediated neurotoxicity is observed both in vitro and in vivo, the relationship between mutant APP expression, A/3 production, and neuronal death observed in the brains of FAD patients remains to be elucidated. In this study, we investigated the mechanisms of Swe-APP-induced cell death in HEK293 and NGF-differentiated PC 12 cells. We found that the expression of Swe-APP induced cytochrome C relase, activation of caspase 3 in HEK 293 and NGF-differentiated PC 12 cells. We also show that the reactive oxygen species (ROS) was detected in Swe-APP expressing HEK 293 cells and NGF-differentiated PC 12 cells and that pretreatment with vitamine E attenuated the cellular death, cytochrome C release induced by Swe-APP expression, indicating the involvement of free radical in these processes. These results suggest one of possible apoptotic mechanisms of Swe-APP which could occur through cytochrome C release from mitochondria and this apoptosis inducing effects could be at least in part, due to ROS generation by Swe-APP expression.

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Dual-Task Training Effect on Cognitive and Body Function, β-amyloid Levels in Alzheimer's Dementia Patients: A Randomized Controlled Trial

  • Nam, Seung-Min;Kim, Seong-gil
    • The Journal of Korean Physical Therapy
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    • v.33 no.3
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    • pp.136-141
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    • 2021
  • Purpose: Dementia is a disease in which cognitive function declines, leading to deterioration of body functions and activities of daily living. The purpose of this study is to explore the effects of dual-task training, including cognitive tasks, on cognitive and body function and β-amyloid levels in Alzheimer's dementia patients. Methods: 34 inpatients diagnosed with Alzheimer's dementia at a nursing hospital located in South Korea. The patients were randomly divided into a dual-task group (n=16) and a single-task group (n=18). Each group was trained for 30 minutes three times a week for eight weeks. The MMSE-K was used to measure the patients' cognitive function. To assess the patients' static balance ability, their LOS was measured using BioRescue. while dynamic balance was measured using the BBS. The 10MWT were conducted to evaluate the patients' walking ability. Blood analysis was performed to measure levels of β-amyloid. Results: Both groups exhibited statistically significant improvements in gait function after the training (p<0.05). The dual-task group exhibited statistically significant differences in cognitive function, static and dynamic balance function, and β-amyloid levels after training (p<0.05). A significant difference was observed between the two groups (p<0.05). Conclusion: Dual-task training were found to be effective in improving cognitive and bodily functioning and reducing β-amyloid levels in Alzheimer's dementia patients. Thus, this may be suggested as an effective exercise method for the treatment and early prevention of Alzheimer's dementia.