Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Effect of Oral Administration of Herbal Medicines on Memory in Alzheimer's Disease Animal Models: A Review of Animal Study Reports Published in Korea

알츠하이머병 유발 동물모델에서 한약제재 경구투여가 기억에 미치는 영향에 대한 국내 연구보고 고찰

  • Han, Da-Young (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University) ;
  • Park, Na-Eun (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University) ;
  • Kim, Sang-Ho (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University) ;
  • Chung, Dae-kyoo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daegu Hanny University)
  • 한다영 (대구한의대학교 한의과대학 신경정신과교실) ;
  • 박나은 (대구한의대학교 한의과대학 신경정신과교실) ;
  • 김상호 (대구한의대학교 한의과대학 신경정신과교실) ;
  • 정대규 (대구한의대학교 한의과대학 신경정신과교실)
  • Received : 2017.11.21
  • Accepted : 2017.12.16
  • Published : 2017.12.30
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Abstract

Objectives: The objective of this study was to review the effect of oral administration of herbal medicines on the improvement of memory in Alzheimer's disease animal model reported in Korean domestic journals. Methods: The Korean databases (Koreantk, KISS) were searched with memory as a popular search term. During the searches, only animal study reports were reviewed. Data of animal models, intervention, observation methods of measuring indicators were extracted from the databases. Results: Typically, 36 articles were reviewed. Twenty-two studies used scopolamine to induce Alzheimer's disease, 24 studies used complex herbal medicines, and 12 studies used simple herbal medicines. Polygalae Radix and Acori Rhizoma were the most frequently used herbal medicines to improve memory in Alzheimer model. To evaluate the effect of herbal medicines, 36 studies used macroscopy, 16 studies used molecular biological analysis, 21 studies used biochemical analysis, 15 studies used histological analysis, and 11 studies used hematological analysis. Each study showed significant improvement with respect to memory indicators. Conclusions: Overall, the results suggest that treatment employing herbal medicines is an effective option to treat memory impairment in Alzheimer's disease.

Keywords

References

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