• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.4
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• pp.13-28
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• 2019

Objectives : The purpose of this study is to report the effectiveness of Korean medical treatment on 222 patients with alopecia areata. Methods : The subjects of this study were 222 patients who had received Korean medical treatment among the patients who visited the Balmer's Korean Medicine Clinic from January 1, 2016 to December 31, 2017. The extent of the alopecia areata was measured every month to determine the improvement. We analyzed the relationship between the types of alopecia areata, the extent of hair loss, duration of illness, age at first visit, and the treatment of alopecia areata. Results : 1. There were 100 males(45.0%) and 122 females(55.0%). The mean age of patients was 35.3 years old. 2. Of the 222 patients, 142(64%) were "cured". 31(14%) showed "good", 21(9.5%) showed "fair", 28(12.6%) showed "poor" improvement. 3. According to clinical records, of the 64 patients with alopecia areata(AA), 48(75.0%) were cured. Of the 100 patients with alopecia areata multiplex(AAM), 68 patients (68.0%), 12(50.0%) out of 24 patients with ophiasis, 5(55.6%) out of 9 with alopecia semi-totalis(AST), 3(50.0%) out of 6 patients with alopecia totalis(AT), 6(31.6%) out of 19 patients with alopecia universalis(AU) were cured. 4. Patients with the wider hair loss extent and with more severe type of alopecia areata required longer treatment period to cure, and the cure rate was lowered(p<0.05). 5. The shorter duration of the disease was related to the higher cure rate(p<0.05). If the treatment was started after six months of the duration, the cure rate was lowered. Therefore, beginning treatment within six months of the onset is recommended. 6. The period until terminal hair showed was 1.5 months for AA, 1.7 months for AAM, 1.6 months for ophiasis, 1.9 months for AST, 2.3 months for AT, 3.2 months for AU. 7. The treatment period to cure was 4.9 months for AA, 7.3 months for AAM, 7.7 months for ophiasis, 6.8 months for AST, 7.7 months for AT, 16.3 months for AU. 8. The major prognostic factors were extent and type of alopecia, duration of the disease and relapse. Conclusions : We analyzed the effectiveness of Korean medical treatment through cure rate according to the prognostic factors. This study will provide useful data for the treatment of alopecia areata.

• Korean Journal of Psychosomatic Medicine
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• v.8 no.2
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• pp.165-171
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• 2000

Objectives : Alopecia areata has been known to be closely related to stress. The purpose of this study is to examine the relationship between stress and alopecia areata investigating how life events(which alopecia areata patients experience), amount of stress, coping strategy, and their personality type affect the oneset and aggravation of the disease. Methods : The subjects were 43 alopecia areata patients who visited the department of dermatology outpatients clinic, and 36 fungal infection diseases patients as the control group. They all completed Scale of Life Events, Coping Style Cheklist, Eysenck A-type Personality Inventory. The analysis of covariance with the age as covariate was carried out. Results : Compared to the control group, alopecia areata patients had significantly more stressful life events, and higher amount of stress, but there was no significant difference in coping strategy. Type A Personality is also resulted to have no significant relationship to alopecia areata. Conclusions : Alopecia areata patients had significantly higher amount of stress than the control group, and this result is consistent with the previous studies which suggest that stress contributes to the oneset of alopecia areata. The causual relationship between stress and alopecia areata should be further examined in order to be applied in clinical setting.

• Annals of Clinical Neurophysiology
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• v.7 no.1
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• pp.58-60
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• 2005

Myasthenia gravis (MG) is occasionally associated with other autoimmune diseases. Alopecia areata has been reported to coincide with MG, particularly with thymoma. A 14-year-old woman was diagnosed as having MG. Seven months before diagnosed with MG, her hair and eyebrows had began to disappear and alopecia areata was diagnosed. We report this patient as a rare case of MG associated with alopecia areata without thymoma.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.31 no.2
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• pp.133-142
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• 2018

Objectives : This study is designed to investigate the effects of Korean medical therapy on 2 Alopecia areata. Methods : This is a case report on 2 patients who has been suffering from alopecia areata. To reduce their symptoms, we provided with internal herbal medicine 2 times a day, acupuncture therapy and Hwangryunhaedok-tang herbal-acupuncture therapy for three or four months. Results : After series of treatments, the symptoms of Alopecia areata were remarkably improved. Conclusions : This study shows us that Korean medical treatment effects on Alopecia areata.

• Journal of Yeungnam Medical Science
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• v.23 no.2
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• pp.232-239
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• 2006

Treatments for alopecia areata include topical corticosteroid treatment, corticosteroid intralesional injection, systemic corticosteroid treatment, PUVA(psoralen-UVA) and topical immunotherapy. The therapeutic effects are variable. Alopecia totalis is hard to treat completely. Topical immunotherapy with dinitrochlorobenzene (DNCB), squaric acid dibutyl ester (SADBE) or diphenylcyclopropenone (diphencyprone, DPCP) represents the most accepted therapeutic modality for the treatment of extensive alopecia areata. We report two cases of alopecia totalis treated with DPCP. After DPCP treatment, total scalp hair was completely recovered.

• The Journal of Pediatrics of Korean Medicine
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• v.33 no.4
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• pp.89-99
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• 2019

Objectives The purpose of this study is to report a case of a child with alopecia areata who was reintroduced with the same herbal treatment that was used before. Methods The patient was treated for 10 months with the herbal medicine. After a relapse, this patient took the same herbal medicine for another 2 months. Results After the treatment, the patient's hair loss and hair conditions were improved. After a relapse, alopecia areata was resolved by reintroducing the same herbal medicine treatment, and the condition was maintained well for several months even after the end of the treatment. Conclusion This study shows the effects of the herbal medicine for alopecia areata in a child. However, further studies are needed, including long-term follow-up studies after the end of the treatment.

• The Journal of Pediatrics of Korean Medicine
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• v.26 no.2
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• pp.47-52
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• 2012

Objectives The purpose of this study is to know the effect of Baekhogainsam-Tang on alopecia areata. Methods We decided the treatment principle through abdominal examinations and symptoms. We used herbal medicine (Baekhogainsam-Tang) to increase the roots of hair and hair. Results After the treatment, patients' hair condition had been improved (Hair loss patch diameter decreased from 2.5 cm to 0.5 cm). In addition, patient's physical symptoms were improved. Conclusions This case shows that herbal medicine, which focused on patient's physical symptom, is seemed to be effective in alopecia areata.

• Journal of Ginseng Research
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• v.36 no.4
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• pp.391-395
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• 2012

Alopecia areata (AA) is an autoimmune disease that can affect any hair-bearing area. AA is known to be caused by immunological disorder but still, the pathogenesis is not fully understood. Many therapeutic modalities have been used to treat alopecia areata, with variable efficacy and safety profiles. Unfortunately, none of these agents is definitely curative or preventive alone. We studied hair growth efficacy and safety of Korean red ginseng (KRG) in AA comparing corticosteroid intra-lesional injection (ILI) alone patient group with ILI with KRG taking patient group using Folliscope 2.5 for 12 wk. Herein, we would like to report the efficacy of KRG in the treatment of AA and recommend KRG as a useful complimentary food for gaining efficacy of treatment for AA.

• Korean Journal of Psychosomatic Medicine
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• v.13 no.1
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• pp.16-23
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• 2005

Objectives : We have studied female patients with either alopecia areata or androgenetic alopecia to evaluate psychological aspects, such as anxiety, depression, alexithymia, and characteristic personalities. In addition, we tried to examine the differences in psychological characteristics between these two types of alopecia, where the alopecia areata has been cotroversial on the role of stress in its etiology and the androgenetic alopecia seems to be more influeced by genetic and biological factors. Methods : All participated patients were females with alopecia for more than 1 you. Among them, 52 were with alopecia areata and 33 were with androgenetic alopecia. They were compared with 54 normal healthy controls by using MMPI, BDI, STAI-S, STAI-T, and TAS-20K. Results The average scores of F, Hs, D, Pd, Pa, Sc, Si in MMPI of alopecia groups were significantly higher than that of normal controls, and the androgenetic alopecia group had highest Hy and Pt scores. The average scores of BDI, STAI-S, and STAI-T in alopecia groups were higher than the normal controls. 94.2% of alopecia areata patients and 97.0% of androgenetic alopecia patients had severe depression, who scored higher than 23 in BDI. In TAS-20K, the average total scores of alopecia groups were higher than the normal control group, and the average Factor 3 score in androgentic alopecia was higher than the other groups. The alopecia groups scored higher than normal control group in STAI-S and STAI-T. Conclusion : Females with chronic alopecia were more depressed, had higher levels of anxiety, and more alexithymic than normal healthy females. In spite of arguments about etiological role of stress to alopecia, psychiatric interventions are needed for depression, and considerations for personality and psychological defense mechanism were needed in both types of alopecia.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.1
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• pp.130-139
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• 2014

Objectives : This is a clinical report on a 27-year-old patient with Multi-patched Alopecia Areata(AA) assumed to be occurred by chronic lymphadenopathy, and treated by oriental medicine treatment. Methods : The patient was treated by herb medication and acupuncture. The improvement of the patient was judged by magnifying glass, camera and VAS scale. Results & Conclusions : The AA patches were shown the regrowth of hair. And the pain from lymphadenopathy was disappeared. Oriental medicine treatment including Gagamsunbangpaedok-tang $(Ji\bar{a}ji\check{a}nxi\bar{a}nf\acute{a}ngb\grave{a}id\acute{u}-t\bar{a}ng)$ was effective to regrow hair on AA patches and reduce the symptom of lymphadenopathy as well.