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http://dx.doi.org/10.6114/jkood.2019.32.4.013

Retrospective Study about the Effectiveness of Korean Medical Treatment on 222 Patients with Alopecia Areata  

Choi, Jin-Woo (Balmer's Korean Medicine Clinic)
Lee, Jung-Hwan (Balmer's Korean Medicine Clinic)
Jung, Bo-Yun (Balmer's Korean Medicine Clinic)
Ji, Yu-Jin (Balmer's Korean Medicine Clinic)
Lee, Keon-Suk (Balmer's Korean Medicine Clinic)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.32, no.4, 2019 , pp. 13-28 More about this Journal
Abstract
Objectives : The purpose of this study is to report the effectiveness of Korean medical treatment on 222 patients with alopecia areata. Methods : The subjects of this study were 222 patients who had received Korean medical treatment among the patients who visited the Balmer's Korean Medicine Clinic from January 1, 2016 to December 31, 2017. The extent of the alopecia areata was measured every month to determine the improvement. We analyzed the relationship between the types of alopecia areata, the extent of hair loss, duration of illness, age at first visit, and the treatment of alopecia areata. Results : 1. There were 100 males(45.0%) and 122 females(55.0%). The mean age of patients was 35.3 years old. 2. Of the 222 patients, 142(64%) were "cured". 31(14%) showed "good", 21(9.5%) showed "fair", 28(12.6%) showed "poor" improvement. 3. According to clinical records, of the 64 patients with alopecia areata(AA), 48(75.0%) were cured. Of the 100 patients with alopecia areata multiplex(AAM), 68 patients (68.0%), 12(50.0%) out of 24 patients with ophiasis, 5(55.6%) out of 9 with alopecia semi-totalis(AST), 3(50.0%) out of 6 patients with alopecia totalis(AT), 6(31.6%) out of 19 patients with alopecia universalis(AU) were cured. 4. Patients with the wider hair loss extent and with more severe type of alopecia areata required longer treatment period to cure, and the cure rate was lowered(p<0.05). 5. The shorter duration of the disease was related to the higher cure rate(p<0.05). If the treatment was started after six months of the duration, the cure rate was lowered. Therefore, beginning treatment within six months of the onset is recommended. 6. The period until terminal hair showed was 1.5 months for AA, 1.7 months for AAM, 1.6 months for ophiasis, 1.9 months for AST, 2.3 months for AT, 3.2 months for AU. 7. The treatment period to cure was 4.9 months for AA, 7.3 months for AAM, 7.7 months for ophiasis, 6.8 months for AST, 7.7 months for AT, 16.3 months for AU. 8. The major prognostic factors were extent and type of alopecia, duration of the disease and relapse. Conclusions : We analyzed the effectiveness of Korean medical treatment through cure rate according to the prognostic factors. This study will provide useful data for the treatment of alopecia areata.
Keywords
Alopecia Areata; SALT score; Korean Medicine;
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Times Cited By KSCI : 9  (Citation Analysis)
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1 Mandani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol. 2000;42(4):549-66.   DOI
2 Jang YH, Kim DW. Clinical Course of Alopecia Areata. Korean J Dermatol. 2018;56(1):10-6.
3 Lee PL, Ahn KS. A Literatural Investigation into Pathology of Alopecia Areata. J of Physiology & Pathology in Korean Medicine. 1992;7(1):111-20.
4 Korean Statistical Information Service[cited 2019 July 3]. Available from: [URL] http://kosis.kr/statisticsList/statisticsListIndex.do?menuId=M_01_01&vwcd=MT_ZTITLE&parmTabId=M_01_01#SelectStatsBoxDiv.
5 Park HK. Studies for External & Internal Application on Alopecia. J Kor Med Opthalmol Otolaryngol Dermatol. 1988;1(1):67-71.
6 Lee YJ. A Bibliographical Study of Oriental Medical Records on Alopecia. J of Korean Oriental Medicine. 1995;16(1):141-159.
7 Jang SE, Chae BY. A Literature Review of Alopecia Areata. J Kor Med Opthalmol Otolaryngol Dermatol. 1996;9(1):84-98.
8 Kim NU, Roh SS. A literatual studies on the yupung(油風). J Kor Med Opthalmol Otolaryngol Dermatol. 1998;11(1):162-79.
9 Kwon GJ, Lee CH, Lee MW, Mun YJ, Choi DH, Lee HJ, et al. Morphological Studies on Hair Growth Effect of Samultang-gamibang in Alopecia Areata Mice. J of physiology & pathology in Korean Medicine. 2005;19(3):696-704.
10 Lee MW, Jo HY, Kim TH, Kim NS, Jeong HS, Lee CH. Experimental Studies on the Hair Growth Activity of Mixed Extracts of Mylabris Phalerata Pall. and Drynariae Rhizoma in Spontaneous Alopecia Model Normal C57BL/6N Mice. J of physiology & pathology in Korean Medicine. 2008;22(4):778-90.
11 Jeong IK, Jo HY, Kim TH, Kim NS, Jeong HS, Lee CH. Experimental Studies on the Hair Growth Activity of Extracts of Pinelliae Rhizoma in Spontaneous Alopecia Model and Normal C57BL/6N Mice. J of physiology & pathology in Korean Medicine. 2009;23(1):84-92.
12 Kwon HJ, Kim MH, Yang WM. Effects of Topical application of Astragalus membranaceus in Spontaneous Alopecia Mice Model. J of Korean Medicine. 2018;39(1):1-12.   DOI
13 Kim KW, Lee GM, Lim SC, Jung TY, Han SW, Seo JC. A Case of Alopecia Areata Treated with Bee Venom and Carthami Flos Herbal Acupuncture. J of Korean pharmacopuncture institute. 2004;7(2):91-6.   DOI
14 Park MS, Piao YJ, Park YO, Seo YJ, Suhr KB, Lee JH, et al. Analysis The Prognostic Factors of Alopecia Areata. Korean J of Dermatology 2004;42(7):825-32.
15 Lee SW, Ko JM, Lee SY, Lee MH, Kim YJ, Lee SH, et al. A Case Study of Beevenom Effect on Alopecia Universalis Started from Alopecia Areata. J of Korean Acupuncture & Moxibustion Society. 2008;25(6):163-73.
16 Lee JH, Kang YR, Jeong YH, Ahn TW. A Case of Extensive Alopecia Areata Treated with Traditional Oriental Hair Care Products. J Kor Med Opthalmol Otolaryngol Dermatol. 2009;22(2):269-80.
17 Park SL. Clinical Analysis of 68 Cases of Severe Alopecia Areata : The results of pulse corticosteroid therapy. Master Thesis. Jeonju:Chonbuk National University. 1994.
18 Im M, Park YO, Seo YJ, Lee JH, Park JK. Prognostic Factors Influencing Therapeutic Effect in Methylprednisolone Pulse Therapy for Alopecia Areata. Korean J of Dermatol. 2005;43(6):774-81.
19 Jang YH, Hong NS, Moon SY, Eun DH, Lee WK, Chi SG, et al. Long-Term Prognosis of Alopecia Totalis and Alopecia Universalis: A Longitudinal Study with More than 10 Years of Follow-Up: Better than Reported. Dermatology. 2017;233(2-3):250-6   DOI
20 Park JH, Yoo KH, Rho YK, Han TY, Li KS, Seo SJ, et al. Comparison of Therapeutic Effect of High Dose Corticosteroid Pulse Therapy and Combination Therapy of Cyclosporine with Low Does Corticosteroid for Severe Alopecia Areata. Korean J of Dermatol. 2009;47(11):1220-6.
21 Hwangbo M, Jeong MJ, Seo HS. A Case Report of Child with Alopecia Areata. J of pediatrics of Korean medicine. 2012;26(2):47-52.   DOI
22 Chong JH, Ihm CW. Clinical Study for Alopecia Areata in Children under 12 Years old. Korean J Dermatol. 2002;40(7):759-65.
23 Yun JH, Kim KH, Jang SJ, Sin MS. One case treated alopecia areata with herbal acupuncture. J Kor Med Opthalmol Otolaryngol Dermatol. 2001;14(1):105-10.
24 Hwang JS, Lee AR, Lim DJ, Cho HS, Kim KH, Kim GS. The Clinical Observation on 1 Case of Alopecia Areata Following Whiplash Injury. J Kor Med Opthalmol Otolaryngol Dermatol. 2004;17(3):138-45.
25 Cho AR, Hong SU. A Case Report of Alopecia Treated by Gagamsunbangpaedoktang - Focused on Multi-patched Alopecia Areata with Lymphadenopathy. J Kor Med Opthalmol Otolaryngol Dermatol. 2014;27(1):130-9.   DOI
26 Kim CY, Seo HS, Lee DJ, Kwon K. Case Study on Treating Scarring alopecia and Alopecia arreata Using Low Level Laser Therapy and Acupuncture. J Kor Med Opthalmol Otolaryngol Dermatol. 2016;29(4):182-8.   DOI
27 Choi SB, Kang JA, Lee JH. Five Cases of Severe Alopecia Areata Treated with Gagamhwajung-hwan. J Kor Med Opthalmol Otolaryngol Dermatol. 2017;30(3):239-49.
28 Korean Dermatology Association. Textbook of Dermatology. 6th ed. Seoul:Med book. 2014:551-7.
29 Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, Canfield D, et al. Alopecia areata investigational assessment guidelines Part II. National Alopecia Areata Foundation. J Am Acad Dermatol. 2004;51(3):440-7.   DOI
30 Jerry S. Nina O. Hair Loss and Restoration. Second Edition. Seoul:Gabon Medial Book. 2015:94-149.
31 Dainichi T, Kabashima K. Alopecia areata: What's new in epidemiology, pathogenesis, diagnosis, and therapeutic options? J Dermatol. 2017;86(1):3-12.
32 Messenger AG, Mckillop J, Farrant P, Mcdonagh AJ, Sladden M. British Association of Dermatologists' guidelines for the management of alopecia areata 2012. Br J Dermatol. 2012;166(5):916-26.   DOI
33 The Textbook Compilation Committee of the Traditional Korean Dermatology & Surgery Society. Text of Traditional Korean Dermatology & Surgery. Busan:Sunwo Publishing Company. 2007:508-11.
34 Tak WJ, Chung YS, Ro BI. A Clinical Study on Alopecia Areata (1996- 2000) (4). Korean J of Dermatol. 2002;40(7):791-800.
35 You HR. Differences in clinical profiles between mild-to-moderate and severe alopecia areata patients : A retrospective study of 1137 Korean patients. Master Thesis. Gwangju:Chonnam National University. 2016.
36 Choi HR, Kim MN, Hong CK, Ro BI. A Clinical Study for Alopecia Totalis and Alopecia Universalis. Korean J of Dermatol. 1993;31(3):341-48.
37 Lee JS, Ihm CW. A Clinical Study of 1505 Cases of Alopecia Patients. Korean J of Dermatol. 2000;38(10):1348-57.
38 Hong CK, Ro BI. A Clinical Study on Alopecia Areata(V). Korean J of Dermatol. 1998;36(5):877-86.
39 Lee JC, Kim HY, Kim HJ, Kim BS, Lee WJ, Lee SJ, et al. Long Term Follow-Up Study of Corticosteroid-Treated Patients with Alopecia Areata. Korean J of Dermatol. 2008;46(4):465-72.