• 동의생리병리학회지
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• 제17권1호
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• pp.146-150
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• 2003

It had been known for a while that Crataegi Fructus(CF; Crataegus pinnatifida Bunge) had only a digestive effect. Recently, it has been demonstrated that CF also has an anti-hypertensive effect. However, its mechanism of relaxant effect has not been investigated yet. This study was examined to investigate the mechanism of vascular relaxation effect of CF in isolated rat thoracic aorta. CF revealed significant relaxation to phenylephrine(PE)-induced arterial contraction but much less to KCI-induced one. When CF was pretreated, it inhibited PE-induced contraction non-competitively. Methylene blue(10/sup -6/M) completely blocked the relaxant effect of CF whereas L-NAME(10/sup -5/M) did almost completely. However, atropine(10/sup -6/M) did not have any influence on vascular relaxation effect of CF. Regarding cNOS activity, CF significantly increased its activity from rat whole brain homogenate in a dose dependent manner which was inhibited by L-NAME(10/sup -5/M). On the other hand, CF did not affect on expression of TNF-α mRNA in RAW 264.7 cells, suggesting that CF is not related to iNOS activity. These results indicate that CF would be effective in relaxing vascular contraction through release of endothelial nitric oxide.

• 천문학회보
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• 제40권1호
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• pp.58.2-58.2
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• 2015

We investigate the decaying incompressible MHD turbulence by including the effect of the expansion and contraction of background medium. In such an environment, incompressible MHD turbulence has two kinds of time scale. One is the eddy turn-over time (teddy), the other is the expansion/contraction time (texp-cntr). The turbulence is expected to behave differently according to the relationship between the two time scales. For instance, for teddy < texp-cntr, the turbulence would be decay more or less as in a static medium. On the other hand, for teddy > texp-cntr, the effects of expansion and contraction would be dominant. We examine the properties of turbulence in these two regime cases. Based on it, we derive a scaling for the time evolution of flow velocity and magnetic field. (i) In the decay effect dominant case, the velocity and magnetic field scale as $\sqrt{{\rho}v}{\sim}a^{-3}$, $b{\sim}a^{-2.5}$(expanding media) and $\sqrt{{\rho}v}{\sim}a^{-2}$, $b{\sim}a^{-1.5}$(contracting media). The total energy and residual spectra follow the $E^T_k{\sim}k^{-5/3}$, $E^R_k{\sim}k^{-7.3}$ in the inertial range. (ii) In the expanding and contracting dominant case, the velocity and magnetic field scale as $\sqrt{{\rho}v}{\sim}a^{-2.5}$, $b{\sim}a^{-2}$ (expanding/contracting media). The Kinetic and magnetic energy spectra follow the $E^K_k{\sim}a^{-5}$, $E^M_k{\sim}a^{-4}$. We have confirmed that scaling of velocity and magnetic filed is almost the same from the analytic estimates and computational models

• 대한한방소아과학회지
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• 제1권1호
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• pp.79-89
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• 1986

During 34 months from October 1982 to July 1985, a clinical study was made on 217 cases of out-patients with pediatric bronchoarthma at Kyung-Hee University Oriental Hospital. ?The observed results were as follows; ?1. In the age of the patients ranged from six months to twelve years; they were almost under six years (73.1 %) The ratio of male to female was 3: 1. ?2. In case of the age to be attacked with bronchoarthma, the age 3 covered 43.9% (95 cases), and the ages of less than 6 years 86.3% (187 cases); and, especially, the age 2 - 3 covered the highest rate (18.4%; 40 cases) ?3. The contraction period of bronchoarthma was almost less than one year (70.1%; 152 cases); especially, less than one week covered the highest rate (22.1 %; 48 cases) ?4. In case of the contraction season; winter (December to February) had the highest rate (33.2%; 72 cases), and fall, spring and summer came after it. And 13 cases (6%) were attacked in all seasons. ?5. Of a day, the severe symptom was shown most frequently from 6 pm to midnight (31.3%; 68 cases), and next from midnight to 6 am (29.1%; 62 cases) ?6. The common symptoms of out-patients were productive cough (24.0%; 147 cases), easily-catch-cold (22.5%; 138 cases), dry cough (11.4%; 70 cases), and so on. ?7. In case of the history of the patients, upper respiratory infections covered 52.1 % (113 cases) bronchitis(29.0%; 63 cases), pneumonia(17.1%; 37 cases), and tonsilitis& pharyngitis(6.0%; ?13 cases): and allergic symptoms covered (42 cases: 19.3%) fetal fever & eczema (11.5%: 25 cases), and allergie Rhinitis (7.8%: 17 cases) ?8. The family of the patients were shown to have the history of bronchitis (21.6%; 47 cases), bronchoarthma (21.2%; 46 cases), and tuberculosis (16.6%; 36 cases) ?9. The factors of bronchoarthma were shown as upper respiratory infections (38.3%; 38 cases), cold weather (18.9%; 41 cases), and exercise (175%; 38 cases) ?10. Of the treatment periods of the patients, less than one month (69.2%; 150 cases) took the highest rate, in which less than a week was 33.2% (72 cases) and one or two weeks 15.2% (33 cases) ?11. The main prescriptions were kunpyunetang (79 cases; 17.0%), Agoayangyuegunpyuetang (73 cases; 15.7%) and Haepyoyangjintang (72 cases; 15.6%) ?12. In the results of treatment, 132 cases (60.9%) was improved; especially, subjective signs of 33 cases (15.2%) of them, was almost removed.

• Bulletin of the Korean Chemical Society
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• 제24권6호
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• pp.728-730
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• 2003

Bond lengths, harmonic vibrational frequencies and dissociation energies of TlAt are calculated at ab initio molecular orbital and density functional theory using effective spin-orbit operator and relativistic effective core potentials. Spin-orbit effects estimated from density functional theory are in good agreement with those from ab initio calculations, implying that density functional theory with effective core potentials can be an efficient and reliable methods for spin-orbit interactions. The estimated $R_e$, $ω_e$ and $D_e$ values are 2.937 ${\AA}$, 120 $cm^{-1}$, 1.96 eV for TlAt. Spin-orbit effects generally cause the bond contraction in Group 13 elements and the bond elongation in the Group 17 elements, and spin-orbit effects on Re of TlAt are almost cancelled out. The spinorbit effects on $D_e$ of TlAt are roughly the sum of spin-orbit effects on $D_e$ of the corresponding element hydrides. Electron correlations and spin-orbit effects are almost additive in the TlAt molecule.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.217-217
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• 1994

Calcium entry blockers, capable of inhibiting transmembrane influx of extracellular calcium through specific calcium channels, are useful drugs in the treatment of angina pectoris, hypertension, cardiac arrythmia, and various cardiovascular disorders. Compounds having isoquinoline structures have recently been reported to possess calcium antagonistic action. Therefore, in the present study, we have attempted to synthesize some isoquinoline and related compound.; in order to search for potentially effective chemicals acting on cardiovascular system, and evaluated their pharmacological properties focusing on calcium antagonistic actions. Almost all of the compounds so far synthesized, had inhibitory action against phenylephrine or high potassium-induced contraction in vascular smooth muscle with different degrees of potencies depending on their structures, However, some of tetrahydroisoquinoline analogs showed directly inhibit calcium current in isolated rabbit cardiac myocytes examined by patch clamp techniques. The pharmacological properties of these compounds need more intensive investigation as to whether these chemicals may have developed as a new cardiovascular active drugs. Therefore, we are now under investigation of the mechanism of action of these compounds.

• Fibers and Polymers
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• 제6권4호
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• pp.306-312
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• 2005

This work looks into the behaviour of the twill weave woven fabrics during relaxation (when the weaving tension is released). Ten, 50-metre rolls of twill weave woven fabrics were produced. The fabrics were marked in a rectangular form at the weaving loom. After 48 hours of relaxation, the new shapes and sizes were recorded. The shapes of almost all of the samples were changed to parallelogram, even though they differed in size. The work showed that the manner of fabric deformation during relaxation depends upon the fabric structure. It indicates that contraction due to relaxation of the twill weave causes the woven fabric to skew. in the direction of the twill. The quantity of the skewness is related to the float length and the twill type. Fabrics with longer float length have higher skewness.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2006년도 추계학술대회 논문집
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• pp.1306-1311
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• 2006

Most of design parameters of Railway Structures are determined by the serviceability requirements, rather than the structural safety requirements. The serviceability requirements come from Ensuring of Running Safety and Ride Comfort of Train, Reduction of Track Maintenance Work Track-Bridge Interaction should be considered in the design of railway structures. In this study, a numerical method which precisely evaluate an axial force in rail and a rail expansion and contraction when turnout exist in succession on a CWR on a ballasted or on a ballastless track of bridge is developed. From the parameter studies using the developed method, additional stress of stock rail almost 25% is generated due to stock and lead rail interaction, even embankment not bridge. In case of ballasted track, additional stress of stock rail on bridge is very greater than on embankment, and therefore require detailed review in bridge design with turnout. Stresses of turnout rails on bridge are very sensitive according to the installed positions. In case of ballastless track, Stresses of turnout rails are similar as those of normal track

• 대한화학회지
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• 제10권2호
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• pp.67-75
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• 1966

Four kinds of clays from Sinyewon mine which is located in Chungchoungnam-Do district and two kinds of Japanese clays (Gairome, Kibushi) were selected and studied on the fundamental properties of these clays and those which are refined by the elutriation method. Chemical analysis, grading analysis such as refractoriness, specific gravity, color, fired color and plasticity, particle size distribution, various thermal tests, X-ray diffraction analysis and electron microscopic survey were carried out on these clays. The comparison of domestic clays with Japanese clays was made. 1. In chemical composition and physical properties, these four kinds of Sinyewon clays are almost similar to each other and also to Gairome and Kibushi clays. In refractoriness, Gairome and Kibushi clays have relatively high value such as SK 34 and 35, while Sinyewon clays have the value of about SK 32. Especially Sinyewon clay B has the low refractoriness (SK 18) and plasticity. Refined clays have the tendency of somewhat higher value than crude ones in refractoriness. 2. When burnt up to $900^{\circ}C$, the coefficients of contraction of Sinyewon clays were under 1.5%, Gairome under 1.3%, Kibushi under 3.0%. Only Sinyewon clay B showed expansion (1.0%) instead of contraction. 3. X-ray diffraction analysis and electron micrography showed that all of four Sinyewon clays and two Japanese clays are mainly composed of poorly crystallized kaolin, containing small amount of halloysite, sericite and considerable amount of quartz and feldspar. Sinyewon clay B contains especially large amount of quartz and feldspar. In general, it has been found out that the refined clays were free from large amount of iron oxide, quartz and feldspar.

• Korea-Australia Rheology Journal
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• 제15권3호
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• pp.131-150
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• 2003

A new numerical algorithm of finite element methods is presented to solve high Deborah number flow problems with geometric singularities. The steady inertialess planar 4 : 1 contraction flow is chosen for its test. As a viscoelastic constitutive equation, we have applied the globally stable (dissipative and Hadamard stable) Leonov model that can also properly accommodate important nonlinear viscoelastic phenomena. The streamline upwinding method with discrete elastic-viscous stress splitting is incorporated. New interpolation functions classified as rational interpolation, an alternative formalism to enhance numerical convergence at high Deborah number, are implemented not for the whole set of finite elements but for a few elements attached to the entrance comer, where stress singularity seems to exist. The rational interpolation scheme contains one arbitrary parameter b that controls the singular behavior of the rational functions, and its value is specified to yield the best stabilization effect. The new interpolation method raises the limit of Deborah number by 2∼5 times. Therefore on average, we can obtain convergent solution up to the Deborah number of 200 for which the comer vortex size reaches 1.6 times of the half width of the upstream reservoir. Examining spatial violation of the positive definiteness of the elastic strain tensor, we conjecture that the stabilization effect results from the peculiar behavior of rational functions identified as steep gradient on one domain boundary and linear slope on the other. Whereas the rational interpolation of both elastic strain and velocity distorts solutions significantly, it is shown that the variation of solutions incurred by rational interpolation only of the elastic strain is almost negligible. It is also verified that the rational interpolation deteriorates speed of convergence with respect to mesh refinement.

• The Korean Journal of Physiology
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• 제26권2호
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• pp.129-136
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• 1992

The effects of $Cd^{2+}$ on spontaneous contraction, and the contractures induced by $0mM\;Na^+,\;60mM\;K^+\;and\;10^{-6}\;M$ acetylcholine, 1mM caffeine were studied in order to elucidate diverse actions of $Cd^{2+}$ on the $Ca^{2+}$ mobilization related with contractility in the antral circular muscle of guinea pig stomach. $Cd^{2+}$ inhibited the spontaneous contraction in a does dependent manner $(10^{-6}\;M\;10^{-4}\;M).\;Cd^{2+}\;(3{\times}10^{-5}M)$ suppressed 60 mM $K^+$ induced contracture composed or a phasic and a tonic response and the increased tonic response by the increased external $Ca^{2+}$ concentration. $Cd^{2+}$ also suppressed acetylcholine induced contracture composed of repetitive phasic and a tonic component and the increased tonic response by the increased external $Ca^{2+}$ concentration. Caffeine in the concentration of 1mM evoked contracture but $Cd^{2+}$ suppressed the contracture. $Cd^{2+}$ suppressed the amplitude of the $Na^+$ tee contracture dose dependently and the amplitude of $Na^+$ free contracture almost decreased to 20% of control amplitude in the concentration of $10^{-4}\;M\;Cd^{2+}$. From the above results, it is suggested that $Cd^{2+}$ may inhibit not only $Ca^{2+}$ influx via voltage sensitive, receptor operated $Ca^{2+}$ channel and Na/ca exchange but also intracellular $Ca^{2+}$ release from the sarcoplasmic reticulum in the antral circular muscle of guinea pig stomach.