• Journal of Preventive Medicine and Public Health
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• 제51권6호
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• pp.275-280
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• 2018

Objectives: The project Seoul Atopy Asthma-friendly School investigated the current status of childhood asthma to enable formulation of a preventative policy. We evaluated the current prevalence of childhood asthma in Seoul and its trends and related factors. Methods: The project was conducted annually from 2011 to 2016 and involved around 35 000 children aged 1-13 years. Based on the International Study of Asthma and Allergies in Childhood guidelines, the survey involved parents. The associations of the particulate matter ($PM_{10}$) concentration, and the number of days on which the daily air quality guidance level was exceeded in the 25 districts of Seoul, with the prevalence of asthma were assessed. Results: The age-standardized asthma prevalence in 2011 and 2016 was 6.74 and 4.02%, respectively. The prevalence of lifetime asthma treatment and treatment during the last 12 months tended to decrease from 2011 to 2016. Asthma treatment was significantly correlated with the number of days on which the daily air quality guidance level was exceeded, but not with the $PM_{10}$ concentration. Conclusions: This study reports the prevalence of asthma among children in Seoul and confirmed the relationship between childhood asthma and known risk factors in a large-scale survey.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 춘계학술대회
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• pp.115-115
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• 2019

Arctium minus (AM), commonly known as lesser burdock, is a dried fruit (seed) of Aructium lappa L. that belong to Asteraceae. It has been used traditionally as herbal medicine because of its anti-inflammatory effects, and it has been applied to treat various diseases like allergies, skin aging, hyperlipidemia and urinary stone. In this study, we investigated the inhibitory effects of AM on the production of pro-inflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Pre-treatment of the RAW 264.7 cells with AM considerably inhibited and reduced production of Nitric Oxide (NO) and pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), and also shows suppression of nuclear factor-kappa B (NF-${\kappa}B$) translocation. In addition, AM treatment considerably reduced phosphorylation of mitogen-activated protein kinase (MAPK) in LPS-stimulated RAW 264.7 cells. Our results indicate that the AM has potential to inhibit inflammation through suppressing production of inflammatory mediators via both the NF-${\kappa}B$ and MAPK signaling pathway. We therefore suggest that AM might be effective therapeutics for the treatment of various inflammatory diseases.

• Journal of Korean Biological Nursing Science
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• 제21권1호
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• pp.37-45
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• 2019

Purpose: This descriptive research was on hand dermatitis in clinical nurses. Nurses often have a high rate of hand dermatitis with several factors associated with the dermatitis. The factors analyzed in this study included; general characteristics, work-related factors, hand washing, and allergies relate to hand dermatitis. Methods: Data were collected from April to May 2016. The subjects were nurses who had worked 12 months or more in a University Hospital. They voluntarily gave their consent for the research. The Symptombased questionnaires were sent to 220 nurses and 199 responses were returned. Collected data were analyzed using frequency, percentage, mean, standard deviation, ${\chi}^2-test$, and logistic regression analysis using SPSS 23.0. Results: Prevalence of dermatitis in nurses was 48.2%. Nurses who had worked for over three years were twice more likely to suffer hand dermatitis than nurses who had worked for 3 years or less (adjusted odds ratio [adj. OR]= 1.97, p= .036). Nurses who used alcohol sponge swabs more than 20 times per shift were 2.5 times more likely to suffer hand dermatitis as compared to those who used them less times (adj. OR = 2.51, p= .023). Conclusion: Results revealed that about a half of the clinical nurses suffered from hand dermatitis, hence it is crucial to find appropriate interventions for dermatitis prevention. This concern needs to be addressed especially in nurses who have more work experience and use more alcohol sponge swabs.

• 대한임상독성학회지
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• 제17권1호
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• pp.1-6
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• 2019

Scombroid fish poisoning (SFP) is a form of histamine food poisoning caused by the ingestion of improperly stored fish. The term "scombroid" derives from the family name of the fish family first implicated, such as tuna and mackerel. On the other hand, non-scombroid fish species, such as sardine and herring, can also cause histamine poisoning. The histamine is converted from histidine by a bacterial enzyme in the causative fish. Because the symptoms of SFP can easily be confused with food allergies, it is believed to have been significantly under-reported. In 2016, an outbreak of SFP occurred among primary school students who had eaten yellowtail steak in Korea. The most common findings consisted of a rapid onset of flushing of the face and trunk, erythematous and urticarial rash, diarrhea, and headache occurring soon after consuming the spoiled fish. Usually, the course is self-limiting and antihistamines can be used successfully to relieve symptoms, but several life-threatening SFP cases have been reported. Clinical toxicologists should be familiar with SFP and have competency to make a differential diagnosis between fish allergy and histamine poisoning. SFP is a histamine-induced reaction caused by the ingestion of histamine-contaminated fish, whereas a fish allergy is an IgE-mediated reaction. This review discusses the epidemiology, pathophysiology, diagnosis, treatment, and preventive measures of SFP.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2019년도 추계 학술논문 발표대회
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• pp.174-175
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• 2019

Recently, due to air pollution caused by fine dust, it is considered as a social problem. Increasing fine dust has intensified air pollution, causing many diseases and damages. This year, Seoul, South Korea, reached a severe level of fine dust pollution worldwide. The Ministry of Environment has strengthened the environmental standard for fine dust (PM2.5) from $50{\mu}g/m^3$ to $35{\mu}g/m^3$ since March 2018. When fine dust enters the human body, it causes bronchial or skin elongation such as respiratory allergies, irritable pneumonia, asthma and atopy. In this study, $TiO_2$ rutile with photocatalytic activity was used, and materials prepared by rutile sulfuric acid method were used. The photocatalytic activity rate is 95% or more and the density is $4.1g/cm^3$. The matrix was based on cement, and the substitution rate of $TiO_2$ was 0, 5, 10, 15, 20 (%). The test item is flexural strength and compressive strength.

• International Journal of Advanced Culture Technology
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• 제8권4호
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• pp.137-143
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• 2020

Traffic-related environmental factors (TREF) are a major problem in developed countries, leading to increased atopic sensitivity, allergy symptoms, and diseases. This study shows an association between traffic-related pollutants, distance of road and gas station from the children's daycare center, and allergy symptoms. Data was obtained from the 2018 survey, an ongoing allergic diseases prevalence survey for children aged 4-7 (n=1175). This survey considered 36 public daycare centers, across 6 districts in Seoul. Allergic symptoms were defined as the presence of at least 1 or more allergic diseases (International Study of Asthma and Allergies in Childhood (ISAAC)). TREF was derived from the distance to the nearest main roads and gas stations. Geographic data processing and variable computation were conducted using ArcGIS version 10.2. The odds ratios for allergy symptoms increased by 1.189 (1.235-2.679) times with decreasing distance to main roads and by 1.846 (1.176-2.896) times with decreasing distance to a gas station. This study concludes that main roads and gas-stations near children's daycare centers are related to the allergy symptoms in children.

• 한국멀티미디어학회논문지
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• 제25권4호
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• pp.610-619
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• 2022

Recently, the market for masks has been growing due to air pollution, sun protection, pollen allergies and other reasons. In addition, the demand for masks has increased dramatically due to the new coronavirus from 2020, and masks are still one of the necessities of life. Although the reliance on masks is increasing, there are many inconveniences associated with wearing masks for long periods of time. At the same time, technology is developing rapidly, and the demand for smart wearable devices is increasing. Therefore, at the moment when the fourth industrial revolution is underway, combining people's common necessities with IoT technology to bring new convenient experiences to people is an important direction for future technology development and product development. In this study, smart masks were designed and implemented using IoT(Internet of Things) technology. The mask uses a microcomputer Adafruit circuit playground express, using the microcomputer's LED, optical sensors, can be in the dark place light, and through the temperature sensor real-time grasp of body temperature changes. If the body temperature rises above normal, the LED will turn "on" and activate the voice sensor to warn yourself and others around you.

• 대한한의학원전학회지
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• 제37권3호
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• pp.11-20
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• 2024

Objectives : This study aims to examine the cause, symptoms, and treatment of Shiji in Korean Medicine, to establish foundation for applied research in the future. Methods : Contents on Shiji in the Donguibogam were selected and categorized according to cause, symptom and treatment. Medical significance and its relationship with contemporary diagnosis were examined. Results : Shiji is caused by weakness in the Spleen and Stomach, overeating, consumption of raw or cold food, external contraction, emotional damage, etc., while gastrointestinal symptoms such as stomach pain and diarrhea and other symptoms such as cold damage, phlegm, cough, back pain, flank pain are triggered. For treatment of gastrointestinal symptoms, Pingweisan is applied as basis, while for other symptoms, Erchentang supplemented with digestion stimulating medicinals such as Shanzhazhi, Shenqu, Maiya, etc., is applied. Conclusions : Shiji is related to conditions such as IBS, gastroesophageal reflux, functional indigestion, food-related skin allergies, polyps, etc. Shiji not only refers to stagnated food within the body, but should be understood as a broad term that includes reactive dysfunction of the nervous system caused by poor food hygiene and gastrointestinal hypofunction.

• 한국생활과학회지
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• 제22권5호
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• pp.491-506
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• 2013

The allergenic food labeling system for 12 foods has been operated in Korean school food service since 2012. This study was conducted to evaluate the food allergy status of Korean elementary school children's and their parents' perceptions of allergenic food labeling system. The parents of school aged(6-9yr olds) children in Gyeongbuk area were recruited to assist in this survey. Surveys were conducted by 404 parents. The prevalence of food allergy was 18.1%(73 students) and about one-half of the food allergic children had a family history of allergies, in particular, maternal family history. The major symptoms were related to skin and the major allergenic foods were mackerel, eggs, milk, wheat, crab and tomatoes. The parents eliminated the allergenic food from diet of 43.8% of the children with food allergy. Participants had an average knowledge score of 68% correct. The average knowledge score was higher for parents with food allergic children than for parents with intact children(p<.05). Over 61% of the respondents were not satisfied with allergenic food labeling system operated in school food service. The requirements for the allergenic food labeling system were the front-of-package labeling, conspicuous description and insert of warning sign. The parents estimated that the most important effect of the allergenic food labeling system was the improvement of psychological and physical health in children with food allergy. Because the only prevention method for food allergy is the restriction of allergenic food, the institutional device to expand the food labeling to unpackaged food as well as packaged food and to make people trust the food labeling should be prepared.

• IMMUNE NETWORK
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• 제15권2호
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• pp.100-109
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• 2015

Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and circumventing diseases caused by Th1/Th2 imbalance. Interleukin 4 (IL-4) is a Th2-type cytokine and often associated with hypersensitivity-related diseases such as atopic dermatitis and allergies when overexpressed. In this study, we have tried to elucidate the function of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) as an essential modulator of Th1/Th2 balance. EC-18 has showed an inhibitory effect on the production of IL-4 in a dose-dependent manner. RT-PCR analysis has proved EC-18 affect the transcription of IL-4. By analyzing the phosphorylation status of Signal transducer and activator of transcription 6 (STAT6), which is a transcriptional activator of IL-4 expression, we discovered that EC-18 induced the decrease of STAT6 activity in several stimulated cell lines, which was also showed in STAT6 reporter analysis. Co-treatment of EC-18 significantly weakened atopy-like phenotypes in mice treated with an allergen. Collectively, our results suggest that EC-18 is a potent Th2 modulating factor by regulating the transcription of IL-4 via STAT6 modulation, and could be developed for immune-modulatory therapeutics.