• 한국임상수의학회지
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• 제24권3호
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• pp.467-472
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• 2007

Alimentary lymphoma accounts for approximately 5% of neoplasm and diffuse lesion is more common than solitary nodular form in dogs. An eleven year-old male Yorkshire terrier was examined because of nonspecific gastrointestinal symptoms such as anorexia and vomiting for 10 days. An abdominal mass was palpated, which was originated from small intestinal wall in abdominal ultrasonography. Small intestine was obstructed by hypoechoic mass and lost normal layering and measured 24.5m. After fine-needle aspiration, septic peritonitis due to intestinal rupture occurred and emergency surgery was performed. Solitary mass was found in small intestine and diagnosed as alimentary lymphoma through histopathologic examination. Conclusively, abdominal ultrasonouaphy could verify the thickened bowel, loss of wall layering and decrease of motility and percutaneous ultrasound-guided fine-needle aspiration is considered as useful diagnostic technique, especially in nodular form of alimentary lymphoma.

• 한국동물위생학회지
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• 제42권4호
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• pp.279-283
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• 2019

An 8-year-old castrated male Korean short hair cat was referred with chronic vomiting, diarrhea, and anorexia. The cat was diagnosed with alimentary lymphoma via fine needle aspiration. Three weeks later, he was presented again with anorexia. Hepatomegaly and hyperechoic change in the liver parenchyma were observed. Computed tomography while awake was performed and revealed hypoattenuation of the hepatic parenchyma. The cat was tentatively diagnosed with feline hepatic lipidosis secondary to alimentary lymphoma. In the feline patient with lymphoma, hepatomegaly is important to differentiate hepatic lipidosis from hepatic infiltration of lymphoma on liver. In the present case, fatty infiltration of the liver was identified via non-invasive, rapid, and convenient computed tomography examination in an awake cat with a lymphoma.

• 한국임상수의학회지
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• 제36권4호
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• pp.225-228
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• 2019

Inflammatory bowel disease and alimentary lymphoma are common gastrointestinal disorder in cats. More recently, ultrasonographic features associated with feline alimentary lymphoma has been recognized as a diffuse thickening of muscular layer of small intestine. We investigated correlation between thickening of muscular layer of small intestine and such disease. We found a significantly increased thickness of the muscular layer of small intestine in cats with lymphoma or IBD compared with healthy cats. When a muscularis to submucosa ratio > 1 and regional lymphadenopathy were found during ultrasonography on cats with gastrointestinal signs, full-thickness biopsy could be recommended to make sure presence confirmation of inflammatory bowel disease or alimentary lymphoma.

• 한국임상수의학회지
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• 제19권3호
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• pp.337-341
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• 2002

In 2001, eight small-sized dogs and three medium-sized dogs with or without clinical signs such as vomiting, dyspnea and enlargement of superficial lymph nodes were diagnosed as lymphoma by radiography, ultrasonography and cytology. Among them, six were female mainly over 7 years old and others were male around 4 years old. There were six cases of multicentric form lymphoma, three cases of mediastinal form, an alimentary and an extranodal form, respectively. Radiographic findings were enlarged cranial mediastinal lymph node, sternal lymph node, and tracheobronchial lymph nodes on thorax and hepatomegaly, splenomegaly, and enlarged sublumbar lymph nodes on abdomen. Ultrasonographic findings revealed enlarged abdominal lymph nodes and multifocal hypoechoic lesions on the liver. Especially, severe wall thickness of small bowel was observed in a dog with alimentary lymphoma. Three dogs were dead during chemotherapy, and three dogs were dead without any treatment. Three dogs did not return and two treated dog showed normal status. Radiography and ultrasonography, although not giving an final diagnosis for lymphoma, are useful for assessment and diagnosis of lymphoma.

• 대한수의학회지
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• 제52권2호
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• pp.147-151
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• 2012

Radiography, ultrasonography with hydrogram, and contrast studies using radiopaque markers were applied to evaluate alimentary lymphoma in two cats. The hydrogram facilitated the differentiation of pseudo-thickening from true wall thickening, and enabled an evaluation of wall layering and lymph nodes. In case 1, mechanical obstruction of the duodenum was confirmed with barium-impregnated polyethylene spheres (BIPS), a radiopaque marker; however, results obtained in case 2 were not as definitive. We expect that hydrograms and BIPS can be used as valuable alternative methods to evaluate the gastrointestinal (GI) tract although further studies in cases involving GI tumors are needed.

• 한국임상수의학회지
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• 제34권3호
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• pp.193-196
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• 2017

A 14-year-old, castrated male, domestic shorthair cat was referred for gastrointestinal (GI) signs, including nausea, regurgitation, anorexia, and weight loss. Abdominal ultrasonography revealed thickening of the wall of the gastric and proximal duodenum, moderately enlarged mesenteric lymph nodes, and coarse echotexture of the splenic parenchyma. The results of the feline leukemia virus test were positive. Based on gastrointestinal endoscopic characteristics and histopathological examinations, low-grade alimentary lymphoma was identified in multiple regions of the gastrointestinal tract. The patient was treated with oral prednisolone and chlorambucil chemotherapy, and the clinical signs resolved gradually. During serial follow-up, ultrasonographic findings demonstrated decreases in the duodenal wall thickness and size of the abdominal lymph nodes over a period of 550 days. Survival time was 886 days with prednisolone and chlorambucil chemotherapy. This report describes clinical features, imaging findings, endoscopic characteristics, histopathological features, and long-term management with chlorambucil chemotherapy in a case of feline low-grade alimentary lymphoma.

• 대한수의학회지
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• 제47권4호
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• pp.479-482
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• 2007

A 2-year-old spayed female ferret with the clinical signs of diarrhea and anorexia for about 8 days was presented to Hansung animal hospital. The diarrhea was black and paste form. Three palpable abdominal masses were detected in physical examination. By cytologic examination using fine need aspiration, the patient was tentatively diagnosed as lymphoma. Chemotherapy was started with prednisone, vincristine and cyclophosphamide. However, the client requested stopping the therapy at day 18 and the ferret was euthanized. Autopsy was performed and the masses were confirmed as lymphoma by histopathology. Microscopically, the mass consisted of unencapsulated and infiltrative neoplasm consisted of closely packed monomorphic round cells and also ininvasive lesions observed in duodenum. On the higher magnification, pleomorphic neoplastic cells with distinct cell border and abundant eosinophilic cytoplasm were observed. Finally, the ferret diagnosed as alimentary lymphoma.

• 한국동물위생학회지
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• 제39권3호
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• pp.193-197
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• 2016

A 12-years-old Maltese (castrated male) dog with jaundice and purulent discharge from the shoulder was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. A physical and laboratory examination revealed that the mucosa of the conjunctiva and the sclera were icteric, and the liver functional enzyme level and the total bilirubin level were increased. Duodenal caudal deviation caused by suspected masses in diameter of about 2 cm was shown by radiographic and ultrasonographic examinations. Using fine needle aspiration (FNA) and computed tomography (CT), the dog was diagnosed with alimentary lymphoma. The dog was treated with chemotherapy. Hematuria was discovered and dysuria occurred because of sterile hemorrhagic cystitis, which is a unique complication resulting from the use of cyclophosphamide.

• 대한수의학회지
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• 제61권1호
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• pp.8.1-8.10
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• 2021

The purpose of this retrospective study was to describe cases of feline intermediateto high-grade alimentary lymphoma regarding signalment, clinical presentation, laboratory findings, response to therapy (modified 25-week University of Wisconsin-Madison [UW-25] vs. COP [cyclophosphamide, vincristine, prednisone]), toxicosis, and outcomes and to identify prognostic factors. Sixteen cats were treated with chemotherapy protocols. Response rates and survival did not differ statistically between the two protocols. The progression-free interval (PFI) and median survival time (MST) in cats achieving a response to therapy were longer than in those with no response [NR] (complete remission [CR] vs. partial remission [PR] vs. NR; PFI, 124 vs. 49 vs. 12 days, p < 0.001; MST, 361 vs. 118 vs. 16 days, p < 0.001). Clinical stage was another prognostic factor for PFI and MST. The PFI and MST in cats in stage I were longer than in those in other stages (PFI, 107 days vs. 30 days; MST, 193 days vs. 54 days). Hematologic and gastrointestinal toxicosis was mostly low grade. In comparing the modified UW-25 protocol with the COP protocol, there was not much difference in the number of neutropenic episodes and grade levels.

• 대한수의학회지
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• 제62권2호
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• pp.17.1-17.5
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• 2022

A 12-year-old castrated male Persian cat presented with abdominal distension and anorexia. The radiography revealed ascites, pleural effusion, and a cranioventral mediastinal mass. Ultrasonography showed a well-defined mass lesion within a thickened ileal segment with a transmural loss of layering and multiple hyperechoic nodules arising from the peritoneum. Computed tomography showed peritoneal thickening with contrast enhancement, a bulky heterogeneous ileal mass, and mesenteric involvement with diffuse nodules. An alimentary lymphoma was confirmed by fine needle aspiration of the small intestinal mass. This report describes the imaging features of lymphoma with peritoneal lymphomatosis in a cat.