Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Sterile hemorrhagic cystitis occurred by cyclophosphamide therapy in a dog with lymphoma

림프종 이환견에서 Cyclophosphamide 치료에 의한 무균성 출혈성 방광염 발생 증례

  • Yoon, Byung-Gook (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Hyung-Jin (College of Veterinary Medicine, Chungnam National University) ;
  • Han, A-Ram (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (College of Veterinary Medicine, Chungnam National University)
  • 윤병국 (충남대학교 수의과대학) ;
  • 박형진 (충남대학교 수의과대학) ;
  • 한아람 (충남대학교 수의과대학) ;
  • 송근호 (충남대학교 수의과대학)
  • Received : 2016.06.02
  • Accepted : 2016.09.27
  • Published : 2016.09.30
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Abstract

A 12-years-old Maltese (castrated male) dog with jaundice and purulent discharge from the shoulder was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. A physical and laboratory examination revealed that the mucosa of the conjunctiva and the sclera were icteric, and the liver functional enzyme level and the total bilirubin level were increased. Duodenal caudal deviation caused by suspected masses in diameter of about 2 cm was shown by radiographic and ultrasonographic examinations. Using fine needle aspiration (FNA) and computed tomography (CT), the dog was diagnosed with alimentary lymphoma. The dog was treated with chemotherapy. Hematuria was discovered and dysuria occurred because of sterile hemorrhagic cystitis, which is a unique complication resulting from the use of cyclophosphamide.

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References

  1. Bagley CM, Bostick FW, DeVita VT. 1973. Clinical pharmacology of cyclophosphamide. Cancer Res 33: 226-233.
  2. Chabner BA, Meyers CE, Coleman CN, Johns DG. 1975. The clinical pharmacology of antineoplastic agents (second of two parts). N Engl J Med 292: 1159-1168. https://doi.org/10.1056/NEJM197505292922206
  3. Couto CG. 2009. Lymphoma in the cat and dog. pp. 1174-1186. In: Nelson RW, Couto CG (ed.). Small Animal Internal Medicine 4rd ed. Mosby ELSEVIER, St. Louis, Missouri.
  4. Crow SE, Theilen GH, Madewell BR. 1977. Cyclophosphamideinduced cystitis in the dog and cat. J Am Vet Med Assoc 171: 259-262.
  5. Edward MD, Pazzi KA, Gumerlock PH. 1993. c-N-ras is activated infrequently in canine malignant lymphoma. Toxicol Pathol 21: 288-291. https://doi.org/10.1177/019262339302100304
  6. Hayes HM, Tarone RE, Cantor KP, Jessen CR, McCurnin DM, Richardson RC. 1991. Case-control study of canine malignant lymphoma: positive association with dog owner's use of 2,4-dichlorophenoxyacetic acid herbicides. J Natl Cancer Inst 83: 1226-1231. https://doi.org/10.1093/jnci/83.17.1226
  7. Henness AM. 1985. Treatment of cyclophosphamide-induced cystitis (letter). J Am Vet Med Assoc 187: 4-5.
  8. Kalota SJ, Stein PC, Parsons CL. 1992. Prevention of acrolein-induced bladder injury by pentosanpolysulfate. J Urol 148: 163-166. https://doi.org/10.1016/S0022-5347(17)36545-X
  9. Laing EJ, Miller CW, Cochrane SM. 1988. Treatment of cyclophosphamide- induced hemorrhagic cystitis in five dogs. J Am Vet Med Assoc 193: 233-236.
  10. Macy DW, Withrow SJ, Hoopes J. 1983. Transitional cell carcinoma of the bladder associated with cyclophosphamide administration. J Am Anim Hosp Assoc 19: 965-969.
  11. Moulton JE, Harvey JW. 1990. Tumors of lymphoid and hematopoietic tissue. pp. 231-307. In: Mouton JE (ed.). Tumors of Domestic Animals. 3rd ed. University of California Press, Berkeley, California.
  12. Onions D. 1980. RNA dependent DNA polymerase activity in canine lymphosarcoma. Eur J Cancer 16: 345-350. https://doi.org/10.1016/0014-2964(80)90351-5
  13. Ozcan A, Korkmaz A, Oter S, Coskun O. 2005. Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced in rats. Arch Toxicol 79: 461-465. https://doi.org/10.1007/s00204-005-0647-7
  14. Sandhu SS, Goldstraw M, Woodhouse CRJ. 2004. The management of haemorrhagic cystitis with sodium pentosan polysulphate. BJU 94: 845-847. https://doi.org/10.1111/j.1464-410X.2004.05044.x
  15. Stanton ME, Legendre AM. 1986. Effects of cyclophosphamide in dogs and cats. J Am Vet Med Assoc 188: 1319-1322.
  16. Strandstrom HV, Rimaila-Parnanen E. 1979. Canine atypical malignant lymphoma. Am J Vet Res 40: 1033-1034.
  17. Terado M, Nomura M, Mineta K, Nishii H, Fujimoto N, Sasaguri T, Matsumoto T. 2005. Involvement of estrogen in the pathogenesis of cyclophosphamide-induced cystitis in rats. Endocrine 26: 55-63. https://doi.org/10.1385/ENDO:26:1:055
  18. Weller RE, Wolf AM, Oyejide A. 1979. Transitional cell carcinoma of the bladder associated with cyclophosphamide therapy in a dog. J Am Anim Hosp Assoc 15: 733-736.