• 생물정신의학
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• 제4권2호
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• pp.225-233
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• 1997

The authors attempted to examine the allelic association between the A1 allele of Dopamine $D_2$ receptor and schizophrenia, alcoholism, drug addiction in Koreans. Schizophrenic patients(n=31), alcoholism(n=65), drug addiction(n=18) and controls(n=52) were examined by case-control study for distribution of the TaqI polymorphism of the dopamine $D_2$ receptor gene in Korean population to minimize the effect of racial differencies in gene frequencies. In schizophrenics, the numbers of schizophrenics with A1A1, A1A2, A2A2 were 9(29.0%), 15(48.4%) and 7(22.6%) respectively and in alcoholics with A1A1, A1A2, A2A2 were 14(21.5%), 36(55.4%) and 15(23.1%) respectively and in drug addiction with A1A1, A1A2, A2A2 were 2(11.1%), 10(55.6%) and 6(33.3%) respectively and in controls with A1A1, A1A2, A2A2 were 4(7.6%), 24(46.2%) and 24(46.2%) respectively. The prevalence of the A1 allele in schizophrenics, alcoholics, drug addiction and controls were 77%, 76.9%, 67% and 53.8% respectively. And the frequency of the A1 allele in schizophrenics, alcoholics, drug addiction and controls were 0.53, 0.49 0.39 and 0.31 respectively. There was significant difference in the frequency of the A1 allele between schizophrenics, alcoholics and controls. We also classified our alcoholic population. For classification by severity, we used the median MAST score 30 in our samples. There was also significant difference in the frequency of the A1 allele between less severe group(0.42) and more severe group(0.57). This data suggest that the A1 allele is associated with schizophrenia and alcoholism in Koreans. Furthermore the prevalence of the A1 allele increassed in more severely affected alcoholics. The authors conclude that our data support an allelic association between the A1 allele at dopamine $D_2$ receptor and schizophrenia, alcoholism. These results suggest the A1 allele of the $DRD_2$ gene is associated with a number of behavior disorders in which it may act as a modifying gene rather than as the primary etiological agent.

• 대한간호
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• 제10권3호통권53호
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• pp.87-90
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• 1971

• 동의생리병리학회지
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• 제18권2호
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• pp.571-574
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• 2004

Effects of the Cheonggansoyo-san added Injinwiryeong-tang on recovery from damaged-liver and mental-faculty improvement in alcoholism were studied using male Sprague-Dawley rats, The rats were assigned into 4 groups; normal, control and CIX group. Control group administered ethanol(25 v/v %) at a dose 3 g/kg, while CIX group administered the water extract of Cheonggansoyo-san added Injinwiryeong-tang (CIX) 30 min before treating same dose of ethanol as control group for 10 days, orally. The GOT and GPT activities of rats were checked by Reitman & Frankel method, and all groups were subjected to trials of straight channel on the 1 st day and to those of multiple T-maze during the following 3 days. The GOT and GPT activities were increased in control group, but decreased in CIX group significantly. The time required in normal group for the straight channel of the 2nd and 3rd trials was significantly shorter than that of the 1 st, while the control group showed no significance. In the time required for the multiple T-maze trials, the control group showed no significance. But in the straight or T-maze trials, the CIX group showed significant decrease in the time required against the control group.

• 대한예방한의학회지
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• 제22권3호
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• pp.21-29
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• 2018

Objectives : The purpose of this study was to examine the lifestyle of korean medicine students based on their drinking patterns and eating attitudes. Methods : The survey was conducted on 101 korean medicine students to investigate their psychological characteristics. They were asked to complete Self-Administered Alcoholism Screening Test, Eating Attitude Test, and Minnesota Multiphasic Personality Inventory-2. Results : A total of 101 Korean medical students participated in the study. Non-drinker 19, drinker were 82. Unlikely to, possible and potential alcoholism 79(78.2%), 17(16.8%) and 5(5%) respectively. The mean and standard deviation of SAAST in the subjects were $3.88{\pm}3.33$ and the EAT score was $8.09{\pm}8.693$. There was a significant difference in the MMPI-2 items between non-drinker and drinker. The SAAST had an effect on the EAT score(${\beta}=0.319$). Conclusions : As a result of MMPI-2 test, in the potential alcoholism group, scale D, Mf, Si, INTR, TPA, SOD, Mt and GF were shown higher, and AAS and GM were shown lower than the normal group. In the bad eating attitude group, scale Hy, RC4, DISC and AA were shown higher than the good eating attitude group.

• 생물정신의학
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• 제9권1호
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• pp.42-49
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• 2002

Objective:This study was to explore the relation of genetic polymorphisms of ALDH2 and CYP2E1 to clinical characteristics of alcoholic patients and alcohol induced liver damage. Methods:The genotype and allele frequencies of 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 healthy male control subjects. The genetic informations of ALDH2 and CYP2E1 were identified with the technique of polymerase chain reaction and restriction fragment length polymorphism. The clinical characteristics of the alcoholic patients were assessed and analyzed in relation to the family history of alcoholism. For the relation of CYP2E1 genetic polymorphism to the liver damage, the blood levels of various liver function indicators such as ALT, AST, and protein were checked out. Results:1) The alcoholic patients with the family history of alcoholism had the earlier onset of age (p=0.001), the longer duration of illness(p=0.045), and higher NCA scores(p=0.018) than those without the family history of alcoholism. 2) Most alcoholic patients were homozygous for $ALDH2^*1$, compared to control subjects.(p=0.000) 3) There was no difference of CYP2E1 distribution between alcoholic patients and control subjects. However, alcoholic patients having mutant c2 allele showed higher alcoholism severity scores(p=0.004) and more hospitalizations(p=0.014) than those having c1 allele. 4) There was no relationship between CYP2E1 genotype and the functional abnormalities of the liver. Conclusion:This study suggests that $ALDH2^*1$ is highly related with alcohol dependence. Also mutant c2 allele of CYP2E1 is correlated with the severity of alcoholism and the number of hospitalization. But genetic polymorphim of CYP2E1 seems to have no relation to liver damages.

• 문화기술의 융합
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• 제4권1호
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• pp.165-174
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• 2018

본 연구는 성인 ADHD 성향이 자아존중감과 알코올 중독에 미치는 영향을 알아보는데 그 목적이 있다. 이를 위하여 대구광역시 및 경상북도에 소재하고 있는 성인 433명을 대상으로 한 결과는 다음과 같다. 첫째, 성인 ADHD 성향에 따라 자아존중감과 알코올 중독의 차이를 알아본 결과, 자아존중감과 알코올 중독의 하위요인에서 모두 유의한 차이가 있었으며, 성인 ADHD가 높을수록 자아존중감의 상위집단의 점수가 낮았고, 알코올 중독은 상위집단의 점수가 높았다. 둘째, 성인 ADHD 성향과 자아존중감 및 알코올 중독의 상관관계를 알아본 결과, 자아존중감은 높은 음의 상관관계를 보였고 알코올 중독은 낮은 양의 상관관계를 보였으며, 하위요인에 따라 차이가 있었다. 셋째, 성인 ADHD 성향이 자아존중감과 알코올 중독에 미치는 영향을 살펴본 결과, 하위요인에 따라 차이가 있었다. 따라서 성인 ADHD 성향이 자아존중감과 알코올 중독의 이차적인 문제에 영향을 미친다는 것을 알 수 있었다. 즉, 낮은 자아존중감과 알코올 중독의 원인이 ADHD가 될 수 있고 이는 다각적이고 통합적인 예방과 치료프로그램 개발이 필요하다는 것을 시사한다.

• 한국콘텐츠학회논문지
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• 제21권5호
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• pp.981-995
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• 2021

본 연구는 단주를 유지하고 있는 알코올 사용장애자의 단주기간에 따른 인구사회학적 특성과 알코올의존 회복, 삶의 질, 임파워먼트, 자아존중감의 차이를 확인하고 그 관계를 비교 연구하였다. 연구대상자는 전국 7개 지역을 중심으로 알코올 사용장애로 진단받은 후 단주 중인 알코올 사용장애자 207명이었다. 선행연구 결과를 바탕으로 207명을 단주 1년 미만, 1년-5년 미만, 5년 이상으로 구분하여 분석한 결과, 집단 간 차이에 영향을 주는 인구사회학적 특성은, 성별, 나이, 결혼 여부, 경제활동 여부였고, 1년 미만의 단주자들보다 1년 이상 단주를 유지하는 단주자들의 알코올의존 회복, 삶의 질, 임파워먼트, 자아존중감 모든 요인에서 높은 점수가 확인되었다. 그리고 단주기간을 불문하고 모든 단주자들에게서 알코올의존 회복, 삶의 질, 임파워먼트, 자아존중감이 서로 유의미한 양의 상관관계를 보였다. 따라서 본 연구 결과를 통해 장기적인 단주에 영향을 주는 요인들과 단주의 효과를 알 수 있었고 이런 요인들을 고려한 알코올의존 회복 프로그램이나 치료적 중재의 필요성을 제안하였다.

• 동의신경정신과학회지
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• 제3권2호
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• pp.127-141
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• 1992

• 한국간호교육학회지
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• 제20권3호
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• pp.362-371
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• 2014

Purpose: The aim of this study was to describe the experiences of student nurses during their clinical practice periods in an alcoholic ward. Methods: A descriptive phenomenological study design was employed. Individual interviews were conducted and audio-taped. Colaizzi's method of data analysis was applied to inductively determine themes and formulated meanings. Data saturation was achieved and methodological rigor was established. Results: Four themes were identified and these themes included anxiety of nursing practice in unfamiliar setting, sympathy with patients, learning about the inpatient alcoholics care, and self-reflection. Conclusion: Nursing students had positive and negative experiences in their clinical practice. The results of this study had important implications regarding clinical practice and research for nursing clinical education.

• 동의신경정신과학회지
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• 제14권2호
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• pp.169-181
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• 2003

In oriental medicine, Psychotherapy has been regarded as a part of physical therapy that seemed inseparable from psychological therapy from old times. Oriental Medical Psychotherapies are like following: Ii-Gyeung-Byun-Qi therapy(移精變氣療法), Oh- Ji-Sang-Seung therapy(五志相勝療法), Kyeongja- pyeongji therapy(驚者平之療法), Jieongoron therapy(至言高論療法) and so on. The special feature of these Psychotherapies is the unification of body and mind. For them, various oriental therapies have been under progress. Especially, Many Oriental Medical Psychotherapist insisted that pain of mind evoke pain of body, or vice versa. We observed Oriental Medical Psychotherapies to treat married couple and had a good result. Husband had alcoholism and wife had functional headache. Especially, wife wanted divorce. The problems of divorce and illness in married couple were resolved from Oriental Medical Psychotherapies.