• The Korean Journal of Pain
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• 제4권2호
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• pp.111-121
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• 1991

It has been well known that the splanchnic nerve block is effective for patients who suffer from intractable upper abdominal pain. However, it is unclear whether the effect of the splanchnic nerve block depends on varied alcoholic concentration. In this study, an attempt was made to use absolute ethanol on patients who recieved a splanchnic nerve block at Severance Hospital during the period from September l990 to April l991. The results are as follows; 1) Among the 33 patients, including 22 males and 1l females, the fifties and sixties were the major age groups. 2) Stomach cancer was the most common underlying disease(13 cases), with pancreatic can- cer next(9 cases). 3) The main locations of pain were the upper abdomen, epigastrium, and entire abdomen in decreasing order. 4) There were 17 cases who had had chemotherapy, and 1l cases of whom had had surgery before the splanchnic nerve block. 5) The volume of alcohol used was 12 ml bilaterally. 6) Among the 33 patients, 15.2% required a second block within two weeks of the first block. One case required a third block. 7) The most common complications of splanchnic nerve block were hypotension(33.3%), occasional transient sharp burning pain, flushing of face, pain on injection site, nausea, vomiting, dyspnea, chest discomfort and diarrhea. 8) The supplemental block most commonly used was a continuous epidural block. It was used both as a diagnostic block and to afford relief from pain before the splanchnic nerve block was done. 9) The interval between the receiving the absolute ethanol block and discharge was within 2 weeks in l5 cases. But, in the patients with poor general health, the interval between the splanchnic nerve block and discharge prolonged. The above results suggest that bilateral splanchnic nerve block done with absolute ethanol after an effective test block with 1% lidocaine under C-arm fluroscopic control is satisfactory and reliable. Still, 26.6% of the patients received a repeat block within 2 weeks. Insufficient spread of ethanol due to its small volume seems to be a major factor in the repeat block. Minimizing the incidence of repeat block remains a problem to be solved.

• 한국보건간호학회지
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• 제7권1호
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• pp.49-65
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• 1993

This study had conducted to push our society for getting some proper measures of the anti-drug abuse and adopting this study as a fundamental data for the school health education. Sample subjects were the 3rd grade of high school in Chungnam Province and the number were 1,014. The data had been collected on Dec. 3th-8th, 1990 according to the tool of Institute on Drug Abuse of Korea. And then Frequency and $x^2-test$ were need to analyse of data by SPSS-X program. The results of this study could be summarized as follows. 1. They had used 14 kinds of drugs: $70.1\%$ of the subjects students used alcohol, $69.2\%$ analgesics, $38.6\%$ cigarette, $15.0\%$ stimulants, $14.7\%$ antitussives, $11.2\%$ antithistamines, $8.9\%$ hypnotics, $7.1\%$tranquilizers, $4.2\%$ inhalants, $2.3\%$ marijuana, $1.4\%$ hallucinogens, $0.9\%$ cocaine, $0.6\%$ amphetamines, and $0.6\%$narcotics. The boys' drug using rate is higher than girls' except in analgesics and stimulants. 2. With respect to misbehaving, $43.0\%$ of the students said they had pop houses, $42.4\%$ adult video, $17.4\%$ unexcused absence from school, $11.0\%$ dangerous weapon, $9.1\%$ sexual intercourse, $70.1\%$ disappearance from home, 8.0% blackmail, and $6.0\%$ assault. In every kinds of misbehaving, the boys' misbehaving rate is higher than the girls'. 3. Almost every kinds of drugs have the students first used at the age of 15 through. 18. And $13.8\%$ of the students smoked every da·y and $1.7\%$ drank every day. 4. The frequency of the drug using such as cigarette (p<.01), marijuana (p<.05), cocaine (p<.05) and narcotics (p<.05) showed the stastically significant differences according to the religions of the subjects 5. The subjects who has complaints about someone use more drugs than the ones who doesn't, and who doesn't have any complaints about five elements have never used drugs such as marijuana, cocaine, amphetamines, narcotics, hallucinogens, and inhalants. 6. The drug using subjects have the more experiences of adult video, pop houses, and unexcused absent from school than the non-drug using ones. It means that the subjects who use drug were apt to do misbehaving more often than the ones who have never used them, and delinquent boys and girls use more drugs.

• 한국산학기술학회논문지
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• 제20권11호
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• pp.446-457
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• 2019

본 연구의 목적은 청소년 남학생 흡연과 가족구성원의 흡연의 관련성을 분석하기 위함이다. '제14차(2018년) 청소년건강행태조사'에 응답한 27,276명을 이용하여 빈도분석, 교차분석, 다중 로지스틱 회귀분석을 실시하였다. 남학생 중 비흡연율은 91.5%, 흡연율은 8.5%(가끔 흡연함 2.5%, 자주 흡연함 6.0%)이다. 연구결과, 가족구성원의 흡연자 수에 따른 남학생의 흡연 상태는 유의한 차이가 있다(p<0.001). 인구사회학적 특성에 따른 흡연은 학년, 학업성적, 경제상태, 아버지 학력, 어머니 학력에서 유의한 차이가 있고(p<0.001), 건강행태관련 특성에 따른 흡연은 음주 정도, 자살 생각률, 우울감 경험률, 스트레스 정도, 아침식사 빈도, 수면 후 피로회복 정도, 주관적 건강 인지 정도에서 유의한 차이가 있다(p<0.001). 남학생의 흡연가능성은 가족구성원 흡연자가 1명일 때보다 가족구성원 흡연자가 2명이상일 때 더 높다(p<0.001). 본 연구의 의의는 남학생 흡연이 가족구성원 흡연상태에 따라 영향을 받는다는 것을 확인하였으며 이러한 연구결과는 청소년 흡연의 예방 및 금연사업을 구성할 때 가족 흡연자의 금연 사업을 병행하여 설계한다면 좋은 효과를 거둘 수 있음을 시사한다.

• 대한한의학원전학회지
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• 제29권1호
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• pp.17-41
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• 2016

Subjects : A literature research on the constitution and medicinal effect & adaptation diseases of "Bullsusan". "Bullsusan" is a herbal prescription composed of Angelicae Gigantis Radix(當歸) and Cnidii Rhizoma(川芎). Objectives : Through the researching on the records of "Bullsusan" in Korean Traditional Medical Books, gain the literature evidence for adaptation to these days child labor as a pre-labor keeping herbal medicine. And have detailed consideration on the constitution of prescription and medicinal effect & adaptation diseases of "Bullsusan". Methods : First, researched the records of "Bullsusan" in Korean Traditional Medical Books which were included at A Series of Korean Medicine(韓國醫學大系) and analysed component ratio, nickname, herbal manufacture and drug processing method, medicinal effect and adaptation diseases. Second, referred related Korean and Chinese researches that examined the medicinal effect and adaptation diseases of "Bullsusan" by scientific experimentation. Conclusions : We found total 46 records of "Bullsusan" from 20 kinds of Korean Traditional Medical Books included at A Series of Korean Medicine. Prescription component ratio of Angelicae Gigantis Radix and Cnidii Rhizoma were 3:2, 1:1, 2:1, 1:1. 3:2 had most 20 records and 1:1 had second 14 records. Especially 1:1 had a tendency of having nickname "Goonguitang", but not must had. First herbal manufacture was powder, it had 8 records. First drug processing method was decocting with water and alcohol, had 19 records. Medical Effects of "Bullsusan" can be induced to next 8, that were "remove get bad blood, give birth new blood", "easy labor by reducing fetal volume", "acceleration of labor", "test of fetal survival, elimination of dead embryo", "elimination of placenta", "revive", "allaying pain", "nourish the blood". From these medical effects, 9 adaptation diseases can be induced. That were "threatened abortion", "womb ache and vaginal bleeding by spontaneous abortion", "pre-labor keeping(prevention of hard labor)", "acceleration of labor", "hard labor", "missed abortion", "postnatal vaginal bleeding, dizziness, asthma, headache, womb ache", "postnatal mastoptosis and mastodynia", "first aid symptom like as dizziness, unconsciousness, stroke caused by excessive bleeding". The medical effect of "acceleration of labor" and "elimination of placenta" have been examined by modern clinical research. The effect of "remove get bad blood, give birth new blood", "allaying pain" and "nourish the blood" have been examined by modern experimental study. But overdosing on "Bullsusan" to pregnant mouse can cause natural abortion, so the proper dose of "Bullsusan" in pregnant period is very important.

• 한국산학기술학회논문지
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• 제16권1호
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• pp.418-428
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• 2015

본 연구는 뇌졸중에 영향을 미치는 요인과 매개효과를 파악하여 뇌졸중 질환자의 올바른 건강행태를 유도하고 이에 따른 뇌졸중 질환 예방의 기초자료를 제공하고자 하였다. 자료는 국민건강영양조사 4기 및 5기 데이터를 이용하였으며 분석방법은 빈도분석과 다중로지스틱회귀분석 및 구조방정식 분석을 실시하였다. 분석결과 남자의 경우 뇌졸중에 영향을 미치는 인구사회학적 특성으로는 연령, 직업, 주관적 건강상태, 음주, 고혈압과 당뇨병 유무 변수이었고, 여자의 경우는 연령, 직업, 주관적 건강상태, 스트레스 정도, 고혈압 유무이었다. 건강행태가 뇌졸중 여부에 영향을 미치는 과정에서 선행질환은 부분매개 모형과 완전매개 모형의 ${\chi}^2$ 값의 차이가 5.80으로 통계적으로 유의하여(p<0.01), 부분매개 효과가 있는 것으로 분석되었다. 뇌졸중 예방을 위해 잘못된 건강행태를 변화시키기 위한 예방적 건강 교육과 건강관리 네트워크를 강화할 수 있는 정책이 필요하며, 선행질환이 있는 경우 건강상태에 대한 장기적인 진단 및 지속적인 생활습관개선이 필요하다.

• 동의생리병리학회지
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• 제18권2호
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• pp.528-533
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• 2004

The immune system acts to protect the host from infectious agents that exist in the environment and from other noxious insults. The immune system has two functional divisions: the innate and the acquired. Both components involve various factors such as cytokines. A number of methodologies exist to assess aspects of immune function. There are large inter-individual variations in many immune functions even among the healthy. Genetics, age, gender, smoking habits, habitual levels of exercise, alcohol consumption, diet, stage in the female menstrual cycle, stress, history of infections and vaccinations, and early life experiences are likely to be important contributors to the observed variation. While it is clear that individuals with immune responses significantly below 'normal' are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality, it is not clear how the variation in immune function among healthy individuals relates to variation in susceptibility to infection. Oriental medicine is an important factor contributing to immune competence. The author investigated the immune enhancement effects of Bojungikkitanggami-bang (BITB). The forced swimming test (FST) has been used as a screening model for new immune enhancement agents. In the present study, the author investigated the effects of BITB on FST and blood biochemical parameters related to fatigue, glucose (Glc); blood urea nitrogen (BUN); lactate dehydrogenase (LDH); creatinine; and total protein (TP). The author found that BITB (1 g/kg) significantly reduced the immobility time in the FST compared to the control. In addition, the contents of Glc, LDH, BUN, TP in the blood serum were increased in BITB (1g/kg)-fed group. Also, the author investigated the effects of BITB on the production of cytokines in human T-cell line, MOLT-4 cells. BITB (1 mg/ml) significantly increased the interferon (IFN)-vproduction compared with media control (about 2.2-fold for IFN-γ) at 24 h. However, BITB has not affect the production of IL-2 and IL-4. In addition, BITB increased the protein expression level of IFN-γ in MOLT-4 cells. Thus, BITB may have therapeutic value in generating or enhancing immune function in a clinical setting.

• Applied Biological Chemistry
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• 제30권3호
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• pp.201-209
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• 1987

흡착제에 대한 식용색소의 흡착특성을 구명하기 위해 6종 색소의 여러 용액을 흡착제와 작용시켜 흡착특성과 영향요소를 조사하였다. Kaolin은 적색(赤色)2호(號)의 증류수(蒸溜水), active carbon은 적색(赤色)2호(號), 3호(號)40호(號) 등(等)의 증류수(蒸溜水), 인공위액(人工胃液), 인공장액(人工腸液), 황색(黃色)4호(號)의 증류수(蒸溜水), 인공위액(人工胃液), 황색(黃色)5호(號)의 인공장액(人工腸液), natural aluminum silicate는 적색(赤色)3호(號)의 증류수(蒸溜水), 인공장액(人工腸液), 황색(黃色) 4호(號), 5호(號)의 증류수(蒸溜水) 등에선 Freundlich 식(式)에 일치(一致)하였다. 또한 talc는 적색(赤色) 2호(號), 3호(號), 황색(黃色)5호(號)의 증류수(蒸溜水), 인공위액(人工胃液), 인공장액(人工腸液), 적색(赤色)40호(號)의 증류수(蒸溜水), 인공위액(人工胃液), 황색(黃色)4 의 인공장액(人工腸液)에서 각각(各各) Langmuir식(式)에 일치(一致)하였다. 그리고 ethanol-water mixture에서는 알코올 비율이 낮을수록 흡착(吸着)이 잘 되며 흡착(吸着)에 미치는 온도의 영향은 온도(溫度)가 증가함에 따라 흡착량(吸着量)은 감소하였다. 또한 각(各) 식품착색제(食品着色劑)의 흡착(吸着) 활화(活化)에너지의 크기순서는 황색(黃色)5호(號) > 황색(黃色)4호(號)> 적색(赤色)2호(號) > 적색(赤色)40호(號) > 적색(赤色)3호(號)의 순(順)이었다.

• 한국식품과학회지
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• 제39권3호
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• pp.309-314
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• 2007

멥쌀에 홍국 쌀을 각각 0, 10, 20, 30, 40% 첨가하여 제조한 약주의 이화학적 특성 및 관능적 특성의 변화를 조사하였다. 홍국 쌀 첨가량의 증가에 따라 pH는 감소되었고 총산의 함량은 증가된 것으로 나타났다. 총당의 함량은 홍국 쌀 첨가량의 증가에 따라 증가하였고 알코올 함량은 감소하였다. 색도 중 L값은 홍국 쌀 첨가량의 증가에 따라 감소되었으나 a와 b값은 증가한 것으로 나타났다. 향기성분은 esters, aldehydes, alcohols, acids로 분류되었고 과일향의 주성분인 esters의 함량은 10% 홍국 쌀을 첨가한 시험구에서 제일 많이 생산된 것으로 나타났다. 관능검사 결과 전체적 기호도에서 10% 홍국 쌀을 첨가하여 제조한 약주가 제일 우수한 것으로 나타났다. 이화학적 특성이나 관능적 특성으로 보아 10% 홍국 쌀을 첨가하는 약주를 제조하는 것이 적합하다고 생각된다.

• 보험의학회지
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• 제2권1호
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• pp.135-142
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• 1985

For the past 10 years, the socioeconomic status of our country was markedly improved. Accordingly, our foodintake patterns and other alt parts are preparing to blance with developed countries. Especially, be westernizing or improving our foodintake patterns, we intake much fat diet(animal food) while our physical activities decrease and alcohol consumtion's population, smoking population gradually increase. For such reasons, the population of obese tendency and cardiovascular diseases are increased. According to recent reports, among all death causes in our country, cardiovascular diseases(hypertension, hypertensive cardiovascular diseases, ischemic heart diseases) occupyd top rank, we know. I(the author) studied the inter-relation between serum cholesterol level which is the important factor of the cardiovascular diseases and essential hypertension liver diseases, hyperglycemia, some cardiac problems which are main decline causes in life insurance's medical assessment, and body weight distribution. Studied samples were selected on 4,313 cases(male; 1,791, female; 2,522) who were tested liver function test from June, 11th, 1980 to Dec., 31st, 1983 on our medical department's laboratory. I selected two groups in those cases: one group was serum cholesterol level 180mg/dl over(11% of whole LFT examed cases: No=502 cases), the other group was serum cholesterol level 120-160mg/dl(No= 502 cases). For convenience, the group of serum cholesterol level 180mg/dl over was "A" the other group was "B", I described. All examed persons of LFT were resident m Tae-Jon city in that time. On the result, 1) Decline rate is 10.5% on the "A" group, 5.9% on the "B" group. "A" group reveals 1.8 times higher than "B" group. 2) On decline causes, Essential hypertension is 4.0 times higher on the "A" group than "B", liver function's abnormalities are 2.0 times higher on "A" group than "B" and other diseases are same on "A" and "B". On the "A" group, essential hypertension is considerably higher than "B" group. 3) On the body weight distribution, the cases of 70kg(B.W.) over is 19.7% on "A", 10.6% on "B" group. Obese tendency is 1.8 folds higher on "A" group than "B" group. Studing the result, we find high serum cholesterol concentration is closely related with essential hypertension, obese tendency and liver function's abnormalities on the life insurance's medical examination part, also. On the future, we will more carefully consider the serum cholesterol concentration on our medical examnination and assessment of life insurance, I think.

• Applied Biological Chemistry
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• 제51권4호
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• pp.281-287
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• 2008

저식염 고추장 제조시 알콜 또는 알콜에 겨자나 키토산을 혼합 첨가한 고추장을 1년간 숙성시켜, $30^{\circ}C$에서 12주간 저장하면서 미생물상과 이화학적 특성 변화를 비교하였다. 고추장의 amylase 활성은 저장 중에 급격히 감소하였고, 저온살균 처리구에서 낮았다. 산성 protease 활성은 저장 중에 증가하였으나 중성 protease는 저장 4주 이후에 서서히 감소하였다. 고추장 중의 효모수는 저장 중에 조금 증가하였으나 세균수는 감소하는 경향이었고, 시험구간의 차이는 없었다. 고추장의 색은 저장 중에 a값은 감소하였으나 L-과 b-값은 저장 4주에 증가한 후에 감소하였고, ${\Delta}E$값의 변화는 4주에 제일 심하였다. 고추장의 수분과 수분활성도는 저장 중에 감소하였으며 수분활성도는 부원료 첨가구들에서 높았다. 고추장의 pH는 저장 중에 저하하였으나, 적정산도는 저장 4주 이후에는 감소하였으며 알콜에 겨자나 키토산을 혼합 첨가한 고추장에서 높았다. 산화환원전위는 저장 4주에 증가하였으나 그 이후에는 감소하였고 부원료 첨가구에서 낮았다. 총당과 환원당은 저장 중에 감소하였으나 부원료 첨가구에서 높았다. 알콜은 저장 중에 증가하나 알콜 첨가구들은 감소하였다. 아미노태 질소와 암모니아태 질소 함량은 저장 중에 감소하였으며 부원료 첨가 고추장에서 아미노태 질소 함량이 낮았다. 따라서 부원료를 첨가한 저식염 고추장을 장기간 숙성시키면 저장 중에 가스 발생이 없어 유통 중에 포장용기의 파열이나 변색이 적고, 환원당과 아미노태 질소의 감소가 적어 품질저하 요인이 상대적으로 적은 것으로 판단되었다.