• 대한수의학회지
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• 제57권3호
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• pp.147-154
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• 2017

The present study was performed to evaluate the hangover relieving effect of germinated buckwheat (GB) and Sanghwang mushroom mycelium cultured in GB (SGB). Both GB and SGB showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities and significantly increased (p < 0.001) aldehyde dehydrogenase (ALDH) activities; up to 140% increase at concentrations of $16{\mu}L/mL$. Locomotor activity test results from alcohol-SGB and alcohol-GB groups showed improved motor activities over that of the alcohol-water group at 90 min post-administration. Both alcohol-GB and alcohol-SGB groups had significantly reduced (p < 0.001) alcohol ($40.02{\pm}33.38{\mu}g/mL$, $66.01{\pm}22.04{\mu}g/mL$, respectively) and aldehyde ($5.72{\pm}0.47{\mu}g/mL$, $6.72{\pm}1.70{\mu}g/mL$, respectively) concentrations in blood compared to those in the alcohol-water group ($199.75{\pm}33.83{\mu}g/mL$, $50.43{\pm}13.88{\mu}g/mL$, respectively) at 90 min post-administration. Based on cDNA microarray analysis, expressions of ALDH genes ALDH1a7 and ALDH18a1 and cytochrome P450 (CY450) gene CYP4a30b were upregulated in the alcohol-GB and alcohol-SGB groups compared to levels in the control group. Overall, the results suggest that both GB and SGB have hangover relieving effects by reducing blood acetaldehyde levels. The molecular mechanisms may involve ALDH activation and upregulated expression of alcohol metabolism-related genes such as ALDH and CYP450.

• 한국콘텐츠학회논문지
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• 제18권11호
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• pp.550-561
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• 2018

본 연구의 목적은 알코올중독 예방을 위한 조기개입 프로그램이 성인 문제음주자의 알코올지식, 음주결과기대 및 음주거절효능감에 미치는 효과를 평가한 후 현장 적용 가능성을 살펴보는데 있다. 본 연구는 비동등성 대조군 전 후 설계를 이용한 유사실험연구이며, 연구 대상은 현재 직업을 유지중인 남성 중 알코올사용장애 선별 검사(AUDIT) 결과상 12-25점이다. 조기개입 프로그램 참여자는 실험군 13명, 대조군 12명 총 25명으로 실험군은 4회기 조기개입 프로그램에 참여하였고, 대조군은 알코올 자료집만 제공받았다. 통계분석은 Chi-square test, t-test, Mann-Whitney U test를 활용하였다. 조기개입 프로그램에 참여한 실험군은 대조군보다 알코올지식(t=1.258, p= .002), 부정적 음주결과기대(t=-1.346, p= .042) 및 음주거절효능감(t=2.817, p= .010)이 유의하게 증가되었다. 향후 문화적 특성을 고려한 문제음주자 선정 기준의 적용, 참여자 모집과 동기면담을 활용한 동기증진 개입이 필요할 것이다. 특히 문제음주에 대한 인식을 제고하기 위하여 웹 기반 알코올정보 제공 프로그램도 도움이 될 것이다. 문제음주자가 쉽게 접근할 수 있는 지역사회 현장에서 조기개입 프로그램이 적용되기를 기대한다.

• 한국안광학회지
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• 제20권2호
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• pp.187-193
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• 2015

목적: 현행법상 음주 단속의 측정기준이 되는 호흡 알코올 농도(BrAC) 증가가 시력과 타각적 굴절검사 값에 미치는 영향을 알아보고자 하였다. 방법: 23명의 20대 남성(평균연령 $21.17{\pm}2.19$세, BMI $22.09{\pm}2.16$)을 대상으로 호흡 알코올 농도 0%, 0.05%, 0.08%에서 원 근거리 시력검사와 개방형 자동굴절력계를 이용한 타각적 굴절검사를 시행하였다. 결과: 호흡 알코올 농도가 증가할수록 원거리 시력은 통계적으로 유의하게 감소하였고 근거리 시력은 변화하지 않았다. 또한 호흡 알코올 농도가 증가할수록 타각적 굴절검사 값은 (-) 방향으로 증가하는 경향을 보였다. 결론: 음주로 인한 호흡 알코올 농도 증가는 교정시력의 감소와 교정굴절력이 (-) 방향으로 증가하는 원인이 될 수 있으므로 시력검사와 굴절검사는 비음주상태에서 진행해야 할 필요성이 있다.

• 동국한의학연구소논문집
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• 제5권
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• pp.187-196
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• 1996

Alcohol is a major risk factor for several diseases and especially excessive, long-term alcohol consumption are caues the damage of immunity such as the inhibiton of secretion of lymphokine and proliferation of immune component cell. This study observed that the inhibition of T lymphocytic differentiation and secretion of interleukin 2(IL-2) induced in thymus of ICR mouse by chronic alcohol administration. After 8% alcohol voluntary administered for 120 days, the thymic tissue immunohistochemically stained by following ABC method that used monoclonal antibody including L3T4(CD4), Ly-2(CD8), and IL-2 receptor(CD25R) after embedding with paraffin. The results were as follows. 1. The size of thymic medulla in test group reduced than control group. 2. The number of helper T lymphocyte, cytotoxic T lymphocyte, and IL-2 receptor were decreased in thymic medulla and cortico-medullary junction of test group and the degree of CD4, CD8, and CD25R positive reaction were soften in test group. These results indicated that the secretion of IL-2 in thymus was inhibited by chronic alcohol administration and subsequently prevent to differentiate from thymocytes to T lymphocytes. As this view, cell mediated immunity were reduced by chronic alcohol administration.

• 대한의용생체공학회:의공학회지
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• 제43권1호
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• pp.27-34
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• 2022

Drunk driving defines a driver as unable to drive a vehicle safely due to drinking. To crack down on drunk driving, alcohol concentration evaluates through breathing and crack down on drinking using S-shaped courses. A method for assessing drunk driving without using BAC or BrAC is measurement via biosignal. Depending on the individual specificity of drinking, alcohol evaluation studies through various biosignals need to be conducted. In this study, we measure biosignals that are related to alcohol concentration, predict BrAC through SVM, and verify the effectiveness of the S-shaped course. Participants were 8 men who have a driving license. Subjects conducted a d2 test and a scenario evaluation of driving an S-shaped course when they attained BrAC's certain criteria. We utilized SVR to predict BrAC via biosignals. Statistical analysis used a one-way Anova test. Depending on the amount of drinking, there was a tendency to increase pupil size, HR, normLF, skin conductivity, body temperature, SE, and speed, while normHF tended to decrease. There was no apparent change in the respiratory rate and TN-E. The result of the D2 test tended to increase from 0.03% and decrease from 0.08%. Measured biosignals have enabled BrAC predictions using SVR models to obtain high Figs in primary and secondary cross-validations. In this study, we were able to predict BrAC through changes in biosignals and SVMs depending on alcohol concentration and verified the effectiveness of the S-shaped course drinking control method.

• 한국안광학회지
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• 제13권2호
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• pp.59-62
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• 2008

목적: 알코올 섭취 후 시간경과에 따른 시력변화를 알아보고자 하였다. 방법: 음주 1시간 및 3시간 후의 자각적 타각적 굴절검사, 원거리 대비감도 검사, 그리고 세막대 입체시 검사를 실시하였다. 결과: 혈중 알코올 농도의 상승과 비례하여 평균 -0.25D ~ -0.35D의 근시성 변화를 일으켰고, 동적입체시 기능이 저하되는 것으로 나타났다. 그러나 대비감도는 모든 공간주파수에서 큰 변화가 없는 것으로 나타났다. 결론: 알코올이 일반적인 시력검사 및 기능검사에 영향을 끼친다는 사실을 숙지하고 피검자의 검사 전 알코올 음용에 대해 문진할 필요성이 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6571-6574
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• 2014

Background: Alcohol is well established as a risk factor for cancer development in many organ sites. To assess the reliability and validity of the Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) for detecting alcohol use disorders or risky drinking in Japanese adults the present study was conducted. Materials and Methods: A test-retest method was applied with a 2-week interval with 113 health care employees. The k coefficient, Cronbach's coefficient alpha, Spearman's correlation coefficient, and intraclass correlation coefficient (ICC) were determined and the validity of the AUDIT-C was analyzed using the data from a nationwide survey on adult alcohol use conducted in 2008 (n=4,123). Results: The reliability of the AUDIT-C score was high (${\kappa}$ coefficient=0.63, Cronbach's alpha=0.98, correlation coefficient=0.95, and ICC=0.95). According to the likelihood ratio and Youden index, appropriate cutoffs for the AUDIT-C were ${\geq}5points$ in men and ${\geq}4$ points in women. The sensitivity and specificity of these cutoffs for identifying ${\geq}8$ points on the AUDIT were 0.88 and 0.80, respectively, for men (positive likelihood ratio [LR+]=4.5) and 0.96 and 0.87, respectively, for women (LR+=7.7). The sensitivity and specificity of the cutoffs for identifying ${\geq}12$ points on the AUDIT were 0.90 and 0.84, respectively, for men (LR+=5.8) and 0.93 and 0.94, respectively, for women (LR+=15.8). The sensitivity and specificity of the cutoffs for identifying ${\geq}16$ points on the AUDIT were 0.93 and 0.80, respectively, for men (LR+=4.7) and 0.92 and 0.98, respectively, for women (LR+=55.6). With higher scores on the AUDIT, the specificity decreased and false-positives increased. The appropriate cutoffs for identifying risky drinking were the same for both genders. Conclusions: The reliability and validity of the AUDIT-C are high, indicating that it is useful for identifying alcohol use disorders or risky drinking among the general population in Japan, a group at high risk of cancer development.

• Journal of Korean Biological Nursing Science
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• 제17권4호
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• pp.363-371
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• 2015

Purpose: The purpose of this study was to assess alcohol and caffeine intake and identify the impact of alcohol and caffeine intake on body mass index, alcohol use disorder, and quality of sleep among university students. Methods: This study design was accomplished with a cross sectional survey and conducted from May to June 2014. One hundred and twenty-four freshmen of E university in S city, Korea were selected and evaluated by self-administered questionnaires. Alcohol and caffeine intake were measured by self-reported recall. The data were analyzed using descriptive analysis, independent t-test, one-way ANOVA, Pearson's correlation, and multiple linear regression. Results: The average amount of alcohol intake was $175.02{\pm}219.97g$ and the proportion of freshmen who took in more than 40 g per day of alcohol was 75%. The average amount of caffeine intake was $116.79{\pm}111.14mg$. Factors influencing alcohol use disorder were dwelling type (t=2.25, p=.027) and alcohol intake (t=8.11, p<.001). And, the factor influencing quality of sleep was caffeine intake (t=3.88, p<.001). Conclusion: In order to reduce the harmful drinking of university students, preventive activities for freshmen are required and efforts on the part of the school needed.

• 한국식생활문화학회지
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• 제26권2호
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• pp.101-112
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• 2011

The objective of this study was to examine alcohol consumption rates and the perception of drinking cultures among college students in the Wonju area. An examination of factors such as frequency of drinking, average quantity consumed, and frequency of heavy drinking suggested that the drinking rates were relatively high. Over 70% of subjects drank at least once a week, 66.2% typically drank more than 5 servings at a time, and 19.2% of males and 13.0% of females were heavy drinkers. It was revealed from an AUDIT (Alcohol Use Disorder Identification Test) assessment that 71.3% of the subjects tested had various levels of alcohol-related problems. These problems were more severe in subjects that were male, selfboarding, or overweight. Alcohol related knowledge was not high because the subjects didn't know or incorrectly recognized some contents such as blood alcohol concentration, the energy content of alcohol, and the empty caloric characteristics of alcohol. Generally male, self-boarding, and overweight persons were not critical of the undesirable characteristics associated with drinking culture. Two opinions that were generally considered to be permissible were: 'Men should be able to drink' and 'Drinking is essential for a smooth human relationship'.

• 한국보건간호학회지
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• 제23권1호
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• pp.17-26
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• 2009

Purpose: In this study, the effects of an alcohol education program for elderly persons with drinking problems and the effects of knowledge of the behavior associated with alcohol use by elderly individuals with drinking problems were evaluated. Method: A single-group repeated study was conducted to evaluate 19 elderly individuals with drinking problems who used the G-city Elderly Welfare Center, with more than eight points in AUDIT results. The changes in drinking knowledge and alcohol behavior following an alcohol education program were evaluated. The effectiveness of the program was analyzed by a Wilcoxon signed rank test. and the relationship between drinking knowledge and changes in alcohol behavior was measured by Spearman's rank correlation coefficient. Results: The results indicated that drinking knowledge after conducting education increased significantly(Z=-3.826, p<.001), and that this increased knowledge resulted in significant changes in alcohol behavior(Z=-3.830, p<.001). There was a significantly positive relationship between drinking knowledge and changes in alcohol behavior(r=.464, p=0.013). Conclusion: Alcohol education programs effectively educate the elderly with drinking problems regarding alcohol, which influences their alcohol behavior.